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21. 发明申请

US20130280752A1 LENS-FREE TOMOGRAPHIC IMAGING DEVICES AND METHODS 有权
公开(公告)号：US20130280752A1
公开(公告)日：2013-10-24
申请号：US13976197
申请日：2012-01-05
申请人： Aydogan Ozcan , Serhan O. Isikman , Waheb Bishara
发明人： Aydogan Ozcan , Serhan O. Isikman , Waheb Bishara
IPC分类号： G01B9/02
CPC分类号： G01B9/02047 , G01B9/02041 , G01B9/02091 , G01N21/453 , G01N21/4795 , G02B21/0008 , G02B21/06 , G02B21/367 , G03H1/0005 , G03H1/02 , G03H1/0443 , G03H1/0866 , G03H1/265 , G03H2001/005 , G03H2001/0212 , G03H2001/0447 , G03H2001/046 , G03H2210/30 , G03H2210/62 , G03H2222/24 , G03H2222/34 , G03H2223/16 , G03H2227/02 , G03H2227/03 , G03H2240/56
摘要： A system for three dimensional imaging of an object contained within a sample includes an image sensor, a sample holder configured to hold the sample, the sample holder disposed adjacent to the image sensor, and an illumination source comprising partially coherent light. The illumination source is configured to illuminate the sample through at least one of an aperture, fiber-optic cable, or optical waveguide interposed between the illumination source and the sample holder, wherein the illumination source is configured to illuminate the sample through a plurality of different angles.
摘要翻译：包含在样品中的物体的三维成像系统包括图像传感器，被配置为保持样本的样本保持器，与图像传感器相邻设置的样本保持器，以及包括部分相干光的照明源。照明源被配置为通过插入在照明源和样本保持器之间的孔径，光纤电缆或光波导中的至少一个来照亮样本，其中照明源被配置为通过多个不同的角度。

22. 发明申请

US20040213462A1 Two-wavelength spatial-heterodyne holography 有权
标题翻译：双波长空间 - 外差全息术
公开(公告)号：US20040213462A1
公开(公告)日：2004-10-28
申请号：US10421444
申请日：2003-04-23
发明人： Gregory R. Hanson , Philip R. Bingham , John T. Simpson , Thomas P. Karnowski , Edgar Voelkl
IPC分类号： G06K009/76
CPC分类号： G03H1/0406 , G03H1/0443 , G03H1/0866 , G03H1/265 , G03H1/28 , G03H2001/0456 , G03H2001/046 , G03H2001/0469 , G03H2226/11 , G03H2226/13
摘要： Systems and methods are described for obtaining two-wavelength differential-phase holograms. A method includes determining a difference between a filtered analyzed recorded first spatially heterodyne hologram phase and a filtered analyzed recorded second spatially-heterodyned hologram phase.
摘要翻译：描述了用于获得双波长差分相位全息图的系统和方法。一种方法包括确定滤波分析的记录的第一空间外差全息图相位与滤波分析的记录的第二空间外差全息图相位之间的差值。

23. 发明申请

US20170199495A1 THREE-DIMENSIONAL IMAGE CAPTURING APPARATUS AND IMAGE CAPTURING METHOD USING DIGITAL HOLOGRAPHY 审中-公开
公开(公告)号：US20170199495A1
公开(公告)日：2017-07-13
申请号：US15391051
申请日：2016-12-27
申请人： CANON KABUSHIKI KAISHA
发明人： Isao Matsubara , Akira Eguchi
IPC分类号： G03H1/04
CPC分类号： G03H1/0443 , G03H1/0465 , G03H1/0866 , G03H1/265 , G03H2001/0445 , G03H2001/0452 , G03H2001/046 , G03H2001/0473 , G03H2210/30 , G03H2222/20 , G03H2223/12
摘要： An image capturing apparatus (500) capable of performing three-dimensional tomography of an object by digital holography, includes a splitting element (502) which splits a light beam emitted from a light source into an object light beam and a reference light beam, an illumination system (503) which controls a plurality of object light beams that are generated from the object light beam and that move in directions different from each other to be incident on the object simultaneously, a composite element (507) which causes the plurality of object light beams to interfere with the reference light beam, an image sensor (508) which acquires hologram generated by interference of each of the plurality of light beams with the reference light beam, and a controller (509) which controls the illumination system so that the plurality of object light beams interfere with each other on the image sensor.

