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31. 发明申请

US20060183237A1 Method of measuring the molecular weight of phoshoric acid monoester compound and additive for mass spectrum measurement 有权
标题翻译：测定磷酸单酯化合物的分子量和质谱测定添加剂的方法
公开(公告)号：US20060183237A1
公开(公告)日：2006-08-17
申请号：US10547972
申请日：2003-12-24
申请人： Tohru Koike , Norio Minami , Akihiko Kawasaki
发明人： Tohru Koike , Norio Minami , Akihiko Kawasaki
IPC分类号： G01N33/00
CPC分类号： G01N33/6818 , G01N2458/15 , Y10S436/815 , Y10T436/16
摘要： The present invention provides a method for confirming existence of a phosphoric acid monoester compound (peptide, saccharine and the like) and easily identifying the molecular weight thereof even among biological samples including a plurality of compounds, and an additive for a mass spectrometry used for the method. In the method according to the present invention, a complex compound exhibiting extremely high coordination ability to a phosphoric acid monoester group and configured of single kind of zinc isotopes is used to obtain a plurality of mass spectrum data, and then the data are compared.
摘要翻译：本发明提供了一种用于确认磷酸单酯化合物（肽，糖精等）的存在并且即使在包括多种化合物的生物样品中也容易鉴别其分子量的方法和用于方法。在根据本发明的方法中，使用对磷酸单酯基具有极高配位能力并由单种锌同位素构成的配位化合物来获得多个质谱数据，然后比较数据。

32. 发明授权

US5637716A Processes for the preparation of hydroquinone and benzoquinone derivatives 失效
标题翻译：制备氢醌和苯醌衍生物的方法
公开(公告)号：US5637716A
公开(公告)日：1997-06-10
申请号：US578695
申请日：1995-12-27
申请人： Yuuki Komatsu , Norio Minami , Ken Furukawa , Hiroshi Nishimura , Yoji Yamagishi
发明人： Yuuki Komatsu , Norio Minami , Ken Furukawa , Hiroshi Nishimura , Yoji Yamagishi
IPC分类号： C07D213/30 , C07D417/06
CPC分类号： C07D213/30 , C07D417/06
摘要： Intermediates for the preparation of benzothiazole derivatives useful for the prevention and treatment of diseases for which an inhibitory action against the production of leukotriene and thromboxane is efficacious, and industrially advantageous processes for the preparation of the intermediates. A hydroquinone derivative is condensed with a pyridylcarboxyaldehyde derivative without the protecting the hydroxyl groups of the hydroquinone derivative to form a pyridylmethylhydroquinone derivative, which is further oxidized into a pyridylmethyl-1,4-benzoquinone derivative: ##STR1##
摘要翻译： PCT No.PCT / JP94 / 01230 Sec。 371 1995年12月27日第 102（e）日期1995年12月27日PCT提交1994年7月26日PCT公布。第WO95 / 04044号公报日期1995年2月9日用于制备可用于预防和治疗对白细胞三烯和血栓烷的生产具有抑制作用的疾病的苯并噻唑衍生物的中间体是有效的，并且在工业上有利于制备中间体的方法。氢醌衍生物与吡啶羧甲醛衍生物缩合而不保护氢醌衍生物的羟基，形成吡啶基甲基氢醌衍生物，进一步被氧化成吡啶基甲基-1,4-苯醌衍生物：＆lt; IMAGE＆gt;＆gt; + TR

33. 发明授权

US5372181A Counter pressure casting and counter pressure casting device 失效
标题翻译：反压铸造和反压铸造装置
公开(公告)号：US5372181A
公开(公告)日：1994-12-13
申请号：US13089
申请日：1993-02-03
申请人： Fukashi Watanabe , Shigeo Hama , Norio Minami
发明人： Fukashi Watanabe , Shigeo Hama , Norio Minami
IPC分类号： B22D18/04 , B22D18/06 , B22D18/08
CPC分类号： B22D18/04
摘要： A counter pressure casting and a counter pressure casting device in which the pressures in a furnace side and a casting mold side are set to be lower than the maximum pressure of the process at a stage of the molten metal charging and increased to the maximum after the molten metal charging step. This technique provides a casting having less casting defects and improves the productivity.
摘要翻译：一种反压铸造和反压铸造装置，其中炉侧和铸模侧的压力设定为低于熔融金属充填阶段的工艺的最大压力，并在熔融金属充电步骤。该技术提供具有较少铸造缺陷并提高生产率的铸件。

