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31. 发明授权

US08097013B2 Skin incision instrument and method for incising skin with the same 有权
标题翻译：皮肤切口仪器和方法切割皮肤相同
公开(公告)号：US08097013B2
公开(公告)日：2012-01-17
申请号：US12827472
申请日：2010-06-30
申请人： Akio Oki , Hiroaki Oka
发明人： Akio Oki , Hiroaki Oka
IPC分类号： A61B17/34
CPC分类号： A61B5/15186 , A61B5/150022 , A61B5/150068 , A61B5/150335 , A61B5/150389 , A61B5/150427 , A61B5/150442 , A61B5/150503 , A61B5/150541 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/157 , A61B5/411
摘要： Provided are skin incision instrument to efficiently incise minimal portions and a method for incising skin with the skin incision instrument. The skin incision instrument according to the present invention comprises a holder, a needle, a needle drive unit, two or more skin expander sets, and a reader, wherein the skin expander sets comprise a first skin expander and a second skin expander; the first skin expander and the second skin expander are capable of expanding skin at both sides of the linear incision portion away from the linear incision portion and expanding the linear incision portion in a direction to expand the linear incision portion; and, minimal portions are efficiently incised by selecting a single skin expander set from two or more of the skin expander set based on the direction of the linear incision portion, such that an angle is adjusted to 45 degrees or more and 90 degrees or less wherein the angle is formed by the direction of the linear incision portion read by the reader and the direction to expand the skin by the single skin expander set.
摘要翻译：提供有效切割最小部分的皮肤切割仪器和用皮肤切开仪器切割皮肤的方法。根据本发明的皮肤切开仪器包括保持器，针头，针驱动单元，两个或更多个皮肤膨胀器组和读取器，其中所述皮肤膨胀器组包括第一皮肤膨胀器和第二皮肤膨胀器; 第一皮肤扩张器和第二皮肤扩张器能够使直线切口部分的两侧的皮肤远离线性切口部分，并使线性切口部分沿着扩大线性切口部分的方向膨胀; 并且通过基于线性切口部分的方向从两个或更多个皮肤扩张器组中选择单个皮肤扩张器组，使得角度被调节到45度以上且90度以下，有效地切割最小部分，其中该角度由读取器读取的线性切口部分的方向和通过单个皮肤扩张器组展开皮肤的方向形成。

32. 发明授权

US08003393B1 Method for determining whether or not a mammal is affected with a lung cancer 有权
标题翻译：用于确定哺乳动物是否受肺癌影响的方法
公开(公告)号：US08003393B1
公开(公告)日：2011-08-23
申请号：US12959040
申请日：2010-12-02
申请人： Yosuke Hanai , Hiroaki Oka
发明人： Yosuke Hanai , Hiroaki Oka
IPC分类号： G01N33/48
CPC分类号： G01N33/57423 , Y10T436/203332
摘要： The present disclosure relates to a method for assessing if a patient is affected with a lung cancer. The method includes analyzing the presence and amount of β-citronellol contained in the urine excreted from the patient and determining if the presence and amount of β-citronellol is indicative of lung cancer.
摘要翻译：本公开涉及用于评估患者是否患有肺癌的方法。该方法包括分析从患者排出的尿液中所含的重庆脑苷胆碱的存在和量，并确定是否存在和数量的“次溴酸”指示肺癌。

