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31. 再颁专利

USRE42603E1 Poultry processing hub and belt assembly 失效
标题翻译：家禽加工中心和皮带组装
公开(公告)号：USRE42603E1
公开(公告)日：2011-08-09
申请号：US12012460
申请日：2008-02-01
申请人： Robert Clarke
发明人： Robert Clarke
IPC分类号： A22C21/02
CPC分类号： A22C21/02 , F16H55/171 , F16H55/30 , F16H55/49
摘要： This invention relates to a hub and belt assembly for driving a poultry de-feathering machine and more particularly to a multiple bearing heat dissipating hub driven by a serrated timing belt. The hub assembly incorporates seals along a drive shaft to reduce wear caused by dirt. The timing belt synchronizes multiple picking hubs and reduces the friction driving required. The combination of a heat dissipating hub and the placement of seals along the drive shaft within the hub minimize maintenance and replacement.
摘要翻译：本发明涉及一种用于驱动家禽脱毛机的轮毂和带组件，更具体地涉及由锯齿同步带驱动的多轴承散热毂。轮毂组件沿着驱动轴包括密封件，以减少由污垢引起的磨损。同步带同步多个采摘轮毂，减少了所需的摩擦力。散热毂与密封件沿毂内的驱动轴的组合最小化维护和更换。

32. 发明授权

US07754242B2 Inhalable sustained therapeutic formulations 有权
标题翻译：可吸入的持续治疗配方
公开(公告)号：US07754242B2
公开(公告)日：2010-07-13
申请号：US10392333
申请日：2003-03-19
申请人： Sujit K. Basu , Giovanni Caponetti , Robert Clarke , Katharina J. Elbert
发明人： Sujit K. Basu , Giovanni Caponetti , Robert Clarke , Katharina J. Elbert
IPC分类号： A61K9/16 , A61K9/12
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/1617 , A61K31/40 , A61K31/438 , A61K31/46 , A61K45/06
摘要： The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. Specifically, particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that contain a phospholipid or combination of phospholipids, wherein the phospholipid or combination of phospholipids is present in the particles in an amount of about 1 to 46 weight percent; and leucine, wherein leucine is present in the particles in an amount of at least 46 weight percent, can contribute to sustained effect of the agent. Particles that comprise at least 46 weight percent leucine but that do not contain phospholipids do not exhibit these same sustained effect properties.
摘要翻译：本发明部分地基于意想不到的发现，即用于肺部递送包含磷脂和足够量的亮氨酸的治疗性，预防性或诊断剂的颗粒可以产生药剂的持久作用。具体地，用于肺部递送含有磷脂或磷脂组合的治疗性预防或诊断剂的颗粒，其中磷脂或磷脂组合以约1至46重量％的量存在于颗粒中; 和亮氨酸，其中亮氨酸以至少46重量％的量存在于颗粒中，可有助于药剂的持续作用。包含至少46重量百分比的亮氨酸但不含磷脂的颗粒不具有这些相同的持续作用特性。

33. 发明申请

US20070270502A1 Formulations decreasing particle exhalation 有权
标题翻译：减少颗粒呼气的配方
公开(公告)号：US20070270502A1
公开(公告)日：2007-11-22
申请号：US11714999
申请日：2007-03-06
申请人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
发明人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
IPC分类号： A61K47/00
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/14 , A61K9/141 , A61K9/16 , A61M15/00
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或降低人类感染病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫等疾病或减轻过敏或其他肺部疾病症状的传染性的制剂疾病。用于肺部给药的制剂包括显着改变诸如等渗盐水和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以作为液体溶液，悬浮液，气雾剂或粉末施用，其中颗粒基本上由渗透活性的溶质组成。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

