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31. 发明公开

KR1020120140450A 인간 중간엽줄기세포의 분화 촉진용 조성물 有权
标题翻译：促进人类间质干细胞分化的组合物
公开(公告)号：KR1020120140450A
公开(公告)日：2012-12-31
申请号：KR1020110060194
申请日：2011-06-21
申请人： (주)아모레퍼시픽
发明人： 신동욱 , 노민수 , 박수남
IPC分类号： A61K36/62 , C12N5/0775 , A61P17/00
CPC分类号： A61K36/62 , A61Q90/00 , C12N5/0662 , C12N5/0669
摘要： PURPOSE: A composition with Nelumbinis Semen extracts as an active ingredient for promoting the differentiation of adipocyte in human mesenchymal stem cell is provided to promote differentiating the adipocyte from a human mesenchymal stem cell to produce lipid droplet, enhance the electricity and the volume of skin and reduce wrinkles. CONSTITUTION: A composition for skin external application for promoting the differentiation of adipocyte contains Nelumbinis Semen extracts as an active ingredient. The composition promotes differentiating adipocyte from a mesenchymal stem cell. The mesenchymal stem cell is a human mesenchymal cell. The composition increases adipocyte tissue. For the total weight of the composition, a Nelumbinis Semen extract weighs ranging from 0.001 to 30%. The composition enhances the volume of skin and the elasticity of skin, and reduces skin wrinkles. A pharmaceutical composition for promoting the differentiation of a adipocyte cell contains Nelumbinis Semen as an active ingredient. A Nelumbinis Semen extract is administered from 0.001mg /kg /day-2000mg /kg /day. [Reference numerals] (AA) Relative revelation amount; (BB) Negative control group; (CC) Ligustri Fructus; (DD) Veratri Rhizoma Et Radix; (EE) Forsythiae Fructus; (FF) Nelumbo semen
摘要翻译：目的：提供具有Nelumbinis Semen提取物作为促进人间充质干细胞中脂肪细胞分化的活性成分的组合物，以促进脂肪细胞与人间充质干细胞的分化，产生脂滴，增强皮肤的电力和体积，减少皱纹。构成：用于促进脂肪细胞分化的皮肤外用应用组合物含有Nelumbinis Semen提取物作为活性成分。该组合物促进脂肪细胞与间充质干细胞分化。间充质干细胞是人类间充质细胞。组合物增加脂肪细胞组织。对于组合物的总重量，Nelumbinis Semen提取物的重量范围为0.001至30％。该组合物增强皮肤的体积和皮肤的弹性，并减少皮肤皱纹。用于促进脂肪细胞分化的药物组合物含有Nelumbinis Semen作为活性成分。 Nelumbinis精液提取物以0.001mg / kg /天-2000mg / kg /天施用。（附图标记）（AA）相对启示量; （BB）阴性对照组; （CC）Ligustri Fructus; （DD）Veratri Rhizoma Et Radix; （EE）连翘; （FF）Nelumbo精液

