专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US4769375A Circulation-active 1,4-dihydropyridine derivatives and use thereas 失效
标题翻译：循环活性的1,4-二氢吡啶衍生物并用于其中
公开(公告)号：US4769375A
公开(公告)日：1988-09-06
申请号：US890998
申请日：1986-07-25
申请人： Horst Meyer , Gerhard Franckowiak , Gunther Thomas , Matthias Schramm , Michael Kayser , Martin Bechem , Rainer Gross
发明人： Horst Meyer , Gerhard Franckowiak , Gunther Thomas , Matthias Schramm , Michael Kayser , Martin Bechem , Rainer Gross
IPC分类号： A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/473 , A61P3/08 , A61P9/00 , A61P9/08 , A61P9/10 , C07D215/06 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/24 , C07D215/36 , C07D215/54 , C07D221/04 , C07D311/74 , C07D311/94 , C07D335/00 , C07D401/04 , C07D405/04 , C07D409/04
CPC分类号： C07D221/04 , C07D215/14 , C07D215/18 , C07D215/24 , C07D215/36 , C07D215/54 , C07D311/74 , C07D311/94 , C07D401/04 , C07D405/04 , C07D409/04
摘要： Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic,R.sup.2 is H, NO.sub.2, CN, C.sub.1 -C.sub.8 -alkylsulphonyl, aryl or carboalkoxy,R.sup.3 is alkyl or aryl,R.sup.4 is H or alkyl,X is C.dbd.O or a direct bond, andn is a number from 1 to 20,or physiologically acceptable salts thereof. A synthesis using morpholines or thiomorpholines is also disclosed.
摘要翻译： R 1为任选取代的芳基或杂环，R 2为H，NO 2，CN，C 1 -C 8 - 烷基磺酰基，芳基或烷氧羰基，R 3为烷基或芳基，R 4为H或烷基， X为C = O或直接键，n为1〜20的数，或其生理上可接受的盐。还公开了使用吗啉或硫代吗啉的合成。

32. 发明授权

US4710501A Circulation active pyrimidinyl-dihydropyridines 失效
标题翻译：循环活性嘧啶基 - 二氢吡啶
公开(公告)号：US4710501A
公开(公告)日：1987-12-01
申请号：US862869
申请日：1986-05-13
申请人： Gerhard Franckowiak , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunter Thomas
发明人： Gerhard Franckowiak , Martin Bechem , Rainer Gross , Michael Kayser , Matthias Schramm , Gunter Thomas
IPC分类号： A61K31/505 , A61K31/70 , A61K31/7028 , A61P9/02 , A61P9/04 , A61P9/08 , C07D401/04 , C07D401/14 , C07H15/06 , C07H15/26 , A61K31/44 , C07D239/24
CPC分类号： C07D401/04 , C07D401/14 , C07H15/26
摘要： Novel compounds of the formula ##STR1## in which R.sup.2 is hydrogen or a substituent, andR.sup.1 is optionally substituted alkyl or alkenyl,exhibit positive inotropic activity on the cardiac muscle, intensifying the contraction power.
摘要翻译：式中，R 2为氢或取代基，R 1为任选取代的烷基或烯基的新颖化合物“IMAGE”表现出对心肌的正性肌力活性，增强收缩力。

33. 发明授权

US4707479A Circulation active dihydropyridine-3-carboxamides 失效
标题翻译：循环活性二氢吡啶-3-甲酰胺
公开(公告)号：US4707479A
公开(公告)日：1987-11-17
申请号：US806057
申请日：1985-12-05
申请人： Horst Meyer , Gerhard Franckowiak , Ulrich Rosentreter , Rainer Gross , Gunter Thomas , Matthias Schramm , Michael Kayser , Friedel Seuter , Elisabeth Perzborn , Martin Bechem
发明人： Horst Meyer , Gerhard Franckowiak , Ulrich Rosentreter , Rainer Gross , Gunter Thomas , Matthias Schramm , Michael Kayser , Friedel Seuter , Elisabeth Perzborn , Martin Bechem
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/50 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , C07D211/90 , C07D237/00 , C07D237/04 , C07D333/00 , C07D335/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D491/048 , C07D495/04 , C07D401/06
CPC分类号： C07D401/12 , C07D211/90 , C07D237/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04
摘要： 1,4-Dihyropyridinecarboxamides of the formula ##STR1## and salts thereof, are effective for treating cardiac insufficiency, thromboses, thromboembolisms and ischaemias, for influencing the blood-sugar level and the circulation and as coronary therapeutic agents and anti-arrhythmic agents.
摘要翻译：具有式“IMAGE”及其盐的1,4-二氢吡啶甲酰胺及其盐对于治疗心功能不全，血栓形成，血栓栓塞和间皮瘤有效，用于影响血糖水平和循环以及作为冠状动脉治疗剂和抗心律不齐剂。