34. 发明申请

US20070105675A1 POULTRY PROCESSING HUB AND BELT ASSEMBLY 审中-公开
标题翻译： POULTRY加工中心和皮带组装
公开(公告)号：US20070105675A1
公开(公告)日：2007-05-10
申请号：US11615446
申请日：2006-12-22
申请人： Robert Clarke
发明人： Robert Clarke
IPC分类号： F16H55/30 , F16H7/00
CPC分类号： A22C21/02 , F16H55/171 , F16H55/30 , F16H55/49
摘要： A hub and belt assembly for driving a poultry de-feathering machine includes multiple bearing heat dissipating hub driven by a serrated timing belt. The hub assembly incorporates seals along a drive shaft to reduce wear caused by dirt. The timing belt synchronizes multiple picking hubs and reduces the friction driving required. The combination of a heat dissipating hub and the placement of seals along the drive shaft within the hub minimize maintenance and replacement.
摘要翻译：用于驱动家禽脱毛机的轮毂和皮带组件包括由锯齿同步皮带驱动的多个轴承散热毂。轮毂组件沿着驱动轴包括密封件，以减少由污垢引起的磨损。同步带同步多个采摘轮毂，减少了所需的摩擦力。散热毂与密封件沿毂内的驱动轴的组合最小化维护和更换。

35. 发明申请

US20070053844A1 FORMULATIONS FOR ALTERATION OF BIOPHYSICAL PROPERTIES OF MUCOSAL LINING 审中-公开
标题翻译：用于改变粘膜内衬生物学特性的配方
公开(公告)号：US20070053844A1
公开(公告)日：2007-03-08
申请号：US11419165
申请日：2006-05-18
申请人： Wiwik Watanabe , Matthew Thomas , Jeffrey Katstra , Robert Clarke
发明人： Wiwik Watanabe , Matthew Thomas , Jeffrey Katstra , Robert Clarke
IPC分类号： A61K48/00 , A61K9/14 , A61L9/04
CPC分类号： A61K33/14 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/007 , A61K9/0078 , A61K31/255 , A61K31/721 , A61K47/02 , A61K47/12 , Y02A50/475
摘要： Conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment, and methods of use, have been developed. One or more active agents, such as antivirals, antimicrobials, anti-inflammatories, proteins or peptides, may optionally be included with the formulation. The active agent may be administered with or incorporated into the formulation, or may be administered after the conductive formulation is administered. When applied to mucosal lining fluids, the formulation alters the physical properties such as the surface tension, surface elasticity, and bulk viscosity of the mucosal lining. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. The formulations may be administered for several different purposes: reducing the spreading of infectious diseases, both viral and bacterial, such as SARS, influenza, tuberculosis, and RSV in humans and hoof and mouth disease in cloven-tooted animals; minimizing ambient contamination due to particle formation during breathing, coughing, sneezing, or talking which is particularly important in the clean room applications; decreasing or preventing the occurrence of obstructive sleep apnea and some cases of irritable bowel syndrome; and controlling the uptake kinetics of drug molecules and pathogens.
摘要翻译：已经开发了含有导电剂，例如盐，离子表面活性剂或处于电离状态或容易在水溶液或有机溶剂环境中离子化的其它物质的导电配方，以及使用方法。制剂中可以任选地包括一种或多种活性剂，例如抗病毒剂，抗微生物剂，抗炎剂，蛋白质或肽。活性剂可以与制剂一起施用或掺入制剂中，或者可以在施用导电制剂后施用。当施用于粘膜衬里液时，制剂会改变物理性质，如粘膜内衬的表面张力，表面弹性和体积粘度。该制剂的施用量足以改变身体粘膜内衬的生物物理性质。制剂可以用于几种不同的目的：减少感染性疾病，包括病毒和细菌，如SARS，流行性感冒，结核病和RSV在人类和蹄和口腔疾病的蔓延的动物; 在洁净室应用中特别重要的是在呼吸，咳嗽，打喷嚏或说话期间由于颗粒形成造成的环境污染最小化; 减少或预防阻塞性睡眠呼吸暂停和一些肠易激综合征的发生; 并控制药物分子和病原体的吸收动力学。