34. 发明授权

US5246946A Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US5246946A
公开(公告)日：1993-09-21
申请号：US930727
申请日：1992-08-14
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
摘要翻译：哌啶化合物具有通用的结构，可用于治疗心律失常。（3）X是-S-，-SO-或-SO 2 - ，R 2（R 2），其中R 1是低级烷基，W是：是氢或 - （CH 2）n Y，n是1至5的整数，Y是芳基，吡啶基或取代的吡啶基，X'是-CO-或-CH（OH） - ，p是1〜 4，R 12是氢或低级烷基，Y'是 - （CH 2）mA，m是1或2，A是芳基，取代的芳基，吡啶基或取代的吡啶基，R 12和Y可以形成5-或6 环或具有一个或多个取代基的5或6元环，R 22是氢，卤素，低级烷基，低级烷氧基或羟基。

35. 发明授权

US5047417A Butenoic or propenoic acid derivatives 失效
标题翻译：丁烯酸或丙烯酸衍生物
公开(公告)号：US5047417A
公开(公告)日：1991-09-10
申请号：US354306
申请日：1989-05-19
申请人： Norio Minami , Fumihiro Ozaki , Keiji Ishibashi , Yasuhiro Kabasawa , Megumi Ikemori , Toshiaki Ogawa , Takanori Kawamura
发明人： Norio Minami , Fumihiro Ozaki , Keiji Ishibashi , Yasuhiro Kabasawa , Megumi Ikemori , Toshiaki Ogawa , Takanori Kawamura
IPC分类号： C07C233/40 , C07C235/34 , C07C235/36 , C07C237/12 , C07C237/20 , C07C255/41 , C07C255/57 , C07C317/44 , C07C323/62 , C07D207/08 , C07D207/32 , C07D207/327 , C07D207/38 , C07D211/22 , C07D211/34 , C07D211/58 , C07D211/86 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/68 , C07D223/16 , C07D231/12 , C07D233/56 , C07D233/61 , C07D235/06 , C07D237/14 , C07D241/18 , C07D249/08 , C07D263/32 , C07D277/22 , C07D277/30 , C07D317/58 , C07D317/60 , C07D319/18 , C07D405/06 , C07D471/04 , C07D521/00
CPC分类号： C07D207/08 , C07C233/40 , C07C235/34 , C07C235/36 , C07C237/12 , C07C237/20 , C07C255/41 , C07C255/57 , C07C317/44 , C07C323/62 , C07D207/327 , C07D207/38 , C07D211/22 , C07D211/34 , C07D211/58 , C07D211/86 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/68 , C07D223/16 , C07D231/12 , C07D233/56 , C07D235/06 , C07D237/14 , C07D241/18 , C07D249/08 , C07D263/32 , C07D277/30 , C07D317/58 , C07D317/60 , C07D319/18 , C07D405/06 , C07D471/04 , C07C2101/08
摘要： A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydrogen or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phenyl having substituents and a heterocyclic ring may be formed between R2, R3 and J is provided here and is useful in the pharmacological field. ##STR1##

36. 发明授权

US4977165A Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US4977165A
公开(公告)日：1990-12-11
申请号：US234468
申请日：1988-08-19
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , Y10S514/821
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R.sup.1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO.sub.2 --, R.sup.2 is hydrogen or --(CH.sub.2).sub.n --Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R.sup.12 is hydrogen or a lower alkyl, Y' is --(CH.sub.2).sub.m --A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R.sup.12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR.sup.22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.

