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31. 发明申请

WO2006053251A3 METHOD OF MEASURING AMYLOID-BETA PEPTIDES 审中-公开
标题翻译：测量淀粉样蛋白肽的方法
公开(公告)号：WO2006053251A3
公开(公告)日：2006-09-21
申请号：PCT/US2005041029
申请日：2005-11-14
申请人： PFIZER , ELAN PHARM INC , SLEMMON JOHN
发明人： SLEMMON JOHN
IPC分类号： G01N33/53
CPC分类号： G01N33/5058 , G01N33/6896 , G01N2333/4709
摘要： The present invention relates to methods for measuring Aß peptides in a sample, particularly a sample of blood, such as whole blood and plasma, and to methods of determining whether a compound alters the amount of Aß produced by a cell or animal.
摘要翻译：本发明涉及用于测量样品中的Aβ肽，特别是血液样品如全血和血浆的方法，以及确定化合物是否改变由细胞或动物产生的Aβ的量的方法。

32. 发明申请

WO2006026532A3 METHODS OF TREATMENT OF AMYLOIDOSIS USING SUBSTITUTED ETHANOLCYCLICAMINE ASPARTYL PROTEASE INHIBITORS 审中-公开
标题翻译：使用取代的乙酰胆碱酯酶蛋白酶抑制剂治疗淀粉样变性的方法
公开(公告)号：WO2006026532A3
公开(公告)日：2006-07-20
申请号：PCT/US2005030608
申请日：2005-08-26
申请人： ELAN PHARM INC , HOM ROY , FANG LAWRENCE , JOHN VARGHESE
发明人： HOM ROY , FANG LAWRENCE , JOHN VARGHESE
IPC分类号： C07D211/48 , A61K31/40 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/445 , A61K31/472 , A61K31/4725 , A61P25/28 , C07D207/12 , C07D217/18 , C07D221/20 , C07D413/06 , C07D417/12 , C07D471/04
CPC分类号： C07D417/12 , C07D207/12 , C07D211/22 , C07D211/48 , C07D211/74 , C07D217/18 , C07D221/20 , C07D401/06 , C07D413/06 , C07D471/04
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein
摘要翻译：本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合

33. 发明申请

WO2005058941A3 Aß IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME 审中-公开
标题翻译： Aß免疫原性载体结合体及其生产方法
公开(公告)号：WO2005058941A3
公开(公告)日：2006-06-01
申请号：PCT/US2004044093
申请日：2004-12-17
申请人： ELAN PHARM INC , WYETH CORP , ARUMUGHAM RASAPPA G , PRASAD A KRISHNA
发明人： ARUMUGHAM RASAPPA G , PRASAD A KRISHNA
IPC分类号： C07K1/00 , A61K39/00 , C07K20060101
CPC分类号： A61K39/0007 , A61K47/643 , A61K47/646 , A61K2039/6031 , A61K2039/6081 , A61K2039/62
摘要： The present invention is directed to methods of producing conjugates of Aß peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.
摘要翻译：本发明涉及产生Aβ肽免疫原的缀合物与可用作免疫原的蛋白质/多肽载体分子的方法，其中肽免疫原通过载体的氨基酸残基上的活化官能团或任选的并且其中氨基酸残基上的任何未偶联的反应性官能团通过封端失活，因此保留载体分子的免疫功能，但降低可能使缀合物更不安全或有效的不期望反应的倾向。此外，本发明还涉及这样的免疫原性产物和含有由这些方法制备的免疫原性产物的免疫原性组合物。

34. 发明申请

WO2005076843A3 METHODS AND COMPOSITIONS FOR TREATING TUMORS AND METASTATIC DISEASE 审中-公开
标题翻译：用于治疗肿瘤和分化疾病的方法和组合物
公开(公告)号：WO2005076843A3
公开(公告)日：2006-01-26
申请号：PCT/US2005002860
申请日：2005-02-03
申请人： ELAN PHARM INC , WEHNER NANCY
发明人： WEHNER NANCY
IPC分类号： A61K39/395 , C07K16/28 , A61K31/541 , A61K31/381 , C12N5/12 , C12N15/13
CPC分类号： C07K16/2839 , A61K31/381 , A61K2039/505 , C07K16/2842 , C07K2317/73
摘要： Compositions, methods, and combination therapies for the treatment of lymphomas, leukemias, melanomas, prostate cancer, and metastatic disease are provided. Specifically, compositions comprising anti-a4 integrin immunoglobulins or immunoglobulins that bind to an a4 integrin ligand (e.g., MadCAM-1 and VCAM-1) are disclosed for use in inhibiting tumor growth and progression and inhibition of metastases. A preferred immunoglobulin for use in treating tumors and metastases is natalizumab. The compositions and methods using these immunoglobulins can be used alone or in combination with other reagents and cancer treatment modalities.
摘要翻译：提供了用于治疗淋巴瘤，白血病，黑素瘤，前列腺癌和转移性疾病的组合物，方法和组合疗法。具体地，公开了包含结合a4整联蛋白配体（例如MadCAM-1和VCAM-1）的抗α4整联蛋白免疫球蛋白或免疫球蛋白的组合物用于抑制肿瘤生长和进展和抑制转移。用于治疗肿瘤和转移瘤的优选免疫球蛋白是那他珠单抗。使用这些免疫球蛋白的组合物和方法可以单独使用或与其它试剂和癌症治疗方式组合使用。

