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21. 发明申请

WO2006073447A2 ENRICHED PAG-55 FRACTION AND METHODS FOR EARLY DETECTION OF PREGNANCY IN UNGULATE ANIMALS 审中-公开
标题翻译：丰富的PAG-55馏分和早期检测结核病患者妊娠的方法
公开(公告)号：WO2006073447A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/014458
申请日：2005-04-27
申请人： MONSANTO TECHNOLOGY LLC , MATHIALAGAN, Nagappan , MCGRATH, Michael , SCHENKEL, Robert
发明人： MATHIALAGAN, Nagappan , MCGRATH, Michael , SCHENKEL, Robert
CPC分类号： C07K16/18 , C07K14/4715 , G01N33/689 , G01N2800/368 , Y10S424/811
摘要： Disclosed are methods for determining the pregnancy status of an ungulate animal by detecting the level of PAG-55 protein fraction. These methods may involve the detection of PAG-55 enriched proteins in the PAG-55 protein fraction by using novel polyclonal and monoclonal antibodies that have been generated using the PAG-55 enriched protein fraction as an immu1ogen. The novel PAG-55 protein fraction indicates that the animal is pregnant when the acidic PAG-55 protein fraction, or antigenic components thereof, are present at an elevated level in a sample. The present invention also provides for methods of obtaining the PAG-55 enriched protein fraction. The invention provides accurate methods of detecting pregnancy at early stages and has the benefit of allowing early post partum detection of the pregnancy status with fewl false positive results. The antibodies for detecting PAG-55 proteins will also be useful in combination with detecting elevated progesterone levels in the animal, thus providing an even more effective pregnancy detection method. The benefit of this early pregnancy detection is that identifying animals that are not pregnant very shortly after breeding, allows for timely rebreeding and minimizes the amount of time the animal is open. Also disclosed are methods for making a breeding decision for an animal. These methods allow a herd manager to make breeding decisions based on the levels of PAG-55 protein fraction and optionally, progesterone levels detected in a biological sample taken from an animal suspected of being in the early stages of pregnancy.
摘要翻译：公开了通过检测PAG-55蛋白组分的水平来确定有蹄动物的怀孕状态的方法。这些方法可能涉及通过使用已经使用富集了PAG-55的蛋白质部分作为免疫原生成的新型多克隆和单克隆抗体来检测PAG-55蛋白质级分中富含PAG-55的蛋白质。新的PAG-55蛋白部分表明，当酸性PAG-55蛋白部分或其抗原性组分在样品中以升高的水平存在时，动物是怀孕的。本发明还提供了获得富含PAG-55的蛋白质部分的方法。本发明提供了在早期阶段检测妊娠的准确方法，并且具有允许在怀孕状态的早期检测以及几乎没有假阳性结果的益处。用于检测PAG-55蛋白的抗体也可用于检测动物体内升高的孕酮水平，从而提供更有效的妊娠检测方法。这种早期妊娠检测的好处在于，能够在繁殖后立即识别未怀孕的动物，以便及时回避和避免;繁殖并最大限度地缩短动物开放的时间。还公开了用于对动物进行育种决定的方法。这些方法允许牧群管理者基于从疑似处于怀孕早期阶段的动物采集的生物样品中检测到的PAG-55蛋白质级分和任选的孕酮水平作出育种决定。

22. 发明申请

WO1990009802A1 HUMAN INTRA-ACROSOMAL SPERM ANTIGEN FOR USE IN A CONTRACEPTIVE VACCINE 审中-公开
标题翻译：人造血管炎抗生素用于合并疫苗
公开(公告)号：WO1990009802A1
公开(公告)日：1990-09-07
申请号：PCT/US1990000978
申请日：1990-03-02
申请人： CENTER FOR INNOVATIVE TECHNOLOGY
发明人： CENTER FOR INNOVATIVE TECHNOLOGY , HERR, John, C. , WRIGHT, Richard, M.
IPC分类号： A61K39/00
CPC分类号： C07K16/28 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/575 , C07K14/705 , C07K16/18 , C07K19/00 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/50 , Y10S424/811 , Y10S530/852
摘要： A substantially purified intra-acrosomal human sperm antigen useful in a contraceptive vaccine is disclosed herein. The antigen remains associated with human sperm after the acrosome reaction. In particular, it remains associated with the inner and outer acrosomal membranes. Modified antigens and fragments thereof prepared by protein modification techniques are also disclosed as well as methods for purifying and using the antigens. Also disclosed are monoclonal and polyclonal antibodies to the antigen and methods of making and using such antibodies. Methods of use include purification of the antigen or use in various diagnostic techniques. Also disclosed are cDNA, expression vectors, and transformed microorganisms that produce the antigen.
摘要翻译：本文公开了可用于避孕疫苗的基本上纯化的顶体内人精子抗原。顶体反应后，抗原与人类精子相关。特别地，它与内部和外部顶体膜保持相关。还公开了通过蛋白质修饰技术制备的修饰抗原及其片段以及纯化和使用抗原的方法。还公开了抗原的单克隆和多克隆抗体以及制备和使用这些抗体的方法。使用的方法包括纯化抗原或用于各种诊断技术。还公开了产生抗原的cDNA，表达载体和转化的微生物。

