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31. 发明授权

US06180651B2 Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics 有权
标题翻译：二芳基亚甲基衍生物，其制备方法及其在治疗中的应用
公开(公告)号：US06180651B2
公开(公告)日：2001-01-30
申请号：US09150388
申请日：1998-09-09
申请人： Eric Nicolai , Jean-Marie Teulon
发明人： Eric Nicolai , Jean-Marie Teulon
IPC分类号： C07D40506
CPC分类号： C07D307/58 , C07D405/06
摘要： The present invention relates to derivatives of the formula the process for their preparation, and to their uses in therapeutics, especially as drugs with anti-inflammatory, analgesic and chemopreventive properties.
摘要翻译：本发明涉及其制备方法的制剂衍生物及其在治疗学中的用途，特别是具有抗炎，止痛和化学预防性能的药物。

32. 发明授权

US5217973A Triazolopyrimidine derivatives which are angiotensin II receptor antagonists processes for preparing them and pharmaceutical compositions containing them 失效
标题翻译：作为血管紧张素Ⅱ受体拮抗剂的三唑并吡啶衍生物制备它们及其含有药物组合物的方法
公开(公告)号：US5217973A
公开(公告)日：1993-06-08
申请号：US741134
申请日：1991-08-07
申请人： Nicole Bru-Magniez , Eric Nicolai , Jean-Marie Teulon
发明人： Nicole Bru-Magniez , Eric Nicolai , Jean-Marie Teulon
IPC分类号： A61K31/505 , A61K31/519 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P43/00 , C07D239/47 , C07D239/48 , C07D249/08 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to the derivatives of formula: ##STR1## as well as to their addition salts and to their use in therapy, in particular for the treatment of cardiovascular diseases, especially for the treatment of hypertension, cardiac insufficiency and diseases of the arterial wall.
摘要翻译：本发明涉及式（I）的衍生物及其加成盐及其在治疗中的用途，特别是用于治疗心血管疾病，特别是用于治疗高血压，心功能不全和动脉壁疾病

33. 发明授权

US08530473B2 Tetrahydroquinoxaline urea derivatives as modulators of 11β-hydroxysteroid dehydrogenase type 1 有权
标题翻译：四氢喹喔啉脲衍生物作为1型11β-羟基类固醇脱氢酶的调节剂
公开(公告)号：US08530473B2
公开(公告)日：2013-09-10
申请号：US13386827
申请日：2010-07-23
申请人： Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Olivier Venier
发明人： Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Olivier Venier
IPC分类号： A61K31/495
CPC分类号： C07D401/10 , C07D401/12
摘要： The invention relates to a compound of the general formula (I), as defined herein which is useful in modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are useful for treating pathologies in which such modulation is beneficial, as in the case of metabolic syndrome or of noninsulin-dependent type 2 diabetes. The invention also relates to pharmaceutical preparations containing such a compound, processes for preparing and intermediates useful in the preparation of a such a compound.
摘要翻译：本发明涉及如本文所定义的通式（I）化合物，其可用于调节1α-型11β-羟类固醇脱氢酶（11betaHSD1）的活性，并且可用于治疗其中这种调节有益的病态，如代谢综合征或非胰岛素依赖型2型糖尿病的病例。本发明还涉及含有这种化合物的药物制剂，制备方法和可用于制备这种化合物的中间体。

34. 发明申请

US20120245148A1 TETRAHYDROQUINOXALINE UERA DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 有权
标题翻译：四氢喹诺酮类UERA衍生物，其制备及其治疗应用
公开(公告)号：US20120245148A1
公开(公告)日：2012-09-27
申请号：US13483710
申请日：2012-05-30
申请人： Alain Jean Braun , Olivier Crespin , Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Christophe Philippo , Olivier Venier
发明人： Alain Jean Braun , Olivier Crespin , Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Christophe Philippo , Olivier Venier
IPC分类号： C07D403/10 , A61K31/5377 , A61K31/498 , C07D403/14 , C07D413/14 , A61P17/02 , C07D401/10 , C07D401/14 , A61P3/10 , A61P3/04 , A61P3/00 , A61P9/12 , A61P9/10 , A61P19/10 , A61P9/00 , A61P1/16 , A61P37/00 , A61K31/551
CPC分类号： C07D239/26 , C07D241/44 , C07D401/10 , C07D401/12
摘要： The present invention relates to tetrahydroquinoxaline urea derivatives, to their preparation and to their therapeutic application.
摘要翻译：本发明涉及四氢喹喔啉脲衍生物，其制备及其治疗应用。

35. 发明授权

US08211892B2 Tetrahydroquinoxaline urea derivatives 有权
标题翻译：四氢喹喔啉脲衍生物
公开(公告)号：US08211892B2
公开(公告)日：2012-07-03
申请号：US12843124
申请日：2010-07-26
申请人： Alain Jean Braun , Olivier Crespin , Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Christophe Philippo , Olivier Venier
发明人： Alain Jean Braun , Olivier Crespin , Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Christophe Philippo , Olivier Venier
IPC分类号： A61K31/495
CPC分类号： C07D239/26 , C07D241/44 , C07D401/10 , C07D401/12
摘要： The present invention relates to tetrahydroquinoxaline urea derivatives of Formula (I): as disclosed herein, to their preparation and to their therapeutic application.
摘要翻译：本发明涉及式（I）的四氢喹喔aline脲衍生物：如本文所公开的，其制备及其治疗应用。