35. 发明申请

WO2004098590A8 4-BROMO-5- (2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (1-(AMINOCARBONYL) ETH-1-YL) AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译： 4-溴-5-（2-氯苯甲酰氨基）-1H-吡唑-3-羧酸（1-（氨基羰基）ETH-1-YL）酰胺衍生物及相关化合物作为治疗炎症性疾病的BRADYKININ B1受体拮抗剂
公开(公告)号：WO2004098590A8
公开(公告)日：2005-12-15
申请号：PCT/US2004013400
申请日：2004-04-30
申请人： ELAN PHARM INC , TUNG JAY S , GAROFALO ALBERT W , PLEISS MICHAEL A , WU JING , WONE DAVID W G , GUINN ASHLEY C , DRESSEN DARREN B , MARUGG JENNIFER , NEITZEL MARTIN
发明人： TUNG JAY S , GAROFALO ALBERT W , PLEISS MICHAEL A , WU JING , WONE DAVID W G , GUINN ASHLEY C , DRESSEN DARREN B , MARUGG JENNIFER , NEITZEL MARTIN
IPC分类号： A61P29/00 , C07D231/16 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08 , A61K31/415 , A61K31/4155
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formulae (I) and (II) that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action. Wherein Z is selected from O, S and NH; Q of formula (III) and the other substituents are as defined in claim 1.
摘要翻译：公开了缓激肽B1受体拮抗剂的式（I）和（II）化合物，并且可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病相关的不良症状。某些化合物表现出更高的效力，并且还预期表现出增加的作用持续时间。其中Z选自O，S和NH; 式（III）的Q和其它取代基如权利要求1中所定义。

36. 发明申请

WO2004066931A3 COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS 审中-公开
标题翻译：复方药物组合物治疗脱发疾病及并发症
公开(公告)号：WO2004066931A3
公开(公告)日：2005-12-15
申请号：PCT/US2004002028
申请日：2004-01-26
申请人： ELAN PHARM INC , KARLIK STEVE J , PLEISS MICHAEL A , KONRADI ANDREI W , GRANT FRANCINE S , SEMKO CHRISTOPHER M , DRESSEN DAREN , MESSERSMITH ELIZABETH , FREEDMAN STEPHEN , YEDNOCK TED
发明人： KARLIK STEVE J , PLEISS MICHAEL A , KONRADI ANDREI W , GRANT FRANCINE S , SEMKO CHRISTOPHER M , DRESSEN DAREN , MESSERSMITH ELIZABETH , FREEDMAN STEPHEN , YEDNOCK TED
IPC分类号： A61K20060101 , A61K6/00 , A61K31/10 , A61K31/16 , A61K31/185 , A61K31/195 , A61K31/198 , A61K31/21 , A61K31/216 , A61K31/381 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/427 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K31/54 , A61K31/541 , A61K31/56 , A61K38/21 , A61K39/395 , A61K45/06 , A61P25/00 , A61P29/00
CPC分类号： A61K45/06 , A61K31/10 , A61K31/16 , A61K31/185 , A61K31/195 , A61K31/21 , A61K31/496 , C07D417/14 , A61K2300/00
摘要： The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.
摘要翻译：本申请提供了在有需要的受试者中抑制脱髓鞘，促进髓鞘再生和/或治疗麻痹的方法和组合物。优选地，这样的组合物包括免疫球蛋白（例如，抗体，抗体片段和重组产生的抗体或片段），多肽（例如，用于整联蛋白的配体蛋白的可溶形式）和小分子，其以有效量施用时抑制脱髓鞘和/ 或促进患者的髓鞘再生。本文所述的组合物和方法还可以利用用于缓解与脱髓鞘相关的病症和疾病的其它抗炎剂。

37. 发明申请

WO2004024096A2 METHOD OF TREATING TREMORS 审中-公开
标题翻译：处理TREMORS的方法
公开(公告)号：WO2004024096A2
公开(公告)日：2004-03-25
申请号：PCT/US0329044
申请日：2003-09-15
申请人： ELAN PHARM INC , SHELLENBERGER M KENT
发明人： SHELLENBERGER M KENT
IPC分类号： A61K31/42 , A61K31/425 , A61K
CPC分类号： A61K31/425
摘要： The present invention is directed to a method of treating action tremor or severe essential tremor. Action tremor includes essential tremor, postural tremor, drug-induced or toxic tremor, primary orthostatic tremor, dystonic tremor, neuropathic tremor, and cerebellar tremor. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of zonisamide, or a pharmaceutically acceptable salt thereof. The methods of the present invention are useful in reducing symptoms of tremor. The compounds of the present method can also be used in conjunction with other therapeutic agents commonly used to treat tremor thus enhancing the therapeutic effect of treating tremor.
摘要翻译：本发明涉及一种治疗动作震颤或严重的本质震颤的方法。动作震颤包括原发性震颤，姿势震颤，药物诱发或中毒性震颤，原发性直立震颤，肌张力障碍性震颤，神经性震颤和小脑震颤。该方法包括向受试者施用包含有效量的唑尼沙胺或其药学上可接受的盐的药物组合物。本发明的方法可用于减轻震颤的症状。本发明方法的化合物还可以与通常用于治疗震颤的其它治疗剂结合使用，从而增强治疗震颤的治疗效果。

