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31. 发明公开

EP1750769A2 METHODS FOR MAKING INJECTABLE POLYMER HYDROGELS 有权
标题翻译：方法用于生产可注射的水凝胶聚合物
公开(公告)号：EP1750769A2
公开(公告)日：2007-02-14
申请号：EP05771131.9
申请日：2005-05-19
申请人： MENTOR CORPORATION
发明人： WANG, Wei
IPC分类号： A61K47/36
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/06 , A61K47/36 , C08B37/0072 , C08J3/075 , C08J3/246 , C08J2305/08 , C08L5/08
摘要： Processes for preparing injectable hydrogels, particularly hydrogels containing hyaluronan. The processes can include, for example, the steps of crosslinking one or more polymers to form a gel, washing the gel, purifying the gel, and homogenizing the gel to produce a hydrogel . Hydrogel products made by the described processes.

32. 发明授权

EP1286724B1 AUTOMATED RADIOISOTOPE SEED CARTRIDGE 有权
标题翻译：幻灯片自动磁带放射性同位素
公开(公告)号：EP1286724B1
公开(公告)日：2006-01-11
申请号：EP01950271.5
申请日：2001-06-05
申请人： MENTOR CORPORATION
发明人： ELLIOTT, Daniel, M. , HOEDEMAN, George, M. , BERKEY, John, J. , ELLIOTT, Jonathan, D.
IPC分类号： A61N5/10 , A61M37/00
CPC分类号： A61M37/0069 , A61N5/1007 , A61N5/1027 , A61N2005/1009 , A61N2005/101 , A61N2005/1011
摘要： An automated cartridge (14) for use in an automated system (12) for low dose radioisotope procedures is replaceable in the automated system and has a housing (80, 81, 82, 83, 84) that contains a selectively positionable member (54) having a plurality of radioisotope seeds (110) preloaded in chambers (54) defined in the positionable member. An aperture (50) in the housing allows an elongated member (62) to selectively eject radioisotope seeds from chambers in the positionable member when a given chamber is aligned with the aperture. A mechanism (32, 56) in the cartridge automatically positions the selectively positionable member in alignment with the aperture. Preferably, a feedback mechanism (64, 66) generates a positional feedback signal of a position of the chambers of the positionable member relative to the aperture.

33. 发明公开

EP0978361A3 Filling device and method for use in manufacturing of gel filled prostheses 审中-公开
标题翻译：填充装置和方法在凝胶填充假体的制备中使用
公开(公告)号：EP0978361A3
公开(公告)日：2001-08-08
申请号：EP99306021.9
申请日：1999-07-29
申请人： MENTOR CORPORATION
发明人： Rodgers, Kenneth W. , Strong, Gary D. , Christy, Michael C. , Mason, Russell C.
IPC分类号： B65B3/18 , B65B3/28 , B29C31/06 , B29C39/42 , B29C39/24 , A61F2/12
CPC分类号： B29C39/42 , A61F2/12 , A61F2/26 , B29C31/041 , B29C31/06 , B29C39/24 , B29C39/44 , B29L2031/7532
摘要： Filling device and method for use in manufacturing of gel filled prostheses which provides fast and accurate filling of prosthesis shells without deterioration of the gel or induction of Air into the prosthesis. The filling method utilizes a dual port cannula (44) for penetrating a preslit (63) fill port (64) on a prosthesis shell (68), the cannula having one port (42) coupled through a flexible tube (38) to a peristaltic pump (36) supplied with gel under pressure, and a second port (46) coupled through a flexible tube (50) to a vacuum system (56). The cannula and prosthesis shell being filled are supported on a scale (74), with the flexible tubes being disposed so that pressure variations in the tubes do not effect the scale readings. Various other novel aspects of the method and apparatus are disclosed.

34. 发明公开

EP0978361A2 Filling device and method for use in manufacturing of gel filled prostheses 审中-公开
标题翻译： Füllgerätund Verfahren benutzt bei der Herstellung von mit GelgefülltenProthesen
公开(公告)号：EP0978361A2
公开(公告)日：2000-02-09
申请号：EP99306021.9
申请日：1999-07-29
申请人： MENTOR CORPORATION
发明人： Rodgers, Kenneth W. , Strong, Gary D. , Christy, Michael C. , Mason, Russell C.
IPC分类号： B29C31/06 , B29C39/42 , B29C39/24 , A61F2/12
CPC分类号： B29C39/42 , A61F2/12 , A61F2/26 , B29C31/041 , B29C31/06 , B29C39/24 , B29C39/44 , B29L2031/7532
摘要： Filling device and method for use in manufacturing of gel filled prostheses which provides fast and accurate filling of prosthesis shells without deterioration of the gel or induction of Air into the prosthesis. The filling method utilizes a dual port cannula (44) for penetrating a preslit (63) fill port (64) on a prosthesis shell (68), the cannula having one port (42) coupled through a flexible tube (38) to a peristaltic pump (36) supplied with gel under pressure, and a second port (46) coupled through a flexible tube (50) to a vacuum system (56). The cannula and prosthesis shell being filled are supported on a scale (74), with the flexible tubes being disposed so that pressure variations in the tubes do not effect the scale readings. Various other novel aspects of the method and apparatus are disclosed.
摘要翻译：填充装置和用于制造凝胶填充的假体的方法，其提供假体壳的快速和准确的填充，而不会使凝胶变坏或将空气诱导到假体中。填充方法利用双端口套管（44）穿透假体外壳（68）上的预照射（63）填充口（64），所述套管具有通过柔性管（38）连接到蠕动状态的一个端口（42）在压力下供应凝胶的泵（36）和通过柔性管（50）耦合到真空系统（56）的第二端口（46）。填充的插管和假体外壳被支撑在刻度尺（74）上，柔性管被设置成使得管中的压力变化不影响刻度读数。公开了该方法和装置的各种其它新颖的方面。

