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31. 发明申请

US20050165303A1 Catheter device 有权
标题翻译：导管装置
公开(公告)号：US20050165303A1
公开(公告)日：2005-07-28
申请号：US11012971
申请日：2004-12-14
申请人： Martin Kleen , Marcus Pfister , Norbert Rahn
发明人： Martin Kleen , Marcus Pfister , Norbert Rahn
IPC分类号： G01N21/64 , A61B1/00 , A61B5/00 , A61B5/06 , A61B19/00 , A61M25/00 , A61B5/05
CPC分类号： A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B5/06 , A61B5/062 , A61B5/7285 , A61B34/20 , A61B90/36 , A61B90/361 , A61B2034/2051 , A61B2090/367 , A61B2090/373
摘要： Catheter device comprising a catheter, in particular an intravascular catheter, for insertion into an area being examined, in particular into a vessel or cavity-containing organ in the body of a person or animal, wherein in the area of the catheter tip a device (3) is provided for emitting excitation light for light-optically exciting an area being examined surrounding said catheter tip, furthermore a device (3) is provided for collecting response light emitted, owing to excitation, from the area being examined, and furthermore a position sensor (13, 24, 27) is provided enabling said catheter tip's spatial position and/or orientation to be registered in a system of coordinates of a position-registering system (7, 14).
摘要翻译：导管装置，其包括导管，特别是血管内导管，用于插入被检查的区域，特别是插入人或动物身体中的血管或含空腔的器官中，其中在导管末端的区域中， 3）用于发射用于光学激发围绕所述导管尖端的被检查区域的激发光，此外，设备（3）用于从被检查的区域收集由于激发而发射的响应光，并且还提供位置传感器（13,24,27）被设置成能够使所述导管尖端的空间位置和/或取向登记在位置登记系统（7,14）的坐标系中。

32. 发明申请

US20050027193A1 Method for automatically merging a 2D fluoroscopic C-arm image with a preoperative 3D image with one-time use of navigation markers 审中-公开
标题翻译：二维透视C臂图像与一次性使用导航标记的术前3D图像自动合并的方法
公开(公告)号：US20050027193A1
公开(公告)日：2005-02-03
申请号：US10851259
申请日：2004-05-21
申请人： Matthias Mitschke , Norbert Rahn , Dieter Ritter
发明人： Matthias Mitschke , Norbert Rahn , Dieter Ritter
IPC分类号： A61B5/05 , A61B19/00 , G06T7/00 , G06T17/00
CPC分类号： A61B34/20 , A61B6/12 , A61B6/4441 , A61B2090/364 , A61B2090/365 , A61B2090/376 , G06T7/33 , G06T7/38 , G06T2207/30004
摘要： In a method and apparatus for the automatic merging of 2D fluoroscopic C-arm images with preoperative 3D images with a one-time use of navigation markers, markers in a marker-containing preoperative 3D image are registered relative to a navigation system, a tool plate fixed on the C-arm system is registered in a reference position relative to the navigation system, a 2D C-arm image (2D fluoroscopic image) that contains the image of at least a medical instrument is obtained in an arbitrary C-arm position, a projection matrix for a 2D-3D merge is determined on the basis of the tool plate and the reference position relative to the navigation system, and the 2D fluoroscopic image is superimposed with the 3D image on the basis of the projection matrix.
摘要翻译：在一次性使用导航标记的2D透视C臂图像与术前3D图像的自动合并的方法和装置中，包含标记的术前3D图像中的标记相对于导航系统，工具板在C臂系统上固定的参考位置相对于导航系统被记录在参考位置，在任意C臂位置处获得包含至少医疗器械的图像的2D C臂图像（2D透视图像）基于工具板和相对于导航系统的参考位置确定用于2D-3D合并的投影矩阵，并且基于投影矩阵将2D透视图像与3D图像叠加。

