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31. 发明授权

US08155750B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08155750B2
公开(公告)日：2012-04-10
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

32. 发明申请

US20120046710A1 METHODS, SYSTEMS, AND DEVICES FOR DEEP BRAIN STIMULATION USING HELICAL MOVEMENT OF THE CENTROID OF STIMULATION 审中-公开
标题翻译：使用刺激性心脏运动的深层脑刺激的方法，系统和装置
公开(公告)号：US20120046710A1
公开(公告)日：2012-02-23
申请号：US13198035
申请日：2011-08-04
申请人： Andrew DiGiore , David Karl Lee Peterson
发明人： Andrew DiGiore , David Karl Lee Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/0534 , A61N1/36185
摘要： A method of treating a target region in the brain includes a) contacting tissue to be stimulated with a lead of a stimulation device, the stimulation device comprising a pulse generator coupled to the lead, the lead having a plurality of segmented electrodes disposed at a distal end of the lead, the stimulation device being configured and arranged to stimulate a target region using a positionable centroid of stimulation; b) providing stimulation current to at least one of the segmented electrodes of the lead to generate a centroid of stimulation at a location and stimulate tissue around the location of the centroid of stimulation; c) repositioning the centroid of stimulation to a next location along a helical path by altering the provision of stimulation current to the plurality of electrodes and stimulating tissue around the location of the repositioned centroid of stimulation; and d) repeating c) for each location along the helical path. The method may optionally include collecting data associated with each of the locations of the centroid of stimulation; and displaying at least a portion of the collected data.
摘要翻译：治疗脑中靶区域的方法包括：a）使刺激装置的引导部分接触被刺激的组织，所述刺激装置包括连接到所述引线的脉冲发生器，所述引线具有设置在远端的多个分段电极所述刺激装置被配置和布置成使用可定位的刺激重心来刺激目标区域; b）向引线的至少一个分段电极提供刺激电流，以在位置处产生刺激的质心并刺激刺激质心位置周围的组织; c）通过改变对所述多个电极的刺激电流的提供并刺激所述重新定位的刺激质心的周围的组织来重新定位刺激的质心到沿着螺旋路径的下一个位置; 和d）重复c）沿着螺旋路径的每个位置。该方法可以可选地包括收集与刺激质心的每个位置相关联的数据; 并显示所收集的数据的至少一部分。

33. 发明申请

US20110160797A1 METHODS TO CONCURRENTLY STIMULATE DIFFERENT BRAIN TARGETS 审中-公开
标题翻译：同时刺激不同脑部目标的方法
公开(公告)号：US20110160797A1
公开(公告)日：2011-06-30
申请号：US12976764
申请日：2010-12-22
申请人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
发明人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/00 , A61N1/0534 , A61N1/36064 , A61N1/36171
摘要： A method for treating a patient having a dysfunction using a stimulation lead within the brain of a patient is provided. The stimulation lead carries a plurality of electrodes adjacent to a plurality of brain regions. Pulsed electrical waveforms having different sets of stimulation parameters are generated and then concurrently delivered to the plurality of electrodes, thereby concurrently stimulating the plurality of brain regions to treat the dysfunction.
摘要翻译：提供了一种使用患者脑内的刺激铅治疗具有功能障碍的患者的方法。刺激引线携带与多个脑区域相邻的多个电极。产生具有不同组刺激参数的脉冲电波形，然后同时传送到多个电极，从而同时刺激多个脑区域来治疗功能障碍。

