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31. 发明授权

US09835529B2 Biological specimen handling apparatus and method 有权
公开(公告)号：US09835529B2
公开(公告)日：2017-12-05
申请号：US14189894
申请日：2014-02-25
申请人： SAKURA FINETEK U.S.A., INC.
发明人： James B. McCormick
IPC分类号： G01N1/36
CPC分类号： G01N1/36
摘要： In accordance with one aspect of the invention, a mold is provided for receiving a tissue specimen and molten embedding material that improves the ease of withdrawing the embedded tissue specimen. The mold has a barrier coating intimately bonded to one or more surfaces of the mold that repels the attraction of the embedding material to the one or more mold surfaces and produces a positive meniscus of the embedding material in the mold. The barrier coating permits the mold to be re-used without needing to manually re-apply a release agent to the mold before using the mold. Further, the barrier coating permits the use of more aggressive draft angles than conventional molds by reducing the frictional engagement between the embedding material and the mold cavity surfaces.

32. 发明授权

US09573278B2 Integrated tissue processing and embedding systems, and methods thereof 有权
标题翻译：综合组织处理和嵌入系统及其方法
公开(公告)号：US09573278B2
公开(公告)日：2017-02-21
申请号：US14479990
申请日：2014-09-08
申请人： SAKURA FINETEK U.S.A., INC.
发明人： Gilles Lefebvre , Robert E. Evans
IPC分类号： B08B7/00 , B08B7/04 , B25J11/00 , G01N1/36 , G05B15/00 , G05B15/02
CPC分类号： B25J11/00 , B08B3/022 , B08B7/00 , B08B7/04 , G01N1/36 , G05B15/02 , Y10S901/02
摘要： Apparatus and methods for integrating tissue processors and embedding systems. An apparatus, of one aspect, includes a robot. The robot has a work envelope that encompasses a location having a tissue holder and an input of an embedding system. The tissue holder has at least one processed tissue. The robot is configured to transfer the tissue holder from the location to the input of the embedding system. A method, of one aspect, may include moving a robot to a location having a tissue holder. The tissue holder may have at least one processed tissue. The robot may engage with the tissue holder at the location. The robot may move the tissue holder from the location to an input to an embedding system. The robot may disengage from the tissue holder at the input to the embedding system. Other methods, apparatus, and systems are also disclosed.
摘要翻译：用于整合组织处理器和嵌入系统的装置和方法。一方面，一种装置包括机器人。机器人具有包括具有组织保持器和嵌入系统的输入的位置的工作信封。组织保持器具有至少一个处理过的组织。机器人被配置为将组织保持器从位置传送到嵌入系统的输入。一个方面的方法可以包括将机器人移动到具有纸巾支架的位置。组织保持器可以具有至少一个处理过的组织。机器人可以在位置处与组织保持器接合。机器人可以将组织保持器从位置移动到输入到嵌入系统。机器人可以在嵌入系统的输入处从组织保持器脱离。还公开了其它方法，装置和系统。

33. 发明授权

US09005980B2 Traceability for automated staining system 有权
标题翻译：自动染色系统的可追溯性
公开(公告)号：US09005980B2
公开(公告)日：2015-04-14
申请号：US14057888
申请日：2013-10-18
申请人： Sakura Finetek U.S.A., Inc.
发明人： Robert E. Evans , Anthony L. Hartman , Richard A. Suchter , Gilles Lefebvre
IPC分类号： G01N35/02 , G06F17/24 , G01N35/00 , G01N1/31
CPC分类号： G06F17/245 , G01N1/312 , G01N35/00732 , Y10T436/115831 , Y10T436/2575
摘要： A method including automatically displaying information obtained from a first identifier associated with a slide and a second identifier associated with a reagent cartridge. The method further including generating a staining log based on the information obtained from the first identifier and the second identifier. A further method includes displaying a location of a slide within a sample processing system and information obtained from a first identifier associated with the slide in a first table and displaying a location of a reagent cartridge within a sample processing system and information obtained from a second identifier associated with the reagent cartridge in a second table. The first table is then aligned with the second table.
摘要翻译：一种方法，包括自动显示从与幻灯片相关联的第一标识符获得的信息和与试剂盒相关联的第二标识符。该方法还包括基于从第一标识符和第二标识符获得的信息生成染色日志。另一种方法包括在样本处理系统内显示幻灯片的位置以及从第一表中与幻灯片相关联的第一标识符获得的信息，并显示样本处理系统内的试剂盒的位置以及从第二标识符获得的信息与第二表中的试剂盒相关联。然后将第一个表与第二个表对齐。

