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31. 发明授权

US4806349A Hybrid cell line for producing monoclonal antibody to a human prothymocyte antigen, antibody, and methods 失效
标题翻译：用于产生人胸腺细胞抗原的单克隆抗体的杂交细胞系，抗体和方法
公开(公告)号：US4806349A
公开(公告)日：1989-02-21
申请号：US646545
申请日：1984-09-04
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , G01N33/569 , A61K39/00 , C12N5/00 , C12N15/00 , G01N33/53
CPC分类号： C07K16/2896 , G01N33/56972 , A61K38/00 , Y10S530/808 , Y10S530/809
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在大约95％的正常人胸腺细胞上发现的用于产生抗原的单克隆抗体的杂交细胞系。通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

32. 发明授权

US4783442A B-cell differentiating peptides 失效
标题翻译： B细胞分化肽
公开(公告)号：US4783442A
公开(公告)日：1988-11-08
申请号：US855011
申请日：1986-04-21
申请人： Tapan Audhya , Daniel J. Kroon , George Heavner , Gideon Goldstein
发明人： Tapan Audhya , Daniel J. Kroon , George Heavner , Gideon Goldstein
IPC分类号： C07K5/08 , A61K38/00 , A61K38/22 , A61P37/00 , C07K1/04 , C07K5/00 , C07K5/09 , A61K37/02
CPC分类号： C07K5/0815
摘要： Synthetic peptides which possess the ability to specifically induce the differentiation of precursor B cells into mature B-cells capable of producing antibody.
摘要翻译：具有特异性诱导前体B细胞分化成能够产生抗体的成熟B细胞的能力的合成肽。

33. 发明授权

US4731244A Monoclonal antibody therapy 失效
标题翻译：单克隆抗体治疗
公开(公告)号：US4731244A
公开(公告)日：1988-03-15
申请号：US797712
申请日：1985-11-13
申请人： Mary A. Talle , Walter Newman , Patricia E. Rao , Gideon Goldstein
发明人： Mary A. Talle , Walter Newman , Patricia E. Rao , Gideon Goldstein
IPC分类号： A61K39/395 , A61K51/10 , A61P37/04 , C07K16/28
CPC分类号： C07K16/2809 , A61K39/395 , A61K51/1042 , A61K2123/00 , Y10S424/804 , Y10S424/81 , Y10S514/885
摘要： A method of seriatim administration to a patient of a plurality of ligands, each of which contains an antigen combining site of a monoclonal antibody of distinct idiotype, is disclosed. This method is useful for therapeutic as well as diagnostic purposes.
摘要翻译：公开了一种对多种配体的患者进行系列性给药的方法，每种配体含有独特型独特型单克隆抗体的抗原结合位点。该方法对于治疗和诊断目的是有用的。

34. 发明授权

US4658020A Monoclonal antibody to human helper T cells 失效
标题翻译：人辅助T细胞的单克隆抗体
公开(公告)号：US4658020A
公开(公告)日：1987-04-14
申请号：US639554
申请日：1984-08-10
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , C07K16/30 , G01N33/569 , C07K15/00 , A61K39/395
CPC分类号： G01N33/56972 , C07K16/2812 , C07K16/3061 , A61K38/00
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在所有正常人辅助T细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

35. 发明授权

US4364934A Monoclonal antibody to a human early thymocyte antigen and methods for preparing same 失效
标题翻译：人早期胸腺细胞抗原的单克隆抗体及其制备方法
公开(公告)号：US4364934A
公开(公告)日：1982-12-21
申请号：US100071
申请日：1979-12-04
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/2881 , A61K38/00 , Y10S530/808
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 10% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于在大约10％的正常人胸腺细胞上发现的用于产生针对抗原的单克隆抗体的杂交细胞系。通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

36. 发明授权

US4363799A Monoclonal antibody to human T cells, and methods for preparing same 失效
标题翻译：对人T细胞的单克隆抗体及其制备方法
公开(公告)号：US4363799A
公开(公告)日：1982-12-14
申请号：US22132
申请日：1979-03-20
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577 , C12N5/00 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/3061 , C07K16/28 , A61K38/00 , Y10S435/948 , Y10S530/806 , Y10S530/808 , Y10S530/809
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于产生针对所有正常人T细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫Balb / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

37. 发明授权

US4361549A Complement-fixing monoclonal antibody to human T cells, and methods of preparing same 失效
标题翻译：对人T细胞的补体固定单克隆抗体及其制备方法
公开(公告)号：US4361549A
公开(公告)日：1982-11-30
申请号：US33669
申请日：1979-04-26
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： C12N15/02 , A61K38/00 , A61K39/395 , A61P37/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/10 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/574 , G01N33/577 , C12Q1/00 , C12N5/02 , C12N15/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/2809 , G01N33/57426 , A61K38/00 , Y10S435/948 , Y10S530/806 , Y10S530/808 , Y10S530/809
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译：用于产生在所有正常人T细胞和皮肤T淋巴瘤细胞上发现的抗原的单克隆抗体的杂交细胞系。通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合而形成杂交体。还公开了单克隆抗体的诊断和治疗用途。

