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31. 发明申请

US20100279346A1 Compositions and Methods for Improved Protein Production 失效
标题翻译：改进蛋白质生产的组合物和方法
公开(公告)号：US20100279346A1
公开(公告)日：2010-11-04
申请号：US12376558
申请日：2007-08-28
申请人： Elizabeth A. Bodie , Steve Kim
发明人： Elizabeth A. Bodie , Steve Kim
IPC分类号： C12P21/00 , C12N1/14 , C07H21/04 , C12N15/63 , C12N5/10 , C12N9/42 , C12N15/64 , C02F3/34
CPC分类号： C12N15/80 , C07K14/37 , C12N9/2437 , C12N15/01 , C12P21/00 , C12P21/02 , Y02P20/52
摘要： The present invention relates to the identification of novel nucleic acid sequences, designated herein as 7p,8k, 7E, 9G, 8Q and 203, in a host cell which effect protein production. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding 7p,8k, 7E, 9G, 8Q and 203, which are presented in FIG. 1, and are SEQ ID NOS.: 1-6, respectively. The present invention also provides host cells further comprising a nucleic acid encoding a desired heterologous protein such as an enzyme.
摘要翻译：本发明涉及在影响蛋白质产生的宿主细胞中鉴定新的核酸序列（本文称为7p，8k，7E，9G，8Q和203）。本发明还提供具有编码7p，8k，7E，9G，8Q和203的基因的部分或全部的突变或缺失的宿主细胞，其在图1中示出。 1，分别为SEQ ID NO：1-6。本发明还提供宿主细胞，其进一步包含编码所需异源蛋白质如酶的核酸。

32. 发明申请

US20090093039A1 REGULATABLE GROWTH OF FILAMENTOUS FUNGI 有权
标题翻译：真菌生长可调节
公开(公告)号：US20090093039A1
公开(公告)日：2009-04-09
申请号：US12184211
申请日：2008-07-31
申请人： Ali R. Akin , Elizabeth A. Bodie , Shirley Burrow , Nigel Dunn-Coleman , Geoffrey Turner , Michael Ward
发明人： Ali R. Akin , Elizabeth A. Bodie , Shirley Burrow , Nigel Dunn-Coleman , Geoffrey Turner , Michael Ward
IPC分类号： C12N9/12 , C12N15/11 , C12N15/00
CPC分类号： C12N9/1205 , C07K14/38 , C12N15/80 , C12P21/02
摘要： The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.
摘要翻译：本发明通常涉及真菌中的菌丝生长，并且具体地描述了丝状真菌中菌丝生长相关基因的调节。本发明提供了用于从丝状真菌生产蛋白质和/或化学物质的方法和系统，其包括调节与菌丝生长相关的基因。具体地，本发明涉及全长cotA基因，其基因产物和使用方法。

33. 发明授权

US07425450B2 Regulatable growth of filamentous fungi 失效
标题翻译：丝状真菌的可调节生长
公开(公告)号：US07425450B2
公开(公告)日：2008-09-16
申请号：US11113837
申请日：2005-04-25
申请人： Ali R. Akin , Elizabeth A. Bodie , Shirley M. Burrow , Nigel Dunn-Coleman , Geoffrey Turner , Michael Ward
发明人： Ali R. Akin , Elizabeth A. Bodie , Shirley M. Burrow , Nigel Dunn-Coleman , Geoffrey Turner , Michael Ward
IPC分类号： C12N15/74 , C12N1/18 , C12Q1/68 , C12P21/06
CPC分类号： C12N9/1205 , C07K14/38 , C12N15/80 , C12P21/02
摘要： The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.
摘要翻译：本发明通常涉及真菌中的菌丝生长，并且具体地描述了丝状真菌中菌丝生长相关基因的调节。本发明提供了用于从丝状真菌生产蛋白质和/或化学物质的方法和系统，其包括调节与菌丝生长相关的基因。具体地，本发明涉及全长cotA基因，其基因产物和使用方法。

34. 发明授权

US06329332B1 Pleurotus phenol oxidizing enzymes 有权
标题翻译：侧耳酚氧化酶
公开(公告)号：US06329332B1
公开(公告)日：2001-12-11
申请号：US09221275
申请日：1998-12-23
申请人： William S. Borneman , Elizabeth A. Bodie , Thomas P. Graycar , Deborah S. Winetzky
发明人： William S. Borneman , Elizabeth A. Bodie , Thomas P. Graycar , Deborah S. Winetzky
IPC分类号： C11D3386
CPC分类号： C12N9/0004 , C11D3/26 , C11D3/386 , C11D3/38654
摘要： The present invention provides novel phenol oxidizing enzymes naturally-produced by strains of the species Pleurotus ostreatus which possess a pH optima in the alkaline range and which are useful in modifying the color associated with dyes and colored compounds at alkaline pH.
摘要翻译：本发明提供由碱性范围内具有最佳pH值的碱性菌种天然产生的新型酚氧化酶，其可用于在碱性pH下改变与染料和有色化合物相关的颜色。