34. 发明申请

US20110125223A1 NEUROSTIMULATION SYSTEM AND METHOD FOR COMPOUNDING CURRENT TO MINIMIZE CURRENT SOURCES 有权
标题翻译：用于组合电流以最小化电流源的神经网络系统和方法
公开(公告)号：US20110125223A1
公开(公告)日：2011-05-26
申请号：US12952738
申请日：2010-11-23
申请人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/36185 , A61N1/37223 , A61N1/37241 , A61N1/37288 , A61N2001/083
摘要： A neurostimulation system and method of providing therapy to a patient implanted with a plurality of electrodes using a plurality of electrical sources is provided. A source-electrode coupling configuration is determined from the electrical sources and electrodes. Electrical current is respectively conveyed between active ones of the plurality of electrical sources and active subsets of the plurality of electrodes in accordance with the determined source-electrode coupling configuration. The total number of the electrodes in the active electrode subsets is greater than the total number of the active electrical sources.
摘要翻译：提供了一种使用多个电源向注入多个电极的患者提供治疗的神经刺激系统和方法。源电极耦合配置由电源和电极确定。根据所确定的源电极耦合配置，电流分别在多个电源中的有效电源和多个电极的有效子集之间传送。有源电极子集中的电极总数大于有源电源的总数。

35. 发明申请

US20110009919A1 METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE 有权
标题翻译：使用噪声共振方法来提高实际和有效的传输
公开(公告)号：US20110009919A1
公开(公告)日：2011-01-13
申请号：US12501170
申请日：2009-07-10
申请人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
发明人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36128 , A61N1/36164
摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.
摘要翻译：提供了向患者提供治疗的方法。在一种方法中，患者具有应用亚阈值生物电刺激的神经元。该方法包括向神经元施加电噪声能量，其中产生生物电刺激和电噪声能量之间的共振，使得动作电位沿神经元的轴突传播。在另一种方法中，患者具有应用超临界生物电刺激的神经元。该方法包括将超阈值电噪声能量应用于神经元，从而防止动作电位沿神经元的轴突传播。另一种方法包括对神经元施加电刺激，以及向神经元施加超阈值电噪声能量，从而防止或反转可能响应于电刺激而发生的神经元的任何神经学适应。

36. 发明申请

US20100331918A1 MOLDABLE CHARGER WITH CURABLE MATERIAL FOR CHARGING AN IMPLANTABLE PULSE GENERATOR 审中-公开
标题翻译：带可固化材料的可充电充电器，用于充电可植入脉冲发生器
公开(公告)号：US20100331918A1
公开(公告)日：2010-12-30
申请号：US12495575
申请日：2009-06-30
申请人： Andrew DiGiore , Brett Schleicher , Greg Baldwin
发明人： Andrew DiGiore , Brett Schleicher , Greg Baldwin
IPC分类号： A61N1/02
CPC分类号： A61N1/3787 , A61N1/3605
摘要： Electrical energy is transcutaneously transmitted from an external charger to an implanted medical device. The external charger includes a charging head comprising a flexible material that is selectively shaped to conform to the surface of a patient to enhance charge efficiency and patient comfort. The flexible material is curable to become inflexible and embody a fixed shape and may comprise, for example, a thermoplastic for being re-shaped and re-cured multiple times, or a thermoset plastic that maintains a permanent shape and cannot be re-cured to form another shape. The charging head may also include one or more sensors for determining the shape of a charging coil in the charging head, which cause the charge of the coil to be adjusted based on the coil shape.
摘要翻译：电能从外部充电器经皮传输到植入式医疗装置。外部充电器包括充电头，该充电头包括柔性材料，该柔性材料选择性地成形为符合患者的表面以增强充电效率和患者舒适度。柔性材料是可固化的以变得不灵活并且体现固定的形状，并且可以包括例如用于重新形状和再固化多次的热塑性塑料，或者保持永久形状并且不能再固化的热固性塑料形成另一种形状。充电头还可以包括用于确定充电头中的充电线圈的形状的一个或多个传感器，这导致基于线圈形状来调节线圈的充电。

