专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US4628061A Prostaglandins 失效
公开(公告)号：US4628061A
公开(公告)日：1986-12-09
申请号：US531899
申请日：1983-08-23
申请人： Robert L. Jones , Norman H. Wilson
发明人： Robert L. Jones , Norman H. Wilson
IPC分类号： C07C59/74 , A61K31/16 , A61K31/17 , A61K31/195 , A61K31/215 , A61K31/557 , A61P7/02 , A61P11/08 , A61P29/00 , C07C43/315 , C07C45/44 , C07C51/00 , C07C59/325 , C07C59/353 , C07C59/62 , C07C59/80 , C07C59/86 , C07C67/00 , C07C69/608 , C07C69/716 , C07C69/738 , C07C229/28 , C07C229/32 , C07C231/00 , C07C233/05 , C07C233/65 , C07C235/06 , C07C235/20 , C07C235/46 , C07C237/24 , C07C239/00 , C07C275/26 , C07C275/28 , C07C335/16 , C07C401/00 , C07C405/00 , C07D213/55 , C07D277/62 , C07D307/00 , C07D493/00 , C07D493/08 , A61K31/34 , C07C177/00
CPC分类号： C07D493/08 , C07C255/00 , C07C405/0041 , C07C405/0091 , C07C43/315 , C07C45/44 , C07C59/62
摘要： Novel compounds have a formula (I) ##STR1## wherein ##STR2## represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1] heptane, 7-oxa-bicyclo [2,2,1] hept-2Z-ene, 7-oxa-bicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] octane substituted at the 5-position by the group R.sup.1 and at the 6-position by the group ANR.sup.2 R, a 6,6-dimethyl-bicyclo [3,1,1] heptane substituted at the 2-position by the group R.sup.1 and at the 3-position by the group ANR.sup.2 R or at the 2-position by the group ANR.sup.2 R and at the 3-position by the group R.sup.1, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R.sup.1 and at the 5-position by the group ANR.sup.2 R or a 1-hydroxycyclopentane substituted at the 2-position by the group R.sup.1 and at the 2-position by the group ANR.sup.2 R, R.sup.1 is a 6-carboxyhex-2-enyl group or a modification thereof as defined herein; A is an unbranched or branched aliphatic hydrocarbon group with a chain length between the points of attachment to the divalent cyclic group and to the group NR.sup.2 R of 1 to 5 carbon atoms or such a group substituted by an aromatic group; R.sup.2 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups; and R is a group --CO.NR.sup.3 R.sup.4, --CS.NR.sup.3 R.sup.4, --CNH.NR.sup.3 R.sup.4, --CO.R.sup.4 or --CS.R.sup.4 in which R.sup.3 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups, and R.sup.4 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted directly by an aromatic group or groups and/or through an oxygen or sulphur atom either by an aromatic group or by an aliphatic hydrocarbon group substituted directly by an aromatic group or groups. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.

22. 发明授权

US4438136A Prostaglandins 失效
标题翻译：前列腺素
公开(公告)号：US4438136A
公开(公告)日：1984-03-20
申请号：US419206
申请日：1982-09-17
申请人： Robert L. Jones , Norman H. Wilson
发明人： Robert L. Jones , Norman H. Wilson
IPC分类号： A61K31/19 , A61K31/557 , A61P7/02 , A61P43/00 , C07C41/54 , C07C43/315 , C07C45/44 , C07C59/46 , C07C59/62 , C07C59/74 , C07C59/80 , C07C67/00 , C07C239/00 , C07C241/00 , C07C251/82 , C07C281/08 , C07C405/00 , A61K31/24
CPC分类号： C07C251/72 , C07C405/0091 , C07C41/48 , C07C45/44 , C07C59/46 , C07C59/62 , C07C59/74 , C07C59/80 , C07C2102/42 , Y10S514/826 , Y10S514/889
摘要： Novel bicyclo [2,2,1] heptanes and hept-2-enes are substituted at the 5-position by a 6-carboxyhex-2-enyl group or a modification thereof, and at the 6-position by a grouping --C(R).dbd.N--NHCO--(NH).sub.a --R' in which R is hydrogen, an aliphatic hydrocarbon residue, an aromatic residue or an aliphatic hydrocarbon residue substituted by an aromatic residue, a is 0 or 1 and R' is an aliphatic hydrocarbon residue, an aromatic residue, or an aliphatic hydrocarbon residue substituted directly or through an oxygen or sulphur atom by an aromatic residue. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.
摘要翻译：新的双环[2,2,1]庚烷和庚-2-烯在5-位被6-羧基己-2-烯基或其修饰取代，并且在6位被-C（ R）= N-NHCO-（NH）aR'，其中R是氢，脂族烃残基，芳族残基或被芳族残基取代的脂族烃残基，a是0或1，R'是脂族烃残基芳族残基，或直接或通过芳族残基被氧或硫原子取代的脂族烃残基。这些化合物在药物组合物中是有用的，特别是在抑制血栓素活性的情况下。

