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31. 发明申请

WO1991003242A1 ANTIVIRAL DRUG 审中-公开
标题翻译：抗病毒药物
公开(公告)号：WO1991003242A1
公开(公告)日：1991-03-21
申请号：PCT/JP1990001141
申请日：1990-09-06
申请人： NIPPON SHINYAKU CO., LTD. , YOSHIKUNI, Yoshiaki , NAKANE, Masayuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K31/445
CPC分类号： C07D211/46 , A61K31/445
摘要： Some of the compounds represented by general formula (I) have been found to have an especially excellent antiviral action including HIV virus inhibition (I), wherein R represents (α) or (β), R6 represents hydrogen or lower alkyl, t is 1 or 2, a symbol ----- represents either a single bond or a double bond, and R11 represents chlorine or fluorine.

32. 发明申请

WO1997040046A1 BENZOQUINOLIZINE DERIVATIVES AND MEDICINAL COMPOSITIONS 审中-公开
标题翻译：苯并喹啉衍生物和药物组合物
公开(公告)号：WO1997040046A1
公开(公告)日：1997-10-30
申请号：PCT/JP1997001320
申请日：1997-04-17
申请人： NIPPON SHINYAKU CO., LTD. , YAMAMOTO, Osamu , SHIROUCHI, Yoshiaki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D455/04
CPC分类号： C07D455/06 , A61K31/473 , C07D455/04
摘要： Benzoquinolizine derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and medicinal compositions containing the same as the active ingredients, wherein R represents hydroxy or alkoxy; R represents hydrogen, hydroxy or alkoxy; R represents alkyl optionally substituted by hydroxy, alkoxy, amino, monoalkylamino or dialkylamino; and R represents alkyl optionally substituted by hydroxy or alkoxy, aryl optionally sustituted by alkyl, halogeno, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino, monoalkylamino or dialkylamino. Because of being capable of regulating the gastro-intestinal tract motion, these compounds are efficacious in the treatment of irritable bowel syndrome.
摘要翻译：由通式（1）表示的苯并喹嗪衍生物，其药学上可接受的盐和含有与活性成分相同的药物组合物，其中R 1表示羟基或烷氧基; R 2表示氢，羟基或烷氧基; R 3表示任选被羟基，烷氧基，氨基，单烷基氨基或二烷基氨基取代的烷基; 并且R 4表示任选被羟基或烷氧基取代的烷基，任选被烷基，卤代，羟基，烷氧基，氨基，单烷基氨基或二烷基氨基，单烷基氨基或二烷基氨基取代的芳基。由于能够调节胃肠道运动，这些化合物对肠易激综合征的治疗是有效的。

33. 发明申请

WO1997031928A1 TRISACCHARIDE 1-DEOXYMANNOJIRIMYCIN DERIVATIVES 审中-公开
标题翻译：三氯乙酸1-脱氧甘露糖苷衍生物
公开(公告)号：WO1997031928A1
公开(公告)日：1997-09-04
申请号：PCT/JP1997000593
申请日：1997-02-27
申请人： NIPPON SHINYAKU CO., LTD. , OHGI, Tadaaki , KYOTANI, Yosuke , OGAWA, Hirotsugu , TANIGUCHI, Naoyuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H15/26
CPC分类号： C07H15/26
摘要： 1-Deoxymannojirimycin derivatives of general formula (I) useful as cancer remedies and ligands for Gnt-V affinity chromatography: wherein R1 is hydrogen, acetyl, benzyl, butoxycarbonyl or optionally hydroxylated, cyanated or aminated linear or branched alkyl having 11 or less carbon atoms; R2 is hydrogen or hydroxyl; and R3 is an acidic group or aminoalkylcarbonyl.
摘要翻译：可用作癌症治疗剂和Gnt-V亲和层析的配体的通式（I）的1-脱氧吗啉霉素衍生物：其中R1是氢，乙酰基，苄基，丁氧基羰基或任选羟基化，氰化或胺化的具有11个或更少碳原子的直链或支链烷基 ; R2是氢或羟基; 并且R 3是酸性基团或氨基烷基羰基。

