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31. 发明授权

US08973234B2 Assembly and method for loading a self-expanding collapsible heart valve 有权
标题翻译：装载自扩张式可折叠心脏瓣膜的装配和方法
公开(公告)号：US08973234B2
公开(公告)日：2015-03-10
申请号：US13234688
申请日：2011-09-16
申请人： Michael A. Johnson , Valerie J. Glazier , Huisun Wang
发明人： Michael A. Johnson , Valerie J. Glazier , Huisun Wang
IPC分类号： B25B27/00 , A61F2/95 , A61F2/24
CPC分类号： A61F2/2436 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2002/9522 , A61F2210/0014 , A61F2210/0028 , A61F2250/0039 , B23P11/025 , Y10T29/49863 , Y10T29/49865 , Y10T29/49927 , Y10T29/53909 , Y10T137/0402
摘要： An assembly for collapsing a prosthetic heart valve includes a compression member and a pusher member. The compression member has a first open end with a first diameter, a second open end with a second diameter less than the first diameter, and a tapered wall between the first open end and the second open end. The pusher member has a base adapted to engage an end of the valve. The pusher member and the compression member are movable relative to one another between an initial position in which the base of the pusher member is relatively far from the first open end of the compression member and an operative position in which the base of the pusher member is relatively close to the first open end of the compression member. Movement of the pusher and compression members from the initial position to the operative position radially compresses the valve.
摘要翻译：用于塌陷假体心脏瓣膜的组件包括压缩构件和推动构件。压缩构件具有第一直径的第一开口端，具有小于第一直径的第二直径的第二开口端和在第一开口端和第二开口端之间的锥形壁。推动器构件具有适于接合阀的端部的基座。推动器构件和压缩构件可以在其中推动器构件的基部相对于压缩构件的第一开口端相对较远的初始位置和推动构件的基座的操作位置之间相对于彼此移动相对靠近压缩构件的第一开口端。推动器和压缩构件从初始位置到操作位置的移动径向地压缩阀。

32. 发明申请

US20140005772A1 PROSTHETIC HEART VALVE FORMATION 有权
标题翻译：先天性心脏瓣膜形成
公开(公告)号：US20140005772A1
公开(公告)日：2014-01-02
申请号：US13932968
申请日：2013-07-01
申请人： Peter Edelman , Horng-Ban Lin , Scott Fisher , Jeffrey S. Lindquist , Huisun Wang , Richard C. Gunderson
发明人： Peter Edelman , Horng-Ban Lin , Scott Fisher , Jeffrey S. Lindquist , Huisun Wang , Richard C. Gunderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/24 , A61F2/2415 , A61F2/2418 , A61F2210/0076 , A61F2250/0014 , A61F2250/0018 , A61F2250/0028 , A61F2250/0036 , A61F2250/0037 , A61L27/18 , A61L27/34 , A61L2430/20 , B05B7/0408 , B05B7/0416 , B05B7/0433 , B05B7/0466 , B05B12/00 , B05B12/1454 , B05B13/0207 , B05B13/0627 , B05D1/02 , B05D7/222 , B05D2254/02 , B33Y80/00 , Y10T29/49405 , C08L75/04 , C08L83/04
摘要： A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets. Each leaflet includes) at least two polymers along at least one portion of the leaflet, and each leaflet has a composition gradient of each of the at least two polymers along at least one portion of the leaflet.
摘要翻译：假体心脏瓣膜包括基部和多个聚合单张。每个小叶具有连接到基部的根部分，并且每个小叶具有基本上与根部相对的边缘部分，并且相对于根部部分可移动以与多个传单中的至少一个其他传单中的至少一个的相应边缘部分配合。每个小叶包括）沿着小叶的至少一部分的至少两种聚合物，并且每个小叶具有沿着小叶的至少一部分的每种至少两种聚合物的组成梯度。

33. 发明授权

US08439909B2 Cooled ablation catheter with reciprocating flow 有权
标题翻译：冷却消融导管与往复流动
公开(公告)号：US08439909B2
公开(公告)日：2013-05-14
申请号：US13093508
申请日：2011-04-25
申请人： Huisun Wang , Jeremy D. Dando
发明人： Huisun Wang , Jeremy D. Dando
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00035 , A61B2018/00196 , A61B2018/0022 , A61B2218/002
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow blood and other biological fluids to flow into and out of an inner cavity of the electrode. This fluid flow produced the desired cooling effect and is accomplished, for example, by a reciprocating plunger or piston, or by a balloon that is alternately inflated and deflated.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管电极上生物流体的凝结，防止与电极接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许增加消融产生的病变大小。电极包括定位成允许血液和其他生物流体流入和流出电极的内腔的通道。该流体流产生期望的冷却效果，并且例如通过往复式柱塞或活塞或交替地膨胀和放气的气球来实现。

