专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明专利

CA2322948A1 CALIBRATION OF A WHOLE BLOOD SAMPLE ANALYSER 未知
公开(公告)号：CA2322948A1
公开(公告)日：1999-09-10
申请号：CA2322948
申请日：1999-02-17
申请人： WARDLAW PARTNERS LP , LEVINE ROBERT A , WARDLAW STEPHEN C
发明人： WARDLAW STEPHEN C
IPC分类号： G01N33/49 , G01N15/14 , G01N21/01 , G01N21/03 , G01N21/78
摘要： Formed constituents of a quiescent anticoagulated whole blood sample are optically analyzed by an optical scanning instrument (54), which sample is contained in a sample chamber (14) that has a varying through plane thickness. The thickness of any fields of view in the blood sample which contain plasma lacunae can be calculated by the instrument as a function of signal emission strength emanating from the colored plasma in the lacunae. The signal emissions can be the result of sample fluorescence or can be the result of signal density emanating from the sample. Particle volumes can be measured as a function of signal emission suppression which is caused by formed particles in the blood sample. The scanning instrument is calibrated by means of the inclusion of a calibration area (13, 38, 40) associated with the chamber which calibration area includes a portion (37) which receives a known depth of colored plasma from the blood sample, and which calibration area also includes a colorant-emission-altering feature (36) which feature has a known volume. The scanning instrument scans the known depth portion of the calibration area to determine what degree of signal emission strength correlates to the known depth, and the scanning instrument also scans the colorant-emission-suppressing feature to determine what degree of signal alteration correlates to the known volume of the aforesaid feature. The instrument stores the information gained from the calibration area and then proceeds to analyze the blood sample for formed constituent volumes and constituent counts per unit of the blood sample.

32. 发明专利

CA2322945A1 DETERMINATION OF WHITE BLOOD CELL DIFFERENTIAL AND RETICULOCYTE COUNTS 未知
公开(公告)号：CA2322945A1
公开(公告)日：1999-09-10
申请号：CA2322945
申请日：1999-02-22
申请人： LEVINE ROBERT A , WARDLAW PARTNERS LP , BECTON DICKINSON CO , WARDLAW STEPHEN C
发明人： LEVINE ROBERT A , WARDLAW STEPHEN C , RODRIGUEZ RODOLFO R
IPC分类号： G01N33/48 , G01N15/00 , G01N15/14 , G01N21/03 , G01N33/49 , G01N33/50
摘要： Target nucleated cells, and target cells containing remanant ribosomal material, which are present in a quiescent anticoagulated whole blood sample are optically detected, enumerated, and analyzed in a sample chamber (14) that has a varying through plane thickness due to convergent opposing sample chamber walls. At least one of the convergent walls (8) of the chamber is transparent so that the blood sample can be observed. The chamber's varying thickness produces a first lesser thickness region (A) in the chamber wherein individual red cells (32) and quiescent monolayers (31) of red cells in the sample will reside after the sample is introduced into and fills the chamber. Larger formed constituents such as white blood cells (34) and nucleated red blood cells present in the sample will reside in greater thickness regions (B) of the chamber, and non-nucleated red cells which reside in such greater thickness regions will agglomerate to form rouleaux (33). By admixing fluorescent dyes with the blood sample, target cells in the sample can be enumerated and differentiated by means of a scanning instrument (54) which is able to measure different wave length color signals emitted from the target cells in the sample, and differentiate the target cells one from another by reason of the nature of the emitted color signals.

33. 发明专利

AU2006304717A8 Apparatus and method for performing counts within a biologic fluid sample 未知
公开(公告)号：AU2006304717A8
公开(公告)日：2008-07-03
申请号：AU2006304717
申请日：2006-10-17
申请人： WARDLAW PARTNERS LP , STEPHEN WARDLAW , ROBERT LEVINE
发明人： WARDLAW STEPHEN C
IPC分类号： G01N21/03 , G01N33/49 , G06M11/00