34. 发明授权

US08752732B2 Fluid dispensing system 有权
标题翻译：流体分配系统
公开(公告)号：US08752732B2
公开(公告)日：2014-06-17
申请号：US13018609
申请日：2011-02-01
申请人： Robert E. Evans , Wolfgang Mueller , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
发明人： Robert E. Evans , Wolfgang Mueller , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
IPC分类号： B67B7/00
CPC分类号： B05B11/048 , A47K5/1215 , B01L3/523 , B01L2200/0605 , B01L2200/141 , F04B43/08
摘要： An apparatus including a fluid reservoir and a compressible metering chamber including a first end coupled to the fluid reservoir and a second end. The apparatus further including a valve coupled to the second end of the metering chamber and a nozzle coupled to the valve. A system including linearly translatable cartridge mounting assembly having a plurality of fluid dispensing cartridge mounting stations and a plurality of fluid dispensing cartridges mounted to respective fluid dispensing cartridge mounting stations. The system further including a plurality of compression assemblies coupled to respective fluid dispensing cartridges and a receiving assembly positioned beneath the mounting assembly. A method includes positioning a fluid dispensing cartridge comprising a fluid reservoir and a metering chamber over a sample retaining member, applying a compressive force to the metering chamber to eject a predetermined amount of fluid and removing the compressive force to refill the metering chamber.
摘要翻译：一种包括流体储存器和可压缩计量室的装置，包括联接到流体储存器的第一端和第二端。该装置还包括联接到计量室的第二端的阀和连接到阀的喷嘴。一种包括具有多个流体分配盒安装台和安装到相应的流体分配盒安装台的多个流体分配盒的线性平移盒安装组件的系统。该系统还包括耦合到相应流体分配盒的多个压缩组件和位于安装组件下方的接收组件。一种方法包括将包括流体储存器和计量室的流体分配筒定位在样品保持构件上方，向计量室施加压缩力以排出预定量的流体并去除压缩力以重新填充计量室。

35. 发明申请

US20130164781A1 AUTOMATED SYSTEM AND METHOD OF PROCESSING BIOLOGICAL SPECIMENS 有权
标题翻译：自动化系统和处理生物样本的方法
公开(公告)号：US20130164781A1
公开(公告)日：2013-06-27
申请号：US13768953
申请日：2013-02-15
申请人： Gilles Lefebvre
发明人： Gilles Lefebvre
IPC分类号： G01N1/31
CPC分类号： G01N35/00029 , G01N1/06 , G01N1/30 , G01N1/312 , G01N35/00732 , G01N35/00871 , G01N35/0092 , G01N35/04 , G01N2035/00039 , G01N2035/00138 , G01N2035/00851 , Y10T436/2575
摘要： An apparatus including at least one of a stainer module and a coverslipper module; an imaging module; a storage module; an automated transport module for transporting at least one slide between at least one of the stainer module and the coverslipper module, the imaging module and the storage module; and a controller. A method including processing at least one slide; determining whether an imaging module is available for imaging of a biological specimen on the at least one slide; transporting the at least one slide to the imaging module using an automated transport module; and transporting the at least one slide to a storage module using the automated transport module when it is determined that the imaging module is not available. A system including a processing module for processing at least one slide including a biological specimen thereon. A machine readable medium.
摘要翻译：一种包括染色器模块和盖玻片模块中的至少一个的装置; 成像模块; 存储模块; 用于在至少一个染色器模块和盖玻片模块，成像模块和存储模块之间传送至少一个滑块的自动传送模块; 和控制器。一种方法，包括处理至少一个幻灯片; 确定成像模块是否可用于所述至少一个载片上的生物样本的成像; 使用自动传送模块将所述至少一个幻灯片传送到所述成像模块; 以及当确定所述成像模块不可用时，使用所述自动运送模块将所述至少一个滑块运送到存储模块。一种系统，包括处理模块，用于在其上处理包括生物样本的至少一个载玻片。机器可读介质