34. 发明申请

WO1997000881A1 MORANOLINE DERIVATIVES 审中-公开
标题翻译：摩尔衍生物
公开(公告)号：WO1997000881A1
公开(公告)日：1997-01-09
申请号：PCT/JP1996001730
申请日：1996-06-21
申请人： NIPPON SHINYAKU CO., LTD. , HASEGAWA, Akira , OHGI, Tadaaki , SETO, Takashi , MORI, Kazuya
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H17/02
CPC分类号： C07H17/02
摘要： Moranoline derivatives represented by structural formula (I), wherein R represents lower alkyl substituted by acyl, alkoxycarbonyl, cyano, alkylcarbamoyl, nitro, acylamino, alkylthio, hydroxy or aryloxy, phenyl-lower alkyl wherein the benzene ring optionally has substituent(s) such as hydroxy, lower alkoxy, lower alkyl, halogeno, cyano, lower alkylcarbamoyl, nitro, acylamino, alkylthio or carboxy, lower alkyl substituted by a 5-membered unsaturated heterocycle optionally substituted by lower alkyl, alkenyl, arylalkenyl or higher alkyl; R and R are different from each other and each represents galactopyranosyl or fucopyranosyl substituted by hydroxysulfonyl or a metal salt thereof; and R represents hydroxy or acetamide. The compounds are useful in the medicinal field, for example, as an antiinflammatory agent or a preventive or remedy for ischemia and reflow disorders.
摘要翻译：烷氧基羰基，氰基，烷基氨基甲酰基，硝基，酰氨基，烷硫基，羟基或芳氧基，其中苯环任选具有取代基的苯基 - 低级烷基（其中R 1表示被酰基，烷氧基羰基，氰基，羟基，低级烷氧基，低级烷基，卤代，氰基，低级烷基氨基甲酰基，硝基，酰氨基，烷硫基或羧基，被任选被低级烷基，烯基，芳基烯基或更高级烷基取代的5元不饱和杂环取代的低级烷基; R 2和R 3彼此不同，并且各自表示被羟基磺酰基或其金属盐取代的吡喃半乳糖基或糠醛吡喃糖基酯; R 4代表羟基或乙酰胺。该化合物可用于药用领域，例如作为抗炎剂或用于缺血和回流障碍的预防或治疗。

35. 发明申请

WO1996032945A1 NEOVASCULARIZATION INHIBITOR 审中-公开
标题翻译：新生血管抑制剂
公开(公告)号：WO1996032945A1
公开(公告)日：1996-10-24
申请号：PCT/JP1996001069
申请日：1996-04-19
申请人： NIPPON SHINYAKU CO., LTD. , UEDA, Fusao , KATOH, Fumitaka
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K31/53
CPC分类号： A61K31/53
摘要： A neovascularization inhibitor which comprises as the active ingredient a compound represented by general formula (I) or its salt or a solvate of the same. In formula (I), R represents hydrogen or optionally substituted alkyl, aralkyl, arylalkenyl or aryl and R represents optionally substituted alkyl, aralkyl, arylalkenyl or aryl. Alternatively, R and R together with N to which they are bonded may form 4- to 8-membered cyclic amino NR R optionally having N, O or S in addition to the above-mentioned N and substituent(s).
摘要翻译：一种新血管形成抑制剂，其包含作为活性成分的由通式（I）表示的化合物或其盐或其溶剂合物。在式（I）中，R 1表示氢或任选取代的烷基，芳烷基，芳基烯基或芳基，R 2表示任选取代的烷基，芳烷基，芳基烯基或芳基。或者，R 1和R 2与它们所键合的N一起可以形成任选具有N，O或S的4-至8-元环氨基NR 1 R 2，所述N和取代基。