38. 发明申请

WO0202506A8 COMPOUNDS TO TREAT ALZHEIMER'S DISEASE 审中-公开
标题翻译：化合物治疗阿尔茨海默病
公开(公告)号：WO0202506A8
公开(公告)日：2003-11-20
申请号：PCT/US0120930
申请日：2001-06-29
申请人： ELAN PHARM INC
发明人： FANG LAWRENCE Y , JOHN VARGHESE
IPC分类号： A61K9/06 , A61K9/08 , A61K9/10 , A61K9/19 , A61K9/20 , A61K9/48 , A61K9/70 , A61K31/166 , A61K31/27 , A61K31/336 , A61K47/48 , A61P7/04 , A61P9/00 , A61P9/10 , A61P25/16 , A61P25/28 , A61P43/00 , C07C215/28 , C07C233/78 , C07C235/84 , C07C239/16 , C07C239/20 , C07C243/22 , C07C243/28 , C07C243/34 , C07C271/16 , C07C271/18 , C07C275/24 , C07C311/03 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/37 , C07C317/44 , C07C323/60 , C07D211/60 , C07D215/12 , C07D277/04 , C07D295/13 , C07D303/36 , C07D307/52 , C07D307/54 , C07D333/24 , A61K31/165
CPC分类号： C07D295/13 , C07C215/28 , C07C233/78 , C07C235/84 , C07C239/20 , C07C243/22 , C07C243/28 , C07C271/16 , C07C271/18 , C07C275/24 , C07C311/03 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/37 , C07C317/44 , C07C323/60 , C07D211/60 , C07D215/12 , C07D277/04 , C07D303/36 , C07D307/52 , C07D307/54 , C07D333/24
摘要： The present invention is substituted amines of formula (XV) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译：本发明是用于治疗阿尔茨海默病和其他类似疾病的式（ⅩⅤ）的取代胺。

39. 发明申请

WO03029169A3 HYDROXYPROPYLAMINES 审中-公开
公开(公告)号：WO03029169A3
公开(公告)日：2003-08-28
申请号：PCT/US0231846
申请日：2002-10-04
申请人： ELAN PHARM INC , UPJOHN CO , FISHER JED F , JACOBS JON S , SHERER BRIAN
发明人： FISHER JED F , JACOBS JON S , SHERER BRIAN
IPC分类号： A61P25/16 , A61P25/28 , C07C215/28 , C07C233/78 , C07C311/17 , C07D263/32 , A61K31/135 , C07D263/04
CPC分类号： C07C233/78 , C07C215/28 , C07C311/17 , C07D263/32
摘要： Disclosed are compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein the variables RN, R1, R2, R3, Rp and Rc are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐，其中变量RN，R1，R2，R3，Rp和Rc在本文中定义。这些化合物可用于治疗阿尔茨海默病和其他类似疾病。这些化合物包括β-分泌酶的抑制剂，其可用于治疗阿尔茨海默氏病和以哺乳动物沉积Aβ肽为特征的其它疾病。本发明的化合物可用于降低Aβ肽形成的药物组合物和治疗方法。

40. 发明申请

WO02085877A2 PROCESSES AND INTERMEDIATES FOR PREPARING BENZYL EPOXIDES 审中-公开
标题翻译：制备苄基环氧化物的方法和中间体
公开(公告)号：WO02085877A2
公开(公告)日：2002-10-31
申请号：PCT/US0212591
申请日：2002-04-23
申请人： ELAN PHARM INC , UPJOHN CO , REEDER MICHAEL R
发明人： REEDER MICHAEL R
IPC分类号： C07D301/28 , C07B61/00 , C07C213/02 , C07C215/28 , C07C217/82 , C07C229/36 , C07C233/78 , C07C269/06 , C07C271/16 , C07C271/18 , C07C271/20 , C07C271/22 , C07D301/26 , C07D301/27 , C07D303/36
CPC分类号： C07D303/36 , C07D301/26
摘要： Disclosed are intermediates and processes for preparing epoxides of the formula (1): where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the production of pharmaceutical agents.
摘要翻译：公开了用于制备式（1）的环氧化物的中间体和方法：其中R和PROT在本文中定义。这些环氧化物可用作生物活性化合物的生产中的中间体，即在制药中。

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