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31. 发明授权

US08754238B2 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto 有权
标题翻译：二芳基和芳基杂芳基脲衍生物作为可用于预防和治疗与之相关的疾病的5-HT2A 5-羟色胺受体的调节剂
公开(公告)号：US08754238B2
公开(公告)日：2014-06-17
申请号：US10895789
申请日：2004-07-21
申请人： Bradley Teegarden , Honnappa Jayakumar , Hongmei Li , Sonja Strah-Pleynet , Peter Ian Dosa
发明人： Bradley Teegarden , Honnappa Jayakumar , Hongmei Li , Sonja Strah-Pleynet , Peter Ian Dosa
IPC分类号： C07D231/12
CPC分类号： A61K31/415 , A61K31/4155 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D231/16 , C07D401/12 , C07D405/12
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the prophylaxis or treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders and the like.The present invention also relates to the method of prophylaxis or treatment of 5-HT2A serotonin receptor mediated disorders in combination with a dopamine D2 receptor antagonist such as haloperidol, administered separately or together.
摘要翻译：本发明涉及式（I）的某些吡唑衍生物及其药物组合物，其调节5-HT2A 5-羟色胺受体的活性。化合物及其药物组合物涉及可用于预防或治疗血小板聚集，冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，中风，心房颤动，降低血块形成风险，哮喘或其症状的方法，激动或症状，行为障碍，药物诱发的精神病，兴奋性精神病，杜蕾特勒杜勒特综合征，躁狂症，有机或非精神病精神病，精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症和精神分裂症以及相关疾病和睡眠障碍，睡眠障碍，糖尿病相关疾病等。本发明还涉及与单独或一起施用的多巴胺D2受体拮抗剂如氟哌啶醇组合预防或治疗5-HT2A 5-羟色胺受体介导的病症的方法。

32. 发明授权

US08673900B2 Gamma secretase modulators 有权
标题翻译：伽玛分泌酶调节剂
公开(公告)号：US08673900B2
公开(公告)日：2014-03-18
申请号：US13128493
申请日：2009-11-12
申请人： Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Jun Qin , Xiaoxiang Liu , Hongmei Li , Wei Zhou , Anandan Palani , Xiaohong Zhu , Monica L. Vicarel , Mihirbaran Mandal , Zhong-Yue Sun , Chad E. Bennett , Troy Michael McCracken , Gioconda V. Gallo
发明人： Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Jun Qin , Xiaoxiang Liu , Hongmei Li , Wei Zhou , Anandan Palani , Xiaohong Zhu , Monica L. Vicarel , Mihirbaran Mandal , Zhong-Yue Sun , Chad E. Bennett , Troy Michael McCracken , Gioconda V. Gallo
IPC分类号： C07D471/04 , C07D498/04 , A61K31/5395
CPC分类号： C07D471/04 , C07D498/04
摘要： In many embodiments, the present invention provides novel heterocyclic compounds which are modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译：在许多实施方案中，本发明提供了新的杂环化合物，其为γ-分泌酶的调节剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及治疗方法，使用这些化合物或药物组合物预防，抑制或改善与中枢神经系统相关的一种或多种疾病。

33. 发明申请

US20130274463A1 PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS 有权
标题翻译：制备MACROLACTAMS的过程和中间件
公开(公告)号：US20130274463A1
公开(公告)日：2013-10-17
申请号：US13993541
申请日：2011-12-13
申请人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
发明人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
IPC分类号： C07D498/16 , C07D209/44 , C07C271/56 , C07C309/85 , C07C311/47 , C07D403/12 , C07C309/80
CPC分类号： C07D498/16 , C07C271/22 , C07C271/24 , C07C271/56 , C07C309/80 , C07C309/85 , C07C311/47 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D209/44 , C07D403/12 , C07D498/18 , C07K5/06034
摘要： The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
摘要翻译：本发明涉及大分子内酰胺化合物，可用于制备大内酰胺的中间体，制备中间体的方法以及制备和改性大环内酯的方法。本文所述的化合物和方法的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。可以使用本文所述方法合成的HCV抑制化合物的实例是化合物A及其衍生物。