37. 发明授权

US4876262A Piperidine derivative and pharmaceutical composition containing the same 失效
标题翻译：哌啶衍生物和含有其的药物组合物
公开(公告)号：US4876262A
公开(公告)日：1989-10-24
申请号：US16035
申请日：1987-02-18
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D473/08 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/50 , A61K31/505 , A61P9/06 , C07D207/08 , C07D211/22 , C07D211/28 , C07D211/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D473/10
CPC分类号： C07D401/04 , C07D211/28 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
摘要： A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH2-- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, --CH2COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## 1 being 1 or 2, --A--B, A being --(CH2)n--, n being an integer of 1 to 5, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, --(CH2)k--S--, k being an integer of 2 to 5, --(CH2)p-CO--, p being an integer of 1 to 4, B being cyano, --NR4R5, a heterocyclic ring or a condensed aromatic ring.
摘要翻译：新的哌啶化合物在治疗心律失常方面是药理学有效的，并由下式定义：其中R1是低级烷基或甲苯基，R2是氢，羟基，低级烷氧基或低级烷基，R3是氢低级烷基，低级烯基，环烷基或环烷基烷基，X为-CO-，-CH 2 - 或-CHOH-，g为1〜3的整数，h为1〜3的整数，Y为氢，低级烷基，低级烯基，氰基，-CH 2 COOR，R为氢或低级烷基，环烷基，环烷基烷基，1为2或-AB，A为 - （CH 2）n - ，n 为1〜5的整数，碳原子数1〜5的直链亚烷基，是直链烷基，苯基或羟基的直链烷烃衍生自二价基团，直链烷烃直接与一个以上碳原子键合通过除去与位于其两端的每个碳原子键合的氢原子构成所述烷烃的原子，具有1至5个碳原子的直链亚烷基，其为通过除去与位于其两端的每个碳原子键合的氢原子，通过除去彼此相邻的碳原子之间形成的双键的直链烯烃的二价基团， - （CH 2）k S - ，k为 2〜5的整数， - （CH 2）p -CO-，p为1〜4的整数，B为氰基，-NR 4 R 5，杂环或稠合芳环。

38. 发明授权

US4291335A Vertical synchronizing signal detector 失效
标题翻译：垂直同步信号检测器
公开(公告)号：US4291335A
公开(公告)日：1981-09-22
申请号：US98632
申请日：1979-11-29
申请人： Isao Nakagawa , Norio Minami
发明人： Isao Nakagawa , Norio Minami
IPC分类号： H04N5/10 , H04N9/00 , H04N9/793 , H04N9/83
CPC分类号： H04N5/10
摘要： A composite synchronizing signal is applied to the D input terminal of a D type flip-flop. A multiplied pulse obtained by multiplying a horizontal reference signal by 40 is applied to the C input terminal thereof, the horizontal reference being in phase with the horizontal synchronizing pulse of the composite synchronizing signal. A logic product of the output of a flip-flop and the multiplied pulse is produced. Pulses in the form of the logic product are counted during a period between two adjacent horizontal reference pulses. A detection pulse is generated which rises when the count exceeds 28 and ends with the end of the later one of two adjacent horizontal reference pulses. In response to this detection pulse, a vertical synchronizing pulse is detected. The timing of the ending of the detection pulse is not affected by noise pulses.
摘要翻译：复合同步信号被施加到D型触发器的D输入端。通过将水平参考信号乘以40获得的相乘脉冲被施加到其C输入端，水平参考与复合同步信号的水平同步脉冲相同。产生触发器的输出和相乘的脉冲的逻辑积。在两个相邻的水平参考脉冲之间的周期内，以逻辑积的形式计数脉冲。产生检测脉冲，其在计数超过28时上升，并且以两个相邻的水平参考脉冲之后的一个结束而结束。响应该检测脉冲，检测垂直同步脉冲。检测脉冲结束的定时不受噪声脉冲的影响。

