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31. 发明申请

WO2004034883A2 SYNCHRONIZATION AND CALIBRATION OF CLOCKS FOR A MEDICAL DEVICE AND CALIBRATED CLOCK 审中-公开
标题翻译：医疗设备和校准时钟的时钟同步和校准
公开(公告)号：WO2004034883A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032941
申请日：2003-10-15
申请人： MEDTRONIC INC. , OSORIO, Ivan , BHAVARAJU, Naresh, C. , PETERS, Thomas, E. , FREI, Mark G. , WERDER, Jonathan, C.
发明人： OSORIO, Ivan , BHAVARAJU, Naresh, C. , PETERS, Thomas, E. , FREI, Mark G. , WERDER, Jonathan, C.
IPC分类号： A61B
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置为所选择的时间而与第一时钟同步（1517）。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定的量，则提供重新同步第一和第二时钟的指示。

32. 发明申请

WO2004034880A2 TIMED DELAY FOR REDELIVERY OF TREATMENT THERAPY FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：定时延迟用于医疗设备系统的治疗治疗
公开(公告)号：WO2004034880A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032909
申请日：2003-10-15
申请人： MEDTRONIC INC. , FREI, Mark, G. , OSORIO, Ivan , BHAVARAJU, Naresh, C. , CARLSON, David, L. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M.
发明人： FREI, Mark, G. , OSORIO, Ivan , BHAVARAJU, Naresh, C. , CARLSON, David, L. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M.
IPC分类号： A61B
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method support a repetitive administration of a therapeutic treatment through a delivery unit during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data. If the medical device system detects a continuation of the seizure, therapeutic treatment continues.
摘要翻译：装置和方法支持在神经系统疾病的神经事件（例如癫痫发作）期间通过递送单元重复施用治疗性治疗。医疗设备系统监控来自传感器和放大器的信号数据。通过使用检测算法的医疗装置系统检测到神经系统事件。因此，电刺激脉冲被施加到电极。在递送电刺激脉冲期间，医疗装置系统消除与电极相关联的信号数据。随后，在可能发生信号伪影的时间间隔内提供额外的消隐，并且放大器正在稳定。然后，医疗装置系统收集用于检测算法的信号数据以稳定。随后，医疗设备系统收集附加信号数据，以获得统计上有意义的数据。如果医疗器械系统检测到持续的癫痫发作，则继续治疗。

33. 发明申请

WO2013062854A1 METHOD, SYSTEM AND APPARATUS FOR AUTOMATED TERMINATION OF A THERAPY FOR AN EPILEPTIC EVENT UPON A DETERMINATION OF EFFECTS OF A THERAPY 审中-公开
标题翻译：方法，系统和装置自动终止治疗效果的治疗方法治疗效果的确定
公开(公告)号：WO2013062854A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/060864
申请日：2012-10-18
申请人： FLINT HILLS SCIENTIFIC, LLC , OSORIO, Ivan
发明人： OSORIO, Ivan
IPC分类号： A61B5/04 , A61N1/36
CPC分类号： A61N1/36064 , A61B5/4094 , A61B5/4836 , A61B5/4848 , A61F7/12 , A61N1/0529 , A61N1/36114 , A61N1/36139 , A61N1/36142 , A61N1/36146 , A61N1/3621 , A61N2/002 , A61N2/006 , A61N5/0622
摘要： A method comprising detecting an epileptic event in a patient; applying an electrical therapy to a first target area in at least one of a brain region or a cranial nerve of said patient in response to said detecting; receiving a body signal responsive to the electrical therapy, wherein said body signal is selected from an autonomic signal, a neurologic signal, a metabolic signal, an endocrine signal, or a tissue stress marker signal; determining whether said body signal indicates that said electrical therapy has an efficacious effect; and terminating the application of said electrical therapy if the response indicates that the electrical therapy has an efficacious effect. An apparatus capable of performing the method. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform the method.
摘要翻译：一种方法，包括检测患者中的癫痫事件; 响应于所述检测，对所述患者的脑区域或脑神经中的至少一个中的第一目标区域施加电疗法; 接收响应于所述电疗法的身体信号，其中所述身体信号选自自主信号，神经信号，代谢信号，内分泌信号或组织应力标记信号; 确定所述身体信号是否表明所述电疗具有有效的作用; 并且如果所述响应表明所述电疗法具有有效效果，则终止所述电疗法的应用。一种能够执行该方法的装置。一种用于存储当由处理器执行时执行该方法的数据的非传递式计算机可读存储装置。