33. 发明申请

US20050004454A1 Method for marker-free automatic fusion of 2-D fluoroscopic C-arm images with preoperative 3D images using an intraoperatively obtained 3D data record 有权
标题翻译：使用术中获得的3D数据记录的2D-D透视C臂图像与术前3D图像的无标记自动融合的方法
公开(公告)号：US20050004454A1
公开(公告)日：2005-01-06
申请号：US10850499
申请日：2004-05-20
申请人： Matthias Mitschke , Norbert Rahn , Dieter Ritter
发明人： Matthias Mitschke , Norbert Rahn , Dieter Ritter
IPC分类号： A61B6/00 , A61B6/12 , G06T7/00 , A61B5/05
CPC分类号： A61B6/547 , A61B6/12 , A61B6/4441 , A61B6/504 , A61B6/5235 , A61B6/5247 , G06T7/38 , G06T2207/30004 , Y10S378/901
摘要： In a method and apparatus for automatic marker-free fusion (matching) of 2D fluoroscopic C-arm images with preoperative 3D images using an intraoperatively acquired 3D data record, an intraoperative 3D image is obtained using a C-arm x-ray system, image-based matching of an existing preoperative 3D image in relation to the intraoperative 3D image is undertaken, which generates a matching matrix of a tool plate attached to the C-arm system is matched in relation to a navigation system, a 2D fluoroscopic image to be matched is obtained, with the C-arm of the C-arm system in any arbitrary location, a projection matrix for matching the 2D fluoroscopic image in relation to the 3D image is obtained, and the 2D fluoroscopic image is fused (matched) with the preoperative 3D image on the basis of the matching matrix and the projection matrix.
摘要翻译：在使用手术中获取的3D数据记录的2D荧光镜C臂图像与术前3D图像进行自动无标记融合（匹配）的方法和装置中，使用C臂x射线系统获得术中3D图像，图像进行与术中3D图像相关的现有术前3D图像的匹配，其生成附接到C臂系统的工具板的匹配矩阵相对于导航系统匹配，2D透视图像为获得与C臂系统的C臂在任意位置匹配的匹配，获得与3D图像相匹配的2D透视图像的投影矩阵，并将2D透视图像与基于匹配矩阵和投影矩阵的术前3D图像。

34. 发明授权

US06806864B2 Operating device for influencing displayed information 有权
标题翻译：影响显示信息的操作装置
公开(公告)号：US06806864B2
公开(公告)日：2004-10-19
申请号：US09726408
申请日：2000-12-01
申请人： Norbert Rahn , Siegfried Wach
发明人： Norbert Rahn , Siegfried Wach
IPC分类号： G09G508
CPC分类号： G06F3/043 , A61B5/742 , A61B6/03 , A61B6/463 , A61B8/00 , G06F3/033 , G06F3/0346 , G06F3/04845
摘要： An operating device for influencing medical image information items displayed at a display surface with a movable operating element has a motion acquisition system for quantitatively determining adjustment motions of the operating element, with the representation of the image information items displayed at the display surface being influenced solely by motions of the operating element.
摘要翻译：用于影响在可移动操作元件上显示在显示表面上的医用图像信息项的操作装置具有用于定量地确定操作元件的调节运动的运动采集系统，显示表面上显示的图像信息项的表示仅仅受到影响通过操作元件的运动。

