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31. 发明授权

EP0393786B1 New retro-inverse, one- or more bond bearing analogues of thymopentin, a method for synthesizing the same and their employment for the preparation of pharmaceutical 失效
标题翻译：逆反肽，Thymopenthin的类似物携带一个或多个键，它们的制备方法以及它们用于制备药物的制备使用流程
公开(公告)号：EP0393786B1
公开(公告)日：1996-01-17
申请号：EP90200954.7
申请日：1990-04-18
申请人： SCLAVO S.p.A.
发明人： Mariotti, Sabina , Sisto, Alessandro , Nencioni, Luciano , Villa, Luigi , Verdini, Antonio Silvio , Pessi, Antonello
IPC分类号： C07K5/02
CPC分类号： C07K7/02 , A61K38/00 , C07K5/0212

32. 发明授权

EP0406931B1 New analogues of all-bond retroinverted thymopentin, the method for the synthesis of the same and their employment for the preparation of pharmaceutical compositions 失效
标题翻译：胸腺五肽与所有反转化合物的类似物，它们的制备方法和它们的药物组合物的制备中的用途。
公开(公告)号：EP0406931B1
公开(公告)日：1995-03-15
申请号：EP90201609.6
申请日：1990-06-20
申请人： SCLAVO S.p.A.
发明人： Mariotti, Sabina , Sisto, Alessandro , Nencioni, Luciano , Villa, Luigi , Pessi, Antonello
IPC分类号： C07K5/02 , C07K7/02
CPC分类号： C07K5/0212 , A61K38/00 , C07K7/02

33. 发明公开

EP0620850A1 IMMUNOGENIC DETOXIFIED MUTANTS OF CHOLERA TOXIN AND OF THE TOXIN LT, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF VACCINES 失效
标题翻译：免疫原性，无毒性突变霍乱毒素毒素LT，生产和使用用于生产疫苗。
公开(公告)号：EP0620850A1
公开(公告)日：1994-10-26
申请号：EP93902138.0
申请日：1992-12-30
申请人： BIOCINE SCLAVO S.p.A.
发明人： DOMENIGHINI, Mario , RAPPUOLI, Rino , PIZZA, Mariagrazia , HOL, Wim
IPC分类号： C12N15 , A61K38 , A61K39 , A61P31 , C07K14 , C12N1 , C12N5 , C12P21
CPC分类号： A61K38/164 , A61K39/00 , C07K14/245 , C07K14/28 , Y02A50/472
摘要： An immunogenic detoxified protein comprising the amino acid sequence of subunit A of cholera toxin (CT-A) or subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein one or more amino acids at, or in positions corresponding to Val-53, Ser-63, Val-97, Tyr-104 or Pro-106 are replaced with another amino acid or deleted. Examples of specific replacements include Val-53-Asp, Val-53-Glu, Val-53-Tyr, Ser-63-Lys, Val-97-Lys, Val-97-Tyr, Tyr-104-Lys, Tyr-104-Asp, Tyr-104-Ser, Pro-106-Ser. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae or an enterotoxigenic strain of Escherichia coli and is produced by recombinant DNA means by site-directed mutagenesis.

34. 发明授权

EP0392095B1 Tuftsin analogues and vaccines containing these as adjuvants 失效
标题翻译：促吞噬肽类似物和含有这些类似物作为佐剂的疫苗。
公开(公告)号：EP0392095B1
公开(公告)日：1994-08-31
申请号：EP89201371.5
申请日：1989-05-30
申请人： SCLAVO S.p.A.
发明人： Nencioni, Luciano , Pileri, Piero , Peppoloni, Samuele , Silvestri, Sergio
IPC分类号： C07K5/02 , A61K39/39
CPC分类号： C07K5/0212 , A61K39/00

35. 发明授权

EP0336413B1 A novel system of inducible positive regulation of use for production of heterologous proteins 失效
标题翻译：用于生产异源蛋白的诱导使用积极的监管体制。
公开(公告)号：EP0336413B1
公开(公告)日：1994-06-15
申请号：EP89106060.0
申请日：1989-04-06
申请人： SCLAVO S.p.A.
发明人： Gross, Roy , Rappuoli, Rino
IPC分类号： C12N15/74 , C12N1/21
CPC分类号： C12N15/74

36. 发明授权

EP0384523B1 New gem-diamino derivatives and their use in the synthesis of retro-inverso peptides 失效
标题翻译：偕二氨基衍生物及其在逆向反转肽的制备。
公开(公告)号：EP0384523B1
公开(公告)日：1994-06-01
申请号：EP90200352.4
申请日：1990-02-16
申请人： ENIRICERCHE S.p.A. , SCLAVO S.p.A.
发明人： Gazerro, Laura , Pinori, Massimo , Verdini, Antonio Silvio
IPC分类号： C07C235/10 , C07C235/78 , C07K1/06 , C07K5/02
CPC分类号： C07K1/063 , C07C235/20 , C07C235/34 , C07C237/20 , C07C237/22 , C07C271/22 , C07K5/0212