34. 发明申请

US20120210283A1 ANALYSIS OF COMPENSATED LAYOUT SHAPES 失效
标题翻译：补偿布局形状分析
公开(公告)号：US20120210283A1
公开(公告)日：2012-08-16
申请号：US13026451
申请日：2011-02-14
申请人： Hongmei Li , Richard Q. Williams
发明人： Hongmei Li , Richard Q. Williams
IPC分类号： G06F17/50
CPC分类号： G06F17/5018 , G06F17/5068
摘要： The disclosure relates to the analysis of compensated layout shapes. A method in accordance with an embodiment includes: analyzing a semiconductor layout using a bucket structure, the layout including a semiconductor device; and applying a pattern template to a content of the bucket structure to identify a shape adjacent to the semiconductor device; wherein the pattern template is derived from layout groundrules.
摘要翻译：本公开涉及补偿布局形状的分析。根据实施例的方法包括：使用铲斗结构分析半导体布局，所述布局包括半导体器件; 以及将图案模板应用到所述桶结构的内容以识别与所述半导体器件相邻的形状; 其中，图案模板是从布局基本原理中导出的。

35. 发明申请

US20110306593A1 GAMMA SECRETASE MODULATORS 有权
标题翻译： GAMMA秘密调节器
公开(公告)号：US20110306593A1
公开(公告)日：2011-12-15
申请号：US13128316
申请日：2009-11-11
申请人： Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
发明人： Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
IPC分类号： A61K31/553 , C07D498/10 , C07D498/04 , A61P25/28 , C07D413/14 , C07D498/14 , A61K31/5395 , C07D498/20 , C07D413/10
CPC分类号： C07D498/04 , C07D409/14 , C07D413/10 , C07D498/14 , C07D498/20
摘要： In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compostions.
摘要翻译：在其许多实施方案中，本发明提供了一类新颖的下式杂环化合物：作为γ-分泌酶的调节剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种这样的化合物的药物制剂的方法化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与中枢神经系统相关的一种或多种疾病的方法。

36. 发明申请

US20110294784A1 GAMMA SECRETASE MODULATORS 有权
标题翻译： GAMMA秘密调节器
公开(公告)号：US20110294784A1
公开(公告)日：2011-12-01
申请号：US13140987
申请日：2009-12-18
申请人： Theodros Asberom , Xianhai Huang , Zhaoning Zhu , John Clader , Dmitri Pissarnitski , Hubert Josien , Hongmei Li
发明人： Theodros Asberom , Xianhai Huang , Zhaoning Zhu , John Clader , Dmitri Pissarnitski , Hubert Josien , Hongmei Li
IPC分类号： A61K31/553 , A61P27/00 , A61P25/28 , A61P9/10 , C07D498/04 , A61P25/00
CPC分类号： C07D498/04
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (Chemical formula should be inserted here as it appears on abstract in paper form). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).
摘要翻译：本发明提供了作为γ分泌酶调节剂的新型化合物。这些化合物具有式（化学式应该插在这里，如纸上所示）。还公开了使用式（I）化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法的方法。

