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31. 发明授权

US07792571B2 Tachyarrhythmia detection and discrimination based on curvature parameters 失效
标题翻译：基于曲率参数的快速性心律失常检测和鉴别
公开(公告)号：US07792571B2
公开(公告)日：2010-09-07
申请号：US10607818
申请日：2003-06-27
申请人： Robert J. Sweeney , Carlos Ricci
发明人： Robert J. Sweeney , Carlos Ricci
IPC分类号： A61B5/04
CPC分类号： G06K9/00523 , A61B5/0245 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61B5/7264 , A61N1/362 , A61N1/3962
摘要： Estimating a frequency of a sampled cardiac rhythm signal and classifying the rhythm. The received signal is sampled and transformed into a curvature series. A lobe in the curvature series corresponds to a characteristic point in the sampled series. Characteristic points are selected based on a time of a lobe in the curvature series and, in one embodiment, an amplitude of the signal at the time of the lobe. A frequency of the sampled series is estimated by autocorrelating a function of the series of the characteristic points. In one embodiment, the function is a time difference function. The rhythm is classified by plotting the timewise proximity of characteristic points derived from an atrial signal with characteristic points derived from a ventricular signal. Regions of the plot are associated with a particular rhythm and the grouping of the data corresponds to the classification.
摘要翻译：估计采样心律信号的频率并对节律进行分类。接收到的信号被采样并转换成曲率系列。曲率系列中的凸角对应于采样系列中的特征点。基于曲率序列中的波瓣的时间选择特征点，并且在一个实施例中，选择在波瓣时的信号的幅度。通过自相关一系列特征点的函数来估计采样序列的频率。在一个实施例中，该功能是时差功能。通过绘制从心房信号得到的特征点与从心室信号得到的特征点的时间接近，分类节律。地块的区域与特定节奏相关联，数据分组对应于分类。

32. 发明授权

US07653431B2 Arrhythmia discrimination based on determination of rate dependency 有权
标题翻译：基于速率依赖性确定的心律失常辨别
公开(公告)号：US07653431B2
公开(公告)日：2010-01-26
申请号：US11312280
申请日：2005-12-20
申请人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Ricci
发明人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Ricci
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/7264
摘要： Cardiac systems and methods provide for discriminating between supraventricular tachyarrhythmia and ventricular tachyarrhythmia based on a determination that the patient's supraventricular rhythm exhibits rate dependency. One approach involves determining if a patient's supraventricular rhythm exhibits rate dependent morphology. If the patient's supraventricular rhythm is determined to exhibit rate dependent morphology, an implantable device classifies a detected tachyarrhythmia episode based on one or more templates selected from a plurality of rate-indexed templates stored in the device. Determining if the supraventricular rhythm exhibits rate dependent morphology may also include determining one or more rates at which the rate dependent morphology occurs.
摘要翻译：心脏系统和方法基于确定患者的室上节律表现出速率依赖性，确定了室上性快速性心律失常与室性快速性心律失常之间的区别。一种方法涉及确定患者的室上节律是否表现出速率依赖性形态。如果确定患者的室上节律表现出与速率相关的形态，则可植入装置基于从存储在装置中的多个速率索引模板中选择的一个或多个模板来分类检测到的快速性心律失常发作。确定室性心律显示出速率依赖性形态还可以包括确定发生速率依赖形态的一个或多个速率。

33. 发明申请

US20060253162A1 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US20060253162A1
公开(公告)日：2006-11-09
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey Stahmann , Carlos Ricci , Scott Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey Stahmann , Carlos Ricci , Scott Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

34. 发明申请

US20060253044A1 Arrhythmia discrimination using electrocardiograms sensed from multiple implanted electrodes 有权
标题翻译：使用从多个植入电极感测的心电图的心律失常辨别
公开(公告)号：US20060253044A1
公开(公告)日：2006-11-09
申请号：US11125020
申请日：2005-05-09
申请人： Yi Zhang , Carlos Ricci , Jeffrey Stahmann , Aaron McCabe , Scott Meyer , Yinghong Yu
发明人： Yi Zhang , Carlos Ricci , Jeffrey Stahmann , Aaron McCabe , Scott Meyer , Yinghong Yu
IPC分类号： A61B5/04
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些功能的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。使用一个或多个心脏信号载体来区分心律失常。

