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31. 发明申请

US20110251392A1 EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS 有权
标题翻译：乙酰胺类似物的外源和二硫选择性合成
公开(公告)号：US20110251392A1
公开(公告)日：2011-10-13
申请号：US13168029
申请日：2011-06-24
申请人： George Wu , Anantha R. Sudhakar , Mingsheng Huang , Tao Wang , Vijay Sabesan , Ji Xie , Frank Xing Chen , Marc Poirier , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie. Lim
发明人： George Wu , Anantha R. Sudhakar , Mingsheng Huang , Tao Wang , Vijay Sabesan , Ji Xie , Frank Xing Chen , Marc Poirier , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie. Lim
IPC分类号： C07F9/141 , C07C205/56 , C07C309/16 , C07D213/02 , C07C235/00 , C07C205/44 , C07D307/77 , C07D277/64
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

32. 发明申请

US20110191182A1 System and Method for Managing and Optimizing Advertising Networks 有权
标题翻译：管理和优化广告网络的系统和方法
公开(公告)号：US20110191182A1
公开(公告)日：2011-08-04
申请号：US12628492
申请日：2009-12-01
申请人： Marc Poirier , Richard Couture
发明人： Marc Poirier , Richard Couture
IPC分类号： G06Q30/00
CPC分类号： G06Q90/00 , G06Q30/02 , G06Q30/0256 , G06Q30/0275
摘要： The system of the present invention is used to execute data consolidation to combine data from Google, MSN and Yahoo, at least. The user does not need anymore to combine by himself data in spreadsheets. The system allows creating consolidated campaigns that span across search providers, letting the user effortlessly build reports that previously took hours to create each month. The system of the present invention is particularly suited for agencies. A tool designed for agencies needs to allow for management at the client level as well as the agency level. The system client center gives each member of the team a summary view of the client accounts that they're responsible for, along with emerging trend indicators for every major metric.
摘要翻译：本发明的系统至少用于执行数据整合以组合Google，MSN和Yahoo的数据。用户不需要自己将数据合并在电子表格中。该系统允许创建跨越搜索提供商的合并广告系列，让用户轻松构建以前每个月创建几个小时的报告。本发明的系统特别适用于机构。为机构设计的工具需要在客户层面和机构层面进行管理。系统客户中心为团队的每个成员提供他们负责的客户帐户的摘要视图，以及每个主要指标的新兴趋势指标。

33. 发明申请

US20090281321A1 EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS 有权
标题翻译：乙酰胺类似物的外 - 和二选择性合成
公开(公告)号：US20090281321A1
公开(公告)日：2009-11-12
申请号：US12505079
申请日：2009-07-17
申请人： George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
发明人： George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
IPC分类号： C07C69/608 , C07D405/08 , C07F9/40 , C07D307/92 , C07D417/08 , C07D277/64
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

34. 发明授权

US07528263B2 Oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-{N-[(tert-butylamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide and related compounds 失效
标题翻译：制备N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3- {N - [（叔丁基氨基）羰基] -3-甲基-L-缬氨酰基} -6的氧化方法，6-二甲基-3-氮杂双环[3.1.0]己烷-2-甲酰胺及相关化合物
公开(公告)号：US07528263B2
公开(公告)日：2009-05-05
申请号：US11598528
申请日：2006-11-13
申请人： George Wu , Ji Xie , Paitoon Rashatasakhon , Frank Xing Chen , Marc Poirier , Victoria M. Sprague
发明人： George Wu , Ji Xie , Paitoon Rashatasakhon , Frank Xing Chen , Marc Poirier , Victoria M. Sprague
IPC分类号： C07D209/52
CPC分类号： C07D209/52 , A61K38/00 , C07K5/0202
摘要： The present application relates to a process for preparing a compound of formula I: wherein R1 is alkyl; R2 is alkyl; and R3 is optionally substituted cycloalklylalkyl which comprises oxidizing a compound of the formula wherein R1, R2 and R3 are defined above to yield a compound of formula I.
摘要翻译：本申请涉及制备式I化合物的方法：其中R1是烷基; R2是烷基; 并且R 3是任选取代的环烷基烷基，其包括氧化下式化合物其中R 1，R 2和R 3如上定义，得到式I化合物。

