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31. 发明授权

US08025403B2 Ophthalmologic apparatus for imaging an eye by optical coherence tomography 有权
标题翻译：用于通过光学相干断层扫描成像眼睛的眼科装置
公开(公告)号：US08025403B2
公开(公告)日：2011-09-27
申请号：US12527957
申请日：2008-02-18
申请人： Peter Maloca , Karim Haroud , Urban Schnell
发明人： Peter Maloca , Karim Haroud , Urban Schnell
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/102
摘要： An OCT appliance (optical coherence tomography appliance) comprises an OCT module and a camera for observing the fundus of an eye. By recognizing characteristic features (biometric features), the means defining the region observed by the OCT module, in particular the scanner of the OCT module, is adjusted so that a predefined region of interest is imaged by the OCT module. In preferred embodiments, the apparatus is apt to be operated by a patient himself, and the data are transferred to a clinical server so that a more frequent, hence closer observation of the eyes of the patient is possible.
摘要翻译： OCT器具（光学相干断层摄影器具）包括OCT模块和用于观察眼底的相机。通过识别特征特征（生物特征），调整由OCT模块观察到的区域，特别是OCT模块的扫描仪所定义的区域的手段，使得通过OCT模块对预定义的区域进行成像。在优选实施例中，该装置易于由患者自己操作，并且数据被传送到临床服务器，使得可以更频繁地，因此更仔细地观察患者的眼睛。

32. 发明申请

US20100331912A1 DEVICE AND METHOD FOR VISUAL STIMULATION 有权
标题翻译：用于视觉刺激的装置和方法
公开(公告)号：US20100331912A1
公开(公告)日：2010-12-30
申请号：US12875619
申请日：2010-09-03
申请人： Peter A. Tass , Birgit Utako Barnikol , Christian Hauptmann , Karim Haroud , Jean-Christophe Roulet , Urban Schnell
发明人： Peter A. Tass , Birgit Utako Barnikol , Christian Hauptmann , Karim Haroud , Jean-Christophe Roulet , Urban Schnell
IPC分类号： A61N1/18 , G02C11/04 , A61B5/00
CPC分类号： A61M21/00 , A61M2021/0044 , A61M2205/332 , A61M2205/3569 , A61M2230/10 , A61M2230/16 , A61M2230/30 , A61M2230/40 , A61M2230/60 , A61M2230/65 , A61N5/0618 , A61N5/0622 , A61N2005/0648 , A61N2005/073
摘要： A device and method for providing stimulation signals that reset the phase of the neuronal activity of neurons in a patient's brain. The device includes a control unit; and a stimulation unit that has a plurality of stimulation elements, and each stimulation element generates visual stimulation signals that reset the phase of the neuronal activity of the neurons when the signals are taken up via an eye of a patient and transmitted to neurons that are exhibiting a pathologically synchronous and oscillatory neuronal activity. The control unit is further capable of actuating the stimulation unit such that the stimulation elements generate the visual stimulation signals with a time offset in respect to one another and/or with differing phase and/or with differing polarity.
摘要翻译：一种用于提供刺激信号的装置和方法，所述刺激信号重置患者大脑中神经元的神经元活动的相位。该装置包括一个控制单元; 以及具有多个刺激元件的刺激单元，并且每个刺激元件产生视觉刺激信号，当信号经由患者的眼睛被摄取并且被传送到正在展现的神经元时，该视觉刺激信号重置神经元的神经元活动的相位病理同步和振荡的神经元活动。控制单元还能够致动刺激单元，使得刺激元件产生相对于彼此和/或具有不同相位和/或具有不同极性的时间偏移的视觉刺激信号。