33. 发明申请

US20100268259A1 SKIN INCISION INSTRUMENT AND METHOD FOR INCISING SKIN WITH THE SAME 有权
标题翻译：皮肤入侵仪器及其相同方法
公开(公告)号：US20100268259A1
公开(公告)日：2010-10-21
申请号：US12827472
申请日：2010-06-30
申请人： Akio Oki , Hiroaki Oka
发明人： Akio Oki , Hiroaki Oka
IPC分类号： A61B17/34
CPC分类号： A61B5/15186 , A61B5/150022 , A61B5/150068 , A61B5/150335 , A61B5/150389 , A61B5/150427 , A61B5/150442 , A61B5/150503 , A61B5/150541 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/157 , A61B5/411
摘要： Provided are skin incision instrument to efficiently incise minimal portions and a method for incising skin with the skin incision instrument. The skin incision instrument according to the present invention comprises a holder, a needle, a needle drive unit, two or more skin expander sets, and a reader, wherein the skin expander sets comprise a first skin expander and a second skin expander; the first skin expander and the second skin expander are capable of expanding skin at both sides of the linear incision portion away from the linear incision portion and expanding the linear incision portion in a direction to expand the linear incision portion; and, minimal portions are efficiently incised by selecting a single skin expander set from two or more of the skin expander set based on the direction of the linear incision portion, such that an angle is adjusted to 45 degrees or more and 90 degrees or less wherein the angle is formed by the direction of the linear incision portion read by the reader and the direction to expand the skin by the single skin expander set.
摘要翻译：提供有效切割最小部分的皮肤切割仪器和用皮肤切开仪器切割皮肤的方法。根据本发明的皮肤切开仪器包括保持器，针头，针驱动单元，两个或更多个皮肤膨胀器组和读取器，其中所述皮肤膨胀器组包括第一皮肤膨胀器和第二皮肤膨胀器; 第一皮肤扩张器和第二皮肤扩张器能够使直线切口部分的两侧的皮肤远离线性切口部分，并使线性切口部分沿着扩大线性切口部分的方向膨胀; 并且通过基于线性切口部分的方向从两个或更多个皮肤扩张器组中选择单个皮肤扩张器组，使得角度被调节到45度以上且90度以下，有效地切割最小部分，其中该角度由读取器读取的线性切口部分的方向和通过单个皮肤扩张器组展开皮肤的方向形成。

34. 发明授权

US07632392B2 Sensor of pyrophosphate and SNP typing sensor using the same 有权
标题翻译：焦磷酸盐和SNP分型传感器的传感器使用相同
公开(公告)号：US07632392B2
公开(公告)日：2009-12-15
申请号：US12112249
申请日：2008-04-30
申请人： Tetsuo Yukimasa , Hiroaki Oka
发明人： Tetsuo Yukimasa , Hiroaki Oka
IPC分类号： G01N27/416 , G01N27/327
CPC分类号： C12Q1/6827 , C12Q2565/301
摘要： A sensor of pyrophosphate which can detect pyrophosphate conveniently with high sensitivity in a method for measuring pyrophosphate in SNP typing utilizing a primer extension reaction is provided.A sensor of pyrophosphate which is characterized by including: an insulative substrate 1; an electrode system that is formed thereon and has a measurement electrode 2 and a counter electrode 3; and a plurality of reaction reagent layers that are provided on the substrate 1 and include pyrophosphatase, glyceraldehyde-3-phosphate dehydrogenase, diaphorase, glyceraldehyde-3-phosphate, oxidized nicotineamide adenine dinucleotide, an electronic mediator, a magnesium salt and a buffer component, reaction reagent layer 36 including the enzyme being separated from reaction reagent layer 35 including the buffer component, and reaction reagent layer 37 including glyceraldehyde-3-phosphate being separated from the reaction reagent layer 35 including the buffer component.
摘要翻译：提供了一种焦磷酸盐传感器，其可以在使用引物延伸反应的SNP分型中测量焦磷酸盐的方法中以高灵敏度方便地检测焦磷酸盐。焦磷酸盐传感器，其特征在于包括：绝缘基板1; 形成在其上并具有测量电极2和对电极3的电极系统; 以及设置在基板1上的多个反应试剂层，包括焦磷酸酶，甘油醛-3-磷酸脱氢酶，心肌黄酶，甘油醛-3-磷酸，氧化尼古丁胺腺嘌呤二核苷酸，电子介体，镁盐和缓冲成分，将包含缓冲成分的反应试剂层35分离出的酶的反应试剂层36和包含甘油醛-3-磷酸的反应试剂层37与包含缓冲成分的反应试剂层35分离。