34. 发明专利

ES2285984T3 PROCEDIMIENTO Y DISPOSITIVO DE SEPARACION DE ELEMENTOS FORMES A PARTIR DE UNA FASE LIQUIDA DE UNA MUESTRA DE UN FLUIDO BIOLOGICO COMPLEJO. 未知
公开(公告)号：ES2285984T3
公开(公告)日：2007-12-01
申请号：ES00117717
申请日：2000-08-17
申请人： WARDLAW STEPHEN C , WARDLAW PARTNERS LP , LEVINE ROBERT A
发明人： WARDLAW STEPHEN C
IPC分类号： G01N1/40 , G01N33/483 , B01L3/00 , G01N1/10 , G01N1/28 , G01N15/10 , G01N33/48 , G01N33/487 , G01N33/49 , G02B21/34 , G06K9/00
摘要： Sistema de recipientes destinado a examinar elementos formes que se encuentran comprendidos en una muestra de fluido biológico acuoso, presentando dicho sistema de recipientes una cámara (4) con un volumen conocido, encontrándose dicha cámara (4) definida por una primera pared (8), unas paredes laterales (6) y una pared transparente de visualización de la muestra (12) que se dispone en la cara opuesta a dicha primera pared (8); una capa (9) de un hidrogel expandible que cubre dicha primera pared (8) de la cámara, presentando dicha capa de hidrogel expandible (9) una superficie plana enfrentada a dicha pared de visualización de la muestra (12) de dicha cámara (4), encontrándose presente dicha capa de hidrogel expandible (9) en una cantidad que puede provocar que dicho hidrogel llene esencialmente dicha cámara (4) y capture todos los elementos formes de la muestra en dicha superficie plana del hidrogel cuando dicha capa de hidrogel (9) se expande debido a la absorción de esencialmente toda lafase acuosa de la muestra del fluido y a la exclusión de los elementos formes de la muestra.

35. 发明专利

DE60034743D1 未知
公开(公告)号：DE60034743D1
公开(公告)日：2007-06-21
申请号：DE60034743
申请日：2000-08-17
申请人： WARDLAW STEPHEN C , LEVINE ROBERT A , WARDLAW PARTNERS LP
发明人： WARDLAW STEPHEN C
IPC分类号： G01N1/40 , G01N33/483 , B01L3/00 , G01N1/10 , G01N1/28 , G01N15/10 , G01N33/48 , G01N33/487 , G01N33/49 , G02B21/34 , G06K9/00
摘要： Formed constituents in an aqueous based fluid biologic material sample are separated from the aqueous constituent of the sample, and are concentrated in an examining instrument's focal plane where they can be examined under magnification. Examples of fluids that can be analyzed in this fashion include urine; cerebrospinal fluid; pleural fluid; ascites; fluids aspirated from cysts such as thyroid and breast cysts; cytologic specimens which have been placed in an aqueous fluid; platelet-rich plasma; and the like. The sample is placed in a chamber having a layer of a hydrophilic hydrogel covering a surface of the chamber. An opposite surface of the chamber is transparent, and may be formed by a microscope slide cover slip, or the like. The volume of hydrogel in the chamber is sufficient so that, when the hydrogel absorbs essentially all of the aqueous fraction of the sample, the hydrogel will expand and fill the chamber. The capture surface of the expanded hydrogel is preferably planar, and any formed constituents in the sample will be captured on the capture surface of the hydrogel layer, and will not be absorbed into the hydrogel. Formed constituents, such as: cells; bacteria; crystals; protozoa; ova; parasites; and the like, can be differentially highlighted by use of labeled antibodies, selective stains, or the like, so as to enable optical examination and differentiation of various formed constituents which may be in the sample. Formed constituents may be harvested from the capture surface of the expanded hydrogel layer for more detailed examination and analysis. The capture surface of the hydrogel may be provided with a plurality of beads for use in locating the capture surface with an optical scanning instrument, and for re-establishing previously scanned fields of view.

36. 发明专利

AT362101T 未知
公开(公告)号：AT362101T
公开(公告)日：2007-06-15
申请号：AT00117717
申请日：2000-08-17
申请人： WARDLAW STEPHEN C , WARDLAW PARTNERS LP , LEVINE ROBERT A
发明人： WARDLAW STEPHEN C
IPC分类号： G01N1/40 , G01N33/483 , B01L3/00 , G01N1/10 , G01N1/28 , G01N15/10 , G01N33/48 , G01N33/487 , G01N33/49 , G02B21/34 , G06K9/00
摘要： Formed constituents in an aqueous based fluid biologic material sample are separated from the aqueous constituent of the sample, and are concentrated in an examining instrument's focal plane where they can be examined under magnification. Examples of fluids that can be analyzed in this fashion include urine; cerebrospinal fluid; pleural fluid; ascites; fluids aspirated from cysts such as thyroid and breast cysts; cytologic specimens which have been placed in an aqueous fluid; platelet-rich plasma; and the like. The sample is placed in a chamber having a layer of a hydrophilic hydrogel covering a surface of the chamber. An opposite surface of the chamber is transparent, and may be formed by a microscope slide cover slip, or the like. The volume of hydrogel in the chamber is sufficient so that, when the hydrogel absorbs essentially all of the aqueous fraction of the sample, the hydrogel will expand and fill the chamber. The capture surface of the expanded hydrogel is preferably planar, and any formed constituents in the sample will be captured on the capture surface of the hydrogel layer, and will not be absorbed into the hydrogel. Formed constituents, such as: cells; bacteria; crystals; protozoa; ova; parasites; and the like, can be differentially highlighted by use of labeled antibodies, selective stains, or the like, so as to enable optical examination and differentiation of various formed constituents which may be in the sample. Formed constituents may be harvested from the capture surface of the expanded hydrogel layer for more detailed examination and analysis. The capture surface of the hydrogel may be provided with a plurality of beads for use in locating the capture surface with an optical scanning instrument, and for re-establishing previously scanned fields of view.