35. 发明授权

US06359960B1 Method for identifying and locating markers in a 3D volume data set 有权
标题翻译：用于识别和定位3D体积数据集中的标记的方法
公开(公告)号：US06359960B1
公开(公告)日：2002-03-19
申请号：US09630968
申请日：2000-08-02
申请人： Eric Wahl , Uwe Weber , Norbert Rahn , Rainer Graumann
发明人： Eric Wahl , Uwe Weber , Norbert Rahn , Rainer Graumann
IPC分类号： A61B603
CPC分类号： G06T7/66 , A61B6/12 , G06T7/70 , G06T2207/30016
摘要： In a method for automatically determining coordinates, relative to a reference coordinate system, of markers contained in a 3D volume data set of a subject provided with markers imaged in 2D projections of the 3D volume data set are detected, the centers of gravity of the imaged markers are determined, and back projection straight lines through the markers are established. The intersection points of the back projection straight lines with each other are identified, or the points with the smallest distance from one another on different back projection straight lines are determined if the back projection lines arc skewed. Spatially limited areas are identified, which contain an accumulation of intersection points of back projection straight lines or an accumulation of points with the smallest distance from one another. The coordinates of the centers of gravity of these spatially limited areas are calculated and are used as the coordinates for the respective markers.
摘要翻译：在用于自动确定相对于参考坐标系的坐标的方法中，检测包含在设置有3D体积数据集的2D投影中的标记的受试者的3D体积数据集中的标记的坐标，所成像的重心确定标记，建立通过标记的背投直线。识别背投直线的交点，或者如果背投影线歪斜，则确定在不同背投直线上彼此之间具有最小距离的点。识别空间有限的区域，其包含背投影直线的交叉点的累积或彼此具有最小距离的点的累积。计算这些空间受限区域的重心的坐标，并将其用作相应标记的坐标。

36. 发明授权

US09668704B2 Method and device for visually assisting an electrophysiological use of a catheter in the heart 有权
公开(公告)号：US09668704B2
公开(公告)日：2017-06-06
申请号：US10569957
申请日：2004-08-24
申请人： Kristine Fuimaono , Gal Hayam , Yuval Karmi , Reinmar Killmann , Assaf Preiss , Norbert Rahn , Frank Sauer , Chenyang Xu
发明人： Kristine Fuimaono , Gal Hayam , Yuval Karmi , Reinmar Killmann , Assaf Preiss , Norbert Rahn , Frank Sauer , Chenyang Xu
IPC分类号： A61B5/05 , A61B6/03 , A61B5/055 , A61B8/14 , A61B5/00 , A61B6/00 , A61B8/00 , A61B18/14 , A61B18/00 , G01R33/56
CPC分类号： A61B6/032 , A61B5/055 , A61B5/7285 , A61B6/541 , A61B8/14 , A61B8/543 , A61B18/1492 , A61B2018/00375 , A61B2018/00839 , G01R33/5608
摘要： The invention relates to a device and to a method for visual assistance during the electrophysiological use of a catheter in the heart, enabling electroanatomic 3D mapping data relating to an area of the heart to be treated to be visualized during the use of the catheter. Before the catheter is used, 3D image data of a body region containing the area to be treated is detected by means of a method for tomographic 3D imaging. The area to be treated or significant parts thereof are extracted from said 3D image data, in order to obtain selected 3D image data. The electroanatomic 3D mapping data and the selected 3D image data obtained are then classed in terms of position and dimension, and are adjacently visualized, for example, during the catheter ablation. The inventive method and associated device enable the orientation of the operator to be improved during the use of a catheter in the heart.