35. 发明申请

US20060116593A1 Cardiac activation sequence monitoring for ischemia detection 有权
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US20060116593A1
公开(公告)日：2006-06-01
申请号：US11079744
申请日：2005-03-14
申请人： Yi Zhang , Scott Meyer , Jeffrey Stahmann , Carlos Ricci , Marina Brockway , Aaron McCabe , Yinghong Yu , Donald Hopper
发明人： Yi Zhang , Scott Meyer , Jeffrey Stahmann , Carlos Ricci , Marina Brockway , Aaron McCabe , Yinghong Yu , Donald Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

36. 发明申请

US20050288600A1 Automatic orientation determination for ECG measurements using multiple electrodes 有权
标题翻译：使用多个电极的ECG测量的自动取向确定
公开(公告)号：US20050288600A1
公开(公告)日：2005-12-29
申请号：US10876008
申请日：2004-06-24
申请人： Yi Zhang , Marina Brockway , Carlos Ricci , Ron Heil , Douglas Daum , Robert Sweeney , Aaron McCabe
发明人： Yi Zhang , Marina Brockway , Carlos Ricci , Ron Heil , Douglas Daum , Robert Sweeney , Aaron McCabe
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0402 , A61B5/042 , A61N1/365 , A61N1/375 , G06K9/62
CPC分类号： A61B5/0006 , A61B5/0031 , A61B5/04011 , A61B5/0422 , A61B5/7207 , A61B5/7217 , A61N1/3756 , G06K9/624
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。如果需要或必要，可以更新所选择的向量。信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。分离可以包括主成分分析和/或独立成分分析。可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

37. 发明申请

US20050065569A1 Neural network based learning engine to adapt therapies 失效
标题翻译：基于神经网络的学习引擎适应治疗
公开(公告)号：US20050065569A1
公开(公告)日：2005-03-24
申请号：US10668428
申请日：2003-09-23
申请人： Carlos Ricci , Surekha Palreddy
发明人： Carlos Ricci , Surekha Palreddy
IPC分类号： A61N1/372 , A61N1/362
CPC分类号： A61N1/37252 , Y10S128/924
摘要： A cardiac device system for implementing a cardiac device having adaptive treatment therapies utilizing a neural network based learning engine includes an implantable cardiac device module and an external data processing system for specifying the operating characteristics of the cardiac device module. Both the cardiac device module and the external processing system possess an artificial neural network to specify the operation of the cardiac device module as it provides adaptive treatment therapies. The external data processing system includes a complete neural network module that trains and validates the operation of the neural network to match the optimal treatment options with a received set of collected patient data. In contrast, a runtime neural network module that only provides real time operation of the neural network using collected patient data is located within the cardiac device module. The cardiac device module and the external processing module communicate with each other to pass collected patient data from the cardiac device module to the external processing system when the operation of the neural network is to be updated. The cardiac device module and the external processing module also communicate with each other to pass operating coefficients for the neural network back from the external processing system to the cardiac device module once these coefficients are updated.
摘要翻译：用于实现具有使用基于神经网络的学习引擎的自适应治疗疗法的心脏装置的心脏装置系统包括可植入心脏装置模块和用于指定心脏装置模块的操作特性的外部数据处理系统。心脏装置模块和外部处理系统均具有人造神经网络，用于指定心脏装置模块的操作，因为它提供适应性治疗疗法。外部数据处理系统包括完整的神经网络模块，其训练和验证神经网络的操作以将最佳治疗选项与收到的一组收集的患者数据进行匹配。相比之下，仅使用收集的患者数据提供神经网络的实时操作的运行时神经网络模块位于心脏装置模块内。当要更新神经网络的操作时，心脏装置模块和外部处理模块相互通信以将收集的患者数据从心脏装置模块传送到外部处理系统。一旦这些系数被更新，心脏装置模块和外部处理模块也相互通信，以将神经网络的操作系数从外部处理系统传回心脏装置模块。

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