24. 发明申请

US20170168285A1 SYSTEMS AND METHODS FOR IMAGE RECONSTRUCTION 审中-公开
公开(公告)号：US20170168285A1
公开(公告)日：2017-06-15
申请号：US15379143
申请日：2016-12-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Aydogan Ozcan , Wei Luo
IPC分类号： G02B21/36 , G03H1/00 , H04N5/265 , G02B21/00 , H04N5/225 , H04N5/357
CPC分类号： G02B21/367 , G02B21/0008 , G02B21/0056 , G02B21/365 , G03H1/0443 , G03H1/0866 , G03H2001/0447 , G03H2001/046 , G03H2222/34 , H04N5/2256
摘要： A method for obtaining a high resolution image of objects contained within a sample is disclosed that combines pixel super-resolution and phase retrieval techniques into a unified algorithmic framework that enables new holographic image reconstruction methods with significantly improved data efficiency, i.e., using much less number of raw measurements to obtain high-resolution and wide-field reconstructions of the sample. Using the unified algorithmic framework, twin image noise and spatial aliasing signals, along with other digital holographic artifacts, can be interpreted as noise terms modulated by digital phasors, which are all analytical functions of the imaging parameters including e.g., the lateral displacement between the hologram and the sensor array planes (x, y shifts), sample-to-image sensor distance (z), illumination wavelength (λ), and the angle of incidence (θ,φ).

25. 发明申请

US20170153106A1 LENS-FREE TOMOGRAPHIC IMAGING DEVICES AND METHODS 审中-公开
公开(公告)号：US20170153106A1
公开(公告)日：2017-06-01
申请号：US15432611
申请日：2017-02-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Aydogan Ozcan , Serhan O. Isikman , Waheb Bishara
IPC分类号： G01B9/02 , G02B21/06 , G03H1/02 , G03H1/26 , G03H1/00 , G02B21/36 , G03H1/04
CPC分类号： G01B9/02047 , G01B9/02041 , G01B9/02091 , G01N21/453 , G01N21/4795 , G02B21/0008 , G02B21/06 , G02B21/367 , G03H1/0005 , G03H1/02 , G03H1/0443 , G03H1/0866 , G03H1/265 , G03H2001/005 , G03H2001/0212 , G03H2001/0447 , G03H2001/046 , G03H2210/30 , G03H2210/62 , G03H2222/24 , G03H2222/34 , G03H2223/16 , G03H2227/02 , G03H2227/03 , G03H2240/56
摘要： A system for three dimensional imaging of an object contained within a sample includes an image sensor, a sample holder configured to hold the sample, the sample holder disposed adjacent to the image sensor, and an illumination source comprising partially coherent light. The illumination source is configured to illuminate the sample through at least one of an aperture, fiber-optic cable, or optical waveguide interposed between the illumination source and the sample holder, wherein the illumination source is configured to illuminate the sample through a plurality of different angles.