37. 发明申请

US20090192558A1 METHODS AND SYSTEMS OF TREATING PANCREATITIS PAIN 有权
标题翻译：治疗胰腺疼痛的方法和系统
公开(公告)号：US20090192558A1
公开(公告)日：2009-07-30
申请号：US12358073
申请日：2009-01-22
申请人： Todd K. Whitehurst , Kristen N. Jaax , Rafael Carbunaru , Greg Baldwin , Brett Schleicher , Andrew DiGiore , Roger Hastings
发明人： Todd K. Whitehurst , Kristen N. Jaax , Rafael Carbunaru , Greg Baldwin , Brett Schleicher , Andrew DiGiore , Roger Hastings
IPC分类号： A61N1/34
CPC分类号： A61N1/36007 , A61N1/0551 , A61N1/36071 , A61N1/37205 , A61N1/37252
摘要： Methods and systems of treating a patient with pancreatitis pain include providing a stimulator, configuring one or more stimulation parameters to treat pancreatitis pain, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to treat pancreatitis pain with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.
摘要翻译：治疗患有胰腺炎疼痛的患者的方法和系统包括提供刺激器，配置一个或多个刺激参数以治疗胰腺炎疼痛，用所述一个或多个刺激参数编程所述刺激器，产生被配置为按照所述刺激器治疗胰腺炎疼痛的刺激与所述一个或多个刺激参数相关联，并且根据所述一个或多个刺激参数将刺激器刺激施加到一个或多个刺激位点。

38. 发明申请

US20090192555A1 FIXATION OF IMPLANTABLE PULSE GENERATORS 有权
标题翻译：可植入脉冲发生器的固定
公开(公告)号：US20090192555A1
公开(公告)日：2009-07-30
申请号：US12361432
申请日：2009-01-28
申请人： Brett Schleicher , Todd K. Whitehurst , Andrew DiGiore
发明人： Brett Schleicher , Todd K. Whitehurst , Andrew DiGiore
IPC分类号： A61N1/375
CPC分类号： A61N1/3756 , A61N1/37205 , A61N1/37518 , A61N1/3787
摘要： Systems and techniques for improving the fixation of implantable pulse generators. In one aspect, a device includes an implantable pulse generator that comprises electrical circuitry configured to generate an electrical pulse and a biocompatible casing that houses the electrical circuitry and on which a collection of electrodes and a collection of fixation elements are mounted. The electrodes are in electrical contact with the electrical circuitry and the fixation elements increase the surface area of the biocompatible casing to reduce the likelihood that the biocompatible casing shifts after implantation;
摘要翻译：用于改善植入式脉冲发生器固定的系统和技术。在一个方面，一种装置包括可植入式脉冲发生器，该可植入脉冲发生器包括构造成产生电脉冲的电路和容纳电路的生物相容性壳体，并且其上安装有一组电极和一组固定元件。电极与电路电接触，并且固定元件增加了生物相容性外壳的表面积，以减少植入后生物相容性外壳移位的可能性;

39. 发明申请

US20090187221A1 PADDLE LEAD CONFIGURATIONS FOR ELECTRICAL STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 失效
标题翻译：用于电刺激系统的梯形引导配置及其制造和使用方法
公开(公告)号：US20090187221A1
公开(公告)日：2009-07-23
申请号：US12018397
申请日：2008-01-23
申请人： Andrew DiGiore , Greg Baldwin
发明人： Andrew DiGiore , Greg Baldwin
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/05 , A61N1/0553
摘要： A paddle lead includes a paddle body with a plurality of electrodes disposed on the paddle body. The plurality of electrodes includes a first electrode and a second electrode. The first electrode and the second electrode are disposed laterally around the circumference of the paddle body. At least one connecting wire is disposed on, or within, the paddle body to electrically couple the first electrode and the second electrode.
摘要翻译：桨引线包括具有设置在桨体上的多个电极的桨体。多个电极包括第一电极和第二电极。第一电极和第二电极围绕桨体的圆周横向设置。至少一个连接线设置在桨体上或其内部，以电耦合第一电极和第二电极。

40. 发明申请

US20090082835A1 Apparatus and Methods For Charging An Implanted Medical Device Power Source 有权
标题翻译：一种植入式医疗器械电源充电装置及方法
公开(公告)号：US20090082835A1
公开(公告)日：2009-03-26
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译：用于对植入的医疗装置充电的装置和方法。

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