36. 发明申请

US20060240598A1 Chip scale package 有权
标题翻译：芯片级封装
公开(公告)号：US20060240598A1
公开(公告)日：2006-10-26
申请号：US11405801
申请日：2006-04-18
申请人： Martin Standing , Robert Clarke
发明人： Martin Standing , Robert Clarke
IPC分类号： H01L21/00
CPC分类号： H01L21/50 , H01L23/10 , H01L23/492 , H01L24/33 , H01L24/83 , H01L2224/26175 , H01L2224/291 , H01L2224/2919 , H01L2224/32245 , H01L2224/73153 , H01L2224/73253 , H01L2224/83191 , H01L2224/83192 , H01L2224/83194 , H01L2224/83801 , H01L2224/83851 , H01L2924/01005 , H01L2924/01029 , H01L2924/01033 , H01L2924/01047 , H01L2924/0105 , H01L2924/01068 , H01L2924/01079 , H01L2924/014 , H01L2924/0665 , H01L2924/13055 , H01L2924/13091 , H01L2924/16152 , H01L2924/00
摘要： A method for manufacturing a semiconductor package that includes forming a frame inside a conductive can, the frame being unwettable by liquid solder.
摘要翻译：一种制造半导体封装的方法，包括在导电罐内部形成框架，所述框架由液体焊料不可控制。

37. 发明申请

US20050209101A1 Process and apparatus for fluid bed reactions 审中-公开
标题翻译：流化床反应的方法和装置
公开(公告)号：US20050209101A1
公开(公告)日：2005-09-22
申请号：US11124141
申请日：2005-05-09
申请人： Stanley Becker , Timothy Bristow , Robert Clarke , Michele Fiorentino , David Newton , Ian Reid , Bruce Williams
发明人： Stanley Becker , Timothy Bristow , Robert Clarke , Michele Fiorentino , David Newton , Ian Reid , Bruce Williams
IPC分类号： B01J8/24 , B01J8/18 , B01J8/22 , C07B61/00 , C07C51/215 , C07C51/25 , C07C53/08 , C07C67/05 , C07C67/055 , C07C69/12 , C07C69/15 , C07C253/24 , C07C253/26 , C07C255/08 , C08G85/00
CPC分类号： C07C253/26 , B01J8/1818 , B01J8/22 , B01J2208/00115 , B01J2208/00884 , B01J2219/00263 , C07C51/215 , C07C51/252 , C07C253/24 , Y02P20/582 , C07C57/145 , C07C53/08 , C07C255/08
摘要： A process and apparatus for contacting (a) at least one gaseous reactant and (b) at least one liquid selected from the group consisting of reactants, coolants and mixtures thereof in the presence of a fluidised bed of catalyst, in which the liquid is introduced into the reactor through at least one inlet located within the fluidisation zone and the gaseous reactant is introduced into the reactor through at least one inlet located within the fluidisation zone adjacent the support means.
摘要翻译：一种用于在（a）至少一种气体反应物和（b）在其中引入液体的催化剂流化床的存在下将选自反应物，冷却剂及其混合物的至少一种液体接触的方法和装置通过位于流化区内的至少一个入口进入反应器，并且通过位于邻近支撑装置的流化区内的至少一个入口将气态反应物引入反应器。

