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31. 发明授权

US08729028B2 Noggin-derived peptide and use thereof 有权
标题翻译：来源于肽的肽及其用途
公开(公告)号：US08729028B2
公开(公告)日：2014-05-20
申请号：US13145390
申请日：2009-11-24
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
IPC分类号： A61K38/03 , C07K4/00
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00
摘要： Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.
摘要翻译：公开了一种头蛋白衍生肽和含有其的组合物，其用于促进毛发生长，改善皮肤状况，提供抗炎功能，或预防或治疗骨骼疾病。所公开的头蛋白衍生肽具有与天然人头蛋白相同或相似的功能，并且与其相比具有优异的稳定性和皮肤渗透性。含有本公开的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着的优异效果，例如，脱发，皮肤状况或切割，或治疗，预防或改善生长因子过表达相关症状。因此，本公开的肽的优异的活性和稳定性在应用于医药，准药物和化妆品方面是非常有利的。

32. 发明申请

US20130043509A1 3-D STRUCTURED NON-VOLATILE MEMORY DEVICE AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译： 3-D结构的非易失性存储器件及其制造方法
公开(公告)号：US20130043509A1
公开(公告)日：2013-02-21
申请号：US13587612
申请日：2012-08-16
申请人： Sung Yoon CHO , Hae Jung LEE , Byung Soo PARK , Eun Mi KIM
发明人： Sung Yoon CHO , Hae Jung LEE , Byung Soo PARK , Eun Mi KIM
IPC分类号： H01L27/04 , H01L21/28
CPC分类号： H01L27/11526 , H01L27/11548 , H01L27/11556 , H01L27/11573 , H01L27/11575 , H01L27/11582
摘要： A non-volatile memory device according to an aspect of the present disclosure includes a substrate, a plurality of word lines stacked over the substrate and having a stepwise pattern, wherein the plurality of word lines each have a pad region, and a plurality of contact plugs coupled to the respective pad regions of the word lines, wherein a width of a pad region of a first one of the plurality of word lines is greater than a width of a pad region of a second word line lower than the first word line.
摘要翻译：根据本公开的一个方面的非易失性存储器件包括衬底，堆叠在衬底上并具有逐步图案的多个字线，其中多个字线各自具有焊盘区域，并且多个接触插头，其耦合到字线的相应焊盘区域，其中多个字线中的第一个字线的焊盘区域的宽度大于低于第一字线的第二字线的焊盘区域的宽度。

33. 发明申请

US20120170117A1 POLARIZER PLATE, OPTICAL APPARATUS, AND METHOD OF MANUFACTURING POLARIZER PLATE 审中-公开
标题翻译：极化板，光学装置和制造极化板的方法
公开(公告)号：US20120170117A1
公开(公告)日：2012-07-05
申请号：US13337627
申请日：2011-12-27
申请人： Hyeon CHO , Eun Mi Kim , Jong Gyu La , Tae Hwan Noh , Jin Sook Kim , Hae Ryong Chung , Moon Yeon Lee , Ji Heon Kim
发明人： Hyeon CHO , Eun Mi Kim , Jong Gyu La , Tae Hwan Noh , Jin Sook Kim , Hae Ryong Chung , Moon Yeon Lee , Ji Heon Kim
IPC分类号： G02B5/30 , B29D11/00 , B29D7/01
CPC分类号： G02B5/3033
摘要： A polarizer plate includes a polarizer that includes polyvinyl alcohol and a dichroic material, the polarizer having a degree of orientation of 15 or more as represented by Equation 1: Degree of orientation=RD/RPVA×100, where RPVA represents a phase difference of the polyvinyl alcohol and RD represents a phase difference of the dichroic material.
摘要翻译：偏振片包括包含聚乙烯醇和二色性材料的偏振片，偏光镜的取向度为15以上，如等式1所示：取向度= RD / RPVA×100，其中RPVA表示相位差聚乙烯醇和RD表示二色性材料的相位差。