37. 发明公开

EP0457214A3 Method and reagent composition for the determination of alanine aminotransferase and HBsAg antigen in the same biological specimen 失效
标题翻译：用于确定相同生物样本中的氨苄青霉素和HBSAG抗原的方法和试剂组合物
公开(公告)号：EP0457214A3
公开(公告)日：1993-05-05
申请号：EP91107627.1
申请日：1991-05-10
申请人： SCLAVO S.p.A.
发明人： Fabrizi, Paolo , Donnini, Francesco , Tabacco, Alessandro , Tarli, Paolo
IPC分类号： G01N33/573 , G01N33/576 , G01N33/577 , C12Q1/52
CPC分类号： G01N33/573 , G01N33/5764 , Y10S435/81 , Y10S436/82
摘要： The enzyme alanine aminotransferase (ALT) is colorimetrically determined as the hydrogen peroxide obtained in the pyruvate hydrolysis reaction catalysed by the enzyme pyruvate oxidase which develops a colour read at 550 nm making use of a reagent composition buffered at pH comprised within 7.0 and 7.5 containing L-alanine, ketoglutaric acid, a source of inorganic phosphorous, the enzyme pyruvate oxidase, a system for revealing the hydrogen peroxide and optionally one or more co-factors which interact in the enzymatic reaction catalysed by the enzyme pyruvate oxidase. It is moreover described a method for the determination of the enzyme alanine aminotransferase making use of said reagent composition and of the surface antigen of the hepatitis B virus (HBsAg), by enzymeimmune assay, in the same serum specimen and in the same well of a microtitration plate. The method is particularly useful for checking the suitability of the blood intended for transfusions since it can be easily carried out with equipments and instruments widely used for the immunoenzymatic screening of infectivity. Furthermore it enables to test in the same analytical assay the two labels of hepatocyte infections necessarily researched in the transfusion centres on biological specimens and to select among the donors the most likely candidates to transmission of the NANB hepatitis virus.

38. 发明授权

EP0254080B1 Malonic acid derivatives and methods for their synthesis 失效
标题翻译：马来酸衍生物及其合成方法
公开(公告)号：EP0254080B1
公开(公告)日：1993-03-17
申请号：EP87109317.5
申请日：1987-06-29
申请人： ENIRICERCHE S.p.A. , SCLAVO S.p.A.
发明人： Di Trapani, Romano , Verdini, Antonio Silvio
IPC分类号： C07C69/34 , C07C69/734 , C07C67/343 , C07C323/57 , C07C319/18 , C07C271/10
CPC分类号： C07K5/0212 , C07C271/22 , C07C323/00 , Y02P20/55

39. 发明公开

EP0489442A1 Synthetic oligonucleotides useful for the diagnosis of infections from different types of virus of the papilloma group and usage thereof 失效
标题翻译：综合不同类型的病毒感染的诊断Papillomagruppe有用的寡核苷酸和使用它。
公开(公告)号：EP0489442A1
公开(公告)日：1992-06-10
申请号：EP91120963.3
申请日：1991-12-06
申请人： SCLAVO S.p.A.
发明人： Mazzatenta, Carlo , Ricci, Stefano , Ratti, Giulio
IPC分类号： C12Q1/70 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/708
摘要： There are described synthetic oligonucleotides suitable both as primers for the amplification of DNA segments from different human Papillomaviruses and as probe for typing said amplified segments and their use for manufacturing suitable diagnostic kits.
摘要翻译：中描述了合适的两个作为用于从不同的人类乳头状瘤病毒的DNA片段的扩增和作为样品用于键入所述扩增片段及其用于制造合适的诊断试剂盒使用合成的寡核苷酸引物。

40. 发明公开

EP0446850A2 Process for purifying recombinant human beta-interferon 失效
标题翻译： Verfahren zur Herstellung von rekombinantem Humaninterferon-beta in reiner Form。
公开(公告)号：EP0446850A2
公开(公告)日：1991-09-18
申请号：EP91103719.0
申请日：1991-03-12
申请人： SCLAVO S.p.A.
发明人： Protasi, Otello , Rappuoli, Paolo
IPC分类号： C07K1/00 , A61K38/21
CPC分类号： C07K14/565
摘要： A process for the chromatographic purification of recombinant human β-interferon wherein:

a) an aqueous solution of recombinant human β-interferon in unrefined state is contacted with a siliceous solid matrix equilibrated with deionized water and then eluted with appropriated eluant;
b) the eluted fractions containing the recombinant human β-interferon purified according to the stage a) are loaded on a cation exchange resin; thereafter the rhu-β-interferon adsorbed upon said matrix is eluted with an appropriated eluant.

The recombinant human β-interferon purified in this way is specifically useful as active agent in the production of pharmaceutic preparations suitable for the treatment of viral infections, tumors and as immunomodulators.
摘要翻译：重组人β-干扰素的色谱纯化方法，其中：a）重组人β-干扰素在未精制状态的水溶液与用去离子水平衡的硅质固体基质接触，然后用适当的洗脱剂洗脱; b）将含有根据阶段a）纯化的重组人β-干扰素的洗脱级分负载在阳离子交换树脂上; 此后吸附在所述基质上的rhu-β-干扰素用适当的洗脱液洗脱。以这种方式纯化的重组人β-干扰素在生产适用于治疗病毒感染，肿瘤和免疫调节剂的药物制剂中特别有用。

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