32. 发明公开

KR1020120088896A 듀옥스 2 ｍｉＲＮＡ를 포함하는 피부 세포 분화 조절용 조성물 审中-实审
标题翻译：用于控制包含DUOX 2 MIRNA的皮肤细胞分化的组合物
公开(公告)号：KR1020120088896A
公开(公告)日：2012-08-09
申请号：KR1020100115854
申请日：2010-11-19
申请人： (주)아모레퍼시픽
发明人： 최현 , 김윤경 , 김규한 , 이태룡 , 노민수 , 신동욱
IPC分类号： C12N15/113 , C12N5/071 , A61K31/7105 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/7105 , C12N5/0625 , C12Q1/68 , C12Q2600/158 , C12Q2600/178
摘要： PURPOSE: A composition containing miRNA molecule or mimic of DUOX2 for controlling skin cell differentiation is provided to regulate DUOX2, filagrin, loricrin, keratin 1, and keratin 10 genes. CONSTITUTION: A composition for controlling skin cell differentiation contains miRNA molecule or mimic of DUOX2 having 7-25 bases with a base sequence of sequence number 1. The miRNA molecule or mimic targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition promotes skin cell differentiation. A miRNA inhibitor of DUOX2 targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition suppresses skin cell differentiation. The skin cell is keratinocytes.
摘要翻译：目的：提供含有miRNA分子或模拟DUOX2用于控制皮肤细胞分化的组合物，用于调节DUOX2，丝胶蛋白，氯氰菊酯，角蛋白1和角蛋白10基因。构成：用于控制皮肤细胞分化的组合物包含miRNA分子或具有7-25个碱基的DUOX2的模拟物，其碱基序列为序列号1. miRNA分子或模拟物靶向DUOX2 mRNA 3'-UTR的第1358至第1364位核酸。该组合物促进皮肤细胞分化。 DUOX2的miRNA抑制剂靶向DUOX2 mRNA 3'-UTR的1358至1364位核酸。该组合物抑制皮肤细胞分化。皮肤细胞是角质细胞。

33. 发明公开

KR1020120058866A 세포외기질을 모사한 지방유래 줄기세포의 줄기세포성 증진용 조성물 审中-实审
标题翻译：从用于促进ADIPOSE衍生干细胞的干细胞的细胞外基质生物学的化妆品组合物
公开(公告)号：KR1020120058866A
公开(公告)日：2012-06-08
申请号：KR1020100120373
申请日：2010-11-30
申请人： (주)아모레퍼시픽
发明人： 심중현 , 김지현 , 심종원 , 민대진 , 김한곤 , 이태룡 , 노민수 , 신동욱
IPC分类号： A61K38/06 , A61K31/728 , A61K35/12 , A61K8/64 , A61Q19/08
CPC分类号： A61K38/06 , A61K8/64 , A61K31/728 , A61K35/12 , A61Q19/08
摘要： PURPOSE: A composition containing tripeptides, low molecular hyaluronic acid, mineral, and vitamin is provided to enhance stemness of adipose-derived stem cells. CONSTITUTION: A composition for enhancing stemness of adipose-derived stem cells contains 0.001-3 wt% of tripeptide of glycine-proline-hydroxyproline(Gly-Pro-Hyp), 0.01-50 wt% of low molecular hyaluronic acid, 0.001-3 wt% of mineral, and 0.001-3 wt% of vitamin as active ingredients. The composition is designed from ECM(extracellular matrix). The stem cell is human adipose derived stem cells(hADSCs).
摘要翻译：目的：提供含有三肽，低分子透明质酸，矿物质和维生素的组合物，以增强脂肪来源的干细胞的干性。构成：用于增强脂肪来源的干细胞的干性的组合物含有0.001-3重量％的甘氨酸 - 脯氨酸 - 羟脯氨酸（Gly-Pro-Hyp）的三肽，0.01-50重量％的低分子透明质酸，0.001-3重量％％的矿物质和0.001-3重量％的维生素作为活性成分。该组合物由ECM（细胞外基质）设计。干细胞是人类脂肪干细胞（hADSCs）。

