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31. 发明授权

US5237992A Implantable pacemaker providing hysteresis in dual-chamber modes 失效
标题翻译：在双室模式中提供滞后的可植入器
公开(公告)号：US5237992A
公开(公告)日：1993-08-24
申请号：US846308
申请日：1992-03-05
申请人： John W. Poore
发明人： John W. Poore
IPC分类号： A61N1/365 , A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682
摘要： An implantable pacemaker provides three types of hysteresis for use in dual chamber and/or atrial tracking modes, such as VDI, VDD, DDI, DDD, VDIR, VDDR, DDIR or DDDR. The pacemaker defines a basic atrial escape interval (AEI) that defines the maximum time between a ventricular event and a subsequent atrial event, as well as an AV delay (AVD) that defines the maximum time between an atrial event and the next ventricular event. The sum of AEI plus AVD thus sets the rate at which stimulation pulses are generated in the absence of sensed natural cardiac activity. A first type of hysteresis, atrial escape rate hysteresis, causes the AEI to be extended upon sensing natural atrial beats (P-waves). The increased AEI remains in force so long as natural P-waves continue to be sensed during the AEI. Should a P-wave not be sensed during the AEI, a stimulation pulse is generated and the AEI reverts to its initial value. A second type of hysteresis, atrial-induced AV delay hysteresis, extends the next AVD and shortens the AEI in response to sensing a P-wave, thereby keeping the pacemaker's programmed rate the same. A third type of hysteresis, ventricular-induced AV delay hysteresis, extends the next AVD and shortens the AEI in response to sensing an R-wave. Any desired combination of the three types of hysteresis may be programmably selected for use within the pacemaker.

32. 发明授权

US4940053A Energy controlled rate-responsive pacemaker having automatically adjustable control parameters 失效
标题翻译：能量控制率响应起搏器具有自动调节的控制参数
公开(公告)号：US4940053A
公开(公告)日：1990-07-10
申请号：US301935
申请日：1989-01-25
申请人： Brian M. Mann , John W. Poore
发明人： Brian M. Mann , John W. Poore
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： A device for use as a rate-responsive pacemaker is disclosed in which the pacing interval is controlled by the amount of energy contained in a raw signal generated by a suitable physiological sensor and processed by an energy converter to generate an output energy signal coupled to the pacemaker control circuits to adjust the pacing interval. The energy converter may be a rectifying amplifier and an integrating circuit, a voltage controlled oscillator whose frequency is measured over a suitable time interval using a time interval generator and a counter with the output of the counter being used by the control circuits of the pacemaker to vary its pacing interval, or means for measuring energy content of the raw signal and storing that measurement in memory and periodically processing it to alter the transfer characteristics of the rate-responsive pacemaker.
摘要翻译：公开了一种用作速率响应起搏器的装置，其中起搏间隔由包含在由合适的生理传感器产生并由能量转换器处理的原始信号中的能量的量控制，以产生耦合到起搏器控制电路调节起搏间隔。能量转换器可以是整流放大器和积分电路，压控振荡器，其频率在适当的时间间隔内使用时间间隔发生器和计数器，计数器的输出由起搏器的控制电路使用，改变其起搏间隔或用于测量原始信号的能量含量并将该测量存储在存储器中并定期处理它以改变速率响应起搏器的传递特性的装置。

33. 发明授权

US08996109B2 Leadless intra-cardiac medical device with dual chamber sensing through electrical and/or mechanical sensing 有权
标题翻译：无铅心脏内心脏医疗器械，通过电气和/或机械感测实现双室感应
公开(公告)号：US08996109B2
公开(公告)日：2015-03-31
申请号：US13485513
申请日：2012-05-31
申请人： Edward Karst , Richard Samade , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret
发明人： Edward Karst , Richard Samade , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/00 , A61N1/365 , A61N1/375 , A61N1/372 , A61B5/00 , A61B5/042 , A61B5/11 , A61B5/0452 , A61N1/368 , A61B5/0464
CPC分类号： A61N1/368 , A61B5/0422 , A61B5/0452 , A61B5/0464 , A61B5/1107 , A61B5/6869 , A61B5/6882 , A61B2560/0468 , A61N1/36507 , A61N1/36514 , A61N1/36578 , A61N1/36592 , A61N1/37205 , A61N1/3756
摘要： A leadless intra-cardiac medical device senses cardiac activity from multiple chambers and applies cardiac stimulation to at least one cardiac chamber and/or generates a cardiac diagnostic indication. The leadless device may be implanted in a local cardiac chamber (e.g., the right ventricle) and detect near-field signals from that chamber as well as far-field signals from an adjacent chamber (e.g., the right atrium).
摘要翻译：无引导心脏内心脏医疗装置感测来自多个腔室的心脏活动，并将心脏刺激应用于至少一个心室，和/或产生心脏诊断指示。无引线装置可以植入局部心室（例如右心室）并检测来自该腔室的近场信号以及来自相邻腔室（例如，右心房）的远场信号。