23. 发明授权

US4172954A Chemical compounds 失效
公开(公告)号：US4172954A
公开(公告)日：1979-10-30
申请号：US830294
申请日：1977-09-02
申请人： Kent P. Lannert
发明人： Kent P. Lannert
IPC分类号： C07C51/41 , C07C59/305 , C07C59/31 , C07C59/62 , C07C59/68 , C11D3/20 , C07C69/74 , C07C61/38
CPC分类号： C11D3/2089 , C07C51/412 , C07C59/305 , C07C59/31 , C07C59/62 , C07C59/68
摘要： Organic compounds having a substituent represented by the formula ##STR1## wherein M is alkali metal or ammonium are useful complexing agents for metal and/or alkaline earth metal ions.

24. 发明授权

US4044051A 9[2-(1-Al koxy-ethyl)-5,5-dimethyl-cyclopent-1-en-1-yl]-3,7-dimethyl-nona-2,4,6,8-t etraen acid compounds 失效
标题翻译： 9 {8 2-（1-烷氧基 - 乙基）-5,5-二甲基 - 环戊-1-烯-1-基{9,3,7-二甲基 - 壬-2,4,6,8-四烯酸化合物
公开(公告)号：US4044051A
公开(公告)日：1977-08-23
申请号：US596499
申请日：1975-07-16
申请人： Werner Bollag , Norbert Rigassi , Ulrich Schwieter
发明人： Werner Bollag , Norbert Rigassi , Ulrich Schwieter
IPC分类号： C07C59/62 , C07C63/04 , A61K31/19 , C07C53/00 , C07C61/38
CPC分类号： C07C59/62 , C07C63/04 , Y10S514/859 , Y10S514/863
摘要： 9-[2-(1-alkoxy-ethyl)-5,5-dimethyl-cyclopent-1-en-1-yl]-3,7-dimethyl-nona-2,4,6,8-tetraen acid compounds are disclosed which are useful for the topical or systemic treatment of dermatological disorders.
摘要翻译： 9- [2-（1-烷氧基 - 乙基）-5,5-二甲基 - 环戊-1-烯-1-基] -3,7-二甲基 - 正 - 2,4,6,8-四烯酸化合物被公开用于皮肤病学的局部或全身治疗。

25. 发明授权

US2400873A Dihydronordicyclopentadienyl ethers of hydroxycarboxylic acid esters 失效
标题翻译：羟基羧酸酯的二氢环戊二烯基醚
公开(公告)号：US2400873A
公开(公告)日：1946-05-28
申请号：US52816844
申请日：1944-03-25
申请人： RESINOUS PROD & CHEMICAL CO
发明人： BRUSON HERMAN A
IPC分类号： C07C59/62
CPC分类号： C07C59/62