37. 发明专利

CA2626271A1 APPARATUS AND METHOD FOR PERFORMING COUNTS WITHIN A BIOLOGICFLUID SAMPLE 未知
公开(公告)号：CA2626271A1
公开(公告)日：2007-04-26
申请号：CA2626271
申请日：2006-10-17
申请人： WARDLAW STEPHEN C , LEVINE ROBERT A , WARDLAW PARTNERS LP
发明人： WARDLAW STEPHEN C , LEVINE ROBERT A
IPC分类号： G01N33/487 , G01N33/49 , G01N33/52

38. 发明专利

CA2321690C DISPOSABLE APPARATUS FOR PERFORMING BLOOD CELL COUNTS 未知
公开(公告)号：CA2321690C
公开(公告)日：2005-07-05
申请号：CA2321690
申请日：1999-03-02
申请人： WARDLAW STEPHEN C , LEVINE ROBERT A , WARDLAW PARTNERS LP
发明人： WARDLAW STEPHEN C
IPC分类号： G01N33/49 , B01L3/00 , G01N1/28 , G01N15/00 , G01N35/00 , G01N35/02
摘要： A container for holding a biologic fluid sample for analysis is provided which includes a chamber (12) and a label (14). The chamber (12) includes a first wall (26), a transparent second wall (28), and a plurality of features including features spatially located within the chamber (12). The transparent second wall (28) permits a fluid sample quiescently residing within the chamber (12) to be imaged through the second wall (28). The plurality of features, including those spatially located within the chamber, are operable to enable the analysis of the biologic fluid. The label (14) directly or indirectly contains information regarding the features and the spatial location of the features within the chamber (12). The sample is analyzed by an analytical device that utilizes the information communicated through the label (14).

39. 发明专利

CA2350349A1 QUALITY CONTROL METHOD AND APPARATUS FOR AUTOMATED ANALYSES OF BIOLOGIC MATTER 未知
公开(公告)号：CA2350349A1
公开(公告)日：2002-02-28
申请号：CA2350349
申请日：2001-06-11
申请人： LEVINE ROBERT A , WARDLAW PARTNERS LP , WARDLAW STEPHEN C
发明人： WARDLAW STEPHEN C
IPC分类号： G01N33/48 , G01N35/00 , G01N35/02 , G06K7/00 , G01N1/28
摘要： According to one aspect of the present invention, an apparatus for analyzing a biologic sample is provided that includes a container for holding the biolog ic sample, an identity tag attached to the container, and an analytical device for analyzi ng the biologic sample that includes a reader for authenticating the identity tag. According to another aspect of the present invention, a method for analyzing a biologic sample is provided that includes the steps of: (a) providing a container for holding the biologic sample that includes an identity tag; (b) providing an analytical device for analyzing the biolog ic sample that includes a reader for authenticating the identity tag; (c) authenticating th e origin of the container using the identity tag and the reader; and (d) producing informati on indicating the authenticity of the container.

40. 发明专利

AU7246900A Method and apparatus for determining the sensitivity of a mic roorganism to a growth altering agent 未知
公开(公告)号：AU7246900A
公开(公告)日：2001-07-12
申请号：AU7246900
申请日：2000-12-21
申请人： WARDLAW PARTNERS LP , LEVINE ROBERT A
发明人： WARDLAW STEPHEN C
IPC分类号： C12M1/34 , C12M1/20 , C12Q1/02 , C12Q1/18 , C12Q1/04
摘要： A method for determining the concentration at which a growth-altering agent has an appreciable effect on the growth of a target microorganism comprises the steps of (a) providing a microorganism growth medium (28); (b) providing a sensible reagent, which includes a growth-altering agent mixed with a marker that has a signal with a magnitude proportional to the concentration of the marker; (c) incorporating the sensible reagent into the growth medium, in a manner that creates a gradient (38) of growth-altering agent and marker concentrations within the growth medium; (d) inoculating the growth medium with the target microorganism; (e) incubating the inoculated growth medium for a period of time sufficient for the target microorganism to grow a detectable amount; (f) evaluating growth characteristics of the microorganism in a region containing the growth-altering agent; (g) measuring the magnitude of the marker signal in that region; and (h) determining the concentration of the growth-altering agent using the measured magnitude of the marker signal. Apparatus for performing the method is also provided.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式