39. 发明授权

US5886197A Process for the preparation of .alpha.-tocopherol 失效
标题翻译：制备α-生育酚的方法
公开(公告)号：US5886197A
公开(公告)日：1999-03-23
申请号：US826504
申请日：1997-04-03
申请人： Noriyasu Hirose , Hiroshi Inoue , Toshio Matsunami , Takashi Yoshimura , Kouzou Morita , Yuh Horikawa , Noriyoshi Iwata , Norio Minami , Kenji Hayashi , Chiaki Seki
发明人： Noriyasu Hirose , Hiroshi Inoue , Toshio Matsunami , Takashi Yoshimura , Kouzou Morita , Yuh Horikawa , Noriyoshi Iwata , Norio Minami , Kenji Hayashi , Chiaki Seki
IPC分类号： C07D311/72 , C07D311/74 , C07C2/58 , C07D311/62 , C07D311/64
CPC分类号： C07D311/72
摘要： A process is provided for the preparation of .alpha.-tocopherol. According to the process, a condensation reaction between trimethylhydroquinone and a specific phytol derivative or isophytol is conducted in the presence of any one of the following solvents:(i) a carbonate ester,(ii) a lower fatty acid ester represented by the following formula:R.sup.1 COOR.sup.2wherein R.sup.1 means a lower alkyl group having 1-4 carbon atoms and R.sup.2 means a lowe alkyl group having 1-5 carbon atoms with the proviso that methyl acetate and ethyl acetate are excluded;(iii) a mixed solvent of a nonpolar solvent and a lower alcohol having 1-5 carbon atoms; and(iv) a mixed solvent of the nonpolar solvent and the lower fatty acid ester.
摘要翻译：提供了一种制备α-生育酚的方法。根据该方法，在以下任一种溶剂的存在下进行三甲基对苯二酚与特定植物醇衍生物或异麦芽糖醇的缩合反应：（i）碳酸酯，（ii）由下式表示的低级脂肪酸酯：R1COOR2其中R1表示具有1-4个碳原子的低级烷基，R2表示具有1-5个碳原子的低级烷基，条件是不包括乙酸甲酯和乙酸乙酯; （iii）非极性溶剂和具有1-5个碳原子的低级醇的混合溶剂; 和（iv）非极性溶剂和低级脂肪酸酯的混合溶剂。

40. 发明授权

US5607953A Butenoic or propenoic acid derivative 失效
标题翻译：丁烯酸或丙烯酸衍生物
公开(公告)号：US5607953A
公开(公告)日：1997-03-04
申请号：US347099
申请日：1994-11-23
申请人： Norio Minami , Fumihiro Ozaki , Keiji Ishibashi , Yasuhiro Kabasawa , Megumi Ikemori , Toshiaki Ogawa , Takanori Kawamura
发明人： Norio Minami , Fumihiro Ozaki , Keiji Ishibashi , Yasuhiro Kabasawa , Megumi Ikemori , Toshiaki Ogawa , Takanori Kawamura
IPC分类号： C07C233/40 , C07C235/34 , C07C235/36 , C07C237/12 , C07C237/20 , C07C255/41 , C07C255/57 , C07C317/44 , C07C323/62 , C07D207/08 , C07D207/32 , C07D207/327 , C07D207/38 , C07D211/22 , C07D211/34 , C07D211/58 , C07D211/86 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/68 , C07D223/16 , C07D233/66 , C07D235/06 , C07D237/14 , C07D241/18 , C07D263/32 , C07D277/30 , C07D317/58 , C07D317/60 , C07D319/18 , C07D405/06 , C07D471/04 , C07D521/00 , A61K31/335 , A61K31/34 , A61K31/38 , C07D213/63 , C07D319/14 , C07D403/06 , A64K31/40
CPC分类号： C07D207/08 , C07C233/40 , C07C235/34 , C07C235/36 , C07C237/12 , C07C237/20 , C07C255/41 , C07C255/57 , C07C317/44 , C07C323/62 , C07D207/327 , C07D207/38 , C07D211/22 , C07D211/34 , C07D211/58 , C07D211/86 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/68 , C07D223/16 , C07D231/12 , C07D233/56 , C07D235/06 , C07D237/14 , C07D241/18 , C07D249/08 , C07D263/32 , C07D277/30 , C07D317/58 , C07D317/60 , C07D319/18 , C07D405/06 , C07D471/04 , C07C2101/08
摘要： A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phenyl having substituents and a heterocyclic ring may be formed between R2, R3 and J is provided here and is useful in the pharmacological field. ##STR1##
摘要翻译：具有下式的丁烯酸或丙烯酸衍生物，其中G是芳基或杂环，R11和R12是氢化或烷基，X是硫或氧，R2和R3是氢，取代基如烷基和J 在这里提供吡啶基或具有取代基的苯基和可以在R2，R3和J之间形成杂环，并且在药理学领域是有用的。

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