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21. 发明授权

US10047343B2 Methods for producing cartilage and bone 有权
公开(公告)号：US10047343B2
公开(公告)日：2018-08-14
申请号：US14599324
申请日：2015-01-16
申请人： Alfred Kuo
发明人： Alfred Kuo
IPC分类号： C12N5/077 , A61K35/32 , A61K35/00
CPC分类号： C12N5/0655 , A61K35/00 , A61K35/32 , C12N2500/90 , C12N2501/15 , C12N2501/155 , C12N2501/37
摘要： The present disclosure provides methods of producing cartilage in vitro. The present disclosure provides treatment methods, involving introducing in vitro-produced cartilage into a treatment site in vivo. The present disclosure provides methods of enhancing bone formation, the method involving introducing in vitro-produced hypertrophic cartilage into a treatment site in vivo.

22. 发明授权

US08691542B2 Tissue engineering methods and compositions 有权
标题翻译：组织工程方法和组成
公开(公告)号：US08691542B2
公开(公告)日：2014-04-08
申请号：US12083619
申请日：2006-09-11
申请人： Farshid Guilak , Bradley T. Estes , Franklin Thomas Moutos
发明人： Farshid Guilak , Bradley T. Estes , Franklin Thomas Moutos
IPC分类号： A61F2/30 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44
CPC分类号： A61L27/54 , A61K35/12 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K38/1875 , A61K38/30 , C12N5/0667 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/15 , C12N2501/155 , C12N2501/23 , C12N2501/37 , C12N2501/39 , C12N2533/30 , C12N2533/40
摘要： The presently disclosed subject matter generally relates to methods and systems for facilitating the growth and differentiation of adipose-derived stem cells for laboratory and therapeutic applications. The cells can be employed alone or in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells.
摘要翻译：目前公开的主题一般涉及促进脂肪来源的干细胞在实验室和治疗应用中的生长和分化的方法和系统。细胞可以单独使用或与独特的生物相容的支架结构结合使用，以在体外和体内产生分化的组织和结构。目前公开的主题还涉及形成和使用改进的组织工程化支架的方法，其可以用作底物以促进细胞的生长和分化。

23. 发明授权

US07994129B2 Methods of using black bear parathyroid hormone 有权
标题翻译：使用黑熊甲状旁腺激素的方法
公开(公告)号：US07994129B2
公开(公告)日：2011-08-09
申请号：US11559285
申请日：2006-11-13
申请人： Seth W. Donahue
发明人： Seth W. Donahue
IPC分类号： A61K38/00 , A61K38/29
CPC分类号： C07K14/635 , A61K38/00 , C12N5/0654 , C12N2501/37
摘要： Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.
摘要翻译：提供黑熊甲状旁腺激素（PTH）及其功能片段。还提供了使用黑熊PTH和功能片段在骨形成细胞中增加cAMP的方法; 减少骨形成细胞凋亡; 降低骨形成细胞中Bax蛋白与Bcl-2蛋白的表达水平之比; 增加骨形成细胞中骨基质蛋白，转录激活子或转录调节子中的一种或多种的表达水平; 在受试者中增强骨矿物质密度，增加骨质量，减少骨丢失或减少骨折的发生率或其任何组合; 还提供针对黑熊甲状旁腺激素（PTH）的抗体及其功能片段。

24. 发明授权

US07943136B2 Parathyroid hormone receptor activation and stem and progenitor cell expansion 有权
标题翻译：甲状旁腺激素受体激活和干细胞和祖细胞扩增
公开(公告)号：US07943136B2
公开(公告)日：2011-05-17
申请号：US12621325
申请日：2009-11-18
申请人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
发明人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
IPC分类号： A61K39/00 , A61K39/38 , A61K35/26
CPC分类号： C12N5/0602 , A01K2217/05 , A01K2227/105 , A61K35/28 , A61K38/17 , A61K38/29 , C07K14/72 , C12N5/0623 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/37 , C12N2502/1311 , C12N2502/1394 , C12Q1/6809 , G01N33/74
摘要： The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells.
摘要翻译：本发明涉及通过激活邻近细胞中的PTH / PTHrP受体来操纵造血干细胞或祖细胞，间充质干细胞，上皮干细胞，神经干细胞和相关产物的方法。

25. 发明申请

US20090220562A1 Osteogenic and anti-adipogenic oxysterols 审中-公开
标题翻译：成骨和抗脂肪氧化固醇
公开(公告)号：US20090220562A1
公开(公告)日：2009-09-03
申请号：US11991322
申请日：2006-09-05
申请人： Farhad Parhami
发明人： Farhad Parhami
IPC分类号： A61K9/00 , A61K31/56 , A61K38/28 , A61K38/22 , A61K33/16 , A61P19/00
CPC分类号： A61K31/575 , A61K31/00 , A61K31/202 , A61K31/557 , A61K31/57 , A61K31/59 , A61K31/663 , A61K38/1841 , A61K38/1875 , A61K38/23 , A61K38/29 , A61K38/30 , C12N5/0654 , C12N2501/02 , C12N2501/105 , C12N2501/15 , C12N2501/155 , C12N2501/37 , C12N2501/39 , C12N2501/415 , C12N2501/999 , A61K2300/00
摘要： The present invention discloses osteogenic and anti-adipogenic oxysterols. Agents and methods for protecting, blocking or rescuing marrow stromal cells from the inhibitory effects of oxidative stress on their osteoblastic cellular differentiation are disclosed. Exemplary agents include oxysterols alone or in synergistic combinations, as well as hedgehog or Wnt signaling activators. The synergistic effects of oxysterols and bone morphogenic proteins are also disclosed.
摘要翻译：本发明公开了成骨和抗脂肪氧化固醇。公开了用于保护，阻断或拯救骨髓基质细胞免受氧化应激对其成骨细胞分化的抑制作用的药剂和方法。示例性药剂包括单独的氧固醇或协同组合，以及刺猬蛋白或Wnt信号传导激活剂。还公开了氧固醇和骨形态发生蛋白的协同作用。

