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21. 发明申请

WO2002090314A1 PYRUVATE DERIVATIVES 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：WO2002090314A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/014057
申请日：2002-05-03
申请人： GALILEO LABORATORIES, INC. , WANG, Bing , MILLER, Guy , FLAIM, Stephen, F. , DEL BALZO, Ughetta , ZHANG, Wei , JANAGANI, Satyanarayana , SONG, Jingao
发明人： WANG, Bing , MILLER, Guy , FLAIM, Stephen, F. , DEL BALZO, Ughetta , ZHANG, Wei , JANAGANI, Satyanarayana , SONG, Jingao
IPC分类号： C07C69/66
CPC分类号： C07D213/30 , A61K31/12 , A61K31/16 , A61K31/215 , A61K31/223 , A61K38/00 , C07C249/12 , C07C319/20 , C07C323/60 , C07D207/16 , C07D207/22 , C07D207/24 , C07D211/62 , C07D211/74 , C07D211/78 , C07D217/04 , C07D233/42 , C07D233/64 , C07D233/84 , C07D235/28 , C07D239/78 , C07D249/14 , C07D271/113 , C07D277/16 , C07D277/74 , C07D279/12 , C07D285/125 , C07D285/135 , C07D295/13 , C07D295/15 , C07D295/185 , C07D339/08 , C07D345/00 , C07D405/12 , C07D473/38 , C07K5/0215 , C07K5/0819 , C07C323/57 , C07C251/60
摘要： Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.
摘要翻译：某些已知和新颖的丙酮酸衍生物在恢复或保持已经遭受氧剥夺的氧化感受态细胞中的代谢完整性方面特别有活性。这些丙酮酸衍生化合物包括但不限于肟，酰胺，丙酮酸盐类似物，改性丙酮酸盐类似物，丙酮酸酯（例如多元醇 - 丙酮酸酯，丙酮酸硫酯，甘油 - 丙酮酸酯和二羟基丙酮 - 丙酮酸酯）。这样的丙酮酸衍生物（包括单互变异构体，单立体异构体和互变异构体和/或立体异构体的混合物及其药学上可接受的盐）可用于制备用于治疗以氧化应激为特征的许多病症的药物组合物。

22. 发明申请

WO00052530A1 OXIME DERIVATIVES AND THE USE THEREOF AS PHOTOINITIATORS 审中-公开
标题翻译： OXIME衍生物及其作为光敏剂的用途
公开(公告)号：WO00052530A1
公开(公告)日：2000-09-08
申请号：PCT/EP2000/001404
申请日：2000-02-21
IPC分类号： C07C309/66 , C07C309/73 , C07C323/57 , C07C381/00 , C07D307/54 , C07D307/66 , C07D333/36 , C07D339/08 , C07F9/09 , C07F9/32 , C07F9/6553 , C08F2/50 , G03F7/031
CPC分类号： G03F7/031 , B33Y70/00 , C07C309/66 , C07C309/73 , C07C323/57 , C07C381/00 , C07D307/66 , C07D333/36 , C07D339/08 , C07F9/097 , C07F9/655345 , C08F2/50 , Y10S430/12 , Y10S430/123
摘要： Radically photopolymerizable compositions comprising (a) at least one ethylenically unsaturated photopolymerizable compound; (b) as photoinitiator, at least one compound of formulae (I, II, III, IV, V and/or VI), wherein m is 0 or 1; n is 0, 1, 2 or 3; x is 1 or 2; R1 is inter alia phenyl, naphthyl, anthracyl or phenanthryl, a heteroaryl radical, C2-C12alkenyl, C4-C8cycloalkenyl, or C6-C12bicycloalkenyl; R'1 is inter alia C2-C12alkylene, or phenylene; R2 has one of the meanings of R1 or inter alia is phenyl; y is 1 or 2; R3 if x is 1 inter alia is C1-C18alkylsulfonyl, or phenyl-C1-C3alkylsulfonyl, R3 if x is 2, is for example C2-C12alkylenedisulfonyl; R4 and R5 inter alia are hydrogen, halogen, or C1-C8alkyl; R6, R7, R8 inter alia are hydrogen, R26Y-, or phenyl; R9 inter alia is C5-C8cycloalkyl, or phenyl; A is for example -S-, -O-, or -NR10- ; Q is C1-C8-alkylene optionally interrupted by -O-; X is -O- or -NR9-; R10 inter alia is hydrogen, or phenyl; and (c) at least one coinitiator; are especially suitable for the preparation of colour filter systems.
摘要翻译：自由基光聚合组合物，其包含（a）至少一种烯属不饱和光聚合化合物; （b）作为光引发剂，至少一种式（I，II，III，IV，V和/或VI）的化合物，其中m为0或1; n为0,1,2或3; x为1或2; R 1特别是苯基，萘基，蒽基或菲基，杂芳基，C 2 -C 12烯基，C 4 -C 8环烯基或C 6 -C 12双环烯基; R'1特别是C 2 -C 12亚烷基或亚苯基; R2具有R1的含义之一，特别是苯基; y为1或2; 如果x是1，则R3如果是C 1 -C 18烷基磺酰基，或苯基-C 1 -C 3烷基磺酰基，如果x是2，则R 3是例如C 2 -C 12亚烷基二磺酰基; R4和R5尤其是氢，卤素或C1-C8烷基; R6，R7，R8特别是氢，R26Y-或苯基; R9尤其是C5-C8环烷基或苯基; A是例如-S-，-O-或-NR 10 - ; Q是任选被-O-间隔的C1-C8-亚烷基; X是-O-或-NR 9 - ; R 10尤其是氢或苯基; 和（c）至少一种共引发剂; 特别适用于制备滤色器系统。