34. 发明公开

KR1020110018067A 피부 각질 줄기세포 증식용 조성물 有权
标题翻译：用于表皮生长因子干细胞增殖的组合物
公开(公告)号：KR1020110018067A
公开(公告)日：2011-02-23
申请号：KR1020090075678
申请日：2009-08-17
申请人： (주)아모레퍼시픽
发明人： 신동욱 , 박준성 , 김동현 , 노민수 , 김덕희
IPC分类号： A61K8/49 , A61K31/37 , A61Q19/08 , A61P17/18
CPC分类号： A61K31/37 , A61K8/498 , A61Q19/08 , A61K8/49
摘要： PURPOSE: A composition containing ortho-dihydroxyisoflavone derivative for improving skin regeneration or skin elasticity is provided to induce proliferation of epidermal keratinocyte stem cells. CONSTITUTION: A composition for improving skin regeneration or skin elasticity contains 0.001-30 weight% of ortho-dihydroxyisoflavoen derivative of 4',7,8-trihydroxyisoflavone, 4',6,7-trihydroxyisoflavone, or 3',4',7-trihydroxyisoflavone as an active ingredient. An external use skin composition, pharmaceutical composition, or cosmetic composition contains the composition.
摘要翻译：目的：提供含有用于改善皮肤再生或皮肤弹性的邻位二羟基异黄酮衍生物的组合物，以诱导表皮角化细胞干细胞的增殖。构成：用于改善皮肤再生或皮肤弹性的组合物含有0.001-30重量％的4'，7,8-三羟基异黄酮，4'，6,7-三羟基异黄酮或3'，4'，7'-三羟基异黄酮的邻二羟基异佛尔酮衍生物，三羟基异黄酮作为活性成分。外用皮肤组合物，药物组合物或化妆品组合物含有该组合物。

35. 发明公开

KR1020110000716A 인간 중간엽줄기세포를 지방세포로 분화하는 것을 촉진시키는 피부 미용 또는 성형용 조성물 有权
标题翻译：化妆品或塑料手术的组合物促进人类细胞干细胞分化成AD细胞的分化
公开(公告)号：KR1020110000716A
公开(公告)日：2011-01-05
申请号：KR1020100117492
申请日：2010-11-24
申请人： (주)아모레퍼시픽
发明人： 박선미 , 신동욱 , 이상민 , 송민정 , 김신형 , 노민수 , 김한곤
IPC分类号： A61K8/97 , A61K36/54 , A61Q19/00
摘要： PURPOSE: A composition containing herb extract for skin care or plasty is provided to promoter differentiation of mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for promoting differentiation to adipocytes contains Cinnamomum cassia extract as an active ingredient. The composition increases fat tissue. The mesenchymal stem cells are human bone marrow stem cells.
摘要翻译：目的：提供含有皮肤护理或整形草药提取物的组合物，以促进间充质干细胞向脂肪细胞的分化。构成：促进脂肪细胞分化的组合物含有肉桂提取物作为活性成分。组合物增加脂肪组织。间充质干细胞是人类骨髓干细胞。

36. 发明公开

KR1020100051286A 피부 기능 향상 물질의 스크리닝 방법 有权
标题翻译：筛选用于改善皮肤功能的材料的方法
公开(公告)号：KR1020100051286A
公开(公告)日：2010-05-17
申请号：KR1020080110377
申请日：2008-11-07
申请人： (주)아모레퍼시픽
发明人： 노민수 , 여현주 , 박선미 , 신동욱 , 이형호 , 김한곤
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/15 , G01N33/5008
摘要： PURPOSE: A screening method of a skin improvement material is provided to effectively screen the skin improvement material capable of preventing skin ageing, maintaining skin moisture, and improving skin barrier function. CONSTITUTION: A screening method of a skin improvement material comprises the following steps: processing a candidate material to a skin cell; detecting an expression amount change of MAP17(membrane-associated protein 17kd); and selecting the candidate material which induces the change of the expression amount as the skin improvement material. The skin cell is a skin keratinocyte.
摘要翻译：目的：提供皮肤改善材料的筛选方法，以有效地筛选能够防止皮肤老化，保持皮肤水分和改善皮肤屏障功能的皮肤改善材料。构成：皮肤改善材料的筛选方法包括以下步骤：将候选材料加工到皮肤细胞; 检测MAP17（膜相关蛋白17kd）的表达量变化; 并选择引起表达量变化的候选材料作为皮肤改善材料。皮肤细胞是皮肤角质形成细胞。

