专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO1993025195A1 PREPARATION AND USE OF NOVEL CYCLODEXTRIN-BASED DISPERSIBLE COLLOIDAL SYSTEMS IN THE FORM OF NANOSPHERES 审中-公开
标题翻译：基于新型环糊精的不同胶体系统在纳米粒子中的制备与应用
公开(公告)号：WO1993025195A1
公开(公告)日：1993-12-23
申请号：PCT/FR1993000594
申请日：1993-06-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ... , SKIBA, Mohamed , WOUESSIDJEWE, Denis , COLEMAN, Antony , FESSI, Hatem , DEVISSAGUET, Jean-Philippe , DUCHENE, Dominique , PUISIEUX, Francis
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ...
IPC分类号： A61K09/51
CPC分类号： B01J13/08 , A61K8/0279 , A61K8/738 , A61K9/5161 , A61K9/5192 , A61K2800/413 , A61K2800/56 , A61Q19/00 , B82Y5/00 , Y10T428/1405 , Y10T428/2989
摘要： A nanoparticulate system prepared by: 1) preparing a liquid phase essentially consisting of a solution of cyclodextrin modified by acyl groups in an organic solvent or solvent mixture, an active molecule being optionally added thereto; 2) preparing a second liquid phase essentially consisting of water or an aqueous mixture optionally containing one or more surfactants, and optionally having an active molecule added thereto; and 3) gently stirring one of the liquid phases resulting from 1) or 2) into the other in order to obtain, almost instantaneously, a colloidal solution of modified cyclodextrin nanospheres. If required, all or part of the solvent and all or part of the water may be removed. Said system may be used as a carrier for pharmaceuticals, cosmetics, chemicals, etc.

22. 发明申请

WO1993025194A1 PREPARATION AND USE OF NOVEL CYCLODEXTRIN-BASED DISPERSIBLE NANOVESICULAR COLLOIDAL SYSTEMS IN THE FORM OF NANOCAPSULES 审中-公开
标题翻译：新型环糊精基于纳米粒子的纳米复合纳米晶体系的制备与应用
公开(公告)号：WO1993025194A1
公开(公告)日：1993-12-23
申请号：PCT/FR1993000593
申请日：1993-06-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ... , SKIBA, Mohamed , WOUESSIDJEWE, Denis , FESSI, Hatem , DEVISSAGUET, Jean-Philippe , DUCHENE, Dominique , PUISIEUX, Francis
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ...
IPC分类号： A61K09/51
CPC分类号： A61K9/5161 , A61K9/5192 , A61K47/6951 , B01J13/04 , B82Y5/00
摘要： A nanovesicular system prepared by (1) preparing a liquid phase essentially consisting of a solution of cyclodextrin modified by acyl groups, and an oil in an organic solvent or solvent mixture; (2) preparing a second liquid phase essentially consisting of water or an aqueous mixture optionally containing one or more surfactants, one of said phases (1) and (2) optionally having an active molecule added thereto; and (3) gently stirring one of the liquid phases resulting from (1) or (2) into the other in order to obtain, almost instantaneously, a colloidal solution of modified cyclodextrin nanocapsules containing oil and optionally said active molecule. If required, all or part of the solvent or solvent mixture and all or part of the water or aqueous mixture may be removed. Said system may be used as a carrier for pharmaceuticals, cosmetics, chemicals, etc.

23. 发明申请

WO1998018455A1 METHOD FOR PREPARING MALONATE METHYLIDENE NANOPARTICLES, NANOPARTICLES OPTIONALLY CONTAINING ONE OR SEVERAL BIOLOGICALLY ACTIVE MOLECULES 审中-公开
标题翻译：制备丙烯酸甲酯纳米颗粒的方法，包含一种或几种生物活性分子的纳米颗粒
公开(公告)号：WO1998018455A1
公开(公告)日：1998-05-07
申请号：PCT/FR1997001907
申请日：1997-10-24
申请人： VIRSOL , BRU-MAGNIEZ, Nicole , GUILLON, Xavier , BRETON, Pascal , COUVREUR, Patrick , LESCURE, François , ROQUES-CARMES, Claude , RIESS, Gérard
发明人： VIRSOL
IPC分类号： A61K09/51
CPC分类号： A61K9/5138 , C08F22/14
摘要： The invention concerns a method for preparing nanoparticles formed of a statistic polymer of at least one compound of formula (I) in which A represents a group (a) or a group (b); R1 and R2, identical or different, represent a C1-C6 alkyl group linear or branched; n = 1, 2, 3, 4, or 5, characterised in that the monomer is previously made soluble in an organic aprotic solvent miscible in water forming with the polymerisation medium a mixture non-solvent of the formed polymer. The invention also concerns said nanoparticles, containing optionally one or several biologically active molecules, and the pharmaceutical compositions containing them.
摘要翻译：本发明涉及一种制备由至少一种式（I）化合物的统计聚合物形成的纳米颗粒的方法，其中A代表基团（a）或基团（b）; R1和R2相同或不同，表示直链或支链的C1-C6烷基; n = 1,2,3,4或5，其特征在于，所述单体预先制备成可溶于形成聚合介质的形成聚合物的非溶剂混合物的水形成的有机非质子溶剂中。本发明还涉及含有任选的一种或多种生物活性分子的所述纳米颗粒和含有它们的药物组合物。