23. 发明申请

US20150133544A1 ETHYL (2R)-2-ACETAMIDO-3-(4-METHYLBENZOYLSULFANYL)PROPANOATE AND USES THEREOF 有权
标题翻译：乙酰（2R）-2-乙酰氨基-3-（4-甲基苯甲酰基）丙酸酯及其用途
公开(公告)号：US20150133544A1
公开(公告)日：2015-05-14
申请号：US14535953
申请日：2014-11-07
申请人： Promentis Pharmaceuticals, Inc.
发明人： Michael Neary , James Nieman , Steven Tanis , Daniel Lawton
IPC分类号： C07C327/34
CPC分类号： C07D277/08 , A61K31/165 , A61K31/265 , A61K31/426 , A61K31/513 , C07C323/57 , C07C323/58 , C07C323/59 , C07C323/60 , C07C327/26 , C07C327/32 , C07C327/34 , C07C329/06 , C07D241/08 , C07D277/14 , C07D327/04
摘要： A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.
摘要翻译：新型取代的N-乙酰基-L-半胱氨酸（NAC）衍生物和使用该化合物治疗疾病和/或病症的方法，包括但不限于中枢神经系统的疾病和/或病症或涉及中枢神经系统 CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿病，头痛性痴呆，HIV相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物成瘾。

26. 发明申请

US20110053901A1 ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE 审中-公开
标题翻译：用于抑制异丙肾上腺素甲基衍生物的乙酰胆碱化合物
公开(公告)号：US20110053901A1
公开(公告)日：2011-03-03
申请号：US12867796
申请日：2009-02-13
申请人： Seung-Yub Lee , Michael Voronkov , Peter Wolanin
发明人： Seung-Yub Lee , Michael Voronkov , Peter Wolanin
IPC分类号： A61K31/5375 , C07D211/72 , A61K31/44 , C07C279/02 , A61K31/22 , C07D257/04 , A61K31/41 , A61K31/155 , C07C257/00 , A61K31/18 , C07C311/01 , A61K31/4164 , C07D233/00 , C07C321/02 , A61K31/195 , C07D265/30 , A61K31/445 , C07D211/60 , C07D233/38 , C07D239/24 , A61K31/505 , A61K31/56 , A61K31/40
CPC分类号： C07D233/88 , C07C323/57 , C07C323/58 , C07C323/59 , C07C323/60 , C07C327/42 , C07C335/08 , C07D207/22 , C07D207/34 , C07D213/74 , C07D233/70 , C07D235/14 , C07D239/42 , C07D249/04 , C07D257/04 , C07D263/48 , C07D265/30 , C07D277/42 , C07D295/215 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
摘要翻译：除此之外，本发明提供能够有效抑制嗜中性粒细胞，巨噬细胞和血小板中G蛋白或GPCR介导的炎症反应的新型化合物。特别地，本发明的化合物作为水肿抑制剂，红斑抑制剂和MPO抑制剂（髓过氧化物酶），含有相同化合物的药物组合物及其用于治疗可能受益于水肿，红斑和MPO抑制的疾病的用途例如炎症（急性或慢性），哮喘，自身免疫疾病和慢性阻塞性肺病（COPD）（例如肺气肿，慢性支气管炎和小气道疾病等），免疫系统的炎症反应，皮肤疾病（例如对于患有酒渣鼻，特应性皮炎，脂溢性皮炎，牛皮癣的患者，肠易激综合征（例如，Chron氏病和溃疡性结肠炎等）以及中枢神经系统疾病（例如帕金森氏病））减少急性皮肤刺激。