36. 发明申请

US20120163680A1 AUTOMATED SYSTEM AND METHOD OF PROCESSING BIOLOGICAL SPECIMENS 有权
标题翻译：自动化系统和处理生物样本的方法
公开(公告)号：US20120163680A1
公开(公告)日：2012-06-28
申请号：US12979666
申请日：2010-12-28
申请人： Gilles Lefebvre
发明人： Gilles Lefebvre
IPC分类号： G01N1/30 , B65G1/00 , G06K9/00 , B25J9/00
CPC分类号： G01N35/00029 , G01N1/06 , G01N1/30 , G01N1/312 , G01N35/00732 , G01N35/00871 , G01N35/0092 , G01N35/04 , G01N2035/00039 , G01N2035/00138 , G01N2035/00851 , Y10T436/2575
摘要： An apparatus including at least one of a stainer module and a coverslipper module; an imaging module; a storage module; an automated transport module for transporting at least one slide between at least one of the stainer module and the coverslipper module, the imaging module and the storage module; and a controller. A method including processing at least one slide; determining whether an imaging module is available for imaging of a biological specimen on the at least one slide; transporting the at least one slide to the imaging module using an automated transport module; and transporting the at least one slide to a storage module using the automated transport module when it is determined that the imaging module is not available. A system including a processing module for processing at least one slide including a biological specimen thereon. A machine readable medium.
摘要翻译：一种包括染色器模块和盖玻片模块中的至少一个的装置; 成像模块; 存储模块; 用于在至少一个染色器模块和盖玻片模块，成像模块和存储模块之间传送至少一个滑块的自动传送模块; 和控制器。一种方法，包括处理至少一个幻灯片; 确定成像模块是否可用于所述至少一个载片上的生物样本的成像; 使用自动传送模块将所述至少一个幻灯片传送到所述成像模块; 以及当确定所述成像模块不可用时，使用所述自动运送模块将所述至少一个滑块运送到存储模块。一种系统，包括处理模块，用于在其上处理包括生物样本的至少一个载玻片。机器可读介质。

37. 发明授权

US07767152B2 Reagent container and slide reaction retaining tray, and method of operation 有权
标题翻译：试剂容器和滑动反应保持托盘及操作方法
公开(公告)号：US07767152B2
公开(公告)日：2010-08-03
申请号：US11346876
申请日：2006-02-03
申请人： Ronald H. Stead , Xuan S. Bui
发明人： Ronald H. Stead , Xuan S. Bui
IPC分类号： B01L3/00 , G01N35/00
CPC分类号： G01N1/312 , B01L3/502715 , B01L9/52 , B01L2300/041 , B01L2300/0822 , B01L2300/0877 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0677 , G01N35/00029 , G01N2035/00138 , Y10T436/11 , Y10T436/112499
摘要： A sample, or slide, retaining tray includes a reagent reservoir, or recess, and a reaction chamber. A slide, or other sample container, can be positioned on the sample retaining tray as desired, with a tissue specimen face down, between a platen on the tray and the slide. A reagent from the reservoir is rendered flowable, such as by heating, and flows from the reservoir into the reaction chamber. Optionally, reagents or other fluids can be provided from above, by dripping onto a drip surface of the sample retaining tray, or below via an inlet port in the platen.
摘要翻译：样品或滑动保持托盘包括试剂储存器，凹槽和反应室。幻灯片或其他样品容器可以根据需要定位在样品保持托盘上，组织样本面朝下，托盘上的压板和载玻片之间。来自储存器的试剂例如通过加热使其流动，并从储存器流入反应室。任选地，可以从上方通过经由压板中的入口滴落到样品保持盘的滴水表面上或下方来提供试剂或其它流体。