24. 发明申请

WO1996025153A1 SITE-SPECIFIC ADHESION WITHIN THE GI TRACT USING NANOPARTICLES STABILIZED BY HIGH MOLECULAR WEIGHT, LINEAR POLY (ETHYLENE OXIDE) POLYMERS 审中-公开
标题翻译：使用高分子量稳定的纳米粒子的GI TRACT中的特定粘合剂，线性聚（乙烯氧化物）聚合物
公开(公告)号：WO1996025153A1
公开(公告)日：1996-08-22
申请号：PCT/US1996002080
申请日：1996-02-14
申请人： NANOSYSTEMS L.L.C.
发明人： NANOSYSTEMS L.L.C. , RUDDY, Stephen, B. , EICKHOFF, W., Mark , LIVERSIDGE, Gary
IPC分类号： A61K09/51
CPC分类号： A61K49/0404 , A61K9/146 , A61K49/0428 , B82Y5/00 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/943 , Y10S977/795 , Y10S977/915 , Y10S977/927
摘要： Nanoparticulate crystalline therapeutic or diagnostic substances formulated with stabilizers and high molecular weight, linear poly (ethylene oxide) polymers, enhance contact between the crystalline therapeutic or diagnostic substances and the gastrointestinal tract providing site-specific and extended therapeutic or diagnostic effect.
摘要翻译：用稳定剂和高分子量线性聚（环氧乙烷）聚合物配制的纳米晶状治疗或诊断物质增强结晶治疗或诊断物质与胃肠道之间的接触，从而提供特异性和延长的治疗或诊断效果。

25. 发明申请

WO1996024340A1 A METHOD OF PREPARING STABLE DRUG NANOPARTICLES 审中-公开
标题翻译：制备稳定的药物纳米颗粒的方法
公开(公告)号：WO1996024340A1
公开(公告)日：1996-08-15
申请号：PCT/US1996001454
申请日：1996-02-06
申请人： NANOSYSTEMS L.L.C.
发明人： NANOSYSTEMS L.L.C. , DE CASTRO, Lan
IPC分类号： A61K09/51
CPC分类号： A61K9/145 , A61K9/146 , Y10S977/738 , Y10S977/801 , Y10S977/90 , Y10S977/915
摘要： Stable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier absorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm are prepared by providing a drug substance, depyrogenating grinding media, mixing the drug substance, grinding media and autoclavin and adding a surface modifier either during autoclaving or after autoclaving and subsequently wet milling. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.
摘要翻译：基本上由具有表面改性剂组成的结晶药物组成的稳定的可分散颗粒通过提供药物，去热原化研磨介质，混合药物，研磨介质和高压灭菌素，并在高压灭菌期间或高压灭菌后，随后湿磨加入表面改性剂。含有该颗粒的药物组合物表现出意想不到的生物利用度，并且可用于治疗哺乳动物的方法。