38. 发明授权

US4289759A Immunoregulatory diketopiperazine compounds 失效
标题翻译：免疫调节二酮哌嗪化合物
公开(公告)号：US4289759A
公开(公告)日：1981-09-15
申请号：US162228
申请日：1980-06-23
申请人： George Heavner , Foe-Siong Tjoeng , Gideon Goldstein
发明人： George Heavner , Foe-Siong Tjoeng , Gideon Goldstein
IPC分类号： A61K31/495 , A61K38/00 , A61P37/00 , C07D241/08 , C07F9/6509 , C07K1/06 , C07K5/12 , A61K37/00 , C07C103/52 , C07D241/04
CPC分类号： C07K5/12 , C07D241/08 , C07K1/061 , A61K38/00
摘要： Immunoregulatory 2,5-diketopiperazine compounds of formula: ##STR1## wherein m is 1 or 2 and n is 3 or 4 possess the ability to regulate the immune system of humans and animals. Administration of the compounds will return to a normal state an immune system in need of regulation.
摘要翻译：其中m为1或2，n为3或4的免疫调节的2,5-二酮哌嗪化合物具有调节人和动物免疫系统的能力。化合物的给药将恢复到需要调节的免疫系统的正常状态。

39. 发明授权

US4232008A Tetrapeptides and methods 失效
标题翻译：四肽和方法
公开(公告)号：US4232008A
公开(公告)日：1980-11-04
申请号：US960550
申请日：1978-11-17
申请人： Gideon Goldstein
发明人： Gideon Goldstein
IPC分类号： A61K38/00 , C07K5/103 , C07K5/113 , C07K7/06 , A61K37/00 , C07C103/52
CPC分类号： C07K7/06 , C07K5/1008 , C07K5/1021 , C07K7/062 , A61K38/00 , Y10S930/18
摘要： There are disclosed new biologically active polypeptides containing the following polypeptide segment:--ALA--LYS--SER--GLN--Biological activity is generally retained upon substitution of a natural or non-natural amino acid residue for either or both of L-alanyl in the first position and L-seryl in the third position.These polypeptides have the capability of inducing the differentiation of T-lymphocytes as measured by the acquisition of the thymic differentiation antigen Th-1, as well as B-lymphocytes as measured by the acquisition of the differentiation antigen Bu-1. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congenital absence of thymus. Also provided are substituted polypeptides, methods of manufacture of the polypeptides, therapeutic compositions, and methods for use of the polypeptides.
摘要翻译：公开了含有以下多肽片段的新的生物活性多肽：-ALA-LYS-SER-GLN-生物活性通常在第一次取代天然或非天然氨基酸残基中的任何一个或两个L-丙氨酰基时保留位置和L-丝氨酰在第三位置。如通过获得分化抗原Bu-1所测得的胸腺分化抗原Th-1以及B淋巴细胞的测定，这些多肽具有诱导T淋巴细胞分化的能力。因此，多肽可用于胸腺功能和免疫领域，例如先天性缺乏胸腺的治疗。还提供了取代的多肽，多肽的制备方法，治疗组合物和多肽的使用方法。

40. 发明授权

US4215112A Tripeptides and methods 失效
标题翻译：三肽和方法
公开(公告)号：US4215112A
公开(公告)日：1980-07-29
申请号：US20159
申请日：1979-03-14
申请人： Gideon Goldstein , George Heavner
发明人： Gideon Goldstein , George Heavner
IPC分类号： C07K5/08 , A61K38/22 , A61P37/04 , A61P43/00 , C07C237/12 , C07C237/22 , C07K5/02 , C07K5/09 , A61K37/00 , C07C103/52
CPC分类号： C07K5/0815 , Y10S930/18
摘要： There are disclosed new biological active polypeptides:A--X--Bwherein A is deamino-LYS or LYS; X is a suitable neutral aliphatic amino acid residue; e.g., one selected from the group consisting of SER, ALA, 2-Me-ALA, GLY, LEU, THR, D-SER, D-ALA, D-THR, allo-THR, D-LEU, and SAR; B is GLN-R', decarboxy-GLN, or ##STR1## and R' is a substituent which does not substantially affect the biological activity of the tripeptide.These polypeptides have the capability of inducing the differentiation of T-lymphocytes as measured by the acquisition of the thymic differentiation antigen Th-1, as well as B-lymphocytes as measured by the acquisition of the differentiation antigen Bu-1. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congenital absence of thymus. Also provided are therapeutic compositions and methods for use of the polypeptides.
摘要翻译：公开了新的生物活性多肽：A-X-B，其中A是脱氨基-LYS或LYS; X是合适的中性脂肪族氨基酸残基; 例如选自由SER，ALA，2-Me-ALA，GLY，LEU，THR，D-SER，D-ALA，D-THR，allo-THR，D-LEU和SAR组成的组中的一种; B是GLN-R'，脱羧-GLN或，R'是基本上不影响三肽生物活性的取代基。如通过获得分化抗原Bu-1所测得的胸腺分化抗原Th-1以及B淋巴细胞的测定，这些多肽具有诱导T淋巴细胞分化的能力。因此，多肽可用于胸腺功能和免疫领域，例如先天性缺乏胸腺的治疗。还提供了用于多肽的治疗组合物和方法。

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