37. 发明申请

US20110110948A1 BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS 有权
标题翻译：苯并呋喃酮，噻吗啉，四氢萘酮和相关的游离氨基酸酶抑制剂
公开(公告)号：US20110110948A1
公开(公告)日：2011-05-12
申请号：US12668550
申请日：2008-07-15
申请人： Thavalakulamgara K. Sasikumar , Duane A. Burnett , Theodros Asberom , Wen-Lian Wu , Hongmei Li , Ruo Xu , Hubert B. Josien
发明人： Thavalakulamgara K. Sasikumar , Duane A. Burnett , Theodros Asberom , Wen-Lian Wu , Hongmei Li , Ruo Xu , Hubert B. Josien
IPC分类号： A61K39/395 , C07D513/04 , C07D493/04 , C07D491/052 , C07D491/147 , C07D513/14 , A61K31/542 , A61K31/352 , A61K31/407 , A61K31/436 , A61K31/4162 , A61K31/519 , A61K31/549 , A61P25/28 , A61P29/00 , A61P31/00
CPC分类号： C07D493/04 , C07D491/04 , C07D513/04 , C07D513/14
摘要： Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L1, n, X, Ar, Y, Z, Q, and Q1 are as defined herein. Also disclosed are methods for inhibiting gamma secretase, methods for treating Alzheimer's disease, methods of treating one or more neurodegenerative diseases, and methods of inhibiting the deposition of amyloid protein (e.g., amyloid beta protein) in, on or around neurological tissue (e.g., the brain) using the compounds of formula 1.0.
摘要翻译：公开了式（I）的新型γ-分泌酶抑制剂：或其药学上可接受的盐，溶剂化物或酯，其中L 1，n，X，Ar，Y，Z，Q和Q 1如本文所定义。还公开了抑制γ分泌酶的方法，治疗阿尔茨海默氏病的方法，治疗一种或多种神经变性疾病的方法，以及抑制淀粉样蛋白（例如，淀粉样β蛋白）沉积在神经组织内或周围的方法（例如，大脑）使用式1.0化合物。

38. 发明申请

US20110027264A1 GAMMA SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的GAMMA分泌调节剂
公开(公告)号：US20110027264A1
公开(公告)日：2011-02-03
申请号：US12919574
申请日：2009-02-26
申请人： Xianhai Huang , Xianghai Huang , Anandan Palani , Robert G. Aslanian , Zhaoning Zhu , Dmitri A. Pissarnitski , Hongmei Li , William J. Greenlee , Zhiqiang Zhao , Robert D. Mazzola, JR. , Jun Qin , Pawan Dhondi
发明人： Xianhai Huang , Xianghai Huang , Anandan Palani , Robert G. Aslanian , Zhaoning Zhu , Dmitri A. Pissarnitski , Hongmei Li , William J. Greenlee , Zhiqiang Zhao , Robert D. Mazzola, JR. , Jun Qin , Pawan Dhondi
IPC分类号： A61K39/395 , C07D401/12 , C07D221/20 , A61K38/16 , A61K31/454 , A61K31/438 , A61P25/28
CPC分类号： C07D401/12 , C07D498/20
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula: Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
摘要翻译：本发明提供了作为γ分泌酶调节剂的新型化合物。化合物具有下式：还公开了使用式（I）化合物调节γ-分泌酶活性的方法和治疗阿尔茨海默氏病的方法。