36. 发明申请

WO1995035157A1 EMULSION MANUFACTURING METHOD OF EMULSIFIER 审中-公开
标题翻译：乳化剂的乳液制造方法
公开(公告)号：WO1995035157A1
公开(公告)日：1995-12-28
申请号：PCT/JP1995001209
申请日：1995-06-19
申请人： NIPPON SHINYAKU CO., LTD. , SAHEKI, Akira , SEKI, Junzo
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： B01F03/08
CPC分类号： B01F5/0662 , B01F3/0811 , B01F5/0256 , B01F5/0268 , B01F5/0609 , B01F5/0647 , B01F5/0648 , B01F5/0651 , B01F5/068 , Y10S514/941 , Y10S516/923 , Y10S516/928
摘要： An emulsion manufacturing method capable of providing an emulsion which comprises fine emulsion particles with a lower energy supply than in the conventional method of this kind, and providing easily an emulsion comprising uniform fine emulsion particles. The method is characterized in that a back pressure which is not less than 0.2 % and less than 5 % of the pressure applied to point of high-pressure emulsification in a high-pressure emulsification unit is exerted on a raw material during the manufacturing of an emulsion in a high-pressure emulsifier. The back pressure can be obtained by providing a discharge unit with, for example, a device having a pipe the inner diameter of which is smaller than that of a pipe in the discharge unit.
摘要翻译：一种能够提供乳液的乳液制造方法，该乳液包含比常规方法中更低能量供应的细乳液颗粒，并且容易地提供包含均匀的细乳液颗粒的乳液。该方法的特征在于，在制造高压乳化装置时，在原料上施加不低于施加于高压乳化装置的高压乳化点的压力的0.2％且小于5％的背压乳液在高压乳化剂中。背压可以通过设置具有例如具有其内径小于排出单元中的管的管的装置的排出单元来获得。

37. 发明申请

WO1995031900A1 PESTICIDE COMPOSITION, PRODUCTION PROCESS, AND PESTICIDAL PREPARATION 审中-公开
标题翻译：杀虫剂组合物，生产工艺和杀虫剂制剂
公开(公告)号：WO1995031900A1
公开(公告)日：1995-11-30
申请号：PCT/JP1995000987
申请日：1995-05-23
申请人： NIPPON SHINYAKU CO., LTD. , NAKAMICHI, Kouichi , IZUMI, Shougo , YASUURA, Hiroyuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A01N25/10
CPC分类号： A01N25/10
摘要： A pesticide composition fixable on the surface of the top soil layer of a paddy field, which has a configuration entirely different from that of conventional pesticide compositions for paddy field. It is characterized in that (1) the pesticidally active ingredient thereof is dispersed or dissolved in a macromolecular compound which swells by forming a gel in water and (2) it has an apparent specific gravity of at least 1 at least until it reaches the surface of the top soil layer of a paddy field. The composition expands in water to undergo a volume increase, thus being effectively prevented from being embedded under the surface of the top soil layer.
摘要翻译：农药组合物可固定在稻田顶层土壤表面，其具有与用于稻田的常规农药组合物完全不同的构型。其特征在于，（1）其杀虫活性成分分散或溶解在通过在水中形成凝胶而溶胀的高分子化合物，和（2）至少具有至少1的表观比重至少达到表面的稻田顶层土层。组合物在水中膨胀以进行体积增加，从而有效地防止其嵌入顶层土壤表面。