26. 发明申请

US20150030744A1 NOVEL SUBSTITUTED CYCLOHEXANE COMPOUNDS 有权
标题翻译：新的替代环己烷化合物
公开(公告)号：US20150030744A1
公开(公告)日：2015-01-29
申请号：US14131920
申请日：2012-08-31
申请人： Louis J. Lombardo , Michael E. Lankin , Jaime M. Ferreira , Jennifer B. Tartaglia , John D. Zanone , Amrit Mankoo
发明人： Louis J. Lombardo , Michael E. Lankin , Jaime M. Ferreira , Jennifer B. Tartaglia , John D. Zanone , Amrit Mankoo
IPC分类号： C07C233/60 , C07C69/67 , A23L1/226 , C07C69/675 , C07C59/62 , C07C233/10 , C07C233/58 , C07C69/708
CPC分类号： C07C233/60 , A23L27/203 , A23L27/204 , A23L27/205 , C07C59/62 , C07C69/67 , C07C69/675 , C07C69/708 , C07C233/10 , C07C233/58 , C07C2601/14
摘要： The presently disclosed subject matter is directed to novel compounds of Formula I, Formula II, and Formula III, and stereoisomers thereof, and flavor compositions comprising the novel compounds.
摘要翻译：目前公开的主题涉及式I，式II和式III的新化合物及其立体异构体，以及包含新化合物的风味组合物。

27. 发明授权

US06255326B1 Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group 失效
标题翻译：含有通过含脂肪族或含杂原子的连接基与芳基或杂芳基连接的苯基的化合物
公开(公告)号：US06255326B1
公开(公告)日：2001-07-03
申请号：US09239075
申请日：1999-01-27
申请人： Michael John Ashton , David Charles Cook , Garry Fenton , Susan Jacqueline Hills , Ian Michael McFarlane , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher , Nigel Vicker
发明人： Michael John Ashton , David Charles Cook , Garry Fenton , Susan Jacqueline Hills , Ian Michael McFarlane , Andrew David Morley , Malcolm Norman Palfreyman , Andrew James Ratcliffe , Brian William Sharp , Sukanthini Thurairatnam , Bernard Yvon Jack Vacher , Nigel Vicker
IPC分类号： C07D21172
CPC分类号： C07C43/225 , C07C45/004 , C07C45/292 , C07C45/71 , C07C47/575 , C07C49/84 , C07C59/58 , C07C59/60 , C07C59/62 , C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07C205/59 , C07C217/88 , C07C235/56 , C07C255/57 , C07C255/60 , C07C275/34 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/42 , C07C327/48 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D213/50 , C07D213/75 , C07D213/89 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D409/12
摘要： This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
摘要翻译：本发明涉及通过各种连接与芳基部分连接的用于抑制肿瘤坏死因子的苯基化合物的药物用途。本发明还涉及含有这些化合物的化合物及其制备方法和药物组合物。此外，本发明涉及化合物抑制环AMP磷酸二酯酶的药物用途。