37. 发明授权

US09078567B2 Method and device for visually supporting an electrophysiology catheter application in the heart 有权
标题翻译：用于在心脏中视觉上支持电生理学导管应用的方法和装置
公开(公告)号：US09078567B2
公开(公告)日：2015-07-14
申请号：US10569958
申请日：2004-08-19
申请人： Kristine Fuimaono , Gal Hayam , Yuval Karmi , Reinmar Killmann , Assaf Preiss , Norbert Rahn , Frank Sauer , Chenyang Xu
发明人： Kristine Fuimaono , Gal Hayam , Yuval Karmi , Reinmar Killmann , Assaf Preiss , Norbert Rahn , Frank Sauer , Chenyang Xu
IPC分类号： A61B5/05 , A61B6/03 , A61B5/055 , A61B8/14 , A61B5/00 , A61B6/00 , A61B8/00 , A61B18/14 , A61B18/00 , G01R33/56
CPC分类号： A61B6/032 , A61B5/055 , A61B5/7285 , A61B6/5247 , A61B6/541 , A61B8/14 , A61B8/543 , A61B18/1492 , A61B2018/00375 , A61B2018/00839 , G01R33/5608
摘要： The invention relates to a method and a device for visually supporting an electrophysiology catheter application in the heart, whereby electroanatomical 3D mapping data of an area of the heart to be treated which are provided during performance of the catheter application are visualized. Before the catheter application is carried out, 3D image data of the area to be treated are recorded by means of a tomographical 3D imaging method, a 3D surface profile of objects in the area to be treated is extracted from the 3D image data by segmentation and the electroanatomical 3D mapping data provided and the 3D images representing the 3D surface profile are associated with each other in the correct position and dimension relative each other and e.g. visualized in an superimposed manner during the catheter application. The present method and the corresponding device allow for an improved orientation of the user who carries out an electrophysiology catheter application in the heart.
摘要翻译：本发明涉及用于视觉上支持心脏中的电生理学导管应用的方法和装置，由此可视化在执行导管应用过程中提供的待治疗心脏区域的电解剖3D绘图数据。在执行导管应用之前，通过断层3D成像方法记录待处理区域的3D图像数据，通过分割从3D图像数据中提取待处理区域中的对象的3D表面轮廓，所提供的电解剖3D图形数据和表示3D表面轮廓的3D图像彼此相对彼此相关联，并且例如彼此相对。在导管应用期间以叠加的方式显现。本方法和相应的装置允许在心脏中进行电生理学导管应用的用户的改进的取向。

38. 发明授权

US08244064B2 Method for registering and merging medical image data 有权
标题翻译：用于注册和合并医学图像数据的方法
公开(公告)号：US08244064B2
公开(公告)日：2012-08-14
申请号：US11043464
申请日：2005-01-26
申请人： Jan Boese , Benno Heigl , Norbert Rahn
发明人： Jan Boese , Benno Heigl , Norbert Rahn
IPC分类号： G06K9/32
CPC分类号： A61B5/1127 , A61B5/721 , A61B6/032 , A61B6/527 , A61B6/583 , G06F19/00 , G06T7/30 , G06T2207/30004
摘要： The present invention relates to a method for the registration and superimposition of image data when taking serial radiographs in medical imaging, wherein a plurality of image data sets for a region of a patient (17) that is being investigated are constructed at time intervals using an imaging system (1) and are referenced with a first image data set for the region that is being investigated that was constructed previously using said imaging system (1). In the above method, a location system (2) is used during the production of serial radiographs constantly, or at least at a respective proximity in time to the construction of individual data sets, to determine a current spatial position of the region being investigated in a reference system that is firmly connected to the imaging system (1), whereby in the construction of the first image data set, a first spatial position of the region that is being investigated is recorded. In the construction of some or all further image data sets, the respective current spatial position of the region that is being investigated is determined and an image content of each first image data set is geometrically adapted on the basis of the difference between the first and the current spatial position, such that compensation is made for a different spatial position of the region that is being investigated. The geometrically adapted first image data set or an image data set derived therefrom, or an image data set that is positionally connected thereto by registration is then displayed superimposed with the respective further image data set.
摘要翻译：本发明涉及一种用于在医学成像中拍摄连续摄影时对图像数据进行配准和叠加的方法，其中，对于正在研究的患者（17）的区域的多个图像数据组以时间间隔使用成像系统（1），并且被使用先前使用所述成像系统（1）构造的正被研究的区域的第一图像数据集参考。在上述方法中，在串行X射线照相制作期间，或者至少在各个相邻的时间内接近单个数据集的构造，使用定位系统（2）来确定正被调查的区域的当前空间位置牢固地连接到成像系统（1）的参考系统，由此在第一图像数据组的构造中记录正被调查的区域的第一空间位置。在构建一些或所有其他图像数据集时，确定正在研究的区域的相应当前空间位置，并且基于第一和第二图像数据组之间的差异来对每个第一图像数据集的图像内容进行几何适配。当前的空间位置，使得对正被调查的区域的不同空间位置进行补偿。然后，将几何适应的第一图像数据集或从其导出的图像数据集或通过登记与其位置连接的图像数据组叠加显示相应的另外的图像数据集。