35. 发明申请

US20090275852A1 EXHALED BREATH ANALYSIS METHOD 有权
标题翻译：呼吸道分析方法
公开(公告)号：US20090275852A1
公开(公告)日：2009-11-05
申请号：US12434324
申请日：2009-05-01
申请人： Akio OKI , Hiroaki OKA
发明人： Akio OKI , Hiroaki OKA
IPC分类号： A61B5/097
CPC分类号： G01N33/497 , A61B5/097 , G01N33/0047 , G01N2033/4975
摘要： Handling of the condensate collecting vessel in conventional breath analysis apparatuses having a cold condensation mechanism is complicated, and time consuming.The present invention provides a method for analyzing exhaled breath using a breath analysis apparatus, the breath analysis apparatus including: a vessel; an injection port of the exhaled breath; an outlet port of the exhaled breath; a cooling unit; an electrode zone; a counter electrode zone; and a chemical substance detection unit, in which the exhaled breath contains water vapor and a volatile organic compound, the volatile organic compound having a molecular weight of no lower than 15 and no higher than 500, and the method for exhaled breath analysis comprising the steps of: injecting the exhaled breath from the injection port into the vessel; condensing the exhaled breath on the outer peripheral surface of the electrode zone by cooling the electrode zone with the cooling unit; forming charged fine particles from the condensed breath; recovering the charged fine particles into the chemical substance detection unit by an electrostatic force; and detecting the volatile organic compound included in the charged fine particles recovered.
摘要翻译：在具有冷冷凝机构的常规呼吸分析装置中处理冷凝物收集容器是复杂的并且耗时。本发明提供一种使用呼吸分析装置分析呼气呼吸的方法，所述呼吸分析装置包括：血管; 呼出呼吸的注射口; 呼出口的出口; 冷却单元; 电极区; 对电极区; 以及其中呼出的呼吸含有水蒸汽和挥发性有机化合物的化学物质检测单元，分子量不低于15且不高于500的挥发性有机化合物，以及呼气分析方法，包括步骤将呼出的呼吸从注射口注入容器中; 通过用冷却单元冷却电极区域来在呼出气体的外周表面上冷凝呼出的呼吸; 从凝结的呼吸形成带电微粒; 通过静电力将带电微粒子回收到化学物质检测单元中; 并检测包含在所回收的带电微粒子中的挥发性有机化合物。