28. 发明授权

US5859054A Leukotriene B4 derivatives, process for their production and their use as pharmaceutical agents 失效
标题翻译：白三烯B4衍生物，其制备方法及其作为药剂的用途
公开(公告)号：US5859054A
公开(公告)日：1999-01-12
申请号：US682724
申请日：1996-11-08
申请人： Werner Skuballa , Bernd Buchmann , Josef Heindl , Wolfgang Frohlich , Roland Ekerdt , Claudia Giesen
发明人： Werner Skuballa , Bernd Buchmann , Josef Heindl , Wolfgang Frohlich , Roland Ekerdt , Claudia Giesen
IPC分类号： C07D521/00 , A61K31/19 , A61K31/195 , A61K47/40 , A61P1/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07C43/115 , C07C59/13 , C07C59/58 , C07C59/62 , C07C59/72 , C07C67/31 , C07C67/343 , C07C69/708 , C07C69/734 , C07C235/04 , C07C235/08 , C07C311/00 , C07C323/14 , A61K31/215
CPC分类号： C07C59/72 , C07C235/08 , C07C59/62 , C07C69/708 , C07C2101/14
摘要： Pharmacologically active leukotriene-B.sub.4 derivatives of general formula I, ##STR1## are described, in whichR.sub.1 represents CH.sub.2 OH, CH.sub.3, CF.sub.3, COOR.sub.4, CONR.sub.5 R.sub.6, orR.sub.2 represents H or an organic acid radical with 1-15 C atoms,R.sub.3 symbolizes H; C.sub.1 -C.sub.14 alkyl, C.sub.3 -C.sub.10 cycloalkyl optionally substituted singly or multiply; C.sub.6 -C.sub.10 aryl radicals, independently of one another, optionally substituted singly or multiply by halogen, phenyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carbonyl, carboxyl or hydroxy; or a 5- to 6-membered aromatic heterocyclic ring with at least 1 heteroatom,R.sub.4 means hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.10 cycloalkyl; C.sub.6 -C.sub.10 aryl radicals optionally substituted by 1-3 halogen, phenyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxyl or hydroxy; CH.sub.2 --CO--(C.sub.6 -C.sub.10) aryl or a 5- to 6-membered ring with at least 1 heteroatom,A symbolizes a trans, trans--CH.dbd.CH--CH.dbd.CH, a --CH.sub.2 CH.sub.2 --CH.dbd.CH-- or a tetramethylene group,B symbolizes a C.sub.1 -C.sub.10 straight-chain or branched-chain alkylene group, which optionally can be substituted by fluorine or the group ##STR2## D means a direct bond, oxygen, sulfur, --C.tbd.C--, --CH.dbd.CR.sub.7, or together with B can also mean a direct bond,R.sub.5 and R.sub.6 are the same or different, and represent H or C.sub.1 -C.sub.4 alkyl or R.sub.6 represents H and R.sub.5 represents C.sub.1 -C.sub.15 alkanoyl or R.sub.8 SO.sub.2, and are optionally substituted with OH,R.sub.7 means H, C.sub.1 -C.sub.5 alkyl, chlorine, bromine,R.sub.8 has the same meaning as R.sub.3,n is 2-5, and, if R.sub.4 means hydrogen, their salts with physiologically compatible bases and their cyclodextrin clathrates.
摘要翻译： PCT No.PCT / EP94 / 00216 Sec。 371日期：1996年11月8日 102（e）日期1996年11月8日PCT 1994年1月27日PCT公布。出版物WO95 / 20564 日期：1995年8月3日描述了通式I的化学活性白三烯-BB衍生物，其中R1表示CH 2 OH，CH 3，CF 3，COOR 4，CONR 5 R 6或R 2表示H或有机酸基团，其中1 -15 C原子，R3表示H; 任选取代的C 1 -C 14烷基，C 3 -C 10环烷基或多或多个; 苯基，C 1 -C 4烷基，C 1 -C 4烷氧基，氟甲基，氯甲基，三氟甲基，羰基，羧基或羟基任意取代; C 6 -C 10芳基独立地彼此独立地被卤素，苯基，或具有至少1个杂原子的5至6元芳族杂环，R 4表示氢，C 1 -C 10烷基，C 3 -C 10环烷基; 任选被1-3个卤素，苯基，C 1 -C 4烷基，C 1 -C 4烷氧基，氟甲基，氯甲基，三氟甲基，羧基或羟基取代的C 6 -C 10芳基; CH2-CO-（C6-C10）芳基或具有至少1个杂原子的5-至6-元环，A表示反式，反式-CH = CH-CH = CH，-CH 2 CH 2 -CH = CH-或四亚甲基，B表示C1-C10直链或支链亚烷基，其任选可以被氟取代，或者基团D表示直接键，氧，硫，-C 3位C，-CH = CR7或与B一起也可以表示直接键合，R5和R6相同或不同，表示H或C1-C4烷基或R6表示H，R5表示C1-C15烷酰基或R8SO2，并且任选被 OH，R7表示H，C1-C5烷基，氯，溴，R8具有与R3相同的含义，n为2-5，如果R 4表示氢，则其与生理上相容的碱和它们的环糊精包合物的盐。