34. 发明授权

US08188049B2 Peptides having activities of epidermal growth factor and its uses 有权
标题翻译：具有表皮生长因子活性的肽及其用途
公开(公告)号：US08188049B2
公开(公告)日：2012-05-29
申请号：US12444874
申请日：2007-10-08
申请人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Sang Su Song
发明人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Sang Su Song
IPC分类号： A61K38/00 , A61K38/04 , A61P17/00 , A61P17/14 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/485 , A61K8/64 , A61K38/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , Y02P20/55
摘要： The present invention relates to peptides comprising the amino acid sequence represented by the following formula 1 and having the activities of epidermal growth factor and their uses: Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp (1) The EGF-mimicking peptides of the present invention possess identical functions or activities to natural-occurring human EGF and are able to promote the generation of autocrine EGF in cells. In addition the peptides of the present invention are much higher stability and skin penetration potency than natural-occurring EGF. Therefore, the composition containing the peptide exhibits excellent treatment and prevention efficacies on diseases or conditions demanding EGF activities, and can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及包含由下式1表示的氨基酸序列并具有表皮生长因子活性及其用途的肽：Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp（1）本发明的EGF模拟肽对天然存在的人类EGF具有相同的功能或活性，并且能促进细胞中自分泌EGF的产生。此外，本发明的肽比天然存在的EGF具有高得多的稳定性和皮肤穿透效力。因此，含有肽的组合物对于要求EGF活性的疾病或病症表现出优异的治疗和预防功效，并且可以有利地应用于药物组合物，准药物和化妆品。

35. 发明申请

US20120114577A1 Peptide Having Activity of Transforming Growth Factor and Production Method Therefor 有权
标题翻译：具有转化生长因子活性的肽及其生产方法
公开(公告)号：US20120114577A1
公开(公告)日：2012-05-10
申请号：US13264290
申请日：2009-04-14
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Jeong Jin Choi , Jun Young Choi
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Jeong Jin Choi , Jun Young Choi
IPC分类号： A61K8/64 , C07K7/08 , A61K38/08 , A61Q19/02 , A61P19/08 , A61P29/00 , A61P27/02 , A61P35/00 , C07K7/06 , A61P9/10
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/02 , A61Q19/08 , C07K14/495
摘要： The present invention relates to a transforming growth factor-beta (TGF-β)-mimicking peptide containing a particular amino acid sequence and a composition for preventing or treating TGF-β-effective disorders or conditions using the same. The peptide of the present invention may be much higher stability than natural-occurring TGF-β and improve drawbacks caused by high molecular weight of natural-occurring TGF-β. The peptide of this invention can be advantageously applied to treatment or improvement of TGF-β-effective disorders or conditions and have excellent efficacies on skin whitening and wrinkle improvement.
摘要翻译：本发明涉及含有特定氨基酸序列的转化生长因子-β（TGF-β）模拟肽和用于预防或治疗TGF-β1有效性障碍或使用其的病症的组合物。本发明的肽可能比天然存在的TGF- 并改善由高分子量天然存在的TGF-β受体引起的缺陷。本发明的肽可有利地应用于治疗或改善TGF-βB活性障碍或病症，并且具有优异的皮肤美白和皱纹改善的功效。