38. 发明申请

US20070272710A1 Fluid dispensing apparatus 有权
标题翻译：流体分配装置
公开(公告)号：US20070272710A1
公开(公告)日：2007-11-29
申请号：US11441668
申请日：2006-05-25
申请人： Xuan S. Bui
发明人： Xuan S. Bui
IPC分类号： B65D37/00
CPC分类号： B01L3/527 , B01L3/0265 , B01L2400/0481 , B01L2400/0605 , B05B11/00446 , B05B11/3002 , B05B11/3015 , B05B11/3016 , B05B11/3069 , G01F11/08 , G01N35/1002 , Y10T436/2575
摘要： A fluid dispensing apparatus includes a fluid reservoir and a dispensing assembly. The dispensing assembly includes a housing and a deformable member that define a metering chamber that is configured to receive a predetermined volume of fluid from the fluid reservoir. The deformable member is deformed from a rest position to an eject position and the deformation causes the volume of the metering chamber to change which results in a change in fluid pressure within the metering chamber. An increase in the fluid pressure within metering chamber causes a predetermined volume of fluid within the metering chamber to be ejected and a decrease in the fluid pressure within the metering chamber causes fluid to be drawn into the metering chamber from the reservoir.
摘要翻译：流体分配装置包括流体储存器和分配组件。分配组件包括壳体和可变形构件，所述可变形构件限定计量腔室，其配置成从流体储存器接收预定体积的流体。可变形构件从静止位置变形到排出位置，并且变形导致计量室的体积改变，这导致计量室内的流体压力的变化。计量腔内的流体压力的增加导致计量腔内的预定体积的流体被喷射并且计量腔内的流体压力的降低导致流体从储存器被吸入计量腔室。

39. 发明授权

US5865081A Anti-roll rake 失效
标题翻译：防滚耙
公开(公告)号：US5865081A
公开(公告)日：1999-02-02
申请号：US410727
申请日：1995-03-27
申请人： John Charles Myers
发明人： John Charles Myers
IPC分类号： G01N1/06 , B26D7/06
CPC分类号： G01N1/06 , Y10T83/2098 , Y10T83/2179 , Y10T83/2181 , Y10T83/219 , Y10T83/2216 , Y10T83/576 , Y10T83/9457
摘要： An apparatus for cutting thin tissue sections using an anti-roll rake. The anti-roll rake comprises a rake head for engaging the cut tissue section and leading it away from the specimen block without rolling. The rake head is hingedly mounted to a mounting surface in the cutting instrument by way of a linkage assembly in order to provide freedom of movement between the various operational and non-operational positions.
摘要翻译：一种使用防倾斜耙切割薄组织切片的装置。防倾斜耙包括用于接合切割的组织部分并且将其从样品块导出而不滚动的前刀头。前刀头通过连杆组件铰接地安装在切割工具中的安装表面上，以便提供各种操作位置和非操作位置之间的移动自由度。

40. 发明申请

US20220018735A1 Forceps with Replaceable Tips 有权
公开(公告)号：US20220018735A1
公开(公告)日：2022-01-20
申请号：US17368765
申请日：2021-07-06
申请人： SAKURA FINETEK U.S.A., INC.
发明人： Joshua Greenlee , Erico von Bueren , Robert Jeffrey Sheppard
IPC分类号： G01N1/08 , G01N1/28 , B25B9/02
摘要： Handheld forceps comprising: a body comprising trunk and a first arm and a second arm extending from a base of the trunk coupled at one end and separated from one another at a second end; a rod disposed in the body, the rod comprising a first end positioned in the first arm and a second end positioned in the second arm and forming an apex in the trunk; a compression spring disposed around the apex of the rod in the trunk; and a button coupled to the apex of the rod and protruding through an opening in the trunk. Also a method of using the handheld forceps.

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