26. 发明申请

WO1996020698A2 SURFACE-MODIFIED NANOPARTICLES AND METHOD OF MAKING AND USING SAME 审中-公开
标题翻译：表面改性纳米粒子及其制备方法和使用方法
公开(公告)号：WO1996020698A2
公开(公告)日：1996-07-11
申请号：PCT/US1996000476
申请日：1996-01-04
申请人： THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN , LEVY, Robert, J. , LABHASETWAR, Vinod, D. , SONG, Cunxian, S.
发明人： THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN
IPC分类号： A61K09/51
CPC分类号： A61K9/5153
摘要： Biodegradable controlled release nanoparticles as sustained release bioactive agent delivery vehicles include surface modifying agents to target binding of the nanoparticles to tissues or cells of living systems, to enhance nanoparticle sustained release properties, and to protect nanoparticle-incorporated bioactive agents. Unique methods of making small (10 nm to 15 nm, and preferably 20 nm to 35 nm) nanoparticles having a narrow size distribution which can be surface-modified after the nanoparticles are formed is described. Techniques for modifying the surface include a lyophilization technique to produce a physically adsorbed coating and epoxy-derivatization to functionalize the surface of the nanoparticles to covalently bind molecules of interest. The manoparticles may also comprise hydroxy-terminated or epoxide-terminated and/or activated multiblock copolymers, having hydrophobic segments which may be polycaprolactone and hydrophilic segments. The nanoparticles are useful for local intravascular administration of smooth muscle inhibitors and antithrombogenic agents as part of interventional cardiac or vascular catheterization such as a balloon angioplasty procedure; direct application to tissues and/or cells for gene therapy, such as the delivery of osteotropic genes or gene segments into bone progenitor cells; or oral administration in an enteric capsule for delivery of protein/peptide based vaccines.
摘要翻译：作为持续释放的生物活性剂递送载体的可生物降解的控制释放纳米颗粒包括靶向纳米颗粒与生物体系的组织或细胞的结合的表面改性剂，以增强纳米颗粒持续释放性质，并保护纳米颗粒引入的生物活性剂。描述了在形成纳米颗粒之后可以进行表面改性的具有窄尺寸分布的小（10nm至15nm，优选20nm至35nm）纳米颗粒的独特方法。用于改性表面的技术包括冷冻干燥技术以产生物理吸附的涂层和环氧衍生化，以官能化纳米颗粒的表面以共价结合感兴趣的分子。人造粒体还可包含羟基封端或环氧化物封端和/或活化的多嵌段共聚物，其具有可以是聚己内酯和亲水链段的疏水链段。纳米颗粒可用于局部血管内施用平滑肌抑制剂和抗血栓形成剂，作为介入性心脏或血管导管插入术的一部分，例如球囊血管成形术程序; 直接应用于用于基因治疗的组织和/或细胞，例如将骨质基因或基因片段递送到骨祖细胞中; 或用于输送蛋白质/肽基疫苗的肠溶胶囊中的口服给药。

27. 发明申请

WO1995035101A1 NANOPARTICLES STABILIZED AND FILTERABLE IN STERILE CONDITIONS 审中-公开
标题翻译： NANOPARTICLES在稳定条件下稳定和过滤
公开(公告)号：WO1995035101A1
公开(公告)日：1995-12-28
申请号：PCT/FR1995000813
申请日：1995-06-20
申请人： RHONE-POULENC RORER S.A.
发明人： RHONE-POULENC RORER S.A. , LABORIE, Michel , VACUS, Joël , VERRECCHIA, Thierry , BISSERY, Marie-Christine
IPC分类号： A61K09/51
CPC分类号： A61K9/5153 , A61K9/5192 , Y10S977/773 , Y10S977/788 , Y10S977/795 , Y10S977/906
摘要： Nanoparticles stabilized and filterable in sterile conditions characterized in that they comprise at least one hydrophobic, non-hydrosoluble and non-hydrodispersible polymer or copolymer (and optionally an active ingredient) emulsified in a phospholipid and biliary salt solution.
摘要翻译：在无菌条件下稳定和可过滤的纳米颗粒，其特征在于它们包含在磷脂和胆汁盐溶液中乳化的至少一种疏水性，非可水解和非可分解的聚合物或共聚物（和任选的活性成分）。

28. 发明申请

WO1995031975A1 PROCESS FOR COATING DROPLETS OR NANOMETRIC PARTICLES 审中-公开
标题翻译：涂覆滴剂或纳米颗粒的方法
公开(公告)号：WO1995031975A1
公开(公告)日：1995-11-30
申请号：PCT/ES1994000085
申请日：1994-09-30
申请人： LABORATORIOS CUSI, S.A. , VALLET MAS, José Alberto , GALAN VALDIVIA, Francisco Javier , CARRERAS PERDIGUER, Nuria
发明人： LABORATORIOS CUSI, S.A.
IPC分类号： A61K09/51
CPC分类号： A61K9/5153 , B01J13/22 , Y10S977/773 , Y10S977/795 , Y10S977/89 , Y10S977/891 , Y10S977/904
摘要： The process comprises: (1) preparing a fine dispersion of droplets or particles which contain or are formed of a chemical or biologically active substance in a phase comprised of a solvent and a non solvent of the polymer forming the coating and optionally a surfactant or suspensor agent; (2) preparing a phase which contains the coat-forming polymer dissolved in a miscible solvent in any proportion with the prior dispersion; (3) mixing both phases continuously while maintaining constant the relationship between the phases and the mixture volume and simultaneously spraying the resultant mixture in an evaporation system with temperature and vacuum conditions which provide for the instantaneous evaporation of the solvent from the polymer, causing the deposition of the polymer around the particles or droplets. Application to pharmacy, medecine, cosmetics, veterinary, chemical industry, agriculture, etc.
摘要翻译：该方法包括：（1）在包含或由化学或生物活性物质形成的相或由形成该涂层的聚合物的非溶剂和任选的表面活性剂或悬浮液组成的相中制备液滴或颗粒的精细分散体剂; （2）以与现有分散体成比例的方式制备含有溶解在可混溶溶剂中的涂层形成聚合物的相; （3）连续混合两相，同时保持相和混合物体积之间的关系恒定，同时将所得混合物在温度和真空条件下蒸发在蒸发系统中，所述温度和真空条件提供溶剂从聚合物瞬时蒸发，导致沉积聚合物周围的颗粒或液滴。适用于药房，医药，化妆品，兽医，化工，农业等