33. 发明授权

US09302069B2 Device and method for visual stimulation 有权
标题翻译：视觉刺激的装置和方法
公开(公告)号：US09302069B2
公开(公告)日：2016-04-05
申请号：US12875619
申请日：2010-09-03
申请人： Peter A. Tass , Birgit Utako Barnikol , Christian Hauptmann , Karim Haroud , Jean-Christophe Roulet , Urban Schnell
发明人： Peter A. Tass , Birgit Utako Barnikol , Christian Hauptmann , Karim Haroud , Jean-Christophe Roulet , Urban Schnell
IPC分类号： A61N1/18 , A61M21/00 , A61N5/06 , A61N5/073
CPC分类号： A61M21/00 , A61M2021/0044 , A61M2205/332 , A61M2205/3569 , A61M2230/10 , A61M2230/16 , A61M2230/30 , A61M2230/40 , A61M2230/60 , A61M2230/65 , A61N5/0618 , A61N5/0622 , A61N2005/0648 , A61N2005/073
摘要： A device and method for providing stimulation signals that reset the phase of the neuronal activity of neurons in a patient's brain. The device includes a control unit; and a stimulation unit that has a plurality of stimulation elements, and each stimulation element generates visual stimulation signals that reset the phase of the neuronal activity of the neurons when the signals are taken up via an eye of a patient and transmitted to neurons that are exhibiting a pathologically synchronous and oscillatory neuronal activity. The control unit is further capable of actuating the stimulation unit such that the stimulation elements generate the visual stimulation signals with a time offset in respect to one another and/or with differing phase and/or with differing polarity.
摘要翻译：一种用于提供刺激信号的装置和方法，所述刺激信号重置患者大脑中神经元的神经元活动的相位。该装置包括一个控制单元; 以及具有多个刺激元件的刺激单元，并且每个刺激元件产生视觉刺激信号，当信号经由患者的眼睛被摄取并且被传送到正在展现的神经元时，该视觉刺激信号重置神经元的神经元活动的相位病理同步和振荡的神经元活动。控制单元还能够致动刺激单元，使得刺激元件产生具有相对于彼此和/或具有不同相位和/或具有不同极性的时间偏移的视觉刺激信号。

34. 发明申请

US20140016087A1 Fluid Lenses, Lens Blanks, and Methods of Manufacturing the Same 有权
标题翻译：流体镜片，镜片坯料及其制造方法
公开(公告)号：US20140016087A1
公开(公告)日：2014-01-16
申请号：US13549078
申请日：2012-07-13
申请人： Amitava GUPTA , Urban Schnell
发明人： Amitava GUPTA , Urban Schnell
IPC分类号： G02C7/08 , B29D11/00
CPC分类号： G02C7/085 , B29D11/00028 , B29D11/00298 , B29D11/0073 , Y10T156/108
摘要： A lens blank for a fluid lens includes a rigid lens and a semi-flexible inflatable membrane attached to the rigid lens. The lens blank is divided into a cavity zone and a bonded zone. The cavity zone extends radially outward from a central area of the lens blank and a cavity is formed between the membrane and the rigid lens within the cavity zone. The bonded zone extends radially outward from the cavity zone and the membrane is bonded and fluidly sealed to the rigid lens throughout the bonded zone. The bonded zone is dimensioned to be trimmed to accommodate a plurality of frame shapes and sizes. Methods of manufacturing lens blanks are also provided. Arrays of lens blanks and fluid lenses are also provided.
摘要翻译：用于流体透镜的透镜毛坯包括刚性透镜和附接到刚性透镜的半柔性可充气膜。镜片坯料分为空腔区和粘合区。空腔区域从透镜毛坯的中心区域径向向外延伸，并且在空腔区域内的膜和刚性透镜之间形成空腔。接合区域从空腔区域径向向外延伸，并且膜粘合并且在整个粘合区域中与刚性透镜流体密封。接合区的尺寸被设计成被修整以容纳多个框架形状和尺寸。还提供了制造镜片坯料的方法。还提供了镜头毛坯和流体镜片的阵列。

35. 发明授权

US09535264B2 Fluid lenses, lens blanks, and methods of manufacturing the same 有权
标题翻译：流体镜片，镜片坯料及其制造方法
公开(公告)号：US09535264B2
公开(公告)日：2017-01-03
申请号：US13549078
申请日：2012-07-13
申请人： Amitava Gupta , Urban Schnell
发明人： Amitava Gupta , Urban Schnell
IPC分类号： G02C7/08 , B29D11/00
CPC分类号： G02C7/085 , B29D11/00028 , B29D11/00298 , B29D11/0073 , Y10T156/108
摘要： A lens blank for a fluid lens includes a rigid lens and a semi-flexible inflatable membrane attached to the rigid lens. The lens blank is divided into a cavity zone and a bonded zone. The cavity zone extends radially outward from a central area of the lens blank and a cavity is formed between the membrane and the rigid lens within the cavity zone. The bonded zone extends radially outward from the cavity zone and the membrane is bonded and fluidly sealed to the rigid lens throughout the bonded zone. The bonded zone is dimensioned to be trimmed to accommodate a plurality of frame shapes and sizes. Methods of manufacturing lens blanks are also provided. Arrays of lens blanks and fluid lenses are also provided.
摘要翻译：用于流体透镜的透镜毛坯包括刚性透镜和附接到刚性透镜的半柔性可充气膜。镜片坯料分为空腔区和粘合区。空腔区域从透镜毛坯的中心区域径向向外延伸，并且在空腔区域内的膜和刚性透镜之间形成空腔。接合区域从空腔区域径向向外延伸，并且膜粘合并且在整个粘合区域中与刚性透镜流体密封。接合区的尺寸被设计成被修整以容纳多个框架形状和尺寸。还提供了制造镜片坯料的方法。还提供了镜头毛坯和流体镜片的阵列。

