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31. 发明申请

US20170095523A1 LOW FREQUENCY GLATIRAMER ACETATE THERAPY 审中-公开
公开(公告)号：US20170095523A1
公开(公告)日：2017-04-06
申请号：US15380579
申请日：2016-12-15
申请人： Yeda Research & Development Co., Ltd.
发明人： Ety Klinger
IPC分类号： A61K38/02 , A61K9/00
CPC分类号： A61K9/0019 , A61K31/19 , A61K31/785 , A61K38/02 , A61K38/07 , A61K38/16 , A61P3/10
摘要： A method of alleviating a symptom of relapsing-remitting multiple sclerosis in a human patient suffering from relapsing-remitting multiple sclerosis or a patient who has experienced a first clinical episode and is determined to be at high risk of developing clinically definite multiple sclerosis comprising administering to the human patient three subcutaneous injections of a therapeutically effective dose of glatiramer acetate over a period of seven days with at least one day between every subcutaneous injection so as to thereby alleviate the symptom of the patient.

32. 发明申请

US20160059027A1 TRANSCRANIAL MAGNETIC STIMULATION SYSTEM AND METHODS 审中-公开
公开(公告)号：US20160059027A1
公开(公告)日：2016-03-03
申请号：US14849632
申请日：2015-09-10
申请人： BRAINSWAY, LTD. , GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH , YEDA RESEARCH & DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
发明人： ABRAHAM ZANGEN , YIFTACH ROTH , PEDRO C. MIRANDA , DAVID HAZANI , MARK HALLETT
IPC分类号： A61N2/02 , A61N2/00
CPC分类号： A61N2/02 , A61N2/006
摘要： A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.

33. 发明授权

US09155776B2 Low frequency glatiramer acetate therapy 有权
标题翻译：低频格拉默姆醋酸酯治疗
公开(公告)号：US09155776B2
公开(公告)日：2015-10-13
申请号：US14720556
申请日：2015-05-22
申请人： Yeda Research & Development Co., Ltd.
发明人： Ety Klinger
IPC分类号： A61K38/02 , A61K38/07 , A61K9/00
CPC分类号： A61K9/0019 , A61K31/19 , A61K31/785 , A61K38/02 , A61K38/07 , A61K38/16
摘要： A method of alleviating a symptom of relapsing-remitting multiple sclerosis in a human patient suffering from relapsing-remitting multiple sclerosis or a patient who has experienced a first clinical episode and is determined to be at high risk of developing clinically definite multiple sclerosis comprising administering to the human patient three subcutaneous injections of a therapeutically effective dose of glatiramer acetate over a period of seven days with at least one day between every subcutaneous injection so as to thereby alleviate the symptom of the patient.
摘要翻译：一种减轻患有复发性多发性硬化的人类患者复发缓解多发性硬化的症状的方法或经历了第一次临床发作的患者，并且被确定为具有发展为临床确定性多发性硬化症的高风险的方法，该方法包括给予人类患者在七天内三次皮下注射治疗有效剂量的醋酸格拉默，每次皮下注射至少一天，从而减轻患者的症状。

34. 发明申请

US20150202247A1 LOW FREQUENCY GLATIRAMER ACETATE THERAPY 审中-公开
标题翻译：低频玻璃酸乙酯治疗
公开(公告)号：US20150202247A1
公开(公告)日：2015-07-23
申请号：US14673257
申请日：2015-03-30
申请人： Yeda Research & Development Co., Ltd.
发明人： Ety Klinger
IPC分类号： A61K38/02
CPC分类号： A61K9/0019 , A61K31/19 , A61K31/785 , A61K38/02 , A61K38/07 , A61K38/16
摘要： A method of alleviating a symptom of relapsing-remitting multiple sclerosis in a human patient suffering from relapsing-remitting multiple sclerosis or a patient who has experienced a first clinical episode and is determined to be at high risk of developing clinically definite multiple sclerosis comprising administering to the human patient three subcutaneous injections of a therapeutically effective dose of glatiramer acetate over a period of seven days with at least one day between every subcutaneous injection so as to thereby alleviate the symptom of the patient.
摘要翻译：一种减轻患有复发性多发性硬化的人类患者复发缓解多发性硬化的症状的方法或经历了第一次临床发作的患者，并且被确定为具有发展为临床确定性多发性硬化症的高风险的方法，该方法包括给予人类患者在七天内三次皮下注射治疗有效剂量的醋酸格拉默，每次皮下注射至少一天，从而减轻患者的症状。

