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31. 发明公开

EP1378576A1 Storing and detecting nucleic acid administered to a solid carrier 审中-公开
标题翻译： Aufbewahrung und Nachweis von auf einen festenTrägeraufgetragenenNukleinsäuren
公开(公告)号：EP1378576A1
公开(公告)日：2004-01-07
申请号：EP02077697.7
申请日：2002-07-04
申请人： PrimaGen Holding B.V.
发明人： de Rooij, Esther Regina , de Baar, Marinus Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/703 , C12Q2545/114 , C12Q2565/518
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl, more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.
摘要翻译：本发明提供了一种用于在至少一个样品中检测感兴趣的核酸的方法，包括将所述样品施用于至少部分吸收所述样品的固体载体，干燥所述载体，至少提供所述载体的代表性部分核酸分离溶液，使得所述核酸的代表量从所述载体提取，并检测所述代表量的所述核酸。通过本发明的方法，诸如体液样品的样品被稳定，使得其可以从服用部位（例如在较不发达国家的当地医院或实验室）运送并被发送到通过物流手段，通过世界其他地方的服务测试实验室。优选地，向所述载体施用至少100μl，更优选至少250μl样品，以便检测感兴趣的低滴度滴度。还提供了用于检测，鉴定和/或定量样品中感兴趣的核酸的试剂盒，其包含至少部分吸收所述样品的固体载体和核酸分离溶液。

32. 发明公开

EP1229130A3 Tests based on nucleic acids of endosymbiont cellular organelles and compounds identifiable therewith 有权
标题翻译：上被识别它能够基于核酸内共生细胞器和测试化合物
公开(公告)号：EP1229130A3
公开(公告)日：2003-10-22
申请号：EP01204688.4
申请日：2001-12-04
申请人： PrimaGen Holding B.V.
发明人： van Gemen, Bob , de Ronde , Anthonij , Timmermans, Eveline Catherina Anna Clasina , Dobbelaer, Irene Johanna Monica
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6809 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2545/101
摘要： The invention relates to the diagnosis of disease or the determination of functioning of cellular organisms, being of multi-cellular or unicellular nature, being visible by the naked eye or being a micro-organism. The invention provides a method for determining functioning of a cellular organism comprising determining the relative ratio of a first endosymbiont cellular organelle nucleic acid and/or gene product thereof in a sample obtained from said organism in relation to the amount of a second nucleic acid and/or gene product thereof.

33. 发明公开

EP1907414A2 PARECHOVIRUS, VACCINES, MEDICAMENTS AND DIAGNOSTIC KITS 审中-公开
标题翻译： PARECHOVIRUS，疫苗，诊断试剂盒及药物
公开(公告)号：EP1907414A2
公开(公告)日：2008-04-09
申请号：EP06783845.8
申请日：2006-07-14
申请人： PrimaGen Holding B.V.
发明人： BENSCHOP, Kimberly Samantha Meriaha , SCHINKEL, Cornelia Johanna , LUKEN, Manon Elisabeth Maria , VAN DEN BROEK, Petrus Johannes Maria
IPC分类号： C07K14/085 , C12N15/41 , C12N7/00 , A61K39/125 , C12N15/15 , G01N33/53
CPC分类号： C12N7/00 , A61K2039/525 , C12N2770/32511 , C12N2770/32521
摘要： The invention provides a new parechoviral serotype called HPEV 251176, and functional parts, derivatives and analogues of said virus. Compounds capable of specifically binding HPEV 251176, such as isolated or recombinant antibodies and T cells, are also herewith provided. Immunogenic compositions, vaccines, pharmaceutical compositions and diagnostic kits comprising said virus, amino acid sequence or compound are also provided, as well as methods for producing same. A diagnostic kit of the invention may as well comprise a primer/probe capable of amplifying and/or hybridising at least part of the genome of HPEV 251176.

34. 发明公开

EP1807532A2 METHODS USING MITOCHONDRIAL NUCLEIC ACID FOR DETERMINING A HEALTH STATUS OF AN INDIVIDUAL 有权
标题翻译：程序用于确定个人的健康状态从NUCLEIC线粒体的用途
公开(公告)号：EP1807532A2
公开(公告)日：2007-07-18
申请号：EP05797967.6
申请日：2005-10-28
申请人： PrimaGen Holding B.V. , UMC Utrecht Holding B.V.
发明人： PENNING, Maarten Tjerk , MAAS, Henriette Catharina Gerarda Irene Martina , DE BAAR, Marinus Petrus , VOEST, Emile Eugene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6865 , C12Q2545/101
摘要： The invention describes means and methods for determining mitochondrion bound nucleic acid and describes the use thereof in diagnostics. Preferable cell free mitochondrion bound nucleic acid is determined.