34. 发明授权

US4668691A Circulation-active novel 7-aryl-or pyridyl-1-oxo-1,c,4,7-tetrahydrobenzofurans 失效
标题翻译：循环活性的新型7-芳基或吡啶基-1-氧代-1，c，4,7-四氢苯并呋喃
公开(公告)号：US4668691A
公开(公告)日：1987-05-26
申请号：US724374
申请日：1985-04-18
申请人： Siegfried Goldmann , Matthias Schramm , G/u/ nter Thomas , Rainer Gross
发明人： Siegfried Goldmann , Matthias Schramm , G/u/ nter Thomas , Rainer Gross
IPC分类号： A61K31/365 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P3/00 , A61P3/08 , A61P9/00 , A61P9/02 , A61P9/04 , C07D307/88 , C07D333/72 , C07D335/00 , C07D405/04 , C07D409/04 , C07D407/02
CPC分类号： C07D405/04 , C07D307/88 , C07D409/04
摘要： 1-Oxo-1,3,4,7-tetrahydrobenzofuranes of the formula ##STR1## in which X is O or S,R is optionally substituted phenyl or heteroaryl,R.sup.1 is OH, monoalkylamino or dialkylamino, andR.sup.2 is an acyl or esterified carboxy radical, or pharmacologically acceptable salts thereof, which are active in circulation, e.g. they increase myocardial contractility, increase the flow of Ca.sup.2+ into the cell, increase blood pressure, reduce blood sugar, reduce swelling of mucous membranes and affect the salt and/or fluid balance.
摘要翻译：其中X为O或S，R为任选取代的苯基或杂芳基，R 1为OH，单烷基氨基或二烷基氨基，R 2为酰基或酯化的式羧基或其药理学上可接受的盐，其在循环中是有活性的，例如它们增加心肌收缩力，增加Ca2 +流入细胞，增加血压，降低血糖，减少粘膜肿胀并影响盐和/或液体平衡。

35. 发明授权

US4647568A Circulation-active hydroxy-tetra-hydropyridinelactones 失效
公开(公告)号：US4647568A
公开(公告)日：1987-03-03
申请号：US673296
申请日：1984-11-20
申请人： Klaus Gorlitzer , Ulrich Bartke , Siegfried Goldmann , Matthias Schramm , Gunter Thomas , Rainer Gross
发明人： Klaus Gorlitzer , Ulrich Bartke , Siegfried Goldmann , Matthias Schramm , Gunter Thomas , Rainer Gross
IPC分类号： A61K31/435 , A61K31/47 , A61K31/505 , A61P3/00 , A61P3/08 , A61P9/04 , C07D211/90 , C07D491/04 , C07D491/048 , C07F7/10 , A61K31/455 , A61K31/535 , A61K31/695
CPC分类号： C07D491/04 , C07D211/90
摘要： Hydroxytetrahydropyridinelactones of the formula ##STR1## in which R represents a phenyl, naphthyl, thienyl, furyl, pyrryl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, quinolyl, isoquinolyl, indolyl, benzimidazolyl, quinazolyl, quinoxalyl, thionaphthenyl, isothionaphthenyl, chromonyl, thiochromonyl, chromenyl, thiochromenyl, benzoxadiazolyl or benzthiadiazolyl radical, and the stated radicals may carry 1 to 3 identical or different substituents from the group comprising C.sub.1 -C.sub.20 -alkyl, C.sub.2 -C.sub.20 -alkenyl, C.sub.2 -C.sub.20 -alkinyl, C.sub.1 -C.sub.20 -alkoxy, fluorine, chlorine, bromine, iodine, trifluoromethyl, monofluoro-C.sub.1 -C.sub.10 -alkoxy, polyfluoro-C.sub.1 -C.sub.10 -alkoxy, hydroxyl, amino, mono-C.sub.1 -C.sub.10 -alkylamino, di-C.sub.1 -C.sub.10 -alkylamino, nitro, cyano, azido, carboxyl, carb-C.sub.1 -C.sub.10 -alkoxy, carboxamido, sulphonamido, SO.sub.m -alkyl (m=0 to 2, 1 to 20 C atoms), phenyl, benzyl, benzyloxy or benzylthio, it being possible for the 4 last-mentioned substituents to carry 1 to 3 radicals from the group comprising C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -alkylthio, fluorine, chlorine, bromine, iodine, cyano, nitro, azido, hydroxyl, trifluoromethyl, amino, C.sub.1 -C.sub.6 -alkylamino or di-C.sub.1 -C.sub.6 -alkylamino,R.sup.1 represents a straight-chain, branched or cyclic saturated or unsaturated hydrocarbon radical which has 1-20 C atoms, may be interrupted in the chain by 1 or 2 oxygen or sulphur atoms and may be optionally substituted by one or more fluorine atoms, NO.sub.2, C.sub.3 -C.sub.12 -trialkyl-silyl, hydroxyl, chlorine, bromine, iodine or cyano,R.sup.2 represents hydrogen, --NH.sub.2, --CHO, cyano, --CH.sub.2 OH or a straight-chain or branched saturated or unsaturated hydrocarbon radical having 1 to 8 C atoms,R.sup.3 represents hydrogen or a straight-chain or branched C.sub.1 -C.sub.10 -alkyl radical which may be interrupted in the alkyl chain by one or two oxygen atoms and may be optionally substituted by fluorine, chlorine, bromine, iodine, --CN, --NH.sub.2, --OH or morpholino, which can be used as cardiotonics for improving the contractility of the heart. Moveover, they increase the flow of Ca.sup.++ into the cells and can therefore be employed as antihypotonics, for lowering the blood sugar level, for reducing the swelling of mucous membranes and for influencing the salt balance and/or fluid balance.