36. 发明申请

US20090211922A1 ELECTRODE PLATE FOR ELECTROCHEMICAL MEASUREMENTS, APPARATUS FOR ELECTROCHEMICAL MEASUREMENTS HAVING THE ELECTRODE PLATE FOR ELECTROCHEMICAL MEASUREMENTS, AND METHOD OF THE QUANTITATIVE DETERMINATION OF A TARGET SUBSTANCE USING THE ELECTRODE PLATE FOR ELECTROCHEMICAL MEASUREMENTS 有权
标题翻译：用于电化学测量的电极板，具有用于电化学测量的电极板的电化学测量的装置，以及使用电极板进行电化学测量的定量物质的定量测定方法
公开(公告)号：US20090211922A1
公开(公告)日：2009-08-27
申请号：US12436418
申请日：2009-05-06
申请人： Hidehiro SASAKI , Hiroaki Oka
发明人： Hidehiro SASAKI , Hiroaki Oka
IPC分类号： G01N27/403 , G01N27/30
CPC分类号： G01N27/3271
摘要： An electrode plate for electrochemical measurements capable of measuring the concentration of a target substance included in a sample solution with favorable accuracy and high sensitivity is providedThe electrode plate for electrochemical measurements 1 of the present invention includes a substrate 31, an upper layer 40 provided on the superior face of the substrate, a lower layer 11 provided on the inferior face of the substrate, a first electrode body 32 sandwiched between the superior face of the substrate and the upper layer, and a second electrode body 12 sandwiched between the inferior face of the substrate and the lower layer, wherein: the upper layer has a plurality of upper layer through-holes 41; the first electrode body has a plurality of first electrodes 32d including a portion exposed from the superior face of the upper layer via the upper layer through-hole in the first electrode body; the substrate has a plurality of substrate through-holes 33; and the second electrode body has a plurality of second electrodes including a portion exposed from the superior face of the upper layer via the upper layer through-hole and the substrate through-hole in the second electrode body 12d in the second electrode body.
摘要翻译：提供了一种用于电化学测量的电极板，其能够以良好的精度和高灵敏度测量包含在样品溶液中的目标物质的浓度。本发明的电化学测量用电极板1包括基板31，设置在基板31上的上层40 衬底的上表面，设置在衬底的下表面上的下层11，夹在衬底的上表面和上层之间的第一电极体32和夹在衬底的下表面之间的第二电极体12 基板和下层，其中：上层具有多个上层通孔41; 第一电极体具有多个第一电极32d，第一电极32d包括经由第一电极体中的上层通孔从上层的上表面露出的部分; 基板具有多个基板通孔33; 并且所述第二电极体具有多个第二电极，所述多个第二电极包括从所述上层的上表面经由所述上层通孔露出的部分和所述第二电极体中的所述第二电极体12d中的所述基板通孔。

37. 发明申请

US20090035846A1 DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL AND METHOD OF MANUFACTURING DEVICE 有权
标题翻译：用于测量细胞外潜能的装置和制造装置的方法
公开(公告)号：US20090035846A1
公开(公告)日：2009-02-05
申请号：US12245091
申请日：2008-10-03
申请人： Masaya Nakatani , Hiroaki Oka , Fumiaki Emoto
发明人： Masaya Nakatani , Hiroaki Oka , Fumiaki Emoto
IPC分类号： C12M1/34
CPC分类号： G01N33/48728 , G01N33/54353 , G01N33/552
摘要： A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well and extending toward a second face of the substrate, a first hollow section communicating with the first opening via a first connecting portion, and a second opening extending reaching the second surface and communicating with the first hollow section via a second connecting portion. The first connecting portion has a diameter smaller than a maximum diameter of the first hollow section, greater than a diameter of the second connecting portion, and smaller than a diameter of the test cell. The device can retain the test cell securely and accept chemicals and the test cell to be put into the device easily.
摘要翻译：用于测量测试电池的细胞外电位的装置包括在其第一表面中形成良好的衬底和形成在其中的第一陷阱。井有一个底部。第一陷阱包括形成在井的底部并朝向基板的第二面延伸的第一开口，经由第一连接部分与第一开口连通的第一中空部分，以及延伸到第二表面的第二开口，通过第二连接部与第一中空部连通。第一连接部分的直径小于第一中空部分的最大直径，大于第二连接部分的直径，并且小于测试电池的直径。该装置可以牢固地保持测试电池，并容易接受化学品和测试电池放入设备中。