38. 发明申请

WO1995026970A1 MORANOLINE DERIVATIVE 审中-公开
标题翻译：摩尔衍生物
公开(公告)号：WO1995026970A1
公开(公告)日：1995-10-12
申请号：PCT/JP1995000610
申请日：1995-03-30
申请人： NIPPON SHINYAKU CO., LTD. , HASEGAWA, Akira , KISO, Makoto , YOSHIKUNI, Yoshiaki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H17/02
CPC分类号： C07H17/02
摘要： A trisaccharide Lewis sugar-chain antigen derivative having a novel structure involving a moranoline represented by general formula (I) and being useful as a medicine, wherein R represents hydrogen or lower alkyl; and R and R represent each independently galactopy-ranosyl or fucopyranosyl each substituted by hydroxysulfonyl or a metal salt thereof. It has a cell adhesion inhibitor activity and is useful for preventing or treating inflammation and accompanying thrombus formation, rheumatism, immunopathy, viral infection and cancer.
摘要翻译：一种具有由通式（I）表示的山梨糖醇的新型结构并可用作药物的三糖路易斯糖链抗原衍生物，其中R 1表示氢或低级烷基; R 2和R 3各自独立地表示各自被羟基磺酰基或其金属盐取代的半乳糖 - 乳糖基或糠醛。它具有细胞粘附抑制剂活性，可用于预防或治疗炎症和伴随的血栓形成，风湿病，免疫病，病毒感染和癌症。

39. 发明申请

WO1995026969A1 MORANOLINE DERIVATIVE 审中-公开
标题翻译：摩尔衍生物
公开(公告)号：WO1995026969A1
公开(公告)日：1995-10-12
申请号：PCT/JP1995000609
申请日：1995-03-30
申请人： NIPPON SHINYAKU CO., LTD. , HASEGAWA, Akira , KISO, Makoto , YOSHIKUNI, Yoshiaki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H17/02
CPC分类号： A61K31/706 , C07H17/02
摘要： A compound represented by general formula (I), wherein R represents C8-C30 alkyl, C8-C30 alkenyl or C8-C30 alkynyl; and R and R represent each independently galactosyl, sialylgalactosyl or fucosyl. It is useful for treating inflammation and accompanying thrombus formation, asthma and rheumatism, and preventing and treating immunopathy and cancer, because it has a cell adhesion inhibitor activity and antagonistically inhibit secretin.
摘要翻译：由通式（I）表示的化合物，其中R 1表示C 8 -C 30烷基，C 8 -C 30烯基或C 8 -C 30炔基; R 2和R 3各自独立地表示半乳糖基，唾液酸半乳糖基或岩藻糖基。因为它具有细胞粘附抑制剂活性并拮抗抑制促胰液素，因此可用于治疗炎症和伴随的血栓形成，哮喘和风湿病以及预防和治疗免疫病和癌症。

40. 发明申请

WO1995019758A1 HAIR-CARE COMPOSITION 审中-公开
标题翻译：头发护理组合物
公开(公告)号：WO1995019758A1
公开(公告)日：1995-07-27
申请号：PCT/JP1995000083
申请日：1995-01-25
申请人： SHISEIDO COMPANY, LTD. , NIPPON SHINYAKU CO., LTD. , KOMASAKI, Hisayuki , OHTA, Masahiro , SAKAMOTO, Okihiko , HANZAWA, Chika , TUJI, Yoshiharu , SAKAI, Tetsuya , KANDORI, Kazuhisa , SANO, Akira
发明人： SHISEIDO COMPANY, LTD. , NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K07/06
CPC分类号： A61K8/4913 , A61K8/97 , A61Q7/00
摘要： A hair-care composition containing as the active ingredient at least one member selected from among bis-tetrahydrofuran analogs and esters thereof originating in a plant of the family Annonaceae; the use of the bis-tetrahydrofuran compounds, in particular, a method of preventing depilation or promoting hair growth by administering the compounds to the scalp; and the use of the above compounds in the preparation of the hair-care composition.
摘要翻译：一种护发组合物，含有作为活性成分的至少一种选自源自芸香科植物的双 - 四氢呋喃类似物和酯类; 使用双 - 四氢呋喃化合物，特别是通过向头皮施用化合物来防止脱毛或促进毛发生长的方法; 以及使用上述化合物来制备护发组合物。

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