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31. 发明授权

US07587231B2 Water fat separated magnetic resonance imaging method and system using steady-state free-precession 有权
标题翻译：水脂分离磁共振成像方法和系统采用稳态自由进动
公开(公告)号：US07587231B2
公开(公告)日：2009-09-08
申请号：US10753342
申请日：2004-01-09
申请人： Weiguo Zhang
发明人： Weiguo Zhang
IPC分类号： A61B5/05
CPC分类号： G01R33/4828 , A61B5/055 , G01R33/5613
摘要： Water-fat separated magnetic resonance (MR) images with balanced steady-state free precession (SSFP) are produced. The acquired SSFP signals are isolated into multiple echo components in which the phase arrangements between the water and fat signals are controlled by appropriately selecting the TR and TE values of the SSFP imaging sequence. From the isolated echo components, the effects of the field inhomogeneities are corrected and water and fat images are separated.
摘要翻译：产生具有平衡稳态自由进动（SSFP）的水脂分离磁共振（MR）图像。所获得的SSFP信号被隔离成多个回波分量，其中通过适当选择SSFP成像序列的TR和TE值来控制水和脂肪信号之间的相位布置。从孤立的回声分量中，校正不均匀场的影响，并分离水分和脂肪图像。

32. 发明申请

US20070052417A1 Method and apparatus for diffusion magnetic resonance imaging with the effects of eddy currents compensated 有权
公开(公告)号：US20070052417A1
公开(公告)日：2007-03-08
申请号：US11217405
申请日：2005-09-02
申请人： Weiguo Zhang , David Kramer
发明人： Weiguo Zhang , David Kramer
IPC分类号： G01V3/00
CPC分类号： G01R33/56341
摘要： A method and a system for acquiring diffusion magnetic resonance images with compensation of the effects of eddy currents induced by the diffusion weighting (DW) gradient pulses. Prescan data are first acquired using the same DW sequence to be used for imaging. The prescan data are used to obtain eddy current parameters that model the effects of DW-induced eddy currents under the exact conditions under which DW images are to be acquired. The DW imaging sequence is then slightly modified according to the eddy current parameters and used to acquire DW image data with the effects of DW-induced eddy currents compensated.

33. 发明申请

US20060073562A1 Protein tyrosine kinase substrate LAT and its use in the indentification of (ANT)agonists of the kinase 失效
标题翻译：蛋白酪氨酸激酶底物LAT及其在（ANT）激动剂鉴定中的应用
公开(公告)号：US20060073562A1
公开(公告)日：2006-04-06
申请号：US11218020
申请日：2005-08-31
申请人： Lawrence Samelson , Weiguo Zhang
发明人： Lawrence Samelson , Weiguo Zhang
IPC分类号： C12N9/12 , C07H21/04 , C12P21/06 , C07K16/40
CPC分类号： C07K16/40 , C07K14/705 , C07K14/7051 , C07K2319/00 , C12N9/1205 , G01N33/5041 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their intracellular ligands and other members of the signaling pathway.
摘要翻译：本发明一般涉及用于鉴定和测试酪氨酸激酶信号通路激动剂和拮抗剂的组合物和方法，更具体地说，用于筛选化合物和鉴定将调节蛋白质酪氨酸激酶底物与其细胞内配体相互作用的化合物的方法和组合物，以及在它们的细胞内配体和信号通路的其他成员之间。