36. 发明申请

US20110312179A1 SUBSTRATE PROCESSING METHOD AND SUBSTRATE PROCESSING APPARATUS 审中-公开
标题翻译：基板加工方法和基板加工装置
公开(公告)号：US20110312179A1
公开(公告)日：2011-12-22
申请号：US13115410
申请日：2011-05-25
申请人： Takashi Nakagawa , Eun-mi Kim , Naomu Kitano , Kimiko Mashimo
发明人： Takashi Nakagawa , Eun-mi Kim , Naomu Kitano , Kimiko Mashimo
IPC分类号： H01L21/285 , B05C11/00
CPC分类号： H01L27/11568 , C23C14/14 , C23C14/3492 , C23C14/5853 , H01L21/02181 , H01L21/02244 , H01L21/28185 , H01L21/28229 , H01L21/31683 , H01L29/40117 , H01L29/517 , H01L29/792
摘要： The present invention provides a substrate processing method and a substrate processing apparatus, which are capable of forming a high-k dielectric film with few trapping levels due to oxygen deficiencies and hot carriers by a sputtering method in one and the same vacuum vessel. The substrate processing method according to a first embodiment of the present invention includes: a first step of heating a to-be-processed substrate (102) arranged in a film forming treatment chamber (100) and depositing a metal film on the to-be-processed substrate (102) by physical vapor deposition using a target (106); and a second step of supplying a gas containing elements for oxidizing a metal film in the film forming treatment chamber (100) to oxidize the metal film by a thermal oxidation reaction.
摘要翻译：本发明提供了一种基板处理方法和基板处理装置，其能够通过溅射法在同一真空容器中形成由于氧缺陷而具有很少的捕获水平的高k电介质膜和热载流子。根据本发明第一实施例的基板处理方法包括：加热布置在成膜处理室（100）中的待处理基板（102）的第一步骤，并将金属膜沉积在待 - 处理的基底（102），通过使用靶（106）的物理气相沉积; 以及第二步骤，在成膜处理室（100）中供给含有氧化金属膜的元素的气体，以通过热氧化反应来氧化金属膜。

37. 发明申请

US20100299767A1 TREM-2 GENE AND PROTEIN AS INHIBITORS OF EXPRESSION OF GA733-2, AND TRANSGENIC ANIMALS COMPRISING THE SAME AND USES THEREOF 失效
标题翻译：作为GA733-2表达的抑制剂的TREM-2基因和蛋白质以及包含其的转基因动物及其用途
公开(公告)号：US20100299767A1
公开(公告)日：2010-11-25
申请号：US12863548
申请日：2009-02-18
申请人： Hyung-Sik Kang , Eun-Mi Kim , Dong-Hern Kim , Ha-Rim Choi , Eun-Hee Lee , Il-Soo Kim , Chang-Eon Park
发明人： Hyung-Sik Kang , Eun-Mi Kim , Dong-Hern Kim , Ha-Rim Choi , Eun-Hee Lee , Il-Soo Kim , Chang-Eon Park
IPC分类号： A61K49/00 , A01K67/00 , C12Q1/68 , G01N33/574 , A61K31/711 , A61K38/16 , A61P35/00
CPC分类号： C07K14/705 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0331 , A61K48/00 , C12N15/8509
摘要： Disclosed are a composition for inhibiting the expression of GA733-2 or for detecting GA733-2, which comprises TREM-2 gene or protein, a transgenic animal containing same, and a method using the same.
摘要翻译：公开了抑制GA733-2的表达或检测GA733-2的组合物，其包含TREM-2基因或蛋白质，含有它们的转基因动物及其使用方法。

38. 发明授权

US07838361B2 Method for fabricating recess gate in semiconductor device 有权
标题翻译：在半导体器件中制造凹槽的方法
公开(公告)号：US07838361B2
公开(公告)日：2010-11-23
申请号：US12239492
申请日：2008-09-26
申请人： Yong-Tae Cho , Eun-Mi Kim
发明人： Yong-Tae Cho , Eun-Mi Kim
IPC分类号： H01L21/336
CPC分类号： H01L21/28114 , H01L29/4236 , H01L29/42372 , H01L29/66621
摘要： A method for fabricating a recess gate in a semiconductor device includes etching a silicon substrate to form a trench that defines an active region, forming a device isolation layer that gap-fills the trench, forming a hard mask layer over the silicon substrate, the hard mask layer comprising a stack of an oxide layer and an amorphous carbon layer, wherein the hard mask layer exposes a channel target region of the active region, and forming a recess region with a dual profile by first etching and second etching the channel target region using the hard mask layer as an etch barrier, wherein the second etching is performed after removing the amorphous carbon layer.
摘要翻译：一种在半导体器件中制造凹陷栅的方法，包括蚀刻硅衬底以形成限定有源区的沟槽，形成间隙填充沟槽的器件隔离层，在硅衬底上形成硬掩模层，硬的掩模层，其包括氧化物层和非晶碳层的堆叠，其中所述硬掩模层暴露所述有源区的沟道目标区域，并且通过第一蚀刻形成具有双轮廓的凹陷区域，并且使用所述硬掩模层作为蚀刻阻挡层，其中所述第二蚀刻在去除所述无定形碳层之后进行。