34. 发明授权

US08798740B2 Single chamber leadless intra-cardiac medical device with dual-chamber functionality 有权
标题翻译：具有双室功能的单室无引线心脏内心脏医疗设备
公开(公告)号：US08798740B2
公开(公告)日：2014-08-05
申请号：US13352048
申请日：2012-01-17
申请人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
发明人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
IPC分类号： A61N1/00
CPC分类号： A61N1/3684 , A61N1/0573 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes a housing configured to be implanted entirely within a single local chamber of the heart.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为完全植入心脏的单个局部室内的壳体。

35. 发明授权

US08647675B2 Silver nanoparticle antimicrobial coating for long-term and short-term infection resistance 有权
标题翻译：银纳米颗粒抗菌涂层长期和短期感染抗性
公开(公告)号：US08647675B2
公开(公告)日：2014-02-11
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61K9/14 , A01N55/02
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

36. 发明申请

US20130110127A1 MULTI-PIECE DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE AND METHOD OF IMPLANTING SAME 有权
公开(公告)号：US20130110127A1
公开(公告)日：2013-05-02
申请号：US13352005
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
IPC分类号： A61N1/05 , A61B19/00
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/36521 , A61N1/37288 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

37. 发明授权

US08150512B2 Use of impedance to assess electrode locations 有权
标题翻译：使用阻抗来评估电极位置
公开(公告)号：US08150512B2
公开(公告)日：2012-04-03
申请号：US12273286
申请日：2008-11-18
申请人： Gene A. Bornzin , Peter Boileau , John W. Poore
发明人： Gene A. Bornzin , Peter Boileau , John W. Poore
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61N1/3706
摘要： A process for determining whether the location of a stimulation electrode meets a selected heart performance criteria includes providing stimulation to the heart through the electrode and obtaining an impedance measurement during stimulation delivery using an impedance sensing vector formed by electrodes that do not include the stimulation electrode. The impedance measurements are processed, either alone or in combination with an electrogram, also obtained during stimulation, to obtain a measure of hemodynamic performance.
摘要翻译：用于确定刺激电极的位置是否满足所选择的心脏性能标准的过程包括通过电极向心脏提供刺激，并且使用由不包括刺激电极的电极形成的阻抗感测向量在刺激递送期间获得阻抗测量。阻抗测量单独地或与刺激期间获得的电描绘图结合进行处理，以获得血液动力学性能的量度。

38. 发明授权

US07587239B1 Cardiac pacemaker system, lead and method for rejecting far-field signals 有权
标题翻译：心脏起搏器系统，用于排除远场信号的导联和方法
公开(公告)号：US07587239B1
公开(公告)日：2009-09-08
申请号：US11475482
申请日：2006-06-26
申请人： Mark W. Kroll , John W. Poore
发明人： Mark W. Kroll , John W. Poore
IPC分类号： A61N1/362
CPC分类号： A61N1/3621 , A61N1/368 , Y10S128/902
摘要： An implantable cardiac lead comprises a lead body having a proximal end and a distal end, the proximal end of the lead body carrying a connector assembly connectable to an implantable medical device, and the distal end of the lead body carrying a distal electrode, a proximal electrode and an intermediate electrode positioned between the distal and proximal electrodes. The distal and proximal electrodes are connected together at a node point located within the distal end of the lead body, the node point being electrically connected to a first terminal contact on the connector assembly and the intermediate electrode being electrically connected to a second terminal contact on the connector assembly. Preferably, the intermediate electrode is positioned approximately midway between the distal and proximal electrodes. Also disclosed are a system and a method for differentiating signals generated by a plurality of electrodes carried by a lead body to provide an output signal representative of a second spatial derivative of the generated signals, the output signal being substantially devoid of far-field signals.
摘要翻译：可植入心脏引线包括具有近端和远端的引线主体，引线主体的近端承载可连接到可植入医疗装置的连接器组件，并且引线主体的远端承载远端电极，近端电极和位于远端和近端电极之间的中间电极。远端电极和近端电极在位于引线主体远端内的节点处连接在一起，该节点与电连接到连接器组件上的第一端子触点，并且中间电极与第二端子触点电连接连接器组件。优选地，中间电极位于远端和近端电极之间的大致中间位置。还公开了一种用于区分由引线体承载的多个电极产生的信号的系统和方法，以提供表示所生成的信号的第二空间导数的输出信号，该输出信号基本上没有远场信号。

