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31. 发明授权

US07291598B2 Nanoparticles for protein drug delivery 有权
标题翻译：用于蛋白质药物递送的纳米颗粒
公开(公告)号：US07291598B2
公开(公告)日：2007-11-06
申请号：US11398440
申请日：2006-04-05
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
IPC分类号： A61K38/00 , A61K9/16 , A61K51/00
CPC分类号： A61K9/5146 , A61K9/5161 , A61K47/36 , A61K47/6931 , A61K47/6939 , B82Y5/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
摘要翻译：本发明公开了由壳聚糖，聚谷氨酸和至少一种生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷和增强细胞旁药物递送的渗透性。

32. 发明授权

US07282194B2 Nanoparticles for protein drug delivery 有权
标题翻译：用于蛋白质药物递送的纳米颗粒
公开(公告)号：US07282194B2
公开(公告)日：2007-10-16
申请号：US11284734
申请日：2005-11-21
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K51/00 , A61K9/50
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
摘要翻译：本发明公开了由壳聚糖，聚-γ-谷氨酸和至少一种生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷及其对细胞旁药物递送的增强的渗透性。

33. 发明授权

US07265090B2 Nanoparticles for paracellular drug delivery 有权
标题翻译：纳米颗粒用于细胞外药物递送
公开(公告)号：US07265090B2
公开(公告)日：2007-09-04
申请号：US11029082
申请日：2005-01-04
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K38/00 , A61N43/04
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan/poly-γ-glutamic acid characterized with a positive surface charge and their enhanced permeability through Caco-2 cells for paracellular drug delivery.
摘要翻译：本发明公开了由壳聚糖/聚-γ-谷氨酸组成的纳米颗粒，其特征在于具有阳性表面电荷并且通过Caco-2细胞提高细胞外药物递送的通透性。

34. 发明申请

US20070116771A1 Nanoparticles for protein drug delivery 有权
公开(公告)号：US20070116771A1
公开(公告)日：2007-05-24
申请号：US11398145
申请日：2006-04-05
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
IPC分类号： A61K31/55 , A61K31/445 , A61K31/13 , A61K9/14
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.

35. 发明申请

US20070104693A1 Breast augmentation system 审中-公开
标题翻译：乳房增大系统
公开(公告)号：US20070104693A1
公开(公告)日：2007-05-10
申请号：US11268432
申请日：2005-11-07
申请人： Rodolfo Quijano , Tuoc Nguyen , Kenneth Williams , Hosheng Tu , Robert Carter
发明人： Rodolfo Quijano , Tuoc Nguyen , Kenneth Williams , Hosheng Tu , Robert Carter
IPC分类号： A61K35/12 , C12N5/08
CPC分类号： A61L27/3839 , A61K35/12 , A61L27/3804 , A61L27/3895 , C12N5/0667 , C12N2539/10
摘要： A stem-cell-seeded porous scaffold implant and delivery systems for treating or augmenting a breast tissue defect in a patient.
摘要翻译：用于治疗或增加患者的乳腺组织缺陷的干细胞种子多孔支架植入物和递送系统。

36. 发明申请

US20070092493A1 Living cell sheet 审中-公开
标题翻译：活细胞片
公开(公告)号：US20070092493A1
公开(公告)日：2007-04-26
申请号：US11256729
申请日：2005-10-24
申请人： Hsing-Wen Sung , Chun-Hung Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Chun-Hung Chen , Hosheng Tu
IPC分类号： A61K35/12 , C12N5/08
CPC分类号： C12N5/0068 , C12N2539/10
摘要： A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet with ECM. The coated hydrogel system is reusable and can be used for culturing a multi-layer cell sheet. The obtained living cell sheets may be used for tissue reconstructions.
摘要翻译：一种新颖的方法，使用涂覆在TCPS皿上的热可逆MC / PBS /胶原水凝胶，用ECM收集活细胞片。涂覆的水凝胶体系是可重复使用的，可用于培养多层细胞片。获得的活细胞片可以用于组织重建。

