专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明专利

DE19650216A1 未知
公开(公告)号：DE19650216A1
公开(公告)日：1998-06-10
申请号：DE19650216
申请日：1996-12-04
申请人： INST PFLANZENGENETIK & KULTUR
发明人： GRIMM BERNHARD DR
IPC分类号： A01H5/00 , C12N9/10 , C12N9/90 , C12N15/09 , C12N15/60 , C12N15/82 , A01H1/00 , C07H21/04 , C12N15/63
摘要： A gene encoding a hybrid protein consisting of ALA-S yeast and a N-terminal transit sequence for the small carboxydismutase sub-unit is introduced into the genim of tobacco (nicotania tabacum) and a chlorophyll-poor tobacco transformant which expresses glutamate-1-semialdehyde-transminase (GSA-AT) antisense RNA. The expression of ALA-S in the GSA-AT transgenic antisense strain has produced green co-transformants, the chlorophyll content of which is similar to that of the wild type, while the wild-type transformants have shown no phenotypical changes. The capacity of plants to synthetize ALA and chlorophyll is increased, thereby demonstrating the contribution of ALA-S to the ALA supply required for the chlorophyll synthesis. The transgenic plants produce chlorophyll in the presence of gabaculine, a GSA-AT inhibitor. The permanent RNA and protein content of GSA-AT have been reduced, as well has the enzymatic activity of plants expressing ALA-S. The additional synthesis of ALA also explains the expression of GSA-AT in the C5 way.

32. 发明专利

DE19625049A1 未知
公开(公告)号：DE19625049A1
公开(公告)日：1998-01-02
申请号：DE19625049
申请日：1996-06-22
申请人： INST PFLANZENGENETIK & KULTUR
发明人： BECKER KLAUS DR , KAINA BERND PROF
IPC分类号： A01K67/027 , C12N9/10 , C12N15/85
摘要： A transgenic, non-human mammal (in particular a mouse) is disclosed, whose body and sexual cells contain an additional DNA repair gene parasexually transmitted to the original animal at the 1-8 cell stage of embryonary development. The invention finds applications in the medical field, in particular the prevention and therapy of malign diseases, and in the pharmaceutical industry. The object of the invention is to provide a transgenic animal suitable for carrying out detailed research on the significance of cellular defence mechanisms and specific DNA-damages during tumour formation. This should give a new impulsion to the prevention and therapy of malign diseases. For this purpose, a transgenic, non-human mammal is provided which contains an additional DNA repair gene coding for a function suitable for eliminating alkylated DNA lesions, the coded function being an O -methylguanine-DNA-methyltransferase (MGMT), or for a function that corrects UV-induced damages. In a specially preferred embodiment of the invention, an additional recombinant repair gene is inserted which is expressed in the epidermis of the claimed mammal.

33. 发明专利

DE10034578B4 未知
公开(公告)号：DE10034578B4
公开(公告)日：2009-08-27
申请号：DE10034578
申请日：2000-07-14
申请人： INST PFLANZENGENETIK & KULTUR
发明人： TAG KRISTINA , KUNZE GOTTHARD , RIEDEL KLAUS , GRABERT ELMAR
IPC分类号： C12N11/02 , C12M1/34 , C12M1/40 , C12N1/14 , C12Q1/02

34. 发明专利

DE10060133B4 未知
公开(公告)号：DE10060133B4
公开(公告)日：2006-07-13
申请号：DE10060133
申请日：2000-11-27
申请人： INST PFLANZENGENETIK & KULTUR , UFZ LEIPZIGHALLE GMBH
发明人： KUNZE GOTTHARD , BABEL WOLFGANG , TERENTIEV YAROSLAV , WARTMANN THOMAS , BREUER UTA , HURTADO-PICO ALMUDENA , BERGMANN HORST
IPC分类号： C12N15/81

35. 发明专利

AT271612T 未知
公开(公告)号：AT271612T
公开(公告)日：2004-08-15
申请号：AT99962041
申请日：1999-10-27
申请人： INST PFLANZENGENETIK & KULTUR
发明人： HEIM UTE , WEBER HANS
IPC分类号： A01H5/00 , C07K14/415 , C12N5/10 , C12N15/09 , C12N15/63 , C12N15/82

