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31. 发明授权

US06656216B1 Composite stent with regioselective material 有权
标题翻译：具有区域选择性材料的复合支架
公开(公告)号：US06656216B1
公开(公告)日：2003-12-02
申请号：US09895753
申请日：2001-06-29
申请人： Syed F. A. Hossainy , Orlando Padilla , Daryush Mirzaee
发明人： Syed F. A. Hossainy , Orlando Padilla , Daryush Mirzaee
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2230/0076 , A61F2250/0018 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10S623/916
摘要： A composite stent and methods for making the same are provided. In one embodiment a regioselective band is formed in situ on the stent. In one embodiment, the band is made of a regioselective material having a high creep compliance and having a second modulus of elasticity lower than that of a structural material comprising the stent. In one embodiment, the regioselective material is drip-coated or dip-coated on the stent near the ends. In one embodiment, the regioselective material includes a therapeutic agent, which may be a radioactive emitter, an anti-platelet drug, or an anti-proliferative drug.
摘要翻译：提供复合支架及其制造方法。在一个实施例中，在支架上原位形成区域选择性带。在一个实施方案中，带由区域选择性材料制成，具有高蠕变柔量并且具有低于包含支架的结构材料的第二弹性模量。在一个实施方案中，区域选择性材料在端部附近滴加或浸涂在支架上。在一个实施方案中，区域选择性材料包括治疗剂，其可以是放射性发射体，抗血小板药物或抗增殖药物。

32. 发明授权

US06641607B1 Double tube stent 有权
标题翻译：双管支架
公开(公告)号：US06641607B1
公开(公告)日：2003-11-04
申请号：US09753294
申请日：2000-12-29
申请人： Syed F. A. Hossainy , Shamim M. Malik , Steven Wu
发明人： Syed F. A. Hossainy , Shamim M. Malik , Steven Wu
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/91575 , A61F2210/0095 , A61F2230/0054 , A61F2250/0068 , A61F2250/0098
摘要： A stent or intraductal medical device manufactured from a tubular member having an inner tube tightly fitted into an outer tube is provided. Microdepots may be formed on the outer surface of the inner tube, and may contain radioactive, radiopaque or therapeutic substances. A method for manufacturing such a medical device or stent is also described. The material to be deposited on the inner tube may be deposited on the inner tube by dipping or immersion, or the material may be applied to the inner tube using micro-injection or electrodeposition. The material to be deposited may be applied to cavities or microdepots formed in the outer surface of the inner tube. Excess material may be removed from the inner tube by centrifugation or shaking, and the material to be deposited may be heated to bond the material to the surface of the microdepots on the inner tube.
摘要翻译：提供了由具有紧密配合到外管中的内管的管状构件制造的支架或导管内医疗装置。微口可以形成在内管的外表面上，并且可以包含放射性，不透射线或治疗物质。还描述了制造这种医疗装置或支架的方法。要沉积在内管上的材料可以通过浸渍或浸渍沉积在内管上，或者可以使用微注射或电沉积将材料施加到内管。待沉积的材料可以应用于形成在内管的外表面中的腔或微口。可以通过离心或摇动从内管中除去多余的材料，并且可以加热待沉积的材料以将材料粘合到内管上的微口头表面上。

33. 发明授权

US06623733B1 Methods for treatment of vascular disease and device for preparation of an autologous composition for treating vascular disease 有权
标题翻译：用于治疗血管疾病的方法和用于制备用于治疗血管疾病的自体组合物的装置
公开(公告)号：US06623733B1
公开(公告)日：2003-09-23
申请号：US09893022
申请日：2001-06-27
申请人： Syed F. A. Hossainy , Jeffrey A. Steward , Paul M. Consigny
发明人： Syed F. A. Hossainy , Jeffrey A. Steward , Paul M. Consigny
IPC分类号： A61K4800
CPC分类号： A61K38/195 , A61K35/15 , A61K35/19 , A61K35/35 , A61K35/44 , A61K35/545 , A61K38/191 , A61K38/2006 , A61K38/4886 , A61K2300/00
摘要： A method for making a composition for administration to a patient, where the method includes: harvesting tissue including cells from a patient, lysing the cells to form a lysate, filtering the lysate to yield a filtrate, and collecting the filtrate as a composition comprising the filtrate for administration to said patient.
摘要翻译：一种用于制备用于给予患者的组合物的方法，其中所述方法包括：从患者收获包括细胞的组织，裂解细胞以形成裂解物，过滤裂解物以产生滤液，并收集滤液作为组合物，其包含用于给予所述患者的滤液。