29. 发明授权

US5282987A Carboxy ethers 失效
标题翻译：羧基醚
公开(公告)号：US5282987A
公开(公告)日：1994-02-01
申请号：US740460
申请日：1991-08-05
申请人： Dieter Balzer , Heinz Riemer , Werner Friedrich
发明人： Dieter Balzer , Heinz Riemer , Werner Friedrich
IPC分类号： B01F17/00 , B01F17/44 , C07C59/125 , C07C59/60 , C07C59/62 , C08G65/26 , C08G65/32 , C08G65/337 , C10M173/00 , C11D1/06 , C10M129/32 , C10M145/36
CPC分类号： B01F17/0028 , C07C59/125 , C07C59/60 , C07C59/62 , C08G65/26 , C08G65/337 , C10M173/00 , C11D1/06 , C10M2201/02 , C10M2209/104 , C10M2209/107 , C10N2240/06 , C10N2240/08 , C10N2250/02
摘要： A carboxy ether of formula (II):[R--O(C.sub.3 H.sub.6 O).sub.x (C.sub.2 H.sub.4 O).sub.y (C.sub.3 H.sub.6 O).sub.z ].sub.2 CHCOOM (II)is disclosed. In formula (II) R is (i) a saturated or unsaturated, linear or branched group containing 6 to 20 carbon atoms, (ii) an alkylaromatic group or an alkylcycloaliphatic group, each containing a total of 4 to 16 carbon atoms in its alkyl group, (iii) a dialkylaromatic, dialkylcycloaliphatic, or trialkylcycloaliphatic group, each containing a total of 5 to 24 carbon atoms in its alkyl groups, or (iv) a trialkylaromatic group with a total of 7 to 28 carbon atoms in its alkyl groups; x is 0 to 15, y is 1 to 40, z is 0 to 15; and M is an alkali metal cation, an alkaline earth metal cation, an ammonium cation, an alkanolammonium cation, or a proton.
摘要翻译：公开了式（II）的羧基醚：[R-O（C 3 H 6 O）x（C 2 H 4 O）y（C 3 H 6 O）z] 2 CHCOOM（II）。在式（II）中，R是（i）含有6至20个碳原子的饱和或不饱和的直链或支链基团，（ii）烷基芳族基团或烷基环脂族基团，其烷基中含有总共4至16个碳原子基团，（iii）二烷基芳基，二烷基环脂族或三烷基环脂族基团，其烷基中含有总共5至24个碳原子，或（iv）其烷基中总共具有7至28个碳原子的三烷基芳族基团; x为0〜15，y为1〜40，z为0〜15， M是碱金属阳离子，碱土金属阳离子，铵阳离子，链烷醇铵阳离子或质子。

30. 发明授权

US5117037A Cis-bicyclo[4,3.0]non-2-end derivatives 失效
标题翻译： CIS-BICYCLO（4,3.0）非2-D衍生物
公开(公告)号：US5117037A
公开(公告)日：1992-05-26
申请号：US622471
申请日：1990-12-05
申请人： Masakatsu Shibasaki , Takahashi Atsuo , Tuyoshi Aoki , Hiroyasu Sato , Shin-ichi Yamada , Michiko Kudo , Takaji Yamaguchi , Kentaro Kogi , Sen-ichi Narita
发明人： Masakatsu Shibasaki , Takahashi Atsuo , Tuyoshi Aoki , Hiroyasu Sato , Shin-ichi Yamada , Michiko Kudo , Takaji Yamaguchi , Kentaro Kogi , Sen-ichi Narita
IPC分类号： C07C59/46 , C07C59/62 , C07C69/712 , C07C69/732 , C07C69/738 , C07C405/00
CPC分类号： C07C69/738 , C07C405/0083 , C07C59/46 , C07C59/62 , C07C69/712 , C07C69/732 , Y02P20/55
摘要： A cis-bicyclo[4.3.0]non-2-ene derivative of the formula: ##STR1## wherein R is a hydrogen atom, or a protecting group for a hydroxyl group, R.sup.1 is a hydrogen atom, A C.sub.1 -C.sub.12 straight or branched chain alkyl group, a substituted or unsubstituted phenyl group, a C.sub.6 -C.sub.12 aralkyl group containing a condensed aromatic ring or an aromatic hetero ring, or 1 equivalent of a cation, A is --CH.dbd.CH--CH.sub.2 --, or --CH.sub.2 --CH.sub.2 --O--, R.sup.2 is a C.sub.3 -C.sub.10 straight or branched chain alkyl group, a C.sub.1 -C.sub.3 alkyl group substituted by an aryloxy group which may be substituted, a C.sub.3 -C.sub.12 straight or branched chain alkenyl group, a C.sub.3 -C.sub.8 straight or branched chain alkynyl group, a C.sub.1 -C.sub.3 alkyl group substituted by a phenyl or phenoxy group which may be substituted, by a C.sub.1 -C.sub.6 alkoxy group or by a C.sub.5 -C.sub.8 cycloalkyl group, R.sup.3 is a hydrogen atom, a methyl group, or a vinyl group, and X is a halogen atom.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式