36. 发明申请

US20110015733A1 Folding Designs for Intraocular Lenses 审中-公开
标题翻译：眼镜镜片折叠设计
公开(公告)号：US20110015733A1
公开(公告)日：2011-01-20
申请号：US12836154
申请日：2010-07-14
申请人： Urban Schnell , Jean-Noël Fehr , Alain Saurer , Amitava Gupta
发明人： Urban Schnell , Jean-Noël Fehr , Alain Saurer , Amitava Gupta
IPC分类号： A61F2/16
CPC分类号： A61F2/16 , A61F2002/169053
摘要： Folding patterns for intraocular lenses are provided.
摘要翻译：提供了眼内透镜的折叠图案。

37. 发明申请

US20130261744A1 IMPLANTABLE OPHTHALMIC DEVICE WITH AN ASPHERIC LENS 审中-公开
标题翻译：具有双面镜片的可植入手术装置
公开(公告)号：US20130261744A1
公开(公告)日：2013-10-03
申请号：US13701432
申请日：2011-05-31
申请人： Amitava Gupta , Nicholas Wooder , Ronald D. Blum , Rudy Mazzocchi , Urban Schnell
发明人： Amitava Gupta , Nicholas Wooder , Ronald D. Blum , Rudy Mazzocchi , Urban Schnell
IPC分类号： A61F2/16
CPC分类号： A61F2/1616 , A61B3/10 , A61B5/0031 , A61B5/0496 , A61B2560/0219 , A61F2/1624 , A61F2/1627 , A61F2/164 , A61F2/1648 , A61F2250/0002
摘要： Implantable ophthalmic devices with aspheric lenses and dynamic electro-active elements offer excellent depth of field and image quality while providing high optical throughput. An exemplary implantable ophthalmic device includes an aspheric lens with a negative spherical aberration that varies with radius. The aspheric lens can have peak optical powers at its geometric centers surrounded by a region of varying optical power (with varying slope) that extends radially from its center. When implanted, these aspheric lenses provide an incremental optical power that varies as a function of pupil diameter, which changes with object distance, for viewing far, intermediate, and near objects. The aspheric lens may also bonded or integrally formed with a spherical lens that provides fixed optical power for viewing far objects and/or a dynamic electro-active element that with two or more states (e.g., on and off) for increasing the effective optical power when viewing near objects.
摘要翻译：具有非球面透镜和动态电活性元件的可植入眼科装置提供优异的景深和图像质量，同时提供高的光学吞吐量。示例性的可植入眼科装置包括具有随半径变化的负球面像差的非球面透镜。非球面透镜在其几何中心处可以具有由其从其中心径向延伸的具有变化的光焦度（具有变化的斜率）的区域包围的峰值光焦度。当植入时，这些非球面透镜提供增加的光学功率，其随瞳孔直径的变化而变化，瞳孔直径随物体距离而变化，用于观察远，中和近物体。非球面透镜也可以与提供用于观察远物体的固定光焦度的球形透镜结合或整体形成，和/或具有两个或更多个状态（例如，接通和关断）以增加有效光功率的动态电活性元件查看近物体时。

38. 发明申请

US20130211516A1 HERMETICALLY SEALED IMPLANTABLE OPHTHALMIC DEVICES AND METHODS OF MAKING SAME 有权
标题翻译：密封的可植入的眼部器械及其制造方法
公开(公告)号：US20130211516A1
公开(公告)日：2013-08-15
申请号：US13812226
申请日：2011-07-25
申请人： Ronald D. Blum , Amitava Gupta , Jean-Noel Fehr , Jean-Christophe Roulet , Urban Schnell , Walter Doll , Roland Michaely
发明人： Ronald D. Blum , Amitava Gupta , Jean-Noel Fehr , Jean-Christophe Roulet , Urban Schnell , Walter Doll , Roland Michaely
IPC分类号： A61F2/16
CPC分类号： A61F2/1624 , A61F2/14 , A61F2/1613 , A61F2002/482 , A61F2240/001 , A61F2250/0069 , G02F1/1341 , H01L23/15 , H01L23/5389 , H05K3/301 , H05K3/36 , Y10T29/49126
摘要： Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically scaled within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5×10−12 Pa m3 s−1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.
摘要翻译：许多现代可植入眼科装置包括可将有害物质渗入眼睛和/或周围组织的电子部件，例如电活性细胞。在本文公开的可植入眼科装置中，电子部件通过将两个或更多个玻璃晶片结合在一起形成的空腔内被气密地缩放。通过激光熔接，压力粘合或阳极接合将玻璃晶片结合在一起形成密封，当进行氦气泄漏测试时，密封件以小于约5×10-12 Pa m3 s-1的速率泄漏。由导电材料形成的密封馈通通过晶片中的通道提供电连接到密封空腔内的组件。在一些情况下，导电材料的热膨胀系数（CTE）大致等于玻璃晶片的CTE的（例如，在10％以内），以最小化由于导致导电材料的热诱导的膨胀和收缩引起的泄漏，玻璃晶片。