36. 发明专利

DE10290025T1 未知
公开(公告)号：DE10290025T1
公开(公告)日：2003-10-09
申请号：DE10290025
申请日：2002-04-19
申请人： DEVELOGEN AG , INST PFLANZENGENETIK & KULTUR
发明人： ST-ONGE LUC , HOFFMANN URSULA , WOBUS ANNA M , BLYSZCZUK PRZEMYSLAW
IPC分类号： C12N15/09 , A61K35/12 , A61K35/39 , A61P1/18 , A61P3/10 , A61P5/48 , C12N5/02 , C12N5/071 , C12N15/85 , C12Q1/02 , G01N33/50 , G01N33/74 , C12N5/08 , C12N5/10

37. 发明专利

ES2176467T3 未知
公开(公告)号：ES2176467T3
公开(公告)日：2002-12-01
申请号：ES96921885
申请日：1996-06-27
申请人： INST PFLANZENGENETIK & KULTUR
发明人： RODER MARION , PLASCHKE JENS , GANAL MARTIN
IPC分类号： C12Q1/68 , C12Q1/6858 , C12Q1/6876 , C12Q1/6895
摘要： The invention relates to novel microsatellite markers for wheats (Triticum aestivum) and closely related species (Genus Triticeae) and to the use of said markers for the genetic analysis of plants of the Triticum aestivum species.

38. 发明专利

DE59609128D1 未知
公开(公告)号：DE59609128D1
公开(公告)日：2002-05-29
申请号：DE59609128
申请日：1996-06-27
申请人： INST PFLANZENGENETIK & KULTUR
发明人： ROEDER MARION , PLASCHKE JENS , GANAL MARTIN
IPC分类号： C12Q1/68 , C12Q1/6858 , C12Q1/6876 , C12Q1/6895
摘要： The invention relates to novel microsatellite markers for wheats (Triticum aestivum) and closely related species (Genus Triticeae) and to the use of said markers for the genetic analysis of plants of the Triticum aestivum species.

39. 发明专利

DK0835325T3 未知
公开(公告)号：DK0835325T3
公开(公告)日：2001-07-16
申请号：DK96922735
申请日：1996-06-27
申请人： INST PFLANZENGENETIK & KULTUR
发明人： WOBUS ANNA MAGDALENE , FRANZ WOLFGANG-MICHAEL
IPC分类号： C12Q1/02 , C12Q1/68 , C12Q1/6897 , G01N33/50
摘要： PCT No. PCT/DE96/01183 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Jun. 27, 1996 PCT Pub. No. WO97/01644 PCT Pub. Date Jan. 16, 1997The invention concerns an in vitro test procedure for the detection of chemically induced effects on embryonic development and for differentiation for the purpose of embryotoxicity/teratogenicity screening based on differentiated pluripotent embryonic stem (ES) cells from mice and rats using embryonic germ (EG) cells obtained from primoridial germ cells. The proposed test procedure is characterised in that stable transgenic ES or EG cell clones containing tissue-specific promoters and reporter genes are selected, differentiation-dependent expression of tissue-specific genes is carried out following differentiation of ES cells in the presence of embryotoxic substances acting at specific times into different germination path derivatives; this is followed by detection of chemically induced activation, repression or modulation of tissue-specific genes which regulate embryonic development.

40. 发明专利

DE59606520D1 未知
公开(公告)号：DE59606520D1
公开(公告)日：2001-04-05
申请号：DE59606520
申请日：1996-06-27
申请人： INST PFLANZENGENETIK & KULTUR
发明人： WOBUS MAGDALENE , FRANZ WOLFGANG-MICHAEL
IPC分类号： C12Q1/02 , C12Q1/68 , C12Q1/6897 , G01N33/50
摘要： PCT No. PCT/DE96/01183 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Jun. 27, 1996 PCT Pub. No. WO97/01644 PCT Pub. Date Jan. 16, 1997The invention concerns an in vitro test procedure for the detection of chemically induced effects on embryonic development and for differentiation for the purpose of embryotoxicity/teratogenicity screening based on differentiated pluripotent embryonic stem (ES) cells from mice and rats using embryonic germ (EG) cells obtained from primoridial germ cells. The proposed test procedure is characterised in that stable transgenic ES or EG cell clones containing tissue-specific promoters and reporter genes are selected, differentiation-dependent expression of tissue-specific genes is carried out following differentiation of ES cells in the presence of embryotoxic substances acting at specific times into different germination path derivatives; this is followed by detection of chemically induced activation, repression or modulation of tissue-specific genes which regulate embryonic development.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式