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1. 发明专利

JP2013046880A Transcranial magnetic stimulation system and methods 有权
标题翻译：转移磁刺激系统及方法
公开(公告)号：JP2013046880A
公开(公告)日：2013-03-07
申请号：JP2012268579
申请日：2012-12-07
申请人： Brainsway Inc , ブレインズウェイインコーポレイテッド , Yeda Research & Development Co Ltd , イェダリサーチアンドデベロップメントカンパニーリミテッド , Government Of The United States Of America National Inst Of Health , ザガバメントオブザユナイテッドステイツオブアメリカナショナルインスティテューツオブヘルス
发明人： ZANGEN ABRAHAM , ROTH YIFTACH , MIRANDA PEDRO C , HAZANI DAVID , HALLET MARK
IPC分类号： A61N2/00
CPC分类号： A61N2/02 , A61N2/006
摘要： PROBLEM TO BE SOLVED: To disclose system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system.SOLUTION: The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure. In some embodiments, a multi-channel system is used, and in other embodiments, a control unit is used with a single-channel system. The present invention provides methods for stimulating individual coil members and/or multiple coils non-simultaneously to enable focal stimulation of deep brain regions while minimizing stimulation of cortical regions of the brain.
摘要翻译：要解决的问题：为了公开经颅磁刺激的系统和方法，该系统包括头盔，定位部分，刺激器和冷却系统。
解决方案：头盔包括用于深部脑磁刺激的线圈。线圈具有基部和返回部，其可以包括突出的返回部和接触返回部。线圈设计用于减少大脑部分的意外刺激，同时减少表面电荷的累积。线圈在几个位置和/或不同时间被刺激，以将电场聚焦在特定的深部神经元结构上。在一些实施例中，使用多通道系统，并且在其他实施例中，控制单元与单通道系统一起使用。本发明提供了用于同时刺激单个线圈构件和/或多个线圈以使得能够对深部脑区域进行局部刺激同时最小化对脑的皮质区域的刺激的方法。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2014155867A Transcranial magnetic stimulation system and methods 有权
标题翻译：转移磁刺激系统及方法
公开(公告)号：JP2014155867A
公开(公告)日：2014-08-28
申请号：JP2014096324
申请日：2014-05-07
申请人： Brainsway Inc , ブレインズウェイインコーポレイテッド , Yeda Res & Dev Co Ltd , イェダリサーチアンドデベロップメントカンパニーリミテッド , Government Of The United States Of America National Institute Of Health:The , ザガバメントオブザユナイテッドステイツオブアメリカナショナルインスティテューツオブヘルス
发明人： ABRAHAM ZANGEN , ROTH YIFTACH , MIRANDA PEDRO C , HAZANI DAVID , HALLET MARK
IPC分类号： A61N2/00
CPC分类号： A61N2/02 , A61N2/006
摘要： PROBLEM TO BE SOLVED: To provide a system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system.SOLUTION: The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure. In some embodiments, a multi-channel system is used, and in other embodiments, a control unit is used with a single-channel system. The present invention provides methods for stimulating individual coil members and multiple coils non-simultaneously to enable focal stimulation of deep brain regions while minimizing stimulation of cortical regions of the brain.
摘要翻译：要解决的问题：为了提供经颅磁刺激的系统和方法，该系统包括头盔，定位部分，刺激器和冷却系统。解决方案：头盔包括用于深脑磁刺激的线圈。线圈具有基部和返回部，其可以包括突出的返回部和接触返回部。线圈设计用于减少大脑部分的意外刺激，同时减少表面电荷的累积。线圈在几个位置和/或不同时间被刺激，以将电场聚焦在特定的深部神经元结构上。在一些实施例中，使用多通道系统，并且在其他实施例中，控制单元与单通道系统一起使用。本发明提供了用于同时刺激单个线圈构件和多个线圈的方法，以使得能够对深部脑区域进行局部刺激，同时最小化对脑的皮层区域的刺激。