37. 发明公开

KR1020100025070A 키메린을 함유하는 지방세포 분화 억제 및 지방세포 내의 지질체 수준 감소용 조성물 有权
标题翻译：用于抑制ADIPOCYTE中脂质体降解水平和降低水平的组合物
公开(公告)号：KR1020100025070A
公开(公告)日：2010-03-09
申请号：KR1020080083683
申请日：2008-08-27
申请人： (주)아모레퍼시픽
发明人： 최현 , 노민수 , 김한곤
IPC分类号： A61K38/16 , A61P3/04
摘要： PURPOSE: A composition for suppressing differentiation and growth of adipocytes is provided to treat or prevent circulatory system disease or ischemic heart disease. CONSTITUTION: A composition for suppressing differentiation or growth of adipocytes contains 0.00001 to 15 weight% of chemerin. The adipocyte is human bone marrow mesenchymal stem cell. A pharmaceutical composition is used in the form of oral administration formulation or injection. The oral administration formulation is formulated in capsule, tablet, suspension, syrup or powder. A functional health food composition for preventing or treating diabetes, hyperlipidemia, hypercholesterolemia, circulatory system diseases contains 0.00001-10 weight% of chemerin. The health food is used in the form of caramel, chocolate, diet bar or snack. A cosmetic composition for treating obesity contains 0.00001-10 weight% of chemerin as an active ingredient. The cosmetic composition is used in the form of massage cream, body lotion, body cream, body oil, or body essence.
摘要翻译：目的：提供一种抑制脂肪细胞分化和生长的组合物，用于治疗或预防循环系统疾病或缺血性心脏病。构成：用于抑制脂肪细胞分化或生长的组合物含有0.00001〜15重量％的凯美宾。脂肪细胞是人骨髓间充质干细胞。药物组合物以口服给药制剂或注射剂的形式使用。口服给药制剂配制成胶囊，片剂，悬浮液，糖浆或粉剂。用于预防或治疗糖尿病，高脂血症，高胆固醇血症，循环系统疾病的功能保健食品组合物含有0.00001-10重量％的凯美瑞。保健食品以焦糖，巧克力，饮食酒吧或小吃的形式使用。用于治疗肥胖的化妆品组合物含有0.00001-10重量％的作为活性成分的凯美瑞。化妆品组合物以按摩霜，身体乳液，身体霜，身体油或身体精华的形式使用。

38. 发明公开

KR1020100005480A 흑축 추출물, 전호 추출물 또는 이들의 혼합물을 함유하는슬리밍용 조성물 有权
标题翻译：用于含有药用植物提取物或神经递质萃取物的组合物
公开(公告)号：KR1020100005480A
公开(公告)日：2010-01-15
申请号：KR1020080065529
申请日：2008-07-07
申请人： (주)아모레퍼시픽
发明人： 신동욱 , 이상민 , 송민정 , 박선미 , 김신형 , 노민수 , 김한곤
IPC分类号： A61K36/736 , A61P3/04
CPC分类号： A61K36/39 , A61K36/23 , Y10S514/909
摘要： PURPOSE: A composition containing pharbitidis seed, Anthriscs aemula Schisch and their mixture for body sliming is provided to suppress adipocyte differentiation and reduce lipid level. CONSTITUTION: A composition for body sliming contains pharbitidis seed extract, Anthriscs aemula Schisch extract or their mixture as an active ingredient. A composition for suppressing adipocyte differentiation contains the pharbitidis seed extract, Anthriscs aemula Schisch extract or their mixture as an active ingredient. Mesenchymal stem cells from human bone marrow are differentiated to adipocytes. The composition for sliming is used in the form of cosmetic composition, health food or pharmaceutical composition.
摘要翻译：目的：提供含有pharbitidis种子，Anthriscs aemula Schisch及其混合物用于身体瘦身的组合物，以抑制脂肪细胞分化和降低脂质水平。构成：用于身体瘦身的组合物含有药草种子提取物，Anthriscs aemula Schisch提取物或其混合物作为活性成分。用于抑制脂肪细胞分化的组合物含有苦楝子种子提取物，Anthriscs aemula Schisch提取物或其混合物作为活性成分。来自人骨髓的间充质干细胞被分化成脂肪细胞。用于苗条的组合物以化妆品组合物，保健食品或药物组合物的形式使用。