35. 发明公开

EP0784987A3 Method of making in situ filler material for mammary, penile and testicular prosthesis and tissue expanders 失效
标题翻译：一种用于在原位的填充材料制备用于乳房，阴茎和睾丸假体，和组织扩张器过程
公开(公告)号：EP0784987A3
公开(公告)日：1999-04-07
申请号：EP97300087.0
申请日：1997-01-08
申请人： MENTOR CORPORATION
发明人： Purkait, Bobby
IPC分类号： A61L27/00
CPC分类号： A61L27/18 , A61F2/0059 , A61F2/12 , A61L27/16 , A61L27/20 , A61L27/52 , C08L5/08 , C08L5/04 , C08L1/26 , C08L39/06 , C08L33/26 , C08L29/04 , C08L75/04 , C08L67/04 , C08L71/02
摘要： An inflatable prosthesis which contains a dehydrated substance that forms a gel when mixed with an aqueous solution. The dehydrated substance is a biocompatible material such as an hydrophilic polymer which includes but is not limited to polyacrylamide, polyvinylprolidone, hydroxypropyl methylcellulose, polyvinyl alcohol, polyethylene oxides, polypropylene oxides, polyethylene glycol, polylactic, polyglycoloic acids, hydrogel polyurethane, chrondotoin sulfate, hyaluronic acid and alginate. The prosthesis includes a flexible inflatable outer shell that has an inner cavity. The inner cavity may contain the sterile dehydrated substance. The prosthesis is provided to the surgical site while the substance is in the dehydrated state. An initial volume of aqueous solution can be added to the inner cavity of the outer shell. The dehydrated substance combines with the aqueous solution to form a gel within the implant. The semi-inflated prosthesis can be implanted into a breast and inflated to a desired size with an additional volume of aqueous solution. The dehydrated substance may be coated along the inner surface of the prosthesis to form a lubricant which reduces crease-fold rupture. As an alternate embodiment, the dehydrated substance may be supplied in a package separate from the outer shell. An aqueous solution can be added to the package in situ to form a gel which can be subsequently added to the inner cavity of the outer shell.

36. 发明公开

EP0775474A3 Haptic attachment system for intraocular lenses using diode laser 失效
标题翻译：使用激光二极管上Intraohulerlinsen支撑元件紧固
公开(公告)号：EP0775474A3
公开(公告)日：1998-01-14
申请号：EP96308521.2
申请日：1996-11-26
申请人： MENTOR CORPORATION
发明人： O'Connor, John J. , Wissman, Lawrence Y.
IPC分类号： A61F2/14 , A61F2/16
CPC分类号： B29C66/69 , A61F2002/1686 , B29C65/1616 , B29C65/1638 , B29C65/1674 , B29C65/1687 , B29C65/169 , B29C66/71 , B29C66/7392 , B29C66/73921 , B29C66/7394 , B29D11/023 , B29K2023/12 , B29K2033/12 , B29L2011/0041
摘要： A system for staking a haptic to an optic to form an intraocular lens using a laser beam operating near the infrared range with a coaxial aiming laser beam operating in the visible range. A portion of the haptic is inserted into the optic through a radial bore and is exposed through an axial bore spanning from the optic upper surface to the radial bore. The coaxial laser beams are collimated and then focused using a microscope objective through the axial bores, onto the exposed haptic. Aiming of the coaxial beams onto the optic and haptic is aided by the use of a magnifying CCD camera. The coaxial lasers, which are typically focused to a minor diameter which is greater than or equal to the inner diameter of the axial bore, make contact with the exposed haptic. Consequently, the haptic is melted and is then allowed to cool, coalescing into a bead staking the haptic to the optic.