36. 发明授权

US4492703A 4-(2-Substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters active on blood circulation 失效
标题翻译：对血液循环有活性的4-（2-取代苯基）-1,4-二氢吡啶-3,5-二羧酸酯
公开(公告)号：US4492703A
公开(公告)日：1985-01-08
申请号：US468819
申请日：1983-02-22
申请人： Siegfried Goldmann , Horst Boshagen , Jurgen Stoltefuss , Matthias Schramm , Gunter Thomas , Stanislav Kazda
发明人： Siegfried Goldmann , Horst Boshagen , Jurgen Stoltefuss , Matthias Schramm , Gunter Thomas , Stanislav Kazda
IPC分类号： A61K31/435 , A61K31/4427 , A61K31/4433 , A61K31/455 , A61P1/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/28 , C07D211/90 , C07D401/06 , C07D401/12 , C07D409/06 , C07D409/12 , C07D211/82
CPC分类号： C07D401/12 , C07D211/90 , C07D409/12
摘要： 1,4-Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.4, R.sup.5, R.sup.6 and Y are hydrogen or various organic radicals,R.sup.2 and R.sup.3 are various organic radicals, ##STR2## is phenyl, naphthyl or various heterocyclic radicals, X is a direct bond, O, S or SO, andB is a direct bond or alkylene,or pharmaceutically acceptable addition salts thereof exhibit hypotensive, vasodilating and coronary activities.
摘要翻译：其中R 1，R 4，R 5，R 6和Y是氢或各种有机基团的式“IMAGE”的1,4-二氢吡啶类，R 2和R 3是各种有机基团，是苯基，萘基或各种杂环基，X 是直接键合O，S或SO，B是直接键或亚烷基，或其药学上可接受的加成盐表现出降血压，血管扩张和冠状动脉。

37. 发明授权

US07712771B2 Airbag module 有权
标题翻译：安全气囊模块
公开(公告)号：US07712771B2
公开(公告)日：2010-05-11
申请号：US11900126
申请日：2007-09-10
申请人： Werner Freisler , Matthias Schramm
发明人： Werner Freisler , Matthias Schramm
IPC分类号： B60R21/16
CPC分类号： B60R21/231 , B60R21/206 , B60R21/2338 , B60R2021/23169 , B60R2021/23382
摘要： An airbag module has a module housing that has an airbag deployment opening with a predetermined opening dimension. An airbag is arranged folded in the module housing, the airbag having a first wall and a second wall situated opposite from the first wall. At least one holding means is arranged in the airbag. The at least one holding means is arranged in the unfolded airbag in the region of the airbag deployment opening and is attached on the airbag but not attached to the module housing. The holding means joins the first and second walls in the region of the airbag deployment opening and limits a distance between the walls in the region of the airbag deployment opening.
摘要翻译：安全气囊模块具有模块壳体，其具有具有预定开口尺寸的气囊展开开口。安全气囊被折叠在模块壳体中，气囊具有第一壁和与第一壁相对设置的第二壁。至少一个保持装置设置在气囊中。所述至少一个保持装置在所述展开的气囊中在所述气囊展开开口的区域中被布置，并且安装在所述气囊上，但未附接到所述模块壳体。保持装置在气囊展开开口的区域中连接第一壁和第二壁，并限制气囊展开开口区域内的壁之间的距离。