38. 发明申请

US20050020847A1 Integrated process for the manufacture of alkenyl carboxylates 失效
标题翻译：用于制备链烯基羧酸盐的综合方法
公开(公告)号：US20050020847A1
公开(公告)日：2005-01-27
申请号：US10500305
申请日：2002-12-04
申请人： Robert Clarke , Mark Roberts
发明人： Robert Clarke , Mark Roberts
IPC分类号： C07C67/05 , C07B61/00 , C07C51/215 , C07C53/08 , C07C67/00 , C07C67/54 , C07C69/01 , C07C69/15
CPC分类号： C07C67/54 , C07C5/48 , C07C51/215 , C07C51/46 , C07C67/055 , Y02P20/125 , Y02P20/582 , C07C69/15 , C07C53/08 , C07C11/04
摘要： An integrated process for the production of an alkenyl carboxylate, such as vinyl acetate which process comprises the steps of (a) contacting in an oxidation reaction zone a C2 to C4 alkane, such as ethane, a molecular oxygen-containing gas, optionally the corresponding alkene and optionally water, in the presence of a catalyst to produce a stream comprising alkene, carboxylic acid and water; (b) separating at least a portion of the stream from step (a) into a fraction comprising the alkene and a fraction comprising the carboxylic acid and water; (c) contacting in a second reaction zone at least a portion of said alkene fraction produced in step (b), a carboxylic acid and a molecular oxygen-containing gas, in the presence of a catalyst to produce a product stream comprising an alkenyl carboxylate, water and carboxylic acid; (d) separating at least a portion of the product stream from step (c) and at least a portion of the carboxylic acid and water fraction produced in step (b) by azeotropic distillation into an overhead fraction comprising the alkenyl carboxylate and a base fraction comprising the carboxylic acid; (e) recovering the alkenyl carboxylate from the overhead fraction separated in step (d).
摘要翻译：一种用于生产烯基羧酸酯如乙酸乙烯酯的整合方法，其方法包括以下步骤：（a）在氧化反应区中使C2至C4烷烃如乙烷，含分子氧的气体，任选相应的烯烃和任选的水，在催化剂的存在下，产生包含烯烃，羧酸和水的流; （b）将来自步骤（a）的物流的至少一部分分离成包含烯烃的馏分和包含羧酸和水的级分; （c）在第二反应区中在催化剂存在下使步骤（b）中产生的所述烯烃馏分的至少一部分与羧酸和含分子氧的气体接触以产生包含链烯基羧酸酯的产物流，水和羧酸; （d）通过共沸蒸馏将步骤（c）中的产物流的至少一部分和步骤（b）中产生的羧酸和水部分的至少一部分分离成包含烯基羧酸酯和碱部分的塔顶馏分包含羧酸; （e）从步骤（d）中分离的塔顶馏分回收烯基羧酸酯。

39. 发明授权

US6143737A Progesterone analogs to reverse multidrug resistance 失效
标题翻译：孕酮类似物反向多药耐药
公开(公告)号：US6143737A
公开(公告)日：2000-11-07
申请号：US667542
申请日：1996-06-21
申请人： Robert Clarke , Abdel H. Talebian , Alem Ghiorghis , Fabio Leonessa , Charles Hammer
发明人： Robert Clarke , Abdel H. Talebian , Alem Ghiorghis , Fabio Leonessa , Charles Hammer
IPC分类号： C07J41/00 , A61K31/57 , C07J31/00
CPC分类号： C07J41/005
摘要： The present invention is directed to compounds of formula I ##STR1## wherein the substituents are as defined in the specification. Also disclosed are compositions and method of use of the compounds.
摘要翻译：本发明涉及式I化合物，其中取代基如说明书中所定义。还公开了化合物的组合物和使用方法。

40. 发明授权

US5733336A Ported tissue implant systems and methods of using same 失效
标题翻译：移植组织植入物系统及其使用方法
公开(公告)号：US5733336A
公开(公告)日：1998-03-31
申请号：US413309
申请日：1995-03-30
申请人： Steven Neuenfeldt , James Brauker , Robert Clarke
发明人： Steven Neuenfeldt , James Brauker , Robert Clarke
IPC分类号： A61B5/00 , A61F2/02 , A61K9/22 , A61L27/38 , A61L27/56 , A61L29/00 , A61L29/14 , C12M3/06
CPC分类号： A61L29/146 , A61F2/022 , A61L27/38 , A61L27/56 , A61L29/005 , A61B5/14532 , Y10S623/902
摘要： A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for forming a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.
摘要翻译：提供了一种用于在主机中植入细胞的方法和装置。在一个实施例中，提供了一种用于宿主组织的植入物组件，其包括限定用于保持用于植入的细胞的室的壁装置，壁装置包括用于在宿主组织和腔室中的植入细胞之间形成多孔边界的装置，的边界足以将植入的细胞与宿主组织的免疫应答隔离，以及用于提供对腔室的选择性接近的端口装置。

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