34. 发明授权

US06258870B1 Gels for encapsulation of biological materials 失效
标题翻译：用于生物材料包封的凝胶
公开(公告)号：US06258870B1
公开(公告)日：2001-07-10
申请号：US08783387
申请日：1997-01-13
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Syed F. A. Hossainy
IPC分类号： A61K950
CPC分类号： A61L27/36 , A61K9/1635 , A61K9/1647 , A61K9/5031 , A61K9/5073 , A61K38/42 , A61K38/44 , A61K47/645 , A61K47/6925 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/3683 , A61L27/38 , A61L27/3804 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , C08L71/02
摘要： This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material which is already encapsulated.
摘要翻译：本发明提供了使用水溶性分子的光聚合在生物材料周围形成生物相容性膜的新方法。该膜可以用作包封生物材料或生物医学装置的覆盖物，作为使胶粘剂引起不止一种生物物质粘附在一起，或作为生物活性物质的载体。提供了形成这些膜的几种方法。这些方法中的每一种都使用含有水溶性大分子单体的聚合体系，它们是能够进一步聚合的聚合物和大分子的物质。大分子单体使用光引发剂（例如染料），任选的助催化剂，任选的促进剂和可见或长波长UV光的形式的辐射聚合。该反应通过悬浮聚合或通过界面聚合进行。聚合物膜可以直接形成在生物材料的表面上，或者可以在已被包封的材料上形成。

35. 发明授权

US09220584B2 Treatment of diabetic patients with a stent and locally administered adjunctive therapy 有权
标题翻译：用支架治疗糖尿病患者和局部给药辅助治疗
公开(公告)号：US09220584B2
公开(公告)日：2015-12-29
申请号：US13435645
申请日：2012-03-30
申请人： Syed F. A. Hossainy
发明人： Syed F. A. Hossainy
IPC分类号： A61F2/06 , A61F2/00 , A61F2/958
CPC分类号： A61F2/958 , A61F2/00 , A61F2/844 , A61F2/915 , A61F2250/0067 , A61L29/043 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/204 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2400/10 , A61M25/007 , A61M25/10 , A61M2025/105
摘要： Embodiments of the present invention include methods of treating, preventing, and/or ameliorating a vascular disease and/or disorder in a diabetic or pre-diabetic patient. The methods include implanting a stent in a vascular region in a diabetic or pre-diabetic patient, and prior to and/or during the implantation procedure, delivering a lubricant formulation to the vascular region. The stent may be a bare metal stent, or a drug eluting stent, such as a metal stent with a coating including a drug, such as everolimus or sirolimus.
摘要翻译：本发明的实施方案包括治疗，预防和/或改善糖尿病或前期糖尿病患者的血管疾病和/或病症的方法。所述方法包括将支架植入糖尿病患者或糖尿病前患者的血管区域，以及在植入术前和/或期间，将润滑剂制剂输送到血管区域。支架可以是裸金属支架或药物洗脱支架，例如具有包括药物的涂层的金属支架，例如依维莫司或西罗莫司。

36. 发明授权

US09114198B2 Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same 有权
标题翻译：含有氟聚合物的可植入装置的生物有益的涂层及其制造方法
公开(公告)号：US09114198B2
公开(公告)日：2015-08-25
申请号：US10718278
申请日：2003-11-19
申请人： Syed F. A. Hossainy , Yiwen Tang
发明人： Syed F. A. Hossainy , Yiwen Tang
IPC分类号： A61K31/16 , A61L27/14 , A61F2/06 , A61L31/10
CPC分类号： A61L31/10 , C08L71/02 , C08L101/04 , C08L67/02
摘要： Coatings for an implantable medical device and a method of fabricating the coatings are disclosed. The coatings comprise a fluorinated polymer and a biologically beneficial polymer, an example of which includes poly(ethylene-glycol)-block poly(butylene terephthalate)-block poly(ethylene-glycol). A biologically active agent can be additionally conjugated to the biologically beneficial polymer.
摘要翻译：公开了用于可植入医疗装置的涂层和制造涂层的方法。涂层包含氟化聚合物和生物有益的聚合物，其实例包括聚（乙二醇） - 嵌段聚（对苯二甲酸丁二醇酯） - 嵌段聚（乙二醇）。生物活性剂可另外缀合到生物有益的聚合物上。