29. 发明申请

WO1995027482A1 EFFERVESCENT PHARMACEUTICAL FORMULATIONS CONTAINING CONTROLLED RELEASE BIODEGRADABLE MICROCAPSULES 审中-公开
标题翻译：含有控制释放生物降解微生物的有效药物制剂
公开(公告)号：WO1995027482A1
公开(公告)日：1995-10-19
申请号：PCT/IE1995000025
申请日：1995-04-06
申请人： ELAN CORPORATION, PLC , FREEMAN, Virginia , RAMTOOLA, Zebunnissa
发明人： ELAN CORPORATION, PLC
IPC分类号： A61K09/51
CPC分类号： A61K9/5153 , A61K9/0007 , A61K9/1647
摘要： Effervescent pharmaceutical formulations for the sustained and controlled oral administration of a drug selected from a calcium channel blocker, an ACE inhibitor, a narcotic analgesic or analogues or combinations thereof, the formulation comprising microcapsules in which the drug is entrapped in a biodegradable polymer, for example poly-L lactide. The pH of the formulation can be varied to optimize the release of the or each drug from the formulation. Microcapsules suitably have a D 50 % between about 100 nm and 900 nm and a drug loading of the order of about 10 % to 70 % by weight. The formulations can be used to administer the drugs to a patient on a once-daily basis so as to achieve a therapeutic effect over a substantially 24-hour period.
摘要翻译：用于持续和受控口服给药的选自钙通道阻滞剂，ACE抑制剂，麻醉性镇痛剂或其类似物或其组合的药物的泡腾药物制剂，所述制剂包含药物包埋在可生物降解的聚合物中的微胶囊，例如聚-L丙交酯。可以改变制剂的pH以优化药物从制剂中的释放。微胶囊适当地具有约100nm至900nm之间的D 50％和约10重量％至70重量％的药物负载量。该制剂可用于每天一次向患者施用药物，以便在基本上24小时内达到治疗效果。

30. 发明申请

WO1995011012A1 WATER-RESISTANT COSMETICS 审中-公开
标题翻译：防水化妆品
公开(公告)号：WO1995011012A1
公开(公告)日：1995-04-27
申请号：PCT/EP1994003459
申请日：1994-10-21
申请人： ROTRING INTERNATIONAL GMBH & CO KG , HOHMANN, Claudia , KOCH, Detlef , PFLUG, Werner
发明人： ROTRING INTERNATIONAL GMBH & CO KG
IPC分类号： A61K09/51
CPC分类号： A61Q19/00 , A61K8/0283 , A61K8/671 , A61K8/922 , A61K2800/412 , A61K2800/56 , A61K2800/652 , A61Q3/00 , A61Q5/00 , A61Q13/00 , A61Q17/04
摘要： Cosmetic compositions and dispersions containing the same comprise (a) a solid particulate, water-insoluble matrix made of at least one water-insoluble, non-polymer, matrix-forming material solid at room temperature and (b) a water-insoluble, cosmetically active ingredient enveloped by the matrix. The matrix particles have an average size of about 1 mu m or less. Also disclosed is a process for preparing such cosmetic compositions and dispersions and their use.
摘要翻译：本发明涉及一种化妆品组合物和含有分散体（a）一种固体颗粒的水不溶性基质辅助的至少一种不溶于水的，非聚合，基质形成材料，该材料在室温下是固体，以及（b）包围一个在基体中，包括水不溶性化妆作用的活性成分，其具有约1微米或更小的平均尺寸的基体颗粒。此外，它包括制备这样的化妆品组合物和分散体以及它们的用途的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式