34. 发明申请

US20130073032A1 EXPANDABLE RADIOPAQUE MARKER FOR TRANSCATHETER AORTIC VALVE IMPLANTATION 有权
标题翻译：可扩展的放射性标记用于运输管道动脉瓣植入
公开(公告)号：US20130073032A1
公开(公告)日：2013-03-21
申请号：US13552929
申请日：2012-07-19
申请人： Huisun Wang
发明人： Huisun Wang
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/06 , A61F2/24 , A61F2/2427 , A61F2/243 , A61F2/246 , A61F2210/0014 , A61F2250/0098
摘要： A delivery device for a collapsible prosthetic heart valve includes a support shaft around which a compartment for the valve is defined, a distal sheath adapted to selectively cover and uncover the compartment and the valve, and a marker cage having a collapsed condition when the distal sheath covers the compartment and an expanded condition when the compartment is uncovered. The marker cage includes at least one rib having a radiopaque marker for determining the positioning of the valve as it is deployed. The valve may be assembled around the marker cage so that the marker cage does not interfere with the radial expansion of the valve during deployment.
摘要翻译：用于可折叠假体心脏瓣膜的递送装置包括支撑轴，围绕所述支撑轴定义用于所述瓣膜的隔室，所述远侧护套适于选择性地覆盖和暴露所述隔室和所述瓣膜;以及标记器保持架，当所述远端鞘当隔间未被覆盖时，覆盖隔间和膨胀状态。标记器保持架包括至少一个具有不透射线标记的肋，用于确定在其部署时阀的定位。阀可以围绕标记器保持架组装，使得标记器保持架不会在展开期间干扰阀的径向膨胀。

35. 发明授权

US08221409B2 Thermally insulated irrigation catheter assembly 有权
标题翻译：绝热冲洗导管组件
公开(公告)号：US08221409B2
公开(公告)日：2012-07-17
申请号：US11962600
申请日：2007-12-21
申请人： Hong Cao , Huisun Wang
发明人： Hong Cao , Huisun Wang
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00083 , A61B2018/00101 , A61B2218/002
摘要： The present invention relates to ablation electrode assemblies. The present invention further relates to an insulated irrigated ablation electrode assembly. The insulated irrigated ablation electrode assembly of the present invention includes a proximal member, a distal member and an intermediate thermally insulating member. The proximal member includes a body portion defined by an outer surface, an inner cavity defined within the outer body portion, and at least one passageway that extends from the inner cavity to the outer surface of the body portion. The distal member of the electrode assembly includes a distal end. Moreover, the intermediate member of the electrode assembly is disposed between the proximal member and the distal member thereby thermally insulating the proximal member from the distal member.
摘要翻译：本发明涉及消融电极组件。本发明还涉及绝缘灌溉消融电极组件。本发明的绝缘灌溉消融电极组件包括近端构件，远侧构件和中间隔热构件。近端构件包括由外表面限定的主体部分，限定在外主体部分内的内腔以及从内腔延伸到主体部分的外表面的至少一个通道。电极组件的远端构件包括远端。此外，电极组件的中间构件设置在近端构件和远端构件之间，从而使近端构件与远端构件热绝缘。

36. 发明授权

US08216225B2 Irrigated ablation electrode assembly having a polygonal electrode 有权
标题翻译：具有多边形电极的灌注消融电极组件
公开(公告)号：US08216225B2
公开(公告)日：2012-07-10
申请号：US11962617
申请日：2007-12-21
申请人： Huisun Wang , Harry A. Puryear
发明人： Huisun Wang , Harry A. Puryear
IPC分类号： A61B18/14 , A61N1/00
CPC分类号： A61B18/1492 , A61B2218/002
摘要： An irrigated ablation electrode assembly includes a substantially polygonal shaped electrode. The electrode assembly includes a proximal portion having an outer body portion including an outer distal end surface and an inner cavity within the outer body portion. The proximal portion of the electrode assembly further includes at least one passageway for fluid that extends from the inner cavity of the proximal member to the outer distal end surface of the proximal member. The electrode assembly further includes a distal portion defined by a substantially polygonal shaped body. Irrigation fluid flows from the inner cavity of the proximal portion through the passageway and out an orifice provided on the outer distal end surface of the proximal portion. The fluid that exits the passageway flows substantially parallel to the distal portion, therein improving the irrigation of the electrode.
摘要翻译：灌溉消融电极组件包括基本上多边形的电极。电极组件包括具有外主体部分的近端部分，外部主体部分包括外部远端表面和外部本体部分内的内部空腔。电极组件的近端部分还包括至少一个用于流体的通道，该通道从近端构件的内腔延伸到近端构件的外远端表面。电极组件还包括由基本上多边形的主体限定的远侧部分。灌注流体从近端部分的内腔经过通道流出并且设置在近端部分的外远端表面上的孔口。离开通道的流体基本上平行于远端部分流动，从而改善了电极的冲洗。