38. 发明授权

US07462324B2 Measurement device and method for measuring electric signal from biological sample 有权
标题翻译：用于测量生物样品电信号的测量装置和方法
公开(公告)号：US07462324B2
公开(公告)日：2008-12-09
申请号：US10495621
申请日：2002-11-19
申请人： Nobuhiko Ozaki , Hiroaki Oka , Hirokazu Sugihara
发明人： Nobuhiko Ozaki , Hiroaki Oka , Hirokazu Sugihara
IPC分类号： G01N27/00 , G01N15/06 , G01N33/53 , G01N25/18
CPC分类号： G01N33/48707 , B01L3/5027
摘要： A measurement device 10 includes a measurement cell 11. The measurement cell 11 includes a substrates 17 and a substrate 16 formed on the substrate 17. The substrates 16 and 17 are bonded to each other. Thus, a flow pass 9 is formed in the measurement cell 11. As shown in FIG. 3, on the substrate 17 of the measurement cell 11, provided are a concave well 19, a protruding microelectrode 1 connected to a terminal 4a and formed on a side wall surface of the well 19, communicating tubes 15a and 15b connected to both of side surfaces of the well 19 (i.e., the flow pass 9) to face to each other, resistance baths 6a and 6b connected to the communicating tubes 15a and 15b, thin film resistors 3a and 3b arranged in the resistance baths 6a and 6b, and a reference electrode 2 connected to a terminal 4b.
摘要翻译：测量装置10包括测量单元11.测量单元11包括基板17和形成在基板17上的基板16.基板16和17彼此接合。因此，在测量单元11中形成流路9。如图3所示，在测量单元11的基板17上设置凹槽19，连接到端子4a并形成在井19的侧壁表面上的突出微电极1，连接到两侧的连通管15a和15b 孔19的表面（即，流路9）彼此相对，连接到连通管15a和15b的电阻槽6a和6b，布置在电阻槽6a和6b中的薄膜电阻器3a和3b，以及参考电极2连接到端子4b。

39. 发明授权

US07368083B2 Blood processing apparatus and blood introducing method 有权
标题翻译：血液处理装置及血液导入方法
公开(公告)号：US07368083B2
公开(公告)日：2008-05-06
申请号：US11494749
申请日：2006-07-28
申请人： Nobuhiko Ozaki , Hiroaki Oka , Tetsuo Yukimasa , Hidenobu Yaku , Maki Yotsuhashi , Yukari Hataoka
发明人： Nobuhiko Ozaki , Hiroaki Oka , Tetsuo Yukimasa , Hidenobu Yaku , Maki Yotsuhashi , Yukari Hataoka
IPC分类号： G01N33/00
CPC分类号： G01N35/00069 , Y10T436/111666 , Y10T436/2575
摘要： The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.
摘要翻译：本发明提供一种血液处理装置，其能够将计量量的血液样品引入腔室中，并且在引入血液样本之后不需要连接到待关闭的腔室的开口。在血液处理装置的可旋转平台中形成有引入室，注射口和空气口。注入口将引入室与可旋转平台的外部连接。血液样品从注射口引入引入室。血液凝结剂被保持在空气端口的端口壁表面上和/或在空气端口打开的可旋转平台的表面的一部分周围。

40. 发明授权

US07320866B2 Discrimination method of target base in DNA, and allele specific primer used in the method of the same 有权
标题翻译： DNA中靶基因的鉴别方法及其方法中使用的等位基因特异性引物
公开(公告)号：US07320866B2
公开(公告)日：2008-01-22
申请号：US11607900
申请日：2006-12-04
申请人： Hidenobu Yaku , Hiroaki Oka , Tetsuo Yukimasa
发明人： Hidenobu Yaku , Hiroaki Oka , Tetsuo Yukimasa
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6869 , C12Q2535/125
摘要： An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is G, while a base adjacent with one base spaced apart is T. According to the present invention, the 3′ end base is designed to be the base corresponding to SNP; the second base from the 3′ end to be T or G; the third base from the 3′ end to be G or C; and the base sequence of from the fourth from the 3′ end to the 5′ end base to be completely complementary to the sequence of from a base three bases away from the target SNP base on the 3′ side to a desired base.
摘要翻译：本发明的目的是提供一种等位基因特异性引物，当与目标SNP碱基的3'侧紧邻的碱基为G时，伴随着假阳性的可能性较小，并且能够进行确定的鉴别，而邻近的碱基其中一个基座间隔开。根据本发明，3'端基被设计为对应于SNP的基座; 从3'端的第二个基地是T或G; 从3'的第三个基地是G或C; 并且从3'末端到5'末端碱基的第四个碱基序列与从3'侧的目标SNP碱基到碱基的碱基三碱基的序列完全互补。

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