39. 发明申请

US20100093695A1 Substituted N-Arylsulfonylheterocyclic Amines As Gamma-Secretase Inhibitors 失效
标题翻译：取代的N-芳基磺酰基杂环胺作为γ-分泌酶抑制剂
公开(公告)号：US20100093695A1
公开(公告)日：2010-04-15
申请号：US12633311
申请日：2009-12-08
申请人： Hubert B. Josien , John W. Clader , Thomas A. Bara , Ruo Xu , Hongmei Li , Dmitri A. Pissarnitski , Zhiqiang Zhao
发明人： Hubert B. Josien , John W. Clader , Thomas A. Bara , Ruo Xu , Hongmei Li , Dmitri A. Pissarnitski , Zhiqiang Zhao
IPC分类号： A61K31/438 , C07D413/14 , A61K31/5377 , C07D413/12 , C07D487/04 , A61K31/55 , A61K31/551
CPC分类号： C07D265/30 , C07D413/12 , C07D451/02 , C07D487/08
摘要： This invention discloses novel gamma secretase inhibitors of the formula: wherein: L is —O—, —N(R6)—, —S—, —S(O)—, or —S(O2)—; R1 is selected from the group consisting of aryl and heteroaryl; R2 is selected from the group consisting of alkyl, —C(O)—Y, —X—C(O)—Y, -alkylene-X—C(O)—Y, -alkylene-C(O)—Y, -alkylene-cycloalkylene-X—C(O)—Y, -alkylene-cycloalkylene-C(O)—Y, -cycloalkylene-alkylene-X—C(O)—Y, -cycloalkylene-alkylene-C(O)—Y, -cycloalkylene-X—C(O)—Y, -cycloalkylene-C(O)—Y, -alkylene-cycloalkylene-alkylene-X—C(O)—Y, -alkylene-cycloalkylene-alkylene-C(O)—Y, aryl, and heteroaryl; R3 is selected from the group consisting of aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, and alkoxyalkyl; each R4 and R5 is independently selected from the group consisting of H and alkyl; and Y is selected from the group consisting of —NR8R9, —N(R6)—(CH2)b—NR8R9, aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, and arylheterocycloalkyl; or Y is selected from the group consisting of: One or more compounds of formula I, or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
摘要翻译：本发明公开了下式的新型γ-分泌酶抑制剂：其中：L是-O - ， - N（R6） - ， - S - ， - S（O） - 或-S（O 2） - ; R 1选自芳基和杂芳基; R 2选自烷基，-C（O）-Y，-X-C（O）-Y， - 亚烷基-X-C（O）-Y， - 亚烷基-C（O）-Y， - 亚烷基 - 亚环烷基-X-C（O）-Y-亚烷基 - 亚环烷基-C（O）-Y-亚烷基 - 亚烷基-X-C（O）-Y-亚烷基 - 亚烷基-C（O）（O）-Y-亚烷基-C（O）-Y-亚烷基 - 亚环烷基 - 亚烷基-X-C（O）-Y-亚烷基 - 亚环烷基 - 亚烷基-C（O ）-Y，芳基和杂芳基; R 3选自芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基和烷氧基烷基; 每个R 4和R 5独立地选自H和烷基; 并且Y选自-NR 8 R 9，-N（R 6） - （CH 2）b -NR 8 R 9，芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基和芳基杂环烷基。或Y选自：一种或多种式I化合物或包含该化合物的制剂可用于，例如，治疗阿尔茨海默病。

40. 发明申请

US20090108289A1 DESIGN STRUCTURE FOR UNIFORM TRIGGERING OF MULTIFINGER SEMICONDUCTOR DEVICES WITH TUNABLE TRIGGER VOLTAGE 有权
标题翻译：具有可调触发电压的多功能半导体器件的均匀触发设计结构
公开(公告)号：US20090108289A1
公开(公告)日：2009-04-30
申请号：US11931517
申请日：2007-10-31
申请人： Michel J. Abou-Khalil , Robert Gauthier , Hongmei Li , Junjun Li , Souvick Mitra , Christopher S. Putnam
发明人： Michel J. Abou-Khalil , Robert Gauthier , Hongmei Li , Junjun Li , Souvick Mitra , Christopher S. Putnam
IPC分类号： H01L27/06
CPC分类号： H01L27/0266 , H01L27/0259 , H01L27/0727 , H01L27/0817
摘要： A design structure for a circuit providing the same trigger voltage across the multiple fingers is provided, which comprises a data representing an external current injection source connected to individual fingers of a multi-finger semiconductor device. For example, the external injection current is supplied to the body of a MOSFET or the gate of a thyristor. The magnitude of the supplied current from each external current injection source is adjusted so that each finger has the same trigger voltage. The external current supply circuit may comprise diodes or an RC triggered MOSFET. The components of the external current supply circuit may be tuned to achieve a desired predetermined trigger voltage across all fingers of the multi-finger semiconductor device.
摘要翻译：提供了一种用于跨多个指状物提供相同触发电压的电路的设计结构，其包括表示连接到多指半导体器件的各个指状物的外部电流注入源的数据。例如，外部注入电流被提供给MOSFET的主体或晶闸管的栅极。调整来自每个外部电流注入源的供给电流的大小，使得每个手指具有相同的触发电压。外部电流供应电路可以包括二极管或RC触发MOSFET。可以调谐外部电流供应电路的组件以实现多指半导体器件的所有指状物上期望的预定触发电压。

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