26. 发明申请

US20160320602A1 SYSTEM, METHOD AND APPARATUS FOR ULTRA-RESOLVED ULTRA-WIDE FIELD-OF-VIEW MULTISPECTRAL AND HYPERSPECTRAL HOLOGRAPHIC MICROSCOPY 审中-公开
标题翻译：用于超分辨率超视距多视距和超视距全息显微镜的系统，方法和装置
公开(公告)号：US20160320602A1
公开(公告)日：2016-11-03
申请号：US14963662
申请日：2015-12-09
申请人： Farnoud KAZEMZADEH , Alexander Sheung Lai WONG
发明人： Farnoud KAZEMZADEH , Alexander Sheung Lai WONG
IPC分类号： G02B21/36 , G03H1/00 , G03H1/08 , G02B21/00
CPC分类号： G02B21/365 , G02B21/0032 , G02B21/0056 , G02B21/0064 , G02B21/14 , G02B21/26 , G02B27/58 , G03H1/0443 , G03H1/0866 , G03H2001/005 , G03H2001/046 , G03H2226/11 , G03H2240/56
摘要： There is disclosed a novel system and method for achieving ultra-resolution, ultra-wide field-of-view multispectral and hyperspectral holographic microscopy and quantitative phase contrast microscopy. In an embodiment, the method comprises: providing a stationary illumination source; acquiring a plurality of low-resolution holograms of an image subject from different locations utilizing a subpixel sensor-scanning synthetic aperture mechanism whereby a detector scanning translationally, radially and/or rotationally; processing the acquired holograms utilizing a processing algorithm corresponding to the scanning motion of the detector used to acquire the holograms; and reconstructing a subpixel ultra-resolution image of the image subject based on the processed holograms; whereby, a desired synthetic aperture is achieved without loss of resolution. The multispectral and hyperspectral aspect is achieved in the novel system and method by use of different combination of illumination sources (i.e., LEDs, laser sources, broadband lamps, etc.) and wavelength selection mechanisms (i.e., bandpass spectral filters, acousto-optical and liquid crystal tunable filters, a dispersing element, etc.).
摘要翻译：公开了一种用于实现超分辨率，超宽视场多光谱和高光谱全息显微镜和定量相差显微镜的新型系统和方法。在一个实施例中，该方法包括：提供固定照明源; 使用子像素传感器扫描合成孔径机构从不同位置获取图像对象的多个低分辨率全息图，由此检测器以径向和/或旋转方式平移地扫描; 使用与用于获取全息图的检测器的扫描运动相对应的处理算法来处理所获取的全息图; 以及基于所处理的全息图重建所述图像对象的子像素超分辨率图像; 由此，实现期望的合成孔径而不损失分辨率。通过使用不同组合的照明源（即，LED，激光源，宽带灯等）和波长选择机制（即，带通光谱滤波器，声光学和等离子体发射器件），在新系统和方法中实现了多光谱和高光谱方面。液晶可调滤光片，分散元件等）。

27. 发明申请

US20160259297A1 Holographic Microscope and Data Processing Method for High-Resolution Hologram Image 审中-公开
标题翻译：全息显微镜和高分辨率全息图的数据处理方法
公开(公告)号：US20160259297A1
公开(公告)日：2016-09-08
申请号：US15032434
申请日：2014-10-28
申请人： UNIVERSITY OF HYOGO
发明人： Kunihiro SATO
IPC分类号： G03H1/04 , G02B21/36
CPC分类号： G03H1/0443 , G02B21/00 , G02B21/06 , G02B21/365 , G03H2001/005 , G03H2001/0445 , G03H2001/0447 , G03H2001/045 , G03H2001/0452 , G03H2001/046 , G03H2001/0463 , G03H2001/0469 , G03H2001/0471 , G03H2222/42 , G03H2222/44 , G03H2222/52 , G03H2240/56
摘要： The present invention can realize both a transmission type and a reflection type, and provides a holographic microscope which can exceed the resolution of the conventional optical microscope, a hologram data acquisition method for a high-resolution image, and a high-resolution hologram image reconstruction method. In-line spherical wave reference light (L) is recorded in a hologram (ILR) using spherical wave reference light (R), and an object light (Oj) and an illumination light (Qj) are recorded in a hologram (IjOQR) using a spherical wave reference light (R) by illuminating the object with an illumination light (Qj, j=1, . . . , N) which is changed its incident direction. From those holograms, a hologram (JjOQL), from which the component of the reference light (R) is removed, is generated, and from the hologram, a light wave (hj) is generated. A light wave (cj) of the illumination light (Qj) is separated from the light wave (hj), and using its phase component (ξj=cj/|cj|), a phase adjustment reconstruction light wave is derived and added up as (HP=Σhj/ξj), and an object image (SP=|HP|2) is reconstructed.
摘要翻译：本发明可以实现透射型和反射型，并且提供可以超过常规光学显微镜的分辨率的全息显微镜，用于高分辨率图像的全息图数据获取方法和高分辨率全息图像重构方法。使用球面波参考光（R）将球面波参考光（L）记录在全息图（ILR）中，并且将目标光（Oj）和照明光（Qj）记录在全息图（IjOQR）中，使用通过以改变其入射方向的照明光（Qj，j = 1，...，N）照亮物体的球面波参考光（R）。从这些全息图中，产生去除了参考光（R）的分量的全息图（JjOQL），并且从全息图产生光波（hj）。照明光（Qj）的光波（cj）与光波（hj）分离，使用其相位分量（ξj= cj / | cj |），导出相位调整重建光波，并相加为（HP =Σhj/ξj），并且重建对象图像（SP = | HP | 2）。