37. 发明公开

EP0710468A2 Method of texturing soft tissue implant using a porous mandrel and implants made thereby 失效
标题翻译：一种用于通过使用多孔模具的纹理化的软植入物的方法，从而verfertigte植入物
公开(公告)号：EP0710468A2
公开(公告)日：1996-05-08
申请号：EP95307557.9
申请日：1995-10-24
申请人： MENTOR CORPORATION
发明人： Pai, Suresh , Nicosia, Joseph M.
IPC分类号： A61F2/12 , A61F2/00
CPC分类号： A61F2/0077 , A61B90/02 , A61F2/12
摘要： A method of making a textured soft tissue implant and the implant made by the method are described. The implant is made by forming a shell over a mandrel made of a porous material. The porous material is preferably porous ceramic or porous plastic. The pores size is less than 300 microns and preferably in the range of 87 to 108 microns.
摘要翻译：描述一种制造带纹理的软组织植入物，以及由该方法制成的植入物的方法。所述植入物是由上方形成由多孔材料制成的心轴的壳制成。多孔材料是优选的多孔陶瓷或多孔塑料。毛孔大小小于300微米，优选在87至108微米的范围内。

38. 发明公开

EP0532162A1 Unitary inflatable penile prosthesis 失效
标题翻译： Einheitliche aufblasbare Penisprothese。
公开(公告)号：EP0532162A1
公开(公告)日：1993-03-17
申请号：EP92306227.7
申请日：1992-07-07
申请人： MENTOR CORPORATION
发明人： Bley, Robert
IPC分类号： A61F2/26
CPC分类号： A61F2/26
摘要： A factory preassembled, preferably partially prefilled three piece penile prosthesis that can be implanted in a patient as one pre-assembled unit and filled without any required further connection or purging of air. The prosthesis has a pair of inflatable cylinders (12) that can be implanted into the corpora cavernosa regions of the penis, the inflatable cylinders preferably being attached to a solid rear portion (20) to which the various tubing is connected. The prosthesis also has a reservoir (32') for implantation into the abdomen, a pump (14) for implantation into the scrotum for transferring fluid from the reservoir into the cylinders, and a controllable valve (42) associated with the pump for retaining the fluid within the cylinders and for controllably allowing it to escape from the cylinders back into the reservoir when desired. The volume of fluid within the preoperative prosthesis assembly is such that sufficient fluid may be readily displaced from the reservoir into the pump and cylinders to allow the reservoir to be inserted into the pelvic cavity of a patient without disconnecting the pump and cylinders. An alternate embodiment contemplates an unfilled prosthesis assembly, retaining the advantages of a preassembled unit in implantation time required and elimination of the potential for eventual connector failure.
摘要翻译：预先组装的工厂，优选部分预填充的三片阴茎假体，其可以作为一个预组装单元植入患者体内，并且在没有任何需要的进一步连接或排空空气的情况下进行填充。假体具有可以植入阴茎海绵体区域的一对可充气圆柱体（12），该可膨胀圆柱体优选地连接到各种管道连接到的实心后部（20）上。假体还具有用于植入腹部的储存器（32'），用于注入到阴囊中用于将流体从储存器传送到气缸中的泵（14）以及与泵相关联的可控阀（42），用于保持气缸内的流体，并且当需要时可控制地将其从气缸中排出回到储存器中。术前假体组件内的流体体积使得足够的流体可以容易地从储存器移动到泵和气缸中，以允许储存器插入患者的盆腔中而不断开泵和气缸。替代实施例考虑未填充的假体组件，将预组装的单元的优点保留在所需的植入时间中，并消除最终连接器故障的可能性。

39. 发明公开

EP0293256A1 Method of producing textured surface prosthesis implants 有权
标题翻译： Prothesenimplantat mitTexturoberflächeund Methode zu dessen Herstellung。
公开(公告)号：EP0293256A1
公开(公告)日：1988-11-30
申请号：EP88304881.1
申请日：1988-05-27
申请人： MENTOR CORPORATION
发明人： Yan, John Y.J. , Purkait, Bobby K.
IPC分类号： A61F2/12 , B29C43/02
CPC分类号： B29C43/021 , A61F2/12
摘要： A surgical prosthesis (5) is disclosed having a textured exterior surface (7) formed of non-absorbent material substantially free of pores and interstices. The invented device is usable for mammary and other implants. Various methods of manufacturing the device are also disclosed.
摘要翻译：公开了一种手术假体（5），其具有由基本上没有孔隙和间隙的非吸收材料形成的纹理外表面（7）。本发明的装置可用于乳房和其他植入物。还公开了制造该器件的各种方法。

40. 发明公开

EP1902688A1 Texturizing surfaces 有权转让
标题翻译： Oberflächentexturierung
公开(公告)号：EP1902688A1
公开(公告)日：2008-03-26
申请号：EP07018210.0
申请日：2007-09-17
申请人： MENTOR CORPORATION
发明人： Elshout, Robert
IPC分类号： A61F2/12 , B24C1/00
CPC分类号： B24C1/003 , A61F2/0077 , A61F2/12
摘要： A method for texturising a bodily implant, especially a breast implant, is described, comprising contacting the outer surface of the implant with dry ice particles. The implants made by the method are described as well.
摘要翻译：描述了用于对身体植入物，特别是乳房植入物进行纹理化的方法，包括使植入物的外表面与干冰颗粒接触。还描述了由该方法制成的植入物。

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