3. 发明申请

WO2006134598A2 TRANSCRANIAL MAGNETIC STIMULATION SYSTEM AND METHODS 审中-公开
标题翻译：转移磁刺激系统及方法
公开(公告)号：WO2006134598A2
公开(公告)日：2006-12-21
申请号：PCT/IL2006/000694
申请日：2006-06-15
申请人： BRAINSWAY, INC. , ZANGEN, Abraham , ROTH, Yiftach , MIRANDA, Pedro C. , HAZANI, David , HALLET, Mark
发明人： ZANGEN, Abraham , ROTH, Yiftach , MIRANDA, Pedro C. , HAZANI, David , HALLET, Mark
IPC分类号： A61N1/00
CPC分类号： A61N2/02 , A61N2/006
摘要： A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure. In some embodiments, a multi-channel system is used, and in other embodiments, a control unit is used with a single-channel system. The present invention provides methods for stimulating individual coil members and/or multiple coils non-simultaneously to enable focal stimulation of deep brain regions while minimizing stimulation of cortical regions of the brain.
摘要翻译：公开了一种用于经颅磁刺激的系统和方法，该系统包括头盔，定位部分，刺激器和冷却系统。头盔包括用于深脑磁刺激的线圈。线圈具有基部和返回部，其可以包括突出的返回部和接触返回部。线圈设计用于减少大脑部分的意外刺激，同时减少表面电荷的累积。线圈在几个位置和/或不同时间被刺激，以将电场聚焦在特定的深部神经元结构上。在一些实施例中，使用多通道系统，并且在其他实施例中，控制单元与单通道系统一起使用。本发明提供了用于同时刺激单个线圈构件和/或多个线圈以使得能够对深部脑区域进行局部刺激同时最小化对脑的皮质区域的刺激的方法。

4. 发明申请

US20140235928A1 CENTRAL BASE COILS FOR DEEP TRANSCRANIAL MAGNETIC STIMULATION 有权
标题翻译：用于深静脉电磁刺激的中央线圈
公开(公告)号：US20140235928A1
公开(公告)日：2014-08-21
申请号：US13772442
申请日：2013-02-21
申请人： BRAINSWAY, INC.
发明人： ABRAHAM ZANGEN , YIFTACH ROTH
IPC分类号： A61N2/02 , A61N2/00
CPC分类号： A61N2/02 , A61N2/006 , A61N2/008
摘要： A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil.
摘要翻译：针对内侧脑区域或侧脑区域的位置特异性的经颅磁刺激线圈被设计成具有在第一方向上具有电流的多个间隔开的刺激元件，并且多个返回元件在与第一方向相反的第二方向上具有电流方向。多个刺激元件围绕线圈的中心轴分布。

5. 发明申请

US20140235926A1 CIRCULAR COILS FOR DEEP TRANSCRANIAL MAGNETIC STIMULATION 有权
标题翻译：用于深静脉电磁刺激的圆形线圈
公开(公告)号：US20140235926A1
公开(公告)日：2014-08-21
申请号：US13772449
申请日：2013-02-21
申请人： BRAINSWAY, INC.
发明人： ABRAHAM ZANGEN , YIFTACH ROTH
IPC分类号： A61N2/02 , A61N2/00
CPC分类号： A61N2/02 , A61N2/006
摘要： A transcranial magnetic stimulation coil which is location-specific for frontal lobe regions, occipital lobe regions, parietal lobe regions, right temporal regions and left temporal regions is designed with multiple spaced apart stimulating elements having current flow in a substantially circular direction, and multiple return elements having current flow in substantially the same circular direction.
摘要翻译：针对额叶区域，枕叶区域，顶叶区域，右颞区域和左颞区域的位置特异性的经颅磁刺激线圈被设计为具有大致圆形方向的电流流动的多个间隔开的刺激元件，并且多次返回具有基本上相同圆形方向的电流的元件。

6. 发明申请

WO2013121359A2 USE OF TRANSCRANIAL MAGNETIC STIMULATION TO MODULATE PERMEABILITY OF THE BLOOD-BRAIN BARRIER 审中-公开
标题翻译：使用传导磁性刺激来调节血脑屏障的渗透性
公开(公告)号：WO2013121359A2
公开(公告)日：2013-08-22
申请号：PCT/IB2013051171
申请日：2013-02-13
申请人： BRAINSWAY INC
发明人： PELL GABY , ZANGEN ABRAHAM , ROTH YIFTACH
IPC分类号： A61N7/02
CPC分类号： A61N2/004 , A61N2/02
摘要： Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.
摘要翻译：经颅磁刺激（TMS）用于以瞬时，安全和无创的方式调节血脑屏障的通透性。传统的或深的TMS线圈可以放置在例如肿瘤附近的头部上。通过定制的刺激方案向大脑提供一系列磁脉冲。在许多可能的临床应用之一中，可以在提供磁脉冲之前，期间或之后的时间框架期间引入药物，以治疗脑中的肿瘤。