34. 发明授权

US06989672B2 Measurement and correction of gradient-induced cross-term magnetic fields in an EPI sequence 失效
标题翻译： EPI序列中梯度诱导的交叉磁场的测量和校正
公开(公告)号：US06989672B2
公开(公告)日：2006-01-24
申请号：US10960669
申请日：2004-10-08
申请人： Weiguo Zhang
发明人： Weiguo Zhang
IPC分类号： G01V3/00
CPC分类号： G01R33/56554 , G01R33/56518 , G01R33/56563
摘要： A method is disclosed for determining a gradient-induced cross-term magnetic field in a magnetic resonance imaging (MRI) system comprising: positioning an object in a static magnetic field; applying a radio frequency (RF) saturation pulse that spatially saturates nuclei of a slice of the object and applying an echo planar imaging (EPI) sequence to form an image of a slice of the object; generating a cross-field correction factor by analyzing the spatial distribution of the saturation line in the image.
摘要翻译：公开了一种用于确定磁共振成像（MRI）系统中的梯度诱发的交叉磁场的方法，包括：将物体定位在静态磁场中; 施加射频（RF）饱和脉冲，空间上饱和物体切片的核并施加回波平面成像（EPI）序列以形成物体的切片的图像; 通过分析图像中的饱和线的空间分布来产生交叉场校正因子。

35. 发明申请

US20050181135A1 Methods and systems for processing a microelectronic topography 有权
标题翻译：用于处理微电子拓扑的方法和系统
公开(公告)号：US20050181135A1
公开(公告)日：2005-08-18
申请号：US11108589
申请日：2005-04-18
申请人： Igor Ivanov , Weiguo Zhang
发明人： Igor Ivanov , Weiguo Zhang
IPC分类号： H01L21/00 , H01L21/687 , B05D3/04
CPC分类号： H01L21/68728 , H01L21/67051 , H01L21/6708 , Y02P80/30
摘要： Methods and systems are provided which are adapted to process a microelectronic topography, particularly in association with an electroless deposition process. In general, the methods may include loading the topography into a chamber, closing the chamber to form an enclosed area, and supplying fluids to the enclosed area. In some embodiments, the fluids may fill the enclosed area. In addition or alternatively, a second enclosed area may be formed about the topography. As such, the provided system may be adapted to form different enclosed areas about a substrate holder. In some cases, the method may include agitating a solution to minimize the accumulation of bubbles upon a wafer during an electroless deposition process. As such, the system provided herein may include a means for agitating a solution in some embodiments. Such a means for agitation may be distinct from the inlet/s used to supply the solution to the chamber.
摘要翻译：提供了适于处理微电子拓扑的方法和系统，特别是与无电沉积工艺相关联。通常，方法可以包括将形貌加载到腔室中，关闭腔室以形成封闭区域，并将流体供应到封闭区域。在一些实施例中，流体可以填充封闭区域。另外或替代地，围绕地形可以形成第二封闭区域。因此，所提供的系统可以适于在基板保持器周围形成不同的封闭区域。在一些情况下，该方法可以包括搅拌溶液以在无电沉积工艺期间使气泡在晶片上的累积最小化。因此，本文提供的系统可以包括在一些实施例中用于搅拌溶液的装置。用于搅拌的这种手段可能不同于用于将溶液供应到室的入口。

36. 发明授权

US06881437B2 Methods and system for processing a microelectronic topography 失效
标题翻译：用于处理微电子拓扑的方法和系统
公开(公告)号：US06881437B2
公开(公告)日：2005-04-19
申请号：US10462167
申请日：2003-06-16
申请人： Igor C. Ivanov , Weiguo Zhang
发明人： Igor C. Ivanov , Weiguo Zhang
IPC分类号： H01L21/00 , H01L21/687 , B05D5/12 , B05D1/18 , B05D3/12
CPC分类号： H01L21/68728 , H01L21/67051 , H01L21/6708 , Y02P80/30
摘要： Methods and systems are provided which are adapted to process a microelectronic topography, particularly in association with an electroless deposition process. In general, the methods may include loading the topography into a chamber, closing the chamber to form an enclosed area, and supplying fluids to the enclosed area. In some embodiments, the fluids may fill the enclosed area. In addition or alternatively, a second enclosed area may be formed about the topography. As such, the provided system may be adapted to form different enclosed areas about a substrate holder. In some cases, the method may include agitating a solution to minimize the accumulation of bubbles upon a wafer during an electroless deposition process. As such, the system provided herein may include a means for agitating a solution in some embodiments. Such a means for agitation may be distinct from the inlet/s used to supply the solution to the chamber.
摘要翻译：提供了适于处理微电子拓扑的方法和系统，特别是与无电沉积工艺相关联。通常，方法可以包括将形貌加载到腔室中，关闭腔室以形成封闭区域，并将流体供应到封闭区域。在一些实施例中，流体可以填充封闭区域。另外或替代地，围绕地形可以形成第二封闭区域。因此，所提供的系统可以适于在基板保持器周围形成不同的封闭区域。在一些情况下，该方法可以包括搅拌溶液以在无电沉积工艺期间使气泡在晶片上的累积最小化。因此，本文提供的系统可以包括在一些实施例中用于搅拌溶液的装置。用于搅拌的这种手段可能不同于用于将溶液供应到室的入口。