35. 发明授权

US07049440B2 Enantioselective process 失效
公开(公告)号：US07049440B2
公开(公告)日：2006-05-23
申请号：US10676212
申请日：2003-10-01
申请人： Frank X. Chen , Yee-Shing Wong , Jeffrey M. Eckert , Feng Liang , Nanfei Zou , Agnes S. Kim-Meade , Marc Poirier , Tiruvettipuram K. Thiruvengadam , George G. Wu
发明人： Frank X. Chen , Yee-Shing Wong , Jeffrey M. Eckert , Feng Liang , Nanfei Zou , Agnes S. Kim-Meade , Marc Poirier , Tiruvettipuram K. Thiruvengadam , George G. Wu
IPC分类号： C07D211/30 , C07D221/06 , C07D453/04
CPC分类号： C07D401/14 , C07D221/16
摘要： An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I is disclosed.

36. 发明授权

US06372909B1 Synthesis of intermediates useful in preparing tricyclic compounds 有权
标题翻译：可用于制备三环化合物的中间体的合成
公开(公告)号：US06372909B1
公开(公告)日：2002-04-16
申请号：US09442512
申请日：1999-11-18
申请人： Charles F. Bernard , Michael Casey , Frank Xing Chen , Denise C. Grogan , Marc Poirier , Robert P. Williams , Yee-Shing Wong , George G. Wu
发明人： Charles F. Bernard , Michael Casey , Frank Xing Chen , Denise C. Grogan , Marc Poirier , Robert P. Williams , Yee-Shing Wong , George G. Wu
IPC分类号： C07F980
CPC分类号： C07D221/16
摘要： Disclosed is a process for preparing a compound having the formula: wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy, by (A) reacting a compound having the formula wherein RA, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl, with a dehydrating agent to produce an imine having the formula: (B) hydrolyzing the imine produced in step (A) to produce the compound having formula (I). Also disclosed are novel intermediates having the formula: wherein RA, RB, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl. Also disclosed is a process for preparing a compound having the formula: comprising: reacting a compound having the formula: with NH2R5 in the presence of a palladium catalyst, carbon monoxide, a base, and an ether selected from the group consisting of: CH3OCH2CH2OCH3; CH3OCH2CH2OCH2CH2OCH3; and CH3OCH2CH2OCH2CH2OCH2CH2OCH3, wherein X is H, Br, Cl, or F, and R5 is aryl or heteroaryl. The compounds made by these processes are useful intermediates for preparing compounds that are antihistamines or inhibitors of farnesyl protein transferase.
摘要翻译：公开了一种制备具有下式的化合物的方法：其中R，R 1，R 2，R 3和R 4独立地选自H，Br，Cl，F，烷基或烷氧基，通过（A）使具有下式的化合物其中RA，RC，RD和RE独立地选自H，卤素，烷基或烷氧基，R5是芳基或杂芳基，与脱水剂反应生成具有下式的亚胺：（B ）水解步骤（A）中产生的亚胺以制备具有式（I）的化合物。还公开了具有下式的新型中间体：其中RA，RB，RC，RD和RE独立地选自H，卤素，烷基或烷氧基，R5是芳基或杂芳基。还公开了制备具有下式的化合物的方法：包括：在钯催化剂，一氧化碳，碱和选自以下的醚的存在下使具有下式的化合物与NH 2 R 5反应：CH 3 OCH 2 CH 2 OCH 3; CH3OCH2CH2OCH2CH2OCH3; 和CH 3 OCH 2 CH 2 OCH 2 CH 2 OCH 2 CH 2 OCH 3，其中X是H，Br，Cl或F，R 5是芳基或杂芳基。通过这些方法制备的化合物是制备抗组胺剂或法呢基蛋白转移酶抑制剂的化合物的有用中间体。

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