35. 发明申请

US20140354886A1 DEVICE, SYSTEM, AND METHOD OF BLIND DEBLURRING AND BLIND SUPER-RESOLUTION UTILIZING INTERNAL PATCH RECURRENCE 有权
标题翻译：使用内部调节恢复的盲点发生和盲点超分辨率的装置，系统和方法
公开(公告)号：US20140354886A1
公开(公告)日：2014-12-04
申请号：US14289670
申请日：2014-05-29
申请人： Yeda Research & Development Co. Ltd.
发明人： Tomer MICHAELI , Michal Irani
IPC分类号： H04N1/38
CPC分类号： H04N1/4092 , G06T5/003 , G06T2207/20016 , G06T2207/20192
摘要： Devices, systems, and methods of blind deblurring and blind super-resolution utilizing internal patch recurrence. Small signal patches tend to repeat “as is” across multiple scales of a natural signal. This fractal-like behavior is utilized for signal processing tasks, including “Blind Deblurring” or “Blind Super-Resolution”, namely, removing signal blur or increasing signal resolution without a-priori knowledge of the underlying blur kernel. While the cross-scale patch recurrence is strong in signals taken under ideal conditions, the cross-scale patch recurrence significantly diminishes when the acquisition blur deviates from an ideal blur. These deviations from ideal patch recurrences are used for recovering the underlying (unknown) blur kernel. The correct blur kernel is recovered by seeking the kernel which maximizes the patch similarity across scales of a related “reference” signal. For example, this reference signal may be the low-resolution input signal, the sharp deblurred-version of a blurry input signal, or the like. Quantitative and qualitative experiments indicate that this approach yields improved or superior results, in “Blind Deblurring” and in “Blind Super-Resolution”.
摘要翻译：使用内部斑块复发的盲目去除和盲目超分辨率的设备，系统和方法。小信号贴片往往在自然信号的多个尺度上“按原样”重复。这种分形样的行为被用于信号处理任务，包括“Blind Deblurring”或“Blind Super-Resolution”，即去除信号模糊或增加信号分辨率，而无需先验知识的底层模糊内核。虽然在理想条件下获取的信号中交叉尺度贴片复发很强，但是当采集模糊偏离理想模糊时，交叉尺度贴片复发显着减小。这些与理想斑块复发的偏差用于恢复底层（未知）模糊核。通过寻找使相关“参考”信号的尺度上的补片相似度最大化的内核来恢复正确的模糊内核。例如，该参考信号可以是低分辨率输入信号，模糊输入信号的锐利去模糊版本等。定量和定性实验表明，这种方法在“盲目去除”和“盲目超分辨率”中产生了改进或优异的结果。

36. 发明授权

US08771163B2 Transcranial magnetic stimulation system and methods 有权
标题翻译：经颅磁刺激系统及方法
公开(公告)号：US08771163B2
公开(公告)日：2014-07-08
申请号：US13783427
申请日：2013-03-04
申请人： Brainsway, Inc. , Government of the United States of America, as Represented by the Secretary, Depart , Yeda Research & Development Co. Ltd. at the Weizmann Institute of Science
发明人： Abraham Zangen , Yiftach Roth , Pedro C. Miranda , David Hazani , Mark Hallett
IPC分类号： A61N1/00 , A61N2/02
CPC分类号： A61N2/02 , A61N2/006
摘要： A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.
摘要翻译：公开了一种用于经颅磁刺激的系统和方法，该系统包括头盔，定位部分，刺激器和冷却系统。头盔包括用于深脑磁刺激的线圈。线圈具有基部和返回部，其可以包括突出的返回部和接触返回部。线圈设计用于减少大脑部分的意外刺激，同时减少表面电荷的累积。线圈在几个位置和/或不同时间被刺激，以将电场聚焦在特定的深部神经元结构上。

37. 发明授权

US10463870B2 Systems and methods for controlling electric field pulse parameters using transcranial magnetic stimulation 有权
公开(公告)号：US10463870B2
公开(公告)日：2019-11-05
申请号：US15242737
申请日：2016-08-22
申请人： YEDA RESEARCH & DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
发明人： Yiftach Roth , Vadim Chudnovsky , Noach Safra , David Hazani , Abraham Zangen
IPC分类号： A61N2/00 , A61N2/02
摘要： A system and methods for controlling pulse parameters during transcranial magnetic stimulation are provided. Multiple coils are placed on external body parts, and are controlled using an external control unit coupled to a stimulator having fast switches. The timing of the switches, as well as other parameters within the stimulator, determine the pulse parameters, such as pulse shape. The variety of pulse shapes obtainable using such a system and methods provides controlled physiologic effects within an internal body organ.