37. 发明授权

US08167845B2 Catheter having distal sealing member 有权
标题翻译：导管具有远端密封构件
公开(公告)号：US08167845B2
公开(公告)日：2012-05-01
申请号：US12476539
申请日：2009-06-02
申请人： Huisun Wang , Dale Just
发明人： Huisun Wang , Dale Just
IPC分类号： A61M5/178
CPC分类号： A61B5/0422 , A61B1/0008 , A61M25/00 , A61M2025/0079
摘要： A catheter includes a proximal end, a distal end, a tubular member, and an inner member extending through the tubular member. The inner member is movable axially relative to the tubular member. The catheter also includes a seal member including a first portion and a second portion. The seal member extends between the tubular member and the inner member. The first portion of the seal member remains stationary relative to the tubular member, and the second portion of the seal member remains stationary relative to the inner member during relative axial movement between the tubular member and the inner member.
摘要翻译：导管包括近端，远端，管状构件和延伸穿过管状构件的内部构件。内部构件可相对于管状构件轴向移动。导管还包括密封构件，其包括第一部分和第二部分。密封构件在管状构件和内部构件之间延伸。密封构件的第一部分相对于管状构件保持固定，并且密封构件的第二部分在管状构件和内部构件之间的相对轴向移动期间相对于内部构件保持静止。

38. 发明申请

US20110202054A1 Cooled ablation catheter with reciprocating flow 有权
公开(公告)号：US20110202054A1
公开(公告)日：2011-08-18
申请号：US13093508
申请日：2011-04-25
申请人： Huisun Wang , Jeremy D. Dando
发明人： Huisun Wang , Jeremy D. Dando
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00035 , A61B2018/00196 , A61B2018/0022 , A61B2218/002
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow blood and other biological fluids to flow into and out of an inner cavity of the electrode. This fluid flow produced the desired cooling effect and is accomplished, for example, by a reciprocating plunger or piston, or by a balloon that is alternately inflated and deflated.

39. 发明申请

US20110160721A1 Irrigated Catheter Employing Multi-Lumenal Irrigation Tubing 有权
标题翻译：灌溉导管采用多腔灌注管
公开(公告)号：US20110160721A1
公开(公告)日：2011-06-30
申请号：US12650956
申请日：2009-12-31
申请人： Huisun Wang , Dale E. Just , Harry A. Puryear
发明人： Huisun Wang , Dale E. Just , Harry A. Puryear
IPC分类号： A61M25/00 , A61M1/00 , A61B18/18 , B23P17/04
CPC分类号： A61M25/007 , A61B18/1492 , A61B2018/00214 , A61B2218/002 , A61M25/0009 , A61M25/003 , A61M25/0071 , A61M2025/0037 , Y10T29/49826
摘要： An irrigated catheter includes a catheter body having both proximal and distal irrigation passageways. A first fluid delivery tube feeds the proximal irrigation passageway and is fluidly isolated from the distal irrigation passageway, while a second fluid delivery tube feeds the distal irrigation passageway and is fluidly isolated from the proximal irrigation passageway. Typically, the first and second fluid delivery tubes will be unitary, at least through the catheter body. The overall shape of the first and second fluid delivery tubes, as well as their respective lumens, may vary as necessary for a particular application of the irrigated catheter. The system also includes an irrigation fluid source and at least one pump to deliver the irrigation fluid through the irrigation passageways. Typically, the pump will be a volume-driven pump, such as a rolling pump.
摘要翻译：灌注导管包括具有近端和远端冲洗通道的导管体。第一流体输送管馈送近端冲洗通道并与远端冲洗通道流体隔离，而第二流体输送管馈送远端冲洗通道并与近侧冲洗通道流体隔离。通常，第一和第二流体输送管将至少通过导管本体是一体的。第一和第二流体输送管的总体形状以及它们各自的内腔可以根据灌溉导管的特定应用的需要而变化。该系统还包括冲洗流体源和至少一个泵，以通过冲洗通道输送冲洗流体。通常，泵将是体积驱动的泵，例如滚动泵。

40. 发明授权

US07951143B2 Cooled ablation catheter with reciprocating flow 失效
标题翻译：冷却消融导管与往复流动
公开(公告)号：US07951143B2
公开(公告)日：2011-05-31
申请号：US11646255
申请日：2006-12-28
申请人： Huisun Wang , Jeremy D. Dando
发明人： Huisun Wang , Jeremy D. Dando
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00035 , A61B2018/00196 , A61B2018/0022 , A61B2218/002
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow blood and other biological fluids to flow into and out of an inner cavity of the electrode. This fluid flow produced the desired cooling effect and is accomplished, for example, by a reciprocating plunger or piston, or by a balloon that is alternately inflated and deflated.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管电极上生物流体的凝结，防止与电极接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许增加消融产生的病变大小。电极包括定位成允许血液和其他生物流体流入和流出电极的内腔的通道。该流体流产生期望的冷却效果，并且例如通过往复式柱塞或活塞或交替地膨胀和放气的气球来实现。

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