37. 发明申请

US20050016201A1 Multi-staged heating system for fabricating microelectronic devices 审中-公开
标题翻译：用于制造微电子器件的多级加热系统
公开(公告)号：US20050016201A1
公开(公告)日：2005-01-27
申请号：US10624397
申请日：2003-07-22
申请人： Igor Ivanov , Weiguo Zhang
发明人： Igor Ivanov , Weiguo Zhang
IPC分类号： C23C18/16 , H01L21/00 , F25D13/04 , F25D17/02
CPC分类号： H01L21/67248 , C23C18/1619 , C23C18/1676 , H01L21/67023 , H01L21/6715
摘要： A system is provided which is adapted to transport a fluid from a plurality of serially coupled tanks to a chamber configured to process microelectronic wafers. The system further includes a plurality of temperature controllers positioned such that the chamber and the tanks are characterized into at least three zones based upon the adaptations of the controllers to maintain the fluid within each zone within a distinct temperature range. A method is also provided which includes storing a fluid within a preliminary temperature range, transporting the fluid to an intermediate tank and controlling the fluid temperature within the intermediate tank to be within a transitional temperature range distinct from the preliminary temperature range. The method further includes delivering the fluid to a process chamber and controlling the fluid temperature within the process chamber to be within a process temperature range distinct from the preliminary and transitional temperature ranges.
摘要翻译：提供了一种系统，其适于将流体从多个串联耦合的罐输送到被配置为处理微电子晶片的室。该系统还包括多个温度控制器，其定位成使得基于控制器的适应性使得室和罐的特征在于至少三个区域，以将每个区域内的流体保持在不同的温度范围内。还提供了一种方法，其包括将流体存储在初步温度范围内，将流体输送到中间罐并将中间罐内的流体温度控制在与初步温度范围不同的过渡温度范围内。该方法还包括将流体输送到处理室并将处理室内的流体温度控制在与预备温度和过渡温度范围不同的过程温度范围内。

38. 发明授权

US06603990B2 Separation and identification of water and fat MR images at mid-field strength with reduced T2/T2* weighting 有权
公开(公告)号：US06603990B2
公开(公告)日：2003-08-05
申请号：US09925520
申请日：2001-08-10
申请人： Weiguo Zhang , David M. Kramer
发明人： Weiguo Zhang , David M. Kramer
IPC分类号： A61B5055
CPC分类号： G01R33/4828 , A61B5/055
摘要： A magnetic resonance imaging (MRI) method is disclosed for generating and identifying water and fat separated MR images. Image data is first acquired to obtain two echo images with the water and fat signals orthogonal in the first echo image, and parallel/anti-parallel in the second echo image. The effect of background field inhomogeneties are removed, and water and fat images are separated from each other. The separated water and fat images are identified according to the difference of their precessing frequencies.