26. 发明申请

US20070219132A1 BLACK BEAR PARATHYROID HORMONE AND METHODS OF USING BLACK BEAR PARATHYROID HORMONE 有权
标题翻译：黑熊类PARATHYROID HORMONE和使用黑熊PARATHYROID HORMONE的方法
公开(公告)号：US20070219132A1
公开(公告)日：2007-09-20
申请号：US11559285
申请日：2006-11-13
申请人： Seth Donahue
发明人： Seth Donahue
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/635 , A61K38/00 , C12N5/0654 , C12N2501/37
摘要： Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.
摘要翻译：提供黑熊甲状旁腺激素（PTH）及其功能片段。还提供了使用黑熊PTH和功能片段在骨形成细胞中增加cAMP的方法; 减少骨形成细胞凋亡; 降低骨形成细胞中Bax蛋白与Bcl-2蛋白的表达水平之比; 增加骨形成细胞中骨基质蛋白，转录激活子或转录调节子中的一种或多种的表达水平; 在受试者中增强骨矿物质密度，增加骨质量，减少骨丢失或减少骨折的发生率或其任何组合; 还提供针对黑熊甲状旁腺激素（PTH）的抗体及其功能片段。

27. 发明授权

US6066618A Regulation of cell proliferation and differentiation using peptides 失效
标题翻译：使用肽调节细胞增殖和分化
公开(公告)号：US6066618A
公开(公告)日：2000-05-23
申请号：US191192
申请日：1998-11-13
申请人： Michael F. Holick
发明人： Michael F. Holick
IPC分类号： A61K38/00 , A61K38/29 , C07K14/635 , C12N5/071 , A61K38/03 , A61K38/16
CPC分类号： C12N5/0629 , A61K38/29 , C07K14/635 , C12N2501/37
摘要： Disclosed are methods of inhibiting proliferation and enhancing differentiation of a mammalian cell, inducing proliferation of a mammalian cell, enhancing wound healing, and stimulating hair growth using a peptide which has a 10% or greater homology to a region of human parathryoid hormone or human hypercalcemic factor.
摘要翻译：公开了使用与人类parathryoid激素或人类高钙血症的区域具有10％或更高同源性的肽来抑制哺乳动物细胞增殖和增强哺乳动物细胞分化，诱导哺乳动物细胞增殖，增强伤口愈合和刺激毛发生长的方法因子。

29. 发明专利

JP2008521753A Of activation, as well as stem and progenitor cells of the parathyroid hormone receptor growth 有权
公开(公告)号：JP2008521753A
公开(公告)日：2008-06-26
申请号：JP2007541280
申请日：2005-11-08
申请人：ザジェネラルホスピタルコーポレーションThe General Hospitalcorporation
发明人：グレゴールアダムス , ティー．スキャッデンデビッド , コーネンバーグヘンリー , エム．カルビローラ
IPC分类号： A61K45/00 , A61K38/00 , A61K38/22 , A61P1/04 , A61P5/14 , A61P7/00 , A61P7/04 , A61P7/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P43/00 , C12N5/0775 , C12N15/09 , C12Q1/02 , C12Q1/68
CPC分类号： A61K38/29 , C12N5/0647 , C12N2501/37 , C12N2502/1394
摘要： The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells.

30. 发明专利

JP2009512422A Bone formation and anti-fat cell formation oxysterols 审中-公开
公开(公告)号：JP2009512422A
公开(公告)日：2009-03-26
申请号：JP2008529347
申请日：2006-09-05
申请人：ザリージェンツオブザユニヴァーシティーオブカリフォルニア
发明人：ファラッドパラミ
IPC分类号： A61K31/575 , A61K31/58 , A61K35/12 , A61K38/22 , A61P19/08 , A61P19/10 , C07J9/00 , C07J17/00 , C12N5/077 , C12N15/09
CPC分类号： A61K31/575 , A61K31/00 , A61K31/202 , A61K31/557 , A61K31/57 , A61K31/59 , A61K31/663 , A61K38/1841 , A61K38/1875 , A61K38/23 , A61K38/29 , A61K38/30 , C12N5/0654 , C12N2501/02 , C12N2501/105 , C12N2501/15 , C12N2501/155 , C12N2501/37 , C12N2501/39 , C12N2501/415 , C12N2501/999 , A61K2300/00
摘要：本発明は、骨形成及び抗脂肪細胞形成オキシステロール類を開示する。骨髄間質細胞を、骨芽細胞分化に対する酸化ストレスの阻害作用から保護し、ブロックし、又は救出する薬剤及び方法を開示する。代表的な薬剤としては、単独又は相乗的な組合せでのオキシステロール、並びにヘッジホッグ又はＷｎｔシグナル伝達経路の活性剤が挙げられる。オキシステロール類と骨形成タンパク質との相乗効果もまた開示する。

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