23. 发明授权

US08012932B2 Contraceptives based on SP22 and SP22 antibodies 有权
标题翻译：基于SP22和SP22抗体的避孕药
公开(公告)号：US08012932B2
公开(公告)日：2011-09-06
申请号：US11572453
申请日：2005-07-22
申请人： Gary R. Klinefelter
发明人： Gary R. Klinefelter
IPC分类号： A61K38/00
CPC分类号： A61K35/52 , A61K38/00 , A61K39/00 , A61K39/0006 , A61K2039/54 , C07K14/47 , C07K16/18 , C07K16/32 , C07K2317/34 , C07K2317/55 , C07K2317/76 , G01N33/689 , G01N33/6893 , G01N2800/367 , Y10S424/811 , Y10S530/806 , Y10S530/852
摘要： Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided.
摘要翻译：提供基于精子蛋白22kDa（SP22）多肽和抗体和不孕症诊断的口服，局部和可注射的避孕药。

24. 发明申请

US20080153106A1 ME-5, ME-2, and EPP2: human protein antigens reactive with autoantibodies present in the serum of women suffering from endometriosis 审中-公开
标题翻译： ME-5，ME-2和EPP2：与存在于子宫内膜异位症患者血清中的自身抗体相反应的人蛋白质抗原
公开(公告)号：US20080153106A1
公开(公告)日：2008-06-26
申请号：US11593874
申请日：2006-11-06
申请人： A. Said El Shami , Bruce Campbell , Dennis Sustarsic , Niver Sahakian
发明人： A. Said El Shami , Bruce Campbell , Dennis Sustarsic , Niver Sahakian
IPC分类号： G01N33/53 , C07H21/04 , C07K16/00
CPC分类号： G01N33/689 , C07K14/4713 , G01N2800/364 , Y10S424/81 , Y10S424/811 , Y10S530/853 , Y10S530/868
摘要： Three human endometrial antigens, ME-5, ME-2 and EPP2, and combination thereof have been discovered that are the targets of antibodies present in the serum of women suffering from endometriosis. These protein products and the human antibodies reactive with them are used as tools for diagnostic assays that monitor patients with the disease of endometriosis.
摘要翻译：已经发现三种人子宫内膜抗原，ME-5，ME-2和EPP2及其组合是存在于患有子宫内膜异位症的妇女的血清中的抗体的靶标。这些蛋白质产物和与其反应的人类抗体用作诊断分析的工具，用于监测子宫内膜异位症的病人。

25. 发明申请

US20070105153A1 Human gene critical to fertility 有权
公开(公告)号：US20070105153A1
公开(公告)日：2007-05-10
申请号：US11586075
申请日：2006-10-24
申请人： Lawrence Nelson , Zhi-Bin Tong
发明人： Lawrence Nelson , Zhi-Bin Tong
IPC分类号： G01N33/53
CPC分类号： C07H21/04 , A01K2217/05 , C07K14/47 , C07K16/18 , C07K2319/00 , G01N33/689 , G01N2800/361 , G01N2800/367 , Y10S424/811 , Y10S530/806 , Y10S530/853
摘要： Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.

26. 发明授权

US07189812B2 Human gene critical to fertility 有权
标题翻译：人类对生育关键的基因
公开(公告)号：US07189812B2
公开(公告)日：2007-03-13
申请号：US10677943
申请日：2003-10-01
申请人： Lawrence M. Nelson , Zhi-Bin Tong
发明人： Lawrence M. Nelson , Zhi-Bin Tong
IPC分类号： C07K14/00
CPC分类号： C07H21/04 , A01K2217/05 , C07K14/47 , C07K16/18 , C07K2319/00 , G01N33/689 , G01N2800/361 , G01N2800/367 , Y10S424/811 , Y10S530/806 , Y10S530/853
摘要： Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater genomic, cDNA and protein sequences are provided, as are fragments and variants thereof. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility, and kits related to such methods. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
摘要翻译：本文公开了对生育力至关重要的新的核酸和蛋白质序列。特别地，提供人母细胞基因组，cDNA和蛋白质序列，以及其片段和变体。女性生育需要功能性MATER; 来自Mater的卵母细胞不能超过两细胞阶段。描述了使用Mater分子诊断，预后和治疗不孕症和降低生育力的方法，以及与这些方法相关的试剂盒。还提供了使用MATER作为避孕药的方法。本公开还描述了涉及这些方法的化合物以及这些化合物的鉴定。