39. 发明授权

US6147492A Quantitative MR imaging of water and fat using a quadruple-echo sequence 有权
标题翻译：使用四重回波序列对水和脂肪进行定量MR成像
公开(公告)号：US6147492A
公开(公告)日：2000-11-14
申请号：US179955
申请日：1998-10-28
申请人： Weiguo Zhang , Joseph W. Carlson
发明人： Weiguo Zhang , Joseph W. Carlson
IPC分类号： A61B5/055 , G01R33/48 , G01R33/54 , G01V3/00
CPC分类号： G01R33/4828
摘要： A magnetic resonance imaging (MRI) method and apparatus is disclosed for quantitating water and fat content of tissues using nuclear magnetic resonance (NMR) image data of the tissues and for producing an images indicative of the fat and water fractions of the total water and fat content of the tissues. To reduce the overall scanning time, a quadruple field-echo imaging scan sequence is used to acquire the image data. Each imaging sequence comprises an initial slice-selective RF excitation pulse followed by four magnetic field read-out gradient pulses and the acquisition of four separate field-echoes. Each field-echo is generated through the controlled timing and polarity of an applied read gradient. The period of time between field-echoes (T) is selected according to the chemical-shift difference between water and fat signals so that the two signals develop between them an angular phase difference of .pi. radians (180.degree.) during the inter-echo time. Resulting field-echo signals acquired from two scans, one scan preferably having a sequence repetition period (TR) twice that of the other, are analyzed to determine the tissue fat and water fractions for each pixel and produce corresponding fraction images.
摘要翻译：公开了使用组织的核磁共振（NMR）图像数据定量组织的水分和脂肪含量的磁共振成像（MRI）方法和装置，并且用于产生指示总水分和脂肪的脂肪和水分数的图像组织的含量。为了减少整体扫描时间，使用四倍场回波成像扫描序列来获取图像数据。每个成像序列包括初始切片选择性RF激发脉冲，随后是四个磁场读出梯度脉冲，并且获取四个单独的场回波。通过受控的应用读取梯度的定时和极性产生每个场回波。根据水和脂肪信号之间的化学位移差选择场回波（T）之间的时间段，使得两个信号在它们之间产生在回波间时间内的π弧度（180度）的角度相位差。分析从两次扫描获得的所得到的场回波信号，优选地具有两倍的序列重复周期（TR）的一次扫描，以确定每个像素的组织脂肪和水分数并产生相应的分数图像。

40. 发明授权

US5652514A Correction for field variation in steady-state MRI by repeated acquisition of zero k-space line 失效
标题翻译：通过重复采集零k空间线来校正稳态MRI中的场变化
公开(公告)号：US5652514A
公开(公告)日：1997-07-29
申请号：US621240
申请日：1996-03-25
申请人： Weiguo Zhang , David M. Kramer , David M. Goldhaber
发明人： Weiguo Zhang , David M. Kramer , David M. Goldhaber
IPC分类号： G01R33/54 , A61B5/055 , G01R33/565 , G01V3/00
CPC分类号： G01R33/56563
摘要： Methods and apparatus for correcting image artefacts caused by variations in the main magnetic field of an MRI system are disclosed, particularly for MRI with steady-state spin precession. For field correction in MRI with steady-state spin precession, the effects of the field changes can be corrected by quantifying the time course of the field drifts by repeated acquisition of the zero k-space lines. The change in the phase between consecutive zero k-space lines is used as an indicator of field variation and for correction of associated image artifacts. By using for field correction the zero k-space lines acquired using the imaging sequence itself, the steady-states of spin precession are undisturbed throughout the MRI data acquisition.
摘要翻译：公开了用于校正由MRI系统的主磁场的变化引起的图像伪像的方法和装置，特别是对于具有稳态旋转进动的MRI。对于具有稳态自旋进动的MRI中的场校正，可以通过重复采集零k空间线来量化场漂移的时间过程来校正场变化的影响。使用连续零k空间线之间的相位变化作为场变化的指示符和用于校正相关联的图像伪像。通过使用场校正，使用成像序列本身获取的零k空间线，自旋进动的稳态在整个MRI数据采集期间不受干扰。

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