38. 发明授权

US10029113B2 Transcranial magnetic stimulation system and methods 有权
公开(公告)号：US10029113B2
公开(公告)日：2018-07-24
申请号：US14849632
申请日：2015-09-10
申请人： BRAINSWAY, LTD. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH , YEDA RESEARCH & DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
发明人： Abraham Zangen , Yiftach Roth , Pedro C. Miranda , David Hazani , Mark Hallett
IPC分类号： A61N2/00 , A61N2/02
摘要： A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.

39. 发明申请

US20160319287A1 ATYPICAL INTEINS 审中-公开
标题翻译：特殊功能
公开(公告)号：US20160319287A1
公开(公告)日：2016-11-03
申请号：US15103839
申请日：2014-12-12
申请人： WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER , YEDA RESEARCH & DEVELOPMENT CO. LTD.
发明人： Henning Dieter MOOTZ , Ilka THIEL , Gerrit VOLKMANN , Shmuel PIETROKOVSKI , Anne-Lena BACHMANN
IPC分类号： C12N15/62 , C12N9/22 , C07K14/00 , C12N15/10 , C07K14/245 , C07K7/06
CPC分类号： C12N15/62 , C07K7/06 , C07K14/00 , C07K14/005 , C07K14/245 , C07K2319/21 , C07K2319/92 , C12N9/22 , C12N15/102 , C12N2795/10122
摘要： The present invention relates to an isolated polypeptide comprising at least one intein or at least one intein fragment of said intein, wherein said intein is a naturally split intein with a N-terminal intein fragment split after 14-60 amino acids from the intein's N-terminal end and methods of using the same.
摘要翻译：本发明涉及包含所述内含肽的至少一个内含肽或至少一个内含肽片段的分离的多肽，其中所述内含肽是天然裂解的内含肽，其与来自内含肽的N-末端的14-60个氨基酸之间分裂的N-末端内蛋白片段终端及其使用方法。

40. 发明授权

US09075072B2 Means and methods for recognizing the development of cardiovascular disease in an individual 有权
标题翻译：识别个体心血管疾病发展的手段和方法
公开(公告)号：US09075072B2
公开(公告)日：2015-07-07
申请号：US14445281
申请日：2014-07-29
申请人： YEDA RESEARCH & DEVELOPMENT CO. LTD.
发明人： Irun R. Cohen , Eytan Domany , Eli Sahar , Noam Shental
IPC分类号： G01N33/53 , G01N33/68 , G01N33/564
CPC分类号： G01N33/6893 , G01N33/564 , G01N2333/47 , G01N2500/04 , G01N2800/324
摘要： A method of recognizing the development of an Acute Myocardial Infarction (AMI) process in an individual, wherein the method comprises steps of: profiling specific antibody reactivities or biomarkers associated with AMI susceptibility, the profiling comprises steps of: attaching a set of defined antigens to a substrate; obtaining a biological fluid derived specimen from an individual, the specimen containing a specific antibody repertoire; and binding said antibodies of the biological fluid specimen to the attached antigens thereby forming bound antibody antigen complexes; and analyzing results obtained, wherein the presence of the complexes is indicative of AMI.
摘要翻译：识别个体中急性心肌梗死（AMI）过程的发展的方法，其中所述方法包括以下步骤：分析与AMI易感性相关的特异性抗体反应性或生物标志物，所述分析包括以下步骤：将一组限定的抗原连接到底物; 从个体获得生物流体衍生标本，含有特异性抗体库的样本; 并将所述生物流体标本的所述抗体结合至附着的抗原，从而形成结合的抗体抗原复合物; 并分析获得的结果，其中复合物的存在表示AMI。

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