7. 发明申请

WO2006134598A3 TRANSCRANIAL MAGNETIC STIMULATION SYSTEM AND METHODS 审中-公开
标题翻译：转移磁刺激系统及方法
公开(公告)号：WO2006134598A3
公开(公告)日：2007-05-03
申请号：PCT/IL2006000694
申请日：2006-06-15
申请人： BRAINSWAY INC , ZANGEN ABRAHAM , ROTH YIFTACH , MIRANDA PEDRO C , HAZANI DAVID , HALLET MARK
发明人： ZANGEN ABRAHAM , ROTH YIFTACH , MIRANDA PEDRO C , HAZANI DAVID , HALLET MARK
IPC分类号： A61N1/00
CPC分类号： A61N2/02 , A61N2/006
摘要： A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure. In some embodiments, a multi-channel system is used, and in other embodiments, a control unit is used with a single-channel system. The present invention provides methods for stimulating individual coil members and/or multiple coils non-simultaneously to enable focal stimulation of deep brain regions while minimizing stimulation of cortical regions of the brain.
摘要翻译：公开了一种用于经颅磁刺激的系统和方法，该系统包括头盔，定位部分，刺激器和冷却系统。头盔包括用于深脑磁刺激的线圈。线圈具有基部和返回部，其可以包括突出的返回部和接触返回部。线圈设计用于减少大脑部分的意外刺激，同时减少表面电荷的累积。线圈在几个位置和/或不同时间被刺激，以将电场聚焦在特定的深部神经元结构上。在一些实施例中，使用多通道系统，并且在其他实施例中，控制单元与单通道系统一起使用。本发明提供了用于同时刺激单个线圈构件和/或多个线圈以使得能够对深部脑区域进行局部刺激同时最小化对脑的皮质区域的刺激的方法。

8. 发明申请

WO2013121359A3 TRANSCRANIAL MAGNETIC STIMULATION TO MODULATE THE BLOOD BRAIN BARRIER 审中-公开
公开(公告)号：WO2013121359A3
公开(公告)日：2013-08-22
申请号：PCT/IB2013/051171
申请日：2013-02-13
申请人： BRAINSWAY, INC.
发明人： PELL, Gaby , ZANGEN, Abraham , ROTH, Yiftach
IPC分类号： A61N2/02
摘要： Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.

9. 发明申请

US20130178692A1 TRANSCRANIAL MAGNETIC STIMULATION SYSTEM AND METHODS 有权
标题翻译：转移磁刺激系统及方法
公开(公告)号：US20130178692A1
公开(公告)日：2013-07-11
申请号：US13783427
申请日：2013-03-04
申请人： BRAINSWAY, INC. , GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPART , YEDA RESEARCH & DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
发明人： ABRAHAM ZANGEN , YIFTACH ROTH , PEDRO C. MIRANDA , DAVID HAZANI , MARK HALLETT
IPC分类号： A61N2/02
CPC分类号： A61N2/02 , A61N2/006
摘要： A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.
摘要翻译：公开了一种用于经颅磁刺激的系统和方法，该系统包括头盔，定位部分，刺激器和冷却系统。头盔包括用于深脑磁刺激的线圈。线圈具有基部和返回部，其可以包括突出的返回部和接触返回部。线圈设计用于减少大脑部分的意外刺激，同时减少表面电荷的累积。线圈在几个位置和/或不同时间被刺激，以将电场聚焦在特定的深部神经元结构上。

10. 发明专利

AU2006257210B8 Transcranial magnetic stimulation system and methods 未知
公开(公告)号：AU2006257210B8
公开(公告)日：2011-11-03
申请号：AU2006257210
申请日：2006-06-15
申请人： BRAINSWAY INC , THE GOVERNMENT OF THE UNITED STATES OF AMERICA , YEDA RES & DEVELOPMENT CO LTD
发明人： MIRANDA PEDRO C , YIFTACH ROTH , ABRAHAM ZANGEN , DAVID HAZANI , MARK HALLET
IPC分类号： A61N1/00
摘要： A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure. In some embodiments, a multi-channel system is used, and in other embodiments, a control unit is used with a single-channel system. The present invention provides methods for stimulating individual coil members and/or multiple coils non-simultaneously to enable focal stimulation of deep brain regions while minimizing stimulation of cortical regions of the brain.

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