39. 发明公开

KR1020090056584A 스핑고실포스포릴콜린의 작용을 조절하는 약학 조성물 无效
标题翻译：用于控制磷脂酰胆碱的功能的药物组合物
公开(公告)号：KR1020090056584A
公开(公告)日：2009-06-03
申请号：KR1020070123798
申请日：2007-11-30
申请人： (주)아모레퍼시픽 , 재단법인서울대학교산학협력재단
发明人： 고재영 , 한은실 , 김혁 , 김정주 , 노민수 , 김상희 , 임채민
IPC分类号： A61K31/16 , A61K31/13 , A61P31/00
CPC分类号： A61K31/16
摘要： A pharmaceutical composition regulating the activity of sphingosylphosphorylcholine(SPC) is provided to regulate cell proliferation, inflammation and pruritus and treat inflammmatin or pruritus of dermatitis such as atopic dermatitis. A pharmaceutical composition which regulates the activity of sphingosylphosphorylcholine(SPC) comprises a compound of the chemical formula 1 or its pharmaceutically allowable salt. In the chemical formula 1, X is O or S, Y is CH2 or carbonyl. R1 is hydrogen or C1-10 alkyl, R2 is hydrogen or methyl, but when X is O, either R1 or R2 cannot be hydrogen, R3 is C1-4 alkyl. A method for manufacturing a compound of the chemical formula 1a comprises: a step of reacting a compound of the chemical formula 2 and a compound of the chemical formula 3 under the presence of base to obtain a compound of the chemical formula 4; a step of stirring the compound of the chemical formula 4 under the presence of base to obtain a compound of the chemical formula 5; and a step of performing the peptide bond between the compound of the chemical formula 5 and a compound of the chemical formula 6 to obtain the compound of the chemical formula 1a.
摘要翻译：提供调节肌动蛋白磷酰胆碱（SPC）活性的药物组合物，用于调节细胞增殖，炎症和瘙痒，并治疗诸如特应性皮炎等炎性炎症或皮炎瘙痒症。调节鞘糖基磷酰胆碱（SPC）活性的药物组合物包含化学式1的化合物或其药学上可允许的盐。在化学式1中，X为O或S，Y为CH 2或羰基。 R1是氢或C1-10烷基，R2是氢或甲基，但当X是O时，R1或R2不能是氢，R3是C1-4烷基。制备化学式1a化合物的方法包括：使化学式2的化合物与化学式3化合物在碱存在下反应得到化学式4的化合物的步骤; 在碱的存在下搅拌化学式4的化合物以获得化学式5的化合物的步骤; 在化学式5的化合物与化学式6的化合物之间进行肽键的步骤，得到化学式1a的化合物。

40. 发明公开

KR1020170091567A 무라야 패니쿨라타 추출물을 포함하는 피부용 조성물 审中-实审
标题翻译：含有muraya paniculata提取物的皮肤组合物
公开(公告)号：KR1020170091567A
公开(公告)日：2017-08-09
申请号：KR1020170097086
申请日：2017-07-31
申请人： (주)아모레퍼시픽
发明人： 김형준 , 최현 , 김광미 , 고재영 , 박선영 , 이명렬 , 남개원 , 안수미 , 노민수 , 김한곤
IPC分类号： A61K36/75 , A61K8/97 , A61Q19/00
CPC分类号： A61K36/75 , A61K8/97 , A61Q19/005 , A61Q19/007
摘要： 본발명은무라야패니쿨라타추출물을유효성분으로포함하는피부가려움증완화및 억제, 피부보습, 피부염증완화및 억제, 피부면역성강화, 피부과민반응개선또는아토피피부개선및 치료용조성물을개시한다.
摘要翻译：本发明公开了一种村的同伴库拉其他皮肤瘙痒缓解包括提取物作为活性成分和抑制，皮肤保湿剂，皮肤炎症和抑制，皮肤免疫增强，皮肤致敏改善或特应性皮肤改善和治疗组合物。

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