39. 发明申请

US20100278756A1 Peptides having activities of insulin like growth factor-1 and their uses 有权
标题翻译：具有胰岛素如生长因子-1的活性的肽及其用途
公开(公告)号：US20100278756A1
公开(公告)日：2010-11-04
申请号：US12659546
申请日：2010-03-12
申请人： Yong Ji Chung , Young Deug Kim , Eun Mi Kim
发明人： Yong Ji Chung , Young Deug Kim , Eun Mi Kim
IPC分类号： A61K8/64 , A61K38/08 , A61Q11/00 , A61Q19/08 , A61P17/00 , A61P17/10 , A61P17/14
CPC分类号： C07K14/65 , A61K38/00
摘要： The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-1 mimicking peptides of this invention have identical functions or actions to natural-occurring IGF-1 and much better stability and skin permeation than natural-occurring IGF-1. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-1 activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有胰岛素样生长因子-1（IGF-1）的活性并衍生自IGF-1的肽，用于改善皮肤病症或治疗包含该肽的牙周病的组合物。本发明的IGF-1模拟肽与天然存在的IGF-1具有与天然存在的IGF-1相同的功能或作用，并且比天然存在的IGF-1具有更好的稳定性和皮肤渗透性。在这些连接中，包含本发明的肽的组合物可以在治疗，预防和改善需要IGF-1活性的疾病或病症方面表现出优异的功效。此外，本发明的肽可以有利地应用于药物组合物，准药物和化妆品。

40. 发明申请

US20100119723A1 APPARATUS AND METHOD FOR COATING POLYIMIDE LAYER 有权
标题翻译：用于涂覆聚酰亚胺层的装置和方法
公开(公告)号：US20100119723A1
公开(公告)日：2010-05-13
申请号：US12691362
申请日：2010-01-21
申请人： Ki Du CHO , Bong Chul KIM , Hui Jae LEE , Sun Ja KIM , Hwang Un SEO , Hang Sup CHO , Eun Mi KIM
发明人： Ki Du CHO , Bong Chul KIM , Hui Jae LEE , Sun Ja KIM , Hwang Un SEO , Hang Sup CHO , Eun Mi KIM
IPC分类号： B05D1/02
CPC分类号： G02F1/133723 , G02F1/1303 , H01L27/1248
摘要： An apparatus for coating a polyimide layer includes a print table for receiving a substrate thereon, an inkjet head positioned over the print table and having a jetting surface with a plurality of nozzles for jetting polyimide liquid onto the substrate, and a polyimide liquid supply tank for supplying polyimide liquid, and a wiper movable from one side of the jetting surface to an other side of the jetting surface while the wiper contacts the jetting surface of the inkjet head.
摘要翻译：一种用于涂覆聚酰亚胺层的设备包括：用于在其上接收基材的印刷台，位于印刷台上的喷墨头，具有喷射表面，喷射表面具有用于将聚酰亚胺液体喷射到基材上的多个喷嘴;以及聚酰亚胺液体供应罐供应聚酰亚胺液体，以及可在喷射器的喷射面与喷墨头的喷射面接触的状态下从喷射面的一侧移动到喷射面的另一侧的刮水器。

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