39. 发明授权

US06606517B1 Methods and apparatus for preventing atrial arrhythmias by overdrive pacing and prolonging atrial refractoriness using an implantable cardiac stimulation device 有权
$Methods and apparatus for preventing atrial arrhythmias by overdrive pacing and prolonging atrial refractoriness using an implantable cardiac stimulation device$
标题翻译：使用可植入心脏刺激装置通过过度起搏预防房性心律失常和延长心房不应性的方法和装置
公开(公告)号：US06606517B1
公开(公告)日：2003-08-12
申请号：US09548293
申请日：2000-04-12
申请人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , John W. Poore , Laurence S. Sloman , Peter Boileau , Douglas T. Kurschinski
发明人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , John W. Poore , Laurence S. Sloman , Peter Boileau , Douglas T. Kurschinski
IPC分类号： A61N1362
CPC分类号： A61N1/3622
摘要： A method and apparatus for reducing the incidence of atrial arrhythmias by using an overdrive algorithm to determine the application of overdrive stimulation pulses to a patient's heart, e.g., in the atria. In a first aspect of the invention, the apparatus first determines an overdrive pacing rate and then applies pairs of temporally spaced (staggered) pacing pulses, i.e., primary and secondary pacing pulses, at the determined overdrive pacing rate. In a further aspect of the invention, the pairs of pacing pulses are applied at the overdrive pacing rate to multiple spatially spaced electrodes, i.e., electrodes distributed among multiple sites in a patient's heart, e.g., in the atria. In accordance with a first preferred embodiment, the electrodes may be distributed within a single atrium, e.g., the right atrium, of the patient's heart. Alternatively, a first electrode may be placed in the right atrium and a second electrode may be placed in the coronary sinus or the left atrium or multiple electrodes may be placed proximate to the left atrium. Furthermore, the invention relates to techniques for controlling overdrive pacing to multiple sites in a patient's heart so as to achieve and maintain a target degree of pacing and thus suppress tachycardias.
摘要翻译：一种用于通过使用过驱动算法来确定过度驱动刺激脉冲施加到患者心脏（例如在心房）中来减少心房心律失常发生率的方法和装置。在本发明的第一方面中，装置首先确定过驱动起搏速率，然后以确定的超速起搏速率施加时间间隔（交错）的起搏脉冲，即初级和次级起搏脉冲。在本发明的另一方面，以超速起搏速率将多对起搏脉冲施加到多个空间间隔开的电极，即分布在患者心脏中的多个部位之间的电极，例如在心房中。根据第一优选实施例，电极可以分布在患者心脏的单个心房（例如右心房）内。或者，第一电极可以放置在右心房中，并且第二电极可以放置在冠状窦或左心房中，或者多个电极可以放置在靠近左心房的位置。此外，本发明涉及用于控制对患者心脏中的多个部位的超速起搏的技术，以便实现和维持目标起搏程度，从而抑制心动过速。

40. 发明授权

US06519493B1 Methods and apparatus for overdrive pacing heart tissue using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置的超速起搏心脏组织的方法和装置
公开(公告)号：US06519493B1
公开(公告)日：2003-02-11
申请号：US09471788
申请日：1999-12-23
申请人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
发明人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
IPC分类号： A61N136
CPC分类号： A61N1/368
摘要： Techniques are described for overdrive pacing the heart using a pacemaker wherein the overdrive pacing rate only increases when at least two intrinsic beats are detected within a determined search period. In one specific technique, an increase in the pacing rate occurs only if two P-waves are detected within X cardiac cycles. In another specific technique, the overdrive pacing rate is increased only if at least two P-waves are detected within a block of N cardiac cycles. In both techniques, the overdrive pacing rate is decreased if no increase has occurred in the last Z cardiac cycles. By increasing the overdrive pacing rate only in response to detection of at least two P-waves within a determined number of cardiac cycles, an excessively high overdrive pacing rate is avoided. Other techniques are described for adaptively adjusting overdrive pacing parameters so as to achieve a determined target degree of pacing of, for example, 95% paced beats. By adaptively adjusting overdrive parameters to maintain a target degree of pacing, the average overdrive pacing rate is minimized while still maintaining a high number of paced beats, thereby reducing the risk of a tachyarrhythmia occurring within the patient.
摘要翻译：描述了使用起搏器超速起搏心脏的技术，其中在确定的搜索周期内检测到至少两个固有节拍时，超速起搏速率仅增加。在一种特定技术中，只有在X个心动周期内检测到两个P波时，起搏速率才会增加。在另一个具体技术中，只有在N个心动周期的块内检测到至少两个P波时，才能增加超速起搏速率。在两种技术中，如果在最后Z个心动周期中没有发生增加，则超速起搏速率将降低。通过仅在确定的心跳周期内响应于至少两个P波的检测来增加超速起搏速率，避免了过高的超速起搏速率。描述了用于自适应地调节过驱动起搏参数的其它技术，以便实现例如95％起搏节拍的确定的目标起搏程度。通过自适应地调整过驱动参数以保持目标起搏程度，平均超速起搏速度最小化，同时仍然保持大量的起搏节奏，从而降低患者内出现快速性心律失常的风险。

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