34. 发明申请

WO2012122066A3 DETECTING, ASSESSING AND MANAGING EXTREME EPILEPTIC EVENTS 审中-公开
标题翻译：检测，评估和管理极端有趣的事件
公开(公告)号：WO2012122066A3
公开(公告)日：2013-01-24
申请号：PCT/US2012027639
申请日：2012-03-03
申请人： FLINT HILLS SCIENT LLC , OSORIO IVAN
发明人： OSORIO IVAN
IPC分类号： A61B5/0476 , A61B5/0205
CPC分类号： A61B5/4094 , A61B5/0205 , A61B5/02405 , A61B5/0476 , A61B5/08 , A61B5/11 , A61B5/165 , A61B5/4035 , A61B5/4842 , A61N1/36064
摘要： Methods, system and apparatus for identifying extreme epileptic events are provided. In one aspect, an inter-seizure interval (ISI) value related to at least two seizure events is determined, compared to a reference value, and an extreme seizure event is determined from the comparison. In another aspect, a first seizure event is detected, and a body index affected by the seizure is determined. An extreme seizure event is determined when a second seizure event occurs prior to the body index value returning to a reference value. Another method includes determining an one index from body data, identifying a seizure event based upon the index, determining at least one seizure severity index (SSI) value for the seizure, comparing the SSI value to a reference value, and determining an extreme seizure event from the comparison. A further method includes determining an increased risk of death and responding to the increased risk.
摘要翻译：提供了确定极端癫痫事件的方法，系统和装置。在一个方面，与参考值相比，确定与至少两个发作事件相关的癫痫发作时间间隔（ISI）值，并从比较确定极端发作事件。在另一方面，检测到第一发作事件，并确定受癫痫发作影响的身体指数。在身体指标值返回到参考值之前发生第二次发作事件时，确定极度发作事件。另一种方法包括根据身体数据确定一个索引，基于该索引识别癫痫事件，确定癫痫发作的至少一个癫痫发作严重程度指数（SSI）值，将SSI值与参考值进行比较，以及确定极度癫痫发作事件从比较。另一种方法包括确定增加的死亡风险和对风险增加的应对。

35. 发明申请

WO2012122066A2 DETECTING, ASSESSING AND MANAGING EXTREME EPILEPTIC EVENTS 审中-公开
标题翻译：检测，评估和管理极端癫痫事件
公开(公告)号：WO2012122066A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/027639
申请日：2012-03-03
申请人： FLINT HILLS SCIENTIFIC, LLC , OSORIO, Ivan
发明人： OSORIO, Ivan
IPC分类号： A61B5/0476
CPC分类号： A61B5/4094 , A61B5/0205 , A61B5/02405 , A61B5/0476 , A61B5/08 , A61B5/11 , A61B5/165 , A61B5/4035 , A61B5/4842 , A61N1/36064
摘要： Methods, system and apparatus for identifying extreme epileptic events are provided. In one aspect, an inter-seizure interval (ISI) value related to at least two seizure events is determined, compared to a reference value, and an extreme seizure event is determined from the comparison. In another aspect, a first seizure event is detected, and a body index affected by the seizure is determined. An extreme seizure event is determined when a second seizure event occurs prior to the body index value returning to a reference value. Another method includes determining an one index from body data, identifying a seizure event based upon the index, determining at least one seizure severity index (SSI) value for the seizure, comparing the SSI value to a reference value, and determining an extreme seizure event from the comparison. A further method includes determining an increased risk of death and responding to the increased risk.
摘要翻译：提供了用于识别极端癫痫事件的方法，系统和设备。在一个方面，确定与至少两次癫痫发作事件相关的癫痫发作间期（interseizure interval，ISI）值，与参考值相比较，并且根据比较确定极端癫痫发作事件。另一方面，检测到第一发作事件，并确定受发作影响的身体指数。当身体指数值返回到参考值之前发生第二次发作事件时，确定极度发作事件。另一种方法包括从身体数据确定一个指数，基于该指数识别癫痫发作事件，确定癫痫发作的至少一个癫痫发作严重性指数（SSI）值，将该SSI值与参考值进行比较，以及确定极端癫痫发作事件从比较。另一种方法包括确定死亡风险增加和对风险增加作出反应。

36. 发明申请

WO2011150220A1 QUANTITATIVE MULTIVARIATE ANALYSIS OF SEIZURES 审中-公开
标题翻译：定量多元分析
公开(公告)号：WO2011150220A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038158
申请日：2011-05-26
申请人： FLINT HILLS SCIENTIFIC, L.L.C. , OSORIO, Ivan
发明人： OSORIO, Ivan
IPC分类号： A61B5/0476
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/4833 , A61N1/36064 , A61N1/36139 , G06F19/00 , G16H50/20
摘要： Methods, including a method, comprising selecting a plurality of dependent variables ( 720 ) relating to each of a plurality of seizures in a patient; selecting a plurality of independent variables ( 710 ), wherein each independent variable comprises a therapy parameter, a therapy delivery parameter, a temporal factor, an environmental factor, or a patient factor; quantifying at least one relationship between each of at least two dependent variables and each of at least two independent variables ( 740 ); and performing an action in response to said quantifying, selected from reporting said at least one relationship, assessing an efficacy of a therapy, assessing an adverse effect of said therapy, providing a therapy modification recommendation, or adjusting said therapy. A medical device system capable of implementing a method. A non - transitory computer readable program storage medium containing instructions that, when executed by a computer, perform a method.
摘要翻译：方法，包括一种方法，包括选择与患者中的多个癫痫发作中的每一个有关的多个因变量（720）; 选择多个独立变量（710），其中每个独立变量包括治疗参数，治疗递送参数，时间因素，环境因素或患者因素; 定量至少两个因变量中的每一个与至少两个独立变量中的每一个之间的至少一个关系（740）; 以及响应于从报告所述至少一种关系中选择的所述量化来执行动作，评估治疗的功效，评估所述治疗的不良作用，提供治疗改变推荐或调整所述治疗。一种能够实现方法的医疗装置系统。一种非暂时的计算机可读程序存储介质，其包含当被计算机执行时执行方法的指令。