36. 发明授权

US5686460A Carbocyclic diarylmethylene derivatives, processes for their preparation and their uses in therapeutics 失效
标题翻译：碳环二芳基亚甲基衍生物，其制备方法及其在治疗中的应用
公开(公告)号：US5686460A
公开(公告)日：1997-11-11
申请号：US723449
申请日：1996-10-07
申请人： Eric Nicolai , Michele Launay , Dominique Potin , Jean-Marie Teulon
发明人： Eric Nicolai , Michele Launay , Dominique Potin , Jean-Marie Teulon
IPC分类号： A61K31/18 , A61K31/255 , A61K31/44 , A61P15/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07C311/16 , C07C317/14 , C07C317/22 , C07D213/61 , C07D213/74 , A61K31/10
CPC分类号： C07D213/74 , C07C311/16 , C07C317/14 , C07C317/22 , C07D213/61 , C07C2101/08 , C07C2101/10
摘要： The present invention relates to the carbocyclic diarylmethylene derivatives of formula (I): ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
摘要翻译：本发明涉及式（I）的碳环二芳基亚甲基衍生物：＆lt; IMAGE＆gt;及其在治疗学中的用途，特别是具有抗炎和止痛特性的药物。

37. 发明授权

US5124336A Azabenzimidazole derivatives which are thromboxane receptor antagonists 失效
标题翻译：作为血栓素受体拮抗剂的偶氮苯并咪唑衍生物
公开(公告)号：US5124336A
公开(公告)日：1992-06-23
申请号：US650732
申请日：1991-02-05
申请人： Nicole Bru-Magniez , Eric Nicolai , Jean-Marie Teulon
发明人： Nicole Bru-Magniez , Eric Nicolai , Jean-Marie Teulon
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D235/06 , C07D235/16 , C07D235/28 , C07D471/04 , C07F9/6506 , C07F9/6561
CPC分类号： C07D471/04 , C07D235/16 , C07D235/28 , C07F9/65068 , C07F9/6561
摘要： The present invention relates to the derivatives of the formula ##STR1## in which: A is an aromatic ring or a nitrogen heterocycle;X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are independently a hydrogen atom, a halogen atom, a lower alkyl radical, a C.sub.3 -C.sub.7 cycloalkyl radical, an alkoxy radical, an alkylthio radical, a sulfone group, SO.sub.2 -lower alkyl, a sulfoxide group, SO-lower alkyl, a trifluoromethyl group, a nitro group, a hydroxyl group, a methylene alcohol radical or a group COOR', in which R' is a hydrogen or a lower alkyl; X.sub.3 and X.sub.4 can also form a naphthalene with the phenyl;B is CR.sub.5 R.sub.6, R.sub.5 and R.sub.6 being a hydrogen atom, a lower alkyl or a C.sub.3 -C.sub.7 cycloalkyl radical, or the sulfur atom;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently a hydrogen atom, a lower alkyl radical or a C.sub.3 -C.sub.7 cycloalkyl radical; CR.sub.1 R.sub.2 or CR.sub.3 R.sub.4 can form with B, when the latter is CR.sub.5 R.sub.6, a cycloalkyl or a cycloalkene having 3 to 7 carbon atoms; R.sub.1 R.sub.2 and R.sub.3 R.sub.4 can also form a ring having 3 to 7 carbon atoms;n is an integer from 1 to 4 and can be 0 if R.sub.1 and R.sub.2 are other than hydrogen; andD is a chemical group which can be: COOR.sub.7, R.sub.7 being the hydrogen atom, a lower alky radical or a C.sub.3 -C.sub.7 cycloalkyl radical, CONH-R.sub.8, R.sub.8 being the hydrogen atom, a lower alkyl radical or a C.sub.3 -C.sub.7 cycloalkyl radical, or CN,and to their addition salts. The compounds are thromboxane antagonist receptors.
摘要翻译：本发明涉及式（I）的衍生物，其中：A是芳环或氮杂环; X 1，X 2，X 3和X 4独立地为氢原子，卤素原子，低级烷基，C 3 -C 7环烷基，烷氧基，烷硫基，砜基，SO 2 - 低级烷基，亚砜基， SO - 低级烷基，三氟甲基，硝基，羟基，亚甲基基团或COOR'基团，其中R'为氢或低级烷基; X3和X4也可以与苯基形成萘; B是CR5R6，R5和R6是氢原子，低级烷基或C3-C7环烷基或硫原子; R1，R2，R3和R4独立地为氢原子，低级烷基或C3-C7环烷基; CR1R2或CR3R4可与B形成，当后者为CR5R6时，可以具有3-7个碳原子的环烷基或环烯烃; R1R2和R3R4也可以形成具有3至7个碳原子的环; n为1〜4的整数，如果R 1和R 2不是氢，则为0; D为化学基团，可以是：COOR7，R7是氢原子，低级烷基或C3-C7环烷基，CONH-R8，R8是氢原子，低级烷基或C3-C7环烷基自由基或CN，以及它们的加成盐。化合物是血栓素拮抗剂受体。

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