37. 发明授权

US09078958B2 Depot stent comprising an elastin-based copolymer 有权
标题翻译：载体支架包含弹性蛋白基共聚物
公开(公告)号：US09078958B2
公开(公告)日：2015-07-14
申请号：US13224515
申请日：2011-09-02
申请人： Syed F. A. Hossainy , Yiwen Tang , Lothar W. Kleiner
发明人： Syed F. A. Hossainy , Yiwen Tang , Lothar W. Kleiner
IPC分类号： A61F2/00 , A61K9/00 , A61K38/43 , A61K38/44 , C12N11/10 , C12N11/08 , C12N11/04 , A61K38/00 , A61L31/10 , A61K38/08 , A61K38/39 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/08 , A61L31/04 , A61L31/16 , C07K14/00 , C08H1/00 , B05D3/00
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. The copolymer may be used as a coating on a stent. Methods of using a stent coated with the copolymer are also provided.
摘要翻译：提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。共聚物可以用作支架上的涂层。还提供了使用涂覆有共聚物的支架的方法。

38. 发明授权

US09028859B2 Phase-separated block copolymer coatings for implantable medical devices 有权
标题翻译：用于可植入医疗器械的相分离嵌段共聚物涂层
公开(公告)号：US09028859B2
公开(公告)日：2015-05-12
申请号：US11482599
申请日：2006-07-07
申请人： Syed F. A. Hossainy , Thierry Glauser
发明人： Syed F. A. Hossainy , Thierry Glauser
IPC分类号： A61F2/00 , A61L31/16 , A61L31/04 , A61L31/10
CPC分类号： A61L31/16 , A61L31/048 , A61L31/10 , A61L2300/606 , A61L2420/08 , C08L53/00
摘要： Medical devices and coatings for medical devices are disclosed, including methods for forming the devices and coatings. The devices and coatings comprise a phase-separated block copolymer matrix and one or more active agents. The phase-separated block copolymer matrix can be used to modulate the release-rate of one or more active agents from the medical device.
摘要翻译：公开了用于医疗装置的医疗装置和涂层，包括用于形成装置和涂层的方法。所述装置和涂层包括相分离的嵌段共聚物基质和一种或多种活性剂。相分离的嵌段共聚物基质可用于调节来自医疗器械的一种或多种活性剂的释放速率。

39. 发明授权

US08961584B2 Composite stent with regioselective material 有权
标题翻译：具有区域选择性材料的复合支架
公开(公告)号：US08961584B2
公开(公告)日：2015-02-24
申请号：US11641381
申请日：2006-12-18
申请人： Syed F. A. Hossainy , Orlando Padilla , Daryush Mirzaee , Fuh-Wei Tang
发明人： Syed F. A. Hossainy , Orlando Padilla , Daryush Mirzaee , Fuh-Wei Tang
IPC分类号： A61F2/06 , A61F2/915 , A61F2/91 , A61L31/10 , A61L31/16 , A61F2/07
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2230/0076 , A61F2250/0018 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10S623/916
摘要： A composite stent and a method for making the same are provided.
摘要翻译：提供复合支架及其制造方法。

40. 发明授权

US08685433B2 Absorbable coating for implantable device 有权
标题翻译：用于可植入装置的可吸收涂层
公开(公告)号：US08685433B2
公开(公告)日：2014-04-01
申请号：US12751989
申请日：2010-03-31
申请人： Lothar W. Kleiner , Syed F. A. Hossainy , Mikael Trollsas , Stephen D. Pacetti
发明人： Lothar W. Kleiner , Syed F. A. Hossainy , Mikael Trollsas , Stephen D. Pacetti
IPC分类号： A61L31/10 , A61L31/16 , C08L67/04
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/02 , A61L2420/08 , C08L67/04
摘要： The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
摘要翻译：本发明提供了一种用于可植入装置的可吸收涂层及其制造和使用方法。

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