37. 发明申请

WO2004034998A3 CONTROL OF TREATMENT THERAPY DURING START-UP AND DURING OPERATION OF A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗器械系统启动和运行期间治疗治疗的控制
公开(公告)号：WO2004034998A3
公开(公告)日：2005-01-13
申请号：PCT/US0332868
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , FREI MARK G , CARLSON DAVID L
发明人： OSORIO IVAN , FREI MARK G , CARLSON DAVID L
IPC分类号： A61N1/18 , A61N1/36 , A61N1/372
CPC分类号： A61N1/37235 , A61B5/4094 , A61B5/725 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/36135 , A61N1/37229
摘要： A method and medical device system (100) for controlling treatment therapy delivered to treat a nervous system disorder.
摘要翻译：一种用于控制递送以治疗神经系统疾病的治疗疗法的方法和医疗装置系统（100）。

38. 发明申请

WO2004036372A3 SCORING OF SENSED NEUROLOGICAL SIGNALS FOR USE WITH A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：感染神经信号与医疗设备系统的使用
公开(公告)号：WO2004036372A3
公开(公告)日：2004-07-15
申请号：PCT/US0332944
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , FREI MARK G , GRAVES NINA M , GIFTAKIS JONATHON E
发明人： OSORIO IVAN , FREI MARK G , GRAVES NINA M , GIFTAKIS JONATHON E
IPC分类号： A61B5/00 , A61B5/04 , A61B5/048 , A61N1/36 , A61N1/37 , A61N1/372 , G06F20060101
CPC分类号： A61N1/3702 , A61B5/048 , A61B5/4064 , A61B5/4094 , A61N1/36017 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/37252 , Y10S128/92
摘要： A medical device system (100) capable of scoring a severity of sensed neurological signals relating to a nervous system disorder. The system comprises a monitoring element that receives a neurological signal having at least one event to be scored. The medical device system identifies one or more features of the neurological signal to use in scoring and computes a score of relative severity of the event using the identified feature. Once two or more events have been scored, the events may be ranked by severity relative to each other.
摘要翻译：一种医疗装置系统（100），其能够评估与神经系统疾病相关的感觉神经信号的严重性。该系统包括监测元件，其接收具有至少一个待评分事件的神经信号。医疗装置系统识别用于评分的神经信号的一个或多个特征，并且使用所识别的特征来计算事件的相对严重程度的得分。一旦两次或更多次的事件得分，事件可能会相对于彼此的严重程度排序。

39. 发明申请

WO2004034883A3 SYNCHRONIZATION AND CALIBRATION OF CLOCKS FOR A MEDICAL DEVICE AND CALIBRATED CLOCK 审中-公开
标题翻译：医疗仪器和校准钟的时钟同步和校准
公开(公告)号：WO2004034883A3
公开(公告)日：2004-06-10
申请号：PCT/US0332941
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , BHAVARAJU NARESH C , PETERS THOMAS E , FREI MARK G , WERDER JONATHAN C
发明人： OSORIO IVAN , BHAVARAJU NARESH C , PETERS THOMAS E , FREI MARK G , WERDER JONATHAN C
IPC分类号： A61B20060101 , A61B5/00 , A61B5/048 , A61N1/372 , G04F1/00 , G04G7/00
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized (1517) to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向患有神经系统病症的患者提供治疗。可以位于医疗设备系统的不同组件处的多个时钟包括第一时钟和第二时钟。通过禁用运行模式操作并将第二时钟设置为选定时间，第二时钟可以与第一时钟同步（1517）。当第一个时钟的参考时间大约等于所选时间时，第二个时钟启用运行模式操作。另外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

40. 发明申请

WO2004034881A2 SIGNAL QUALITY MONITORING AND CONTROL FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗设备系统的信号质量监测与控制
公开(公告)号：WO2004034881A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032938
申请日：2003-10-15
申请人： MEDTRONIC INC. , FREI, Mark, G. , OSORIO, Ivan , WERDER, Jonathan, C. , CARLSON, David, L.
发明人： FREI, Mark, G. , OSORIO, Ivan , WERDER, Jonathan, C. , CARLSON, David, L.
IPC分类号： A61B
CPC分类号： A61N1/37252 , A61B5/04012 , A61B5/048 , A61B5/4094 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/3702 , A61N1/37229
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗设备系统的监视元件接收的神经信号中可能的干扰的方法和设备。监测元件监测正在治疗的神经系统疾病的状况或症状，并为了提供闭环反馈控制的目的而向医疗设备系统提供神经信号。系统通过对移动窗口中的数据点进行瞬时测量来分析接收信号的各种参数，从而确定信号质量是否差。如果信号质量差，则在闭环反馈控制系统中将其从考虑中移除，直到确定信号质量已被充分恢复。

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