39. 发明授权

US08195271B2 Method and system for performing ablation to treat ventricular tachycardia 有权
标题翻译：进行消融治疗室性心动过速的方法和系统
公开(公告)号：US08195271B2
公开(公告)日：2012-06-05
申请号：US11983027
申请日：2007-11-06
申请人： Norbert Rahn
发明人： Norbert Rahn
IPC分类号： A61B5/055 , A61B6/00
CPC分类号： A61B6/12 , A61B5/7289 , A61B18/1492 , A61B34/25 , A61B34/30 , A61B90/361 , A61B2018/00351 , A61B2018/00839 , A61B2034/2051 , A61B2034/2063 , A61B2034/301 , A61B2090/3762
摘要： A system and method of treating tachycardias and similar syndromes by the use of catheter ablation of tissue is described. A computed tomography (CT)-like image of the heart is obtained and processed to segment the various types of tissue. Papillary muscle areas are identified and displayed differently from the other nearby tissues so that the muscles can be avoided during treatment to avoid or minimize damage to the muscles during ablation treatment. Electrophysical data and scar tissue may also be identified in the image, which may be of the endoscopic type. The position of the catheter may be displayed as a synthetic image on the endoscopic view.
摘要翻译：描述了通过使用导管消融组织治疗心动过速和类似综合征的系统和方法。获得心脏的计算机断层摄影（CT）样图像并进行处理以分割各种类型的组织。识别和显示乳头肌区域与其他附近组织不同，使得在治疗期间可以避免肌肉以避免或最小化在消融治疗期间对肌肉的损伤。也可以在图像中识别电物理数据和瘢痕组织，其可以是内窥镜型。导管的位置可以在内窥镜视图上显示为合成图像。

40. 发明授权

US07939093B2 Method and apparatus for representing myocardial tissues in different states of damage 有权
标题翻译：用于表示不同损伤状态的心肌组织的方法和装置
公开(公告)号：US07939093B2
公开(公告)日：2011-05-10
申请号：US11890400
申请日：2007-08-06
申请人： Matthias John , Stefan Lautenschläger , Norbert Rahn
发明人： Matthias John , Stefan Lautenschläger , Norbert Rahn
IPC分类号： A61B5/05
CPC分类号： A61B6/504 , A61B5/0275 , A61B6/032 , A61B6/481 , A61B6/503 , A61B6/507
摘要： The invention relates to a method for differentially representing myocardial tissue in different states of damage, comprising the following steps: administering a myocardium-suitable contrast agent to a patient under examination; entering at least one patient-specific parameter affecting the speed of uptake by and elimination from the myocardium of said contrast agent; calculating a point in time after administration of the contrast agent at which a difference between a contrast agent content in necrotic myocardial tissue and a contrast agent content in non-necrotic myocardial tissue attains a maximum value, on the basis of the at least one patient-specific parameter, and carrying out, at the point in time calculated, a late-phase CT scan for accentuation of necrotic myocardial tissue compared to non-necrotic myocardial tissue. The invention likewise relates to apparatus, in particular for carrying out the method.
摘要翻译：本发明涉及用于差异代表不同损伤状态的心肌组织的方法，包括以下步骤：向被检查的患者施用适合心肌的造影剂; 输入至少一个影响所述造影剂的心肌的摄取速度和消除速度的患者特异性参数; 计算施用造影剂之后的时间点，其中所述造影剂中的坏死心肌组织中的造影剂含量与非坏死性心肌组织中的造影剂含量之间的差异达到最大值，基于至少一个患者 - 具体参数，并且在计算的时间点进行与非坏死心肌组织相比的坏死心肌组织的晚期CT扫描。本发明同样涉及装置，特别是用于实施该方法。

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