28. 发明申请

US20140268105A1 OPTICAL DEFECT INSPECTION SYSTEM 审中-公开
标题翻译：光学缺陷检测系统
公开(公告)号：US20140268105A1
公开(公告)日：2014-09-18
申请号：US14205728
申请日：2014-03-12
申请人： Zygo Corporation
发明人： Richard Earl Bills , Chris Koliopoulos
IPC分类号： G01N21/88 , G01B9/02
CPC分类号： G01N21/453 , G02B21/0016 , G03H1/0443 , G03H1/0866 , G03H2001/0447 , G03H2001/046 , G03H2001/0469 , G03H2001/0471
摘要： Disclosed herein is a system for determining information about one or more defects on or in a test object. The system includes a light source configured to illuminate a test object with spatially coherent light; a multi-element detector positioned to detect an interference pattern of light associated with one or more defects on or in the illuminated test object; and an electronic control module in communication with the multi-element detector and configured to process the interference pattern to determine information about the one or more defects on or in the test object.
摘要翻译：本文公开了一种用于确定关于测试对象上或测试对象中的一个或多个缺陷的信息的系统。该系统包括被配置为用空间相干光照亮测试对象的光源; 多元素检测器，定位成检测与被照亮的测试对象上或其中的一个或多个缺陷相关联的光的干涉图案; 以及与所述多元件检测器通信并被配置为处理所述干扰图案以确定关于所述测试对象上或所述测试对象中的所述一个或多个缺陷的信息的电子控制模块。