35. 发明授权

US6132716A Thermostable xylanases from Microtetraspora flexuosa as a feed additive 失效
标题翻译：作为饲料添加剂来自Microtetraspora flexuosa的热稳定性木聚糖酶
公开(公告)号：US6132716A
公开(公告)日：2000-10-17
申请号：US732242
申请日：1997-04-07
申请人： Andrew J. Morgan , Kathleen A. Clarkson , Elizabeth A. Bodie , William A. Cuevas
发明人： Andrew J. Morgan , Kathleen A. Clarkson , Elizabeth A. Bodie , William A. Cuevas
IPC分类号： A23K1/165 , C12N9/24 , C12P21/00 , C12R1/00 , C12R1/645 , C12S3/08 , D21C5/00 , D21C9/10 , A61K38/47 , A23L1/28
CPC分类号： C12Y302/01032 , C12N9/248 , C12Y302/01008 , D21C5/005 , Y10S426/807 , Y10S435/822
摘要： A feed additive that provides increased feed conversion ratio is prepared containing a physiologically acceptable carrier and one or more of five thermostable xylanases from Microtetraspora flexuosa, preferably strain ATCC 35864. The xylanases can tolerate heating for one minute in a water bath at 95.degree. C. without substantial loss of activity, and tolerate alkaline conditions in a pH range of 7.0-10.0. A feed for poultry or pigs contains the xylanases in a feed containing at least 20% by weight cereal. The five xylanases have the following characteristics: (i) a molecular weight of about 33,100 daltons, a pI of about 8.5, and a maximum activity at pH 7.0-7.5 at a temperature of about 70.degree. C.; (ii) a molecular weight of about 33,300 daltons, a pI of about 7.5, and a maximum activity at pH 7.0-7.5 at a temperature of about 65.degree. C.; (iii) a molecular weight of about 31,000 daltons, a pI of about 6.2, and a maximum activity at pH 7.5 at a temperature of about 65.degree. C.; (iv) a molecular weight of about 50,000 daltons, a pI of about 5.8, and a maximum activity at pH 7.5 at a temperature of about 65.degree. C.; and (v) a molecular weight of about 35,000 daltons, a pI of about 5.3, and a maximum activity at pH 7.5 at a temperature of about 70.degree. C.
摘要翻译： PCT No.PCT / EP95 / 01628 Sec。 371日期1997年4月7日 102（e）日期1997年4月7日PCT 1995年4月28日PCT PCT。 WO95 / 29997 PCT出版物日期1995年11月9日制备提供增加的饲料转化率的饲料添加剂，其含有生理学上可接受的载体和来自Microtetraspora flexuosa的五种热稳定性木聚糖酶中的一种或多种，优选菌株ATCC 35864.木聚糖酶可以耐受在水浴中加热1分钟在95℃下没有显着的活性损失，并且在7.0-10.0的pH范围内耐受碱性条件。家禽或猪的饲料在含有至少20重量％谷物的饲料中含有木聚糖酶。五种木聚糖酶具有以下特征：（i）约33,100道尔顿的分子量，约8.5的pI值，在约70℃的温度下在pH 7.0-7.5的最大活性。（ii）约33,300道尔顿的分子量，约7.5的pI，在约65℃的温度下在pH 7.0-7.5的最大活性。（iii）约31,000道尔顿的分子量，约6.2的pI，在约65℃的温度下在7.5的最大活性。（iv）约50,000道尔顿的分子量，约5.8的pI，在约65℃的温度下在pH7.5的最大活性。和（v）约35,000道尔顿的分子量，约5.3的pI，在约70℃的温度下在pH7.5的最大活性。

36. 发明授权

US4444793A Fermentation of whey to produce a thickening agent 失效
标题翻译：发酵乳清产生增稠剂
公开(公告)号：US4444793A
公开(公告)日：1984-04-24
申请号：US290766
申请日：1981-08-07
申请人： Robert D. Schwartz , Elizabeth A. Bodie
发明人： Robert D. Schwartz , Elizabeth A. Bodie
IPC分类号： A23C21/02 , C12P19/04 , C12P19/08 , C12N1/20
CPC分类号： A23C21/026 , C12P19/04 , C12P19/08 , Y10S435/822
摘要： Dairy whey, a waste product of cheese production, is fermented to produce a thickening agent for use in the food industry by forming a fermentation broth containing whey and sucrose, and fermenting the broth with Leuconostoc mesenteroides ATCC 14935. The fermentation broth can optionally contain a water-soluble phosphate as a pH buffer and yeast extract.
摘要翻译：奶酪乳清是奶酪生产的废弃产品，通过形成含有乳清和蔗糖的发酵液和用肠系膜梭菌ATCC 14935发酵肉汤，发酵成生产用于食品工业的增稠剂。发酵液可任选地含有水溶性磷酸盐作为pH缓冲液和酵母提取物。

37. 发明授权

US4444792A Fermentation of whey to produce a thickening polymer 失效
标题翻译：发酵乳清产生增稠聚合物
公开(公告)号：US4444792A
公开(公告)日：1984-04-24
申请号：US284422
申请日：1981-07-20
申请人： Robert D. Schwartz , Elizabeth A. Bodie
发明人： Robert D. Schwartz , Elizabeth A. Bodie
IPC分类号： A23C21/02 , C12P19/06 , C12R1/64
CPC分类号： C12R1/64 , A23C21/02 , C12P19/06 , Y10S435/91
摘要： Diary whey, a waste product of cheese production, is fermented with Xanthomonas campestris ATTCC 31923 to produce a fermented whey product containing a thickening polymer. The fermented whey product can be used as a thickening agent by the food industry. Yeast extract may be added to the whey prior to fermentation. Xanthomonas campestris ATCC 31923 is a novel microorganism having the ability to grow on lactose as the sole source of carbon.
摘要翻译：日粮乳清，酪乳生产的废弃物，用黄单胞菌（Stern）的ATTCC 31923发酵，生产含增稠聚合物的发酵乳清产品。发酵乳清产品可用作食品工业的增稠剂。酵母提取物可以在发酵前加入到乳清中。野油菜黄单胞菌ATCC 31923是一种新型微生物，其具有在乳糖上生长的能力，作为唯一的碳源。

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