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31. 发明专利

AU1434292A INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS 未知
公开(公告)号：AU1434292A
公开(公告)日：1992-09-15
申请号：AU1434292
申请日：1992-02-14
申请人： ABBOTT LAB
发明人： SUMMERS JAMES B JR , CARRERA GEORGE M JR , DAVIDSEN STEVEN K , SHEPPARD GEORGE S , PHILLIPS JAMES G , PIREH DAISY , STEINMAN DOUGLAS H , MAY PAUL D , GUINN DENISE E , HEYMAN H ROBIN
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4433 , A61P7/02 , A61P11/00 , A61P29/00 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , A61K31/425
摘要： Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

32. 发明专利

CA2497725C PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 未知
公开(公告)号：CA2497725C
公开(公告)日：2012-04-10
申请号：CA2497725
申请日：2003-09-15
申请人： ABBOTT LAB
发明人： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , FEENSTRA MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC分类号： C07D207/16 , A61K31/40 , A61P3/00 , A61P37/02 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.

33. 发明专利

ES2290511T3 COMPOSICIONES FARMACEUTICAS UTILES COMO INHIBIDORES DE LA DIPEPTIDIL PEPTIDASA-IV (DPP-IV). 未知
公开(公告)号：ES2290511T3
公开(公告)日：2008-02-16
申请号：ES03774478
申请日：2003-09-15
申请人： ABBOTT LAB
发明人： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG
IPC分类号： C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： Un compuesto de fórmula (I), (Ver fórmula) o una sal farmacéuticamente aceptable del mismo, donde X es un miembro seleccionado del grupo que consiste en CH2, CHF y CF2; R se selecciona del grupo que consiste en alquilcarbonilo, arilcarbonilo, ciano, heterociclocarbonilo, R4R5NC (O)-, B(OR6)2, (1, 2, 3)-dioxoborolano y 4, 4, 5, 5-tetrametil-(1, 2, 3)-dioxoborolano; R1 se selecciona del grupo que consiste en alcoxialquilo, alquilo, alquilcarbonilo, alquenilo, alquinilo, alenilo, arilalquilo, cicloalquilo, cicloalquilalquilo, ciano, haloalquilo, haloalquenilo, heterocicloalquilo, e hidroxialquilo; R2 y R3 se seleccionan independientemente del grupo que consiste en hidrógeno, alcoxialquilo, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquil-alquilo, arilo, arilalquilo, heterociclo, heterocicloalquilo, hidroxialquilo; o R2 y R3 tomados junto con los átomos a los que están anclados forman un heterociclo mono o bicíclico seleccionado del grupo que consiste en 2-indolinilo, 2-indolilo, 3-isoquinolina, 2-piperazina, 2-piperidina, 2-pirrolidina, 2-pirrol, 2-piridina, 2-quinolinilo, 2-tetrahidroquinolinilo, y 3-tetrahidroisoquinolinilo, donde dicho heterociclo puede estar sustituido con 0, 1, 2 o 3 sustituyentes seleccionados independientemente entre alquenilo, alcoxi, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo, alquilcarbonilo alquilcarbonilalquilo, alquilcarboniloxi, alquilsulfonilo, alquiltio, alquinilo, arilo, arilalcoxi, arilalquilo, arilcarbonilo, ariloxi, carboxi, carboxialquilo, ciano, cianoalquilo, formilo, halógeno, haloalquilo, hidroxi, hidroxialquilo, mercapto, nitro, fenilo, RARBN-, RCRDNC(O)-, y RCRDNS(O)2-; R4, R5 y R6 se...

34. 发明专利

SI1560811T1 Farmacevtske spojine in njihova uporaba kot inhibitorji dipeptidil peptidaze-IV (DPP-IV) 未知
公开(公告)号：SI1560811T1
公开(公告)日：2007-12-31
申请号：SI200330987
申请日：2003-09-15
申请人： ABBOTT LAB
发明人： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC分类号： C07D207/00

35. 发明专利

DE60315336D1 未知
公开(公告)号：DE60315336D1
公开(公告)日：2007-09-13
申请号：DE60315336
申请日：2003-09-15
申请人： ABBOTT LAB
发明人： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC分类号： C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

36. 发明专利

DE69723848T2 未知
公开(公告)号：DE69723848T2
公开(公告)日：2004-07-01
申请号：DE69723848
申请日：1997-04-25
申请人： ABBOTT LAB
发明人： ELLIOTT L , OR SUN , CHU T , GRIESGRABER W , PLATTNER J , PIREH DAISY
IPC分类号： A61K31/04 , A61K31/70 , A61K31/7048 , A61K31/7052 , C07H17/08
摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

37. 发明专利

ES2203800T3 未知
公开(公告)号：ES2203800T3
公开(公告)日：2004-04-16
申请号：ES97921411
申请日：1997-04-25
申请人： ABBOTT LAB
发明人： ELLIOTT RICHARD L , OR YAT SUN , CHU DANIEL T , GRIESGRABER GEORGE W , PLATTNER JACOB J , PIREH DAISY
IPC分类号： A61K31/04 , A61K31/70 , A61K31/7048 , A61K31/7052 , C07H17/08
摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

38. 发明专利

PT922050E 未知
公开(公告)号：PT922050E
公开(公告)日：2003-12-31
申请号：PT97921411
申请日：1997-04-25
申请人： ABBOTT LAB
发明人： PIREH DAISY , OR YAT SUN , GRIESGRABER GEORGE W , ELLIOTT RICHARD L , CHU DANIEL T , PLATTNER JACOB J
IPC分类号： A61K31/04 , A61K31/70 , A61K31/7048 , A61K31/7052 , C07H17/08
摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

39. 发明专利

DE69723848D1 3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN-DERIVATE 未知
公开(公告)号：DE69723848D1
公开(公告)日：2003-09-04
申请号：DE69723848
申请日：1997-04-25
申请人： ABBOTT LAB
发明人： ELLIOTT L , OR SUN , CHU T , GRIESGRABER W , PLATTNER J , PIREH DAISY
IPC分类号： A61K31/04 , A61K31/70 , A61K31/7048 , A61K31/7052 , C07H17/08
摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

40. 发明专利

AU714176B2 3-deoxy-3-descladinose derivatives of erythromycins A and B 未知
公开(公告)号：AU714176B2
公开(公告)日：1999-12-23
申请号：AU1074497
申请日：1996-11-06
申请人： ABBOTT LAB
发明人： OR YAT SUN , CHU DANIEL T , ELLIOTT RICHARD L , PIREH DAISY
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P31/04 , C07H17/08
摘要： A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

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