27. 发明申请

US20060008876A1 ME-5, ME-2, and EPP2: human protein antigens reactive with autoantibodies present in the serum of women suffering from endometriosis 审中-公开
标题翻译： ME-5，ME-2和EPP2：与存在于子宫内膜异位症患者血清中的自身抗体相反应的人蛋白质抗原
公开(公告)号：US20060008876A1
公开(公告)日：2006-01-12
申请号：US10887540
申请日：2004-07-07
申请人： A. Shami , Bruce Campbell , Dennis Sustarsic , Niver Sahakian
发明人： A. Shami , Bruce Campbell , Dennis Sustarsic , Niver Sahakian
IPC分类号： C07K16/42 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： G01N33/689 , C07K14/4713 , G01N2800/364 , Y10S424/81 , Y10S424/811 , Y10S530/853 , Y10S530/868
摘要： Three human endometrial antigens, ME-5, ME-2 and EPP2, and combination thereof have been discovered that are the targets of antibodies present in the serum of women suffering from endometriosis. These protein products and the human antibodies reactive with them are used as tools for diagnostic assays that monitor patients with the disease of endometriosis.
摘要翻译：已经发现三种人子宫内膜抗原，ME-5，ME-2和EPP2及其组合是存在于患有子宫内膜异位症的妇女的血清中的抗体的靶标。这些蛋白质产物和与其反应的人类抗体用作诊断分析的工具，用于监测子宫内膜异位症的病人。

28. 发明申请

US20040220163A1 Contraceptive method and composition 审中-公开
标题翻译：避孕方法和成分
公开(公告)号：US20040220163A1
公开(公告)日：2004-11-04
申请号：US10753073
申请日：2004-01-08
申请人： Laboratoire Theramex
发明人： Jacques Paris , Jean-Louis Thomas , Michel Lanquetin
IPC分类号： A61K031/56
CPC分类号： A61K45/06 , A61K31/56 , A61K31/565 , A61K31/57 , Y10S424/811 , Y10S514/841 , Y10S514/843 , A61K2300/00
摘要： The present invention relates to a method of achieving contraception in a woman, comprising daily administering to said woman, from the first day of her cycle, a pharmaceutical composition comprising (i) estradiol, an ester thereof or an equine conjugated estrogen and (ii) nomegestrol acetate. The invention further relates to a contraceptive product comprising 21 to 28 dosage forms containing (i) estradiol, an ester thereof or an equine conjugated estrogen and (ii) nomegestrol acetate, and 0 to 7 dosage forms containing a placebo.
摘要翻译：本发明涉及一种在女性中实现避孕的方法，包括从其周期的第一天起对所述妇女进行日常施用的药物组合物，其包含（i）雌二醇，其酯或马共轭雌激素，和（ii）醋酸诺美孕酮本发明还涉及包含21至28个剂型的避孕产品，其包含（i）雌二醇，其酯或马共轭雌激素和（ii）醋酸甲孕酮，以及含有安慰剂的0至7个剂型。

29. 发明申请

US20040028669A1 Human gene critical to fertility 失效
标题翻译：人类对生育关键的基因
公开(公告)号：US20040028669A1
公开(公告)日：2004-02-12
申请号：US10399443
申请日：2003-04-16
发明人： Lawrence M Nelson , Zhi-Bin Tong
IPC分类号： C12Q001/68 , A61K038/43 , C12N009/00 , C07H021/04
CPC分类号： C07H21/04 , A01K2217/05 , C07K14/47 , C07K16/18 , C07K2319/00 , G01N33/689 , G01N2800/361 , G01N2800/367 , Y10S424/811 , Y10S530/806 , Y10S530/853
摘要： Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
摘要翻译：本文公开了对生育力至关重要的新的核酸和蛋白质序列。特别地，提供人母细胞cDNA和蛋白质序列。女性生育需要功能性MATER; 来自Mater的卵母细胞不能超过两细胞阶段。描述了使用Mater分子诊断，预后和治疗不孕症并降低生育力的方法。还提供了使用MATER作为避孕药的方法。本公开还描述了涉及这些方法的化合物以及这些化合物的鉴定。

30. 发明授权

US06455041B1 Immunogenic epitopes of the human zona pellucida protein (ZP1) 失效
标题翻译：人透明质酸蛋白（ZP1）的免疫原性表位
公开(公告)号：US06455041B1
公开(公告)日：2002-09-24
申请号：US09441502
申请日：1999-11-17
申请人： Bonita S. Dunbar
发明人： Bonita S. Dunbar
IPC分类号： A61K3900
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , Y10S424/811
摘要： Immunogenic epitopes of human zona pellucida protein useful in inducing antibodies to zona pellucida protein.
摘要翻译：人透明带蛋白的免疫原性表位可用于诱导透明带蛋白的抗体。

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