38. 发明申请

US20080067789A1 Airbag module 有权
标题翻译：安全气囊模块
公开(公告)号：US20080067789A1
公开(公告)日：2008-03-20
申请号：US11900126
申请日：2007-09-10
申请人： Werner Freisler , Matthias Schramm
发明人： Werner Freisler , Matthias Schramm
IPC分类号： B60R21/16
CPC分类号： B60R21/231 , B60R21/206 , B60R21/2338 , B60R2021/23169 , B60R2021/23382
摘要： An airbag module has a module housing that has an airbag deployment opening with a predetermined opening dimension. An airbag is arranged folded in the module housing, the airbag having a first wall and a second wall situated opposite from the first wall. At least one holding means is arranged in the airbag. The at least one holding means is arranged in the unfolded airbag in the region of the airbag deployment opening and is attached on the airbag but not attached to the module housing. The holding means joins the first and second walls in the region of the airbag deployment opening and limits a distance between the walls in the region of the airbag deployment opening.
摘要翻译：安全气囊模块具有模块壳体，其具有具有预定开口尺寸的气囊展开开口。安全气囊被折叠在模块壳体中，气囊具有第一壁和与第一壁相对设置的第二壁。至少一个保持装置设置在气囊中。所述至少一个保持装置在所述展开的气囊中在所述气囊展开开口的区域中被布置，并且安装在所述气囊上，但未附接到所述模块壳体。保持装置在气囊展开开口的区域中连接第一壁和第二壁，并限制气囊展开开口区域内的壁之间的距离。

39. 发明授权

US5866571A 9-substituted 2-(2-n-alkoxyphenyl)-purin-6-ones 失效
标题翻译： 9-取代的2-（2-n-烷氧基苯基） - 嘌呤-6-酮
公开(公告)号：US5866571A
公开(公告)日：1999-02-02
申请号：US585996
申请日：1996-01-16
申请人： Ulrich Niewohner , Erwin Bischoff , Helmuth Schutz , Elisabeth Perzborn , Matthias Schramm
发明人： Ulrich Niewohner , Erwin Bischoff , Helmuth Schutz , Elisabeth Perzborn , Matthias Schramm
IPC分类号： C07D473/34 , A61K31/52 , A61K31/522 , A61K31/535 , A61K31/63 , A61K31/655 , A61P7/02 , A61P9/00 , A61P13/02 , A61P15/00 , A61P29/00 , A61P43/00 , C07D295/26 , C07D473/00 , C07D473/30
CPC分类号： C07D473/00 , C07D473/30
摘要： 9-Substituted 2-(2-n-alkoxyphenyl)purin-6-ones are prepared by cyclizing correspondingly substituted imidazoles and derivatizing the purines thus obtained. The 9-substituted .sup.2 -(2-n-alkoxyphenyl)purin-6-ones can be employed as active compounds in medicaments, in particular in medicarnents for treatment of inflammations, thromboembolic diseases and cardiovascular diseases.
摘要翻译： 9-取代的2-（2-正烷氧基苯基）嘌呤-6-酮通过环化相应取代的咪唑并衍生得到的嘌呤来制备。 9-取代的2-（2-正烷氧基苯基）嘌呤-6-酮可用作药物中的活性化合物，特别是用于治疗炎症，血栓栓塞性疾病和心血管疾病的药物。

40. 发明授权

US5861404A 2,9-disubstituted purin-6-ones 失效
标题翻译： 2,9-二取代的嘌呤-6-酮
公开(公告)号：US5861404A
公开(公告)日：1999-01-19
申请号：US587321
申请日：1996-01-12
申请人： Ulrich Niewohner , Erwin Bischoff , Helmuth Schutz , Elisabeth Perzborn , Matthias Schramm
发明人： Ulrich Niewohner , Erwin Bischoff , Helmuth Schutz , Elisabeth Perzborn , Matthias Schramm
IPC分类号： A61K31/52 , A61K31/522 , A61P7/02 , A61P9/00 , A61P13/02 , A61P15/00 , A61P29/00 , A61P43/00 , C07D233/90 , C07D473/00 , C07D473/30
CPC分类号： C07D473/00
摘要： 2,9-Disubstituted purin-6-ones are prepared by acylating correspondingly substituted aminoimidazoles in a first step and then cyclizing the product to the purine. The new 2,9-disubstituted purin-6-ones can be employed as active compounds in medicaments, in particular for the treatment of inflammations, thromboembolic and cardiovascular diseases and diseases of the urogenital system.
摘要翻译： 2,9-二取代的嘌呤-6-酮通过在第一步中酰化相应的取代的氨基咪唑然后将产物环化成嘌呤来制备。新的2,9-二取代的嘌呤-6-酮可以用作药物中的活性化合物，特别是用于治疗炎症，血栓栓塞和心血管疾病以及泌尿生殖系统的疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式