35. 发明公开

EP1725679A1 DIAGNOSIS OF (A RISK OF) DISEASE AND MONITORING OF THERAPY 有权
标题翻译：监视器使用的mRNA ACC133肿瘤治疗
公开(公告)号：EP1725679A1
公开(公告)日：2006-11-29
申请号：EP05710924.1
申请日：2005-03-02
申请人： PrimaGen Holding B.V. , UMC Utrecht Holding B.V.
发明人： PENNING, Maarten, Tjerk , VAN DEN BROEK, Sebastiaan, Johannes, Jacobus , VOEST, Emile, Eugene , BEEREPOOT, Laurens, Victor , MEHRA, Niven
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/142 , C12Q2600/158
摘要： The invention provides a method for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from said individual comprises an expression product of AC133 in an amount that is indicative for said disease or for the treatment thereof. Said amount is preferably quantified and compared with a reference value. In one aspect said amount is compared with an amount of said expression product present in a sample that was obtained from said individual before said treatment. A use of a nucleic acid molecule comprising at least part of a sequence of AC133 or an analogue thereof for monitoring a treatment of an individual suffering from a disease is also provided, as well as a diagnostic kit comprising such nucleic acid molecule.

36. 发明公开

EP1639134A2 HMG COENZYME A REDUCTASE INHIBITORS AFFECT THE MITOCHONDRIAL DNA CONTENT OF CELLS 审中-公开
标题翻译： HMG-CoA还原酶的抑制剂AFFECT细胞线粒体的DNA含量
公开(公告)号：EP1639134A2
公开(公告)日：2006-03-29
申请号：EP04748698.0
申请日：2004-07-01
申请人： PrimaGen Holding B.V.
发明人： VAN GEMEN, Bob , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/16
摘要： Statins are widely used for the treatment of high cholesterol levels. In the present invention the effect of statins on mitochondrial nucleic acid and the activation state of mitochondria is used in methods for determining whether a subject is at risk of developing side effects of statin treatment, methods for the treatment of a clinical symptom associated with reduced mitochondrial function. Further provided are kits and the like comprising a means for the detection of mitochondrial nucleic acid, or the activation of a mitochondrion for use in a method mentioned above.

37. 发明公开

EP1479761A1 New enterovirus, vaccines, medicaments and diagnostic kits 审中-公开
标题翻译： Neues Enterovirus，Vakzine，Medikamente und Diagnosekits
公开(公告)号：EP1479761A1
公开(公告)日：2004-11-24
申请号：EP03076529.1
申请日：2003-05-21
申请人： PrimaGen Holding B.V.
发明人： Maas, Henriette, Catharina, Gerarda, Irene , van den Broek, Petrus, Johannes, Maria , Mang, Rui
IPC分类号： C12N7/00 , A61K39/125 , C12Q1/70 , C07K14/085
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2770/32321 , C12N2770/32322 , C12Q1/701
摘要： The invention provides a new enteroviral species called Prima7, and functional parts, derivatives and analogues of said virus. Proteinaceous molecules capable of specifically binding Prima7, such as isolated or recombinant antibodies, are also herewith provided. A virus and/or proteinaceous molecule of the invention is particularly suitable for diagnosis of a Prima7 related disease. Vaccines, pharmaceutical compositions and diagnostic kits comprising said virus or proteinaceous molecule are also provided, as well as methods for producing same. A diagnostic kit of the invention may as well comprise a primer/probe capable of amplifying and/or hybridising the genome or part thereof of Prima7.
摘要翻译：本发明提供了一种称为Prima7的新型肠道病毒物种，以及所述病毒的功能部分，衍生物和类似物。还可以提供能够特异性结合Prima7的蛋白质分子，例如分离的或重组的抗体。本发明的病毒和/或蛋白质分子特别适用于诊断Prima7相关疾病。还提供了包含所述病毒或蛋白质分子的疫苗，药物组合物和诊断试剂盒，以及其制备方法。本发明的诊断试剂盒还可以包含能够扩增和/或杂交Prima7的基因组或其部分的引物/探针。

38. 发明公开

EP1427860A2 STORING AND DETECTING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 有权
标题翻译：存储并固定在载体应用NUCLEIC定量
公开(公告)号：EP1427860A2
公开(公告)日：2004-06-16
申请号：EP03738785.9
申请日：2003-07-03
申请人： PrimaGen Holding B.V.
发明人： DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/703 , C12Q2545/114 , C12Q2565/518
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl , more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.

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