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31. 发明申请

US20080091008A1 METHODS OF MANUFACTURING CRYSTALLINE FORMS OF RAPAMYCIN ANALOGS 有权
标题翻译：制备RAPAMYCIN模拟物的结晶形式的方法
公开(公告)号：US20080091008A1
公开(公告)日：2008-04-17
申请号：US11781807
申请日：2007-07-23
申请人： Shekhar Viswanath , Larry Bartelt , Robert Leanna , Michael Rasmussen , Madhup Dhaon , Rodger Henry , Thomas Borchardt , Shuang Chen , Geoff Zhang
发明人： Shekhar Viswanath , Larry Bartelt , Robert Leanna , Michael Rasmussen , Madhup Dhaon , Rodger Henry , Thomas Borchardt , Shuang Chen , Geoff Zhang
IPC分类号： C07D267/22
CPC分类号： C07D498/18
摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.
摘要翻译：制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。

32. 发明申请

US20080085880A1 CRYSTALLINE FORMS OF RAPAMYCIN ANALOGS 有权
标题翻译：雷帕霉素类似物的晶体形式
公开(公告)号：US20080085880A1
公开(公告)日：2008-04-10
申请号：US11781804
申请日：2007-07-23
申请人： Shekhar Viswanath , Larry Bartelt , Robert Leanna , Michael Rasmussen , Madhup Dhaon , Rodger Henry , Thomas Borchardt , Shuang Chen , Geoff Zhang
发明人： Shekhar Viswanath , Larry Bartelt , Robert Leanna , Michael Rasmussen , Madhup Dhaon , Rodger Henry , Thomas Borchardt , Shuang Chen , Geoff Zhang
IPC分类号： A61K31/33 , A61P43/00
CPC分类号： A61K31/33
摘要： A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula 1, which is optionally a prodrug, salt, derivative, or combination thereof:
摘要翻译：雷帕霉素类似物组合物包括雷帕霉素类似物的结晶形式。该晶体可以是水合物，脱水剂，溶剂化物或去溶剂化物。雷帕霉素类似物可以具有式1的结构，其可任选地是前药，盐，衍生物或其组合：

33. 发明授权

US07189849B2 Synthesis of acyclic nucleoside derivatives 失效
标题翻译：无环核苷衍生物的合成
公开(公告)号：US07189849B2
公开(公告)日：2007-03-13
申请号：US11131646
申请日：2005-05-18
申请人： M. Robert Leanna , Michael Rasmussen , Steven M. Hannick , Jien-Heh J. Tien , Kirill A. Lukin , Zhenping Tian , Sou-Jen Chang , Cynthia B. Curty , Bikshandarkoil A. Narayanan , John Bellettini , Bhadra Shelat , Tiffany Spitz
发明人： M. Robert Leanna , Michael Rasmussen , Steven M. Hannick , Jien-Heh J. Tien , Kirill A. Lukin , Zhenping Tian , Sou-Jen Chang , Cynthia B. Curty , Bikshandarkoil A. Narayanan , John Bellettini , Bhadra Shelat , Tiffany Spitz
IPC分类号： C07D473/18 , C07D473/40 , C07F7/18 , C07C69/66
CPC分类号： C07D473/00 , C07C309/73 , C07D473/18 , Y02P20/55
摘要： Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.
摘要翻译：合成抗病毒伐莫西洛维硬脂酸酯的新方法，其中将酯化的鸟嘌呤缩醛还原成相应的醇，与活化的氨基酸反应并进行N-去保护。酯化鸟嘌呤缩醛由带有无环羟甲基丁缩醛的9-鸟嘌呤衍生物制备。这些过程可以修改为一锅反应。

34. 发明申请

US20060234541A1 Protective cover for DIMM circuit card 失效
标题翻译： DIMM电路卡保护盖
公开(公告)号：US20060234541A1
公开(公告)日：2006-10-19
申请号：US11106008
申请日：2005-04-14
申请人： Michael Graham , Mark Hansen , Michael Rasmussen
发明人： Michael Graham , Mark Hansen , Michael Rasmussen
IPC分类号： H01R13/62
CPC分类号： H01R13/629 , H01R13/62988 , H01R13/6599 , Y10S439/946
摘要： A protective cover for a dual inline memory module (DIMM) circuit card includes a pair of cover members for substantially containing the DIMM circuit card. The cover members are secured to opposite sides of the DIMM circuit card. The pair of cover members defines a socket-receiving channel between respective printed-circuit-board (PCB) mating faces of the cover members. The cover members includes a plurality of positioning features engaging the DIMM circuit card for positioning a portion of the DIMM circuit card within the socket-receiving channel.
摘要翻译：用于双列直插式存储器模块（DIMM）电路卡的保护盖包括用于基本上包含DIMM电路卡的一对盖构件。盖构件固定在DIMM电路卡的相对侧。一对盖构件在盖构件的相应印刷电路板（PCB）配合面之间限定一个插座接收通道。盖构件包括接合DIMM电路卡的多个定位特征，用于将DIMM电路卡的一部分定位在插座接收通道内。