37. 发明申请

US20070014831A1 Biodegradable occlusive device with moisture memory 审中-公开
标题翻译：具有防潮记忆力的可生物降解闭塞装置
公开(公告)号：US20070014831A1
公开(公告)日：2007-01-18
申请号：US11180498
申请日：2005-07-12
申请人： Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
IPC分类号： A61K47/48 , C08G63/91 , C08G63/48 , A61F2/02
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12172 , A61B17/1219 , A61B2017/00004 , A61B2017/1205 , A61F2/82 , A61F2002/30062 , A61F2210/0004 , A61K31/337 , A61K31/436 , A61K47/61 , A61K47/6957 , C08B37/003 , C08B37/0084
摘要： The present invention relates to a biodegradable occlusive device and methods for treating aneurysm of a patient comprising deploying a flexible biodegradable occlusive device with a moisture memory and a controlled biodegradation, and deploying a retaining stent for preventing the occlusive device from being inadvertently dislodged from the sac.
摘要翻译：本发明涉及可生物降解的闭塞装置和用于治疗患者的动脉瘤的方法，包括部署具有湿气记忆和受控生物降解的柔性可生物降解闭塞装置，以及展开保持支架以防止闭塞装置被无意中从囊中移出。

38. 发明申请

US20060200113A1 Liquid jet for glaucoma treatment 审中-公开
标题翻译：液体射流青光眼治疗
公开(公告)号：US20060200113A1
公开(公告)日：2006-09-07
申请号：US11353854
申请日：2006-02-13
申请人： David Haffner , Hosheng Tu , Gregory Smedley
发明人： David Haffner , Hosheng Tu , Gregory Smedley
IPC分类号： A61B18/18
CPC分类号： A61F9/00781 , A61M5/14
摘要： Methods of treating glaucoma are described including treatment of an eye with a liquid jet. The liquid jet can be generated by a laser-induced liquid jet instrument which is inserted through an incision in an eye. A stent can also be used, the stent having an inflow portion that is in fluid communication with an outflow portion. The stent can be inserted into the eye and transported from the incision through the anterior chamber of the eye toward the trabecular meshwork of the eye. In some embodiments, the stent can be advanced through the anterior chamber of the eye and provide fluid communication between the anterior chamber and Schlemm's canal. The method includes infusing fluid into an aqueous cavity and increasing the pressure of the fluid within the aqueous cavity.
摘要翻译：描述治疗青光眼的方法，包括用液体射流治疗眼睛。液体射流可以通过激光诱导的液体喷射器产生，其通过眼睛中的切口插入。还可以使用支架，所述支架具有与流出部分流体连通的流入部分。支架可以插入眼睛，并从切口通过眼睛的前房转移到眼睛的小梁网。在一些实施例中，支架可以推进穿过眼睛的前房并且在前房和施莱姆氏管之间提供流体连通。该方法包括将流体输入水腔并增加水腔内的流体的压力。

39. 发明申请

US20050266047A1 Injectable glaucoma implants with multiple openings 有权
公开(公告)号：US20050266047A1
公开(公告)日：2005-12-01
申请号：US11083713
申请日：2005-03-18
申请人： Hosheng Tu , Jason Artof , David Haffner
发明人： Hosheng Tu , Jason Artof , David Haffner
IPC分类号： A61F2/00 , A61F9/007 , A61K31/215
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2220/0008 , A61F2230/0069 , A61F2250/0067 , A61K31/215
摘要： Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.

40. 发明授权

US06969367B2 Extracorporeal pathogen reduction system 失效
公开(公告)号：US06969367B2
公开(公告)日：2005-11-29
申请号：US10720811
申请日：2003-11-24
申请人： Hosheng Tu , Hun-Chi Lin , Yu-An Chang
发明人： Hosheng Tu , Hun-Chi Lin , Yu-An Chang
IPC分类号： A61K20060101 , A61M1/00 , A61M1/26 , A61M1/34 , A61M5/00 , A61M37/00 , B01D24/28 , B01D33/00 , B01D33/01 , B01D33/15 , B01D61/00 , B01D61/20 , B01D63/16 , C02F1/44 , C07K1/00
CPC分类号： A61M1/3496 , A61M1/26 , A61M1/262 , A61M2202/20 , B01D63/16
摘要： The invention relates to an apparatus system and methods for treatment of virus-infected or pathogen-loaded human blood components separated from normal components comprising a separation apparatus and treatment apparatus system that inactivate pathogens in an extracorporeal body fluid system.

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