39. 发明授权

US08992610B2 Hermetically sealed implantable ophthalmic devices and methods of making same 有权
标题翻译：密封可植入眼科装置及其制造方法
公开(公告)号：US08992610B2
公开(公告)日：2015-03-31
申请号：US13812226
申请日：2011-07-25
申请人： Ronald D. Blum , Amitava Gupta , Jean-Noel Fehr , Jean-Christophe Roulet , Urban Schnell , Walter Doll , Roland Michaely
发明人： Ronald D. Blum , Amitava Gupta , Jean-Noel Fehr , Jean-Christophe Roulet , Urban Schnell , Walter Doll , Roland Michaely
IPC分类号： A61F2/16 , A61F2/14
CPC分类号： A61F2/1624 , A61F2/14 , A61F2/1613 , A61F2002/482 , A61F2240/001 , A61F2250/0069 , G02F1/1341 , H01L23/15 , H01L23/5389 , H05K3/301 , H05K3/36 , Y10T29/49126
摘要： Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically scaled within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5×10−12 Pa m3 s−1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.
摘要翻译：许多现代可植入眼科装置包括可将有害物质渗入眼睛和/或周围组织的电子部件，例如电活性细胞。在本文公开的可植入眼科装置中，电子部件通过将两个或更多个玻璃晶片结合在一起形成的空腔内被气密地缩放。通过激光熔接，压力粘合或阳极接合将玻璃晶片结合在一起形成密封，当进行氦气泄漏测试时，密封件以小于约5×10-12 Pa m3 s-1的速率泄漏。由导电材料形成的密封馈通通过晶片中的通道提供电连接到密封空腔内的组件。在一些情况下，导电材料的热膨胀系数（CTE）大致等于玻璃晶片的CTE的（例如，在10％以内），以最小化由于导致导电材料的热诱导的膨胀和收缩引起的泄漏，玻璃晶片。

40. 发明申请

US20130242256A1 METHOD AND APPARATUS FOR DETECTING ACCOMMODATION 审中-公开
标题翻译：检测住房的方法和装置
公开(公告)号：US20130242256A1
公开(公告)日：2013-09-19
申请号：US13822569
申请日：2011-09-12
申请人： Jean-Noel Fehr , Urban Schnell , Walter Doll , Roland Michaely , Jean-Christophe Roulet , Amitava Gupta , Ronald Blum , Rudy Mazzocchi
发明人： Jean-Noel Fehr , Urban Schnell , Walter Doll , Roland Michaely , Jean-Christophe Roulet , Amitava Gupta , Ronald Blum , Rudy Mazzocchi
IPC分类号： A61B3/11
CPC分类号： A61B3/11 , A61B3/09 , A61B3/112 , A61F2/1624 , A61F2250/0002 , G02C7/083
摘要： A sensor system includes at least two sensors for distinguishing accommodative stimuli from changes in ambient lights levels and task-induced changes in the pupil diameter. When implanted, the first sensor is disposed completely within the pupil; even when fully constricted, the pupil does not occlude the first sensor, allowing the sensor to make precise measurements of ambient luminous flux levels. The pupil occludes part of the second sensor's active area(s) as the pupil dilates and constricts. As a result, the second sensor measures both ambient luminous flux and pupil diameter. A processor estimates the pupil diameter and determines whether it's changing in response to accommodative stimuli or other factors by comparing to predetermined values. The sensor system sends a signal to an optical component, which in turn can respond by changing optical power to focus for near vision upon detection of accommodative stimuli.
摘要翻译：传感器系统包括至少两个传感器，用于区分调节刺激与环境光照水平的变化以及瞳孔直径的任务引起的变化。当植入时，第一传感器完全设置在瞳孔内; 即使完全收缩，瞳孔也不会闭塞第一个传感器，允许传感器对环境光通量水平进行精确测量。当瞳孔扩大和收缩时，瞳孔封闭第二传感器的有效区域的一部分。结果，第二传感器测量环境光通量和瞳孔直径。处理器估计瞳孔直径并且通过与预定值进行比较来确定其是否响应于调节刺激或其他因素而改变。传感器系统将信号发送到光学部件，光学部件又可以通过改变光焦度进行响应，以便在检测到适应刺激时进行近视。

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