29. 发明申请

US20040212807A1 Faster processing of multiple spatially-heterodyned direct to digital holograms 失效
标题翻译：更快地处理多个空间外置直接数字全息图
公开(公告)号：US20040212807A1
公开(公告)日：2004-10-28
申请号：US10607840
申请日：2003-06-27
发明人： Gregory R. Hanson , Philip R. Bingham
IPC分类号： G01B009/021
CPC分类号： G03H1/0406 , G03H1/0443 , G03H1/0866 , G03H1/265 , G03H1/28 , G03H2001/0456 , G03H2001/046 , G03H2001/0469 , G03H2226/11 , G03H2226/13
摘要： Systems and methods are described for faster processing of multiple spatially-heterodyned direct to digital holograms. A method includes of obtaining multiple spatially-heterodyned holograms, includes: digitally recording a first spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis; digitally recording a second spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis; Fourier analyzing the recorded first spatially-heterodyned hologram by shifting a first original origin of the recorded first spatially-heterodyned hologram including spatial heterodyne fringes in Fourier space to sit on top of a spatial-heterodyne carrier frequency defined as a first angle between a first reference beam and a first, object beam; applying a first digital filter to cut off signals around the first original origin and performing an inverse Fourier transform on the result; Fourier analyzing the recorded second spatially-heterodyned hologram by shifting a second original origin of the recorded second spatially-heterodyned hologram including spatial heterodyne fringes in Fourier space to sit on top of a spatial-heterodyne carrier frequency defined as a second angle between a second reference beam and a second object beam; and applying a second digital filter to cut off signals around the second original origin and performing an inverse Fourier transform on the result, wherein digitally recording the first spatially-heterodyned hologram is completed before digitally recording the second spatially-heterodyned hologram and a single digital image includes both the first spatially-heterodyned hologram and the second spatially-heterodyned hologram.
摘要翻译：描述了用于更快处理多空间外差直接数字全息图的系统和方法。一种包括获得多空间外差全息图的方法，包括：数字记录包括用于傅立叶分析的空间外差条纹的第一空间外差全息图; 数字记录包括用于傅立叶分析的空间外差条纹的第二空间外差全息图; 通过将所记录的第一空间外差全息图的第一原始原始位置（包括傅立叶空间中的空间外差条纹）移位到位于第一参考点之间的第一角度的空间外差载波频率之上，从而傅里叶分析所记录的第一空间外差全息图光束和第一个物体光束; 施加第一数字滤波器以切断围绕第一原始原点的信号，并对该结果执行逆傅里叶变换; 通过将所记录的第二空间外差全息图的第二原始原点移动到傅立叶空间中的空间外差条纹，以置于空间外差载波频率的顶部上来对第二空间外差全息图进行傅立叶分析，该空间外差载波频率定义为第二参考光束和第二物体光束; 以及施加第二数字滤波器以截断所述第二原始原点周围的信号并对所述结果执行逆傅里叶变换，其中在对所述第二空间外差全息图和单个数字图像进行数字记录之前完成数字记录所述第一空间外差全息图包括第一空间外差全息图和第二空间外差全息图。

30. 发明公开

EP3175302A4 DEVICE AND METHOD FOR ITERATIVE PHASE RECOVERY BASED ON PIXEL SUPER-RESOLVED ON-CHIP HOLOGRAPHY 有权
公开(公告)号：EP3175302A4
公开(公告)日：2018-03-28
申请号：EP15827025
申请日：2015-07-31
申请人： UNIV CALIFORNIA
发明人： OZCAN AYDOGAN , GREENBAUM ALON , ZHANG YIBO , FEIZI ALBORZ , LUO WEI
IPC分类号： G03H1/04 , G03H1/00
CPC分类号： G03H1/0005 , G01N15/1429 , G01N15/1434 , G01N15/1475 , G01N2015/1006 , G01N2015/144 , G01N2015/1445 , G01N2015/1454 , G03H1/0443 , G03H1/0866 , G03H1/0891 , G03H2001/005 , G03H2001/0447 , G03H2001/0454 , G03H2001/046 , G03H2001/0816 , G03H2001/0883 , G03H2001/2655 , G03H2210/42 , G03H2226/02 , G03H2227/03 , H04N5/2256 , H04N5/23238
摘要： A method for lens-free imaging of a sample or objects within the sample uses multi-height iterative phase retrieval and rotational field transformations to perform wide FOV imaging of pathology samples with clinically comparable image quality to a benchtop lens-based microscope. The solution of the transport-of-intensity (TIE) equation is used as an initial guess in the phase recovery process to speed the image recovery process. The holographically reconstructed image can be digitally focused at any depth within the object FOV (after image capture) without the need for any focus adjustment, and is also digitally corrected for artifacts arising from uncontrolled tilting and height variations between the sample and sensor planes. In an alternative embodiment, a synthetic aperture approach is used with multi-angle iterative phase retrieval to perform wide FOV imaging of pathology samples and increase the effective numerical aperture of the image.

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