35. 发明申请

US20060168499A1 Data archive verify software 审中-公开
标题翻译：数据归档验证软件
公开(公告)号：US20060168499A1
公开(公告)日：2006-07-27
申请号：US11045178
申请日：2005-01-27
申请人： Jathan Edwards , Garry Lundstrom , Gregory Hanson , Michael Rasmussen
发明人： Jathan Edwards , Garry Lundstrom , Gregory Hanson , Michael Rasmussen
IPC分类号： G11C29/00
CPC分类号： G06F11/008 , G06F11/0727 , G06F11/0745 , G06F11/0793 , G11B20/1816 , G11B2220/2537
摘要： The invention is directed to verify software to determine the quality and accuracy of data recorded on an optical data storage disk by an optical disk drive. A verify software module receives error information from the optical disk drive indicative of errors associated with the recovered data. The verify software module then generates an indication of data integrity based on the error information and presents the indication to a user of the optical disk drive via an output device. The data integrity indication identifies whether or not the data was recorded correctly and predicts how long the data will last. The indication is especially useful for data storage applications where reliable data archive is vital. The verify software may be distributed as a CD-ROM included with a multi-disk package of optical disks. The verify software CD-ROM may include a tutorial to be presented to the user via the output device.
摘要翻译：本发明旨在验证软件以确定由光盘驱动器记录在光学数据存储盘上的数据的质量和精度。验证软件模块从光盘驱动器接收指示与恢复的数据相关联的错误的错误信息。验证软件模块然后基于错误信息产生数据完整性的指示，并通过输出设备将指示呈现给光盘驱动器的用户。数据完整性指示识别数据是否被正确记录，并预测数据将持续多长时间。该指示对于可靠的数据归档至关重要的数据存储应用程序尤其有用。验证软件可以作为包括在多盘光盘包中的CD-ROM进行分发。验证软件CD-ROM可以包括通过输出设备呈现给用户的教程。

36. 发明申请

US20060063825A1 Crystalline form of a drug 审中-公开
标题翻译：结晶形式的药物
公开(公告)号：US20060063825A1
公开(公告)日：2006-03-23
申请号：US11230043
申请日：2005-09-19
申请人： Walter Dziki , Ziqi Lu , Michael Rasmussen , Jaqueline Wardrop , Geoff Zhane , Cathie Linton
发明人： Walter Dziki , Ziqi Lu , Michael Rasmussen , Jaqueline Wardrop , Geoff Zhane , Cathie Linton
IPC分类号： A61K31/4025 , C07D405/02
CPC分类号： C07D405/10 , C07D405/04
摘要： Atrasentan Hydrochloride Crystalline Form 2, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
摘要翻译：盐酸阿特拉森结晶形式2，含有它的组合物和治疗疾病的方法以及使用其抑制不良生理事件。

37. 发明授权

US06978062B2 Wavelength division multiplexed device 有权
标题翻译：波分复用器件
公开(公告)号：US06978062B2
公开(公告)日：2005-12-20
申请号：US09790144
申请日：2001-02-21
申请人： Bjarke Rose , Thomas Rasmussen , Chaker Khalfaoui , Michael Rasmussen , Jens Bastue , Per Eld Ibsen , Claus Friis Pedersen
发明人： Bjarke Rose , Thomas Rasmussen , Chaker Khalfaoui , Michael Rasmussen , Jens Bastue , Per Eld Ibsen , Claus Friis Pedersen
IPC分类号： G02B6/34 , H04B10/08 , H04J14/02 , G02B6/28
CPC分类号： H04J14/0212 , G02B6/2713 , G02B6/2793 , G02B6/29311 , G02B6/29313 , G02B6/29383 , G02B6/3512 , G02B6/3514 , G02B6/4215 , H04B10/077 , H04B10/07955 , H04J14/02
摘要： A wavelength division multiplexed device is based on a transmission grating spectrometer having at least two diffractive optical elements. The WDM device provides flexible use and may be widely applied in WDM systems. The device is useful for multiplexing and demultiplexing, channel monitoring, and for adding and dropping channels. The device provides programmability in use as an add/drop multiplexer.
摘要翻译：波分复用装置基于具有至少两个衍射光学元件的透射光栅光谱仪。 WDM设备提供灵活的使用，可广泛应用于WDM系统。该器件可用于复用和解复用，通道监控以及添加和删除通道。该器件提供可编程性，作为分插复用器使用。

38. 发明授权

US06437106B1 Process for preparing 6-o-substituted erythromycin derivatives 有权
标题翻译：制备6-O-取代的红霉素衍生物的方法
公开(公告)号：US06437106B1
公开(公告)日：2002-08-20
申请号：US09518281
申请日：2000-03-03
申请人： Eric J. Stoner , Matthew J. Peterson , Yi-Yin Ku , Russell D. Cink , Arthur J. Cooper , Mahendra N. Deshpande , Tim Grieme , Anthony R. Haight , David R. Hill , Margaret Chi-Ping Hsu , Steven A. King , Marvin Robert Leanna , Elaine C. Lee , Maureen A. McLaughlin , Howard E. Morton , James J. Napier , Daniel J. Plata , Prasad S. Raje , Michael Rasmussen , David Riley , Jien-Heh J. Tien , Steven J. Wittenberger
发明人： Eric J. Stoner , Matthew J. Peterson , Yi-Yin Ku , Russell D. Cink , Arthur J. Cooper , Mahendra N. Deshpande , Tim Grieme , Anthony R. Haight , David R. Hill , Margaret Chi-Ping Hsu , Steven A. King , Marvin Robert Leanna , Elaine C. Lee , Maureen A. McLaughlin , Howard E. Morton , James J. Napier , Daniel J. Plata , Prasad S. Raje , Michael Rasmussen , David Riley , Jien-Heh J. Tien , Steven J. Wittenberger
IPC分类号： C07H100
CPC分类号： C07H17/08
摘要： In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
摘要翻译：一方面，本发明涉及一种制备6-O-取代的红霉素衍生物的方法，其包括在钯催化剂和膦的存在下使2'-取代的和任选的4'-取代的9-肟红霉素衍生物与烷基化剂反应。另一方面，本发明涉及使用钯催化的烷基化反应制备6-O-取代的红霉素酮内酯的方法。

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