27. 发明授权

US06900218B2 Pyruvate derivatives 失效
标题翻译：丙酮酸衍生物
公开(公告)号：US06900218B2
公开(公告)日：2005-05-31
申请号：US10138938
申请日：2002-05-03
申请人： Bing Wang , Guy Miller , Satyanarayana Janagani
发明人： Bing Wang , Guy Miller , Satyanarayana Janagani
IPC分类号： A61K31/12 , A61K31/16 , A61K31/215 , A61K31/223 , A61K38/00 , A61P9/10 , C07C249/12 , C07C251/60 , C07C319/20 , C07C323/57 , C07C323/60 , C07D207/16 , C07D207/22 , C07D207/24 , C07D211/62 , C07D211/74 , C07D211/78 , C07D213/30 , C07D217/04 , C07D233/42 , C07D233/54 , C07D233/84 , C07D235/28 , C07D239/78 , C07D249/14 , C07D271/10 , C07D271/113 , C07D277/16 , C07D277/74 , C07D279/12 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/13 , C07D295/15 , C07D295/185 , C07D339/08 , C07D345/00 , C07D405/12 , C07D473/38 , C07K5/02 , C07K5/093 , C07D235/12 , A61K31/428 , A61K31/517 , C07D239/74 , C07D277/60
CPC分类号： C07D213/30 , A61K31/12 , A61K31/16 , A61K31/215 , A61K31/223 , A61K38/00 , C07C249/12 , C07C319/20 , C07C323/60 , C07D207/16 , C07D207/22 , C07D207/24 , C07D211/62 , C07D211/74 , C07D211/78 , C07D217/04 , C07D233/42 , C07D233/64 , C07D233/84 , C07D235/28 , C07D239/78 , C07D249/14 , C07D271/113 , C07D277/16 , C07D277/74 , C07D279/12 , C07D285/125 , C07D285/135 , C07D295/13 , C07D295/15 , C07D295/185 , C07D339/08 , C07D345/00 , C07D405/12 , C07D473/38 , C07K5/0215 , C07K5/0819 , C07C323/57 , C07C251/60
摘要： Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.
摘要翻译：某些已知和新颖的丙酮酸衍生物在恢复或保持已经遭受氧剥夺的氧化感受态细胞中的代谢完整性方面特别有活性。这些丙酮酸衍生化合物包括但不限于肟，酰胺，丙酮酸盐类似物，改性丙酮酸盐类似物，丙酮酸酯（例如多元醇 - 丙酮酸酯，丙酮酸硫酯，甘油 - 丙酮酸酯和二羟基丙酮 - 丙酮酸酯）。这种丙酮酸衍生物（包括单互变异构体，单立体异构体和互变异构体和/或立体异构体的混合物及其药学上可接受的盐）可用于制备用于治疗以氧化应激为特征的许多病症的药物组合物。

28. 发明授权

US5286750A Phenylacetic acid derivatives and fungicides containing them 失效
标题翻译：苯乙酸衍生物和含有它们的杀真菌剂
公开(公告)号：US5286750A
公开(公告)日：1994-02-15
申请号：US32201
申请日：1993-03-15
申请人： Bernd Mueller , Hubert Sauter , Eberhard Ammermann , Gisela Lorenz , Franz Roehl
发明人： Bernd Mueller , Hubert Sauter , Eberhard Ammermann , Gisela Lorenz , Franz Roehl
IPC分类号： A01N37/10 , A01N37/36 , A01N37/38 , A01N37/40 , A01N37/42 , A01N37/50 , A01N39/00 , A01N39/02 , A01N39/04 , A01N43/40 , A01N43/54 , A01N43/74 , A01N49/00 , A01N53/00 , C07C229/34 , C07C251/24 , C07C251/48 , C07C251/86 , C07C255/41 , C07C323/19 , C07C323/20 , C07C323/56 , C07C323/57 , C07D213/64 , C07D213/70 , C07D213/79 , C07D239/40 , C07D277/70 , A61K31/22 , A61K31/38 , C07C67/02 , C07D239/02
CPC分类号： C07D213/64 , A01N37/10 , A01N37/36 , A01N37/38 , A01N37/40 , A01N37/42 , A01N37/50 , A01N39/00 , A01N39/02 , A01N39/04 , A01N43/40 , A01N43/54 , A01N43/74 , A01N49/00 , A01N53/00 , C07C229/34 , C07C251/24 , C07C251/48 , C07C251/86 , C07C255/41 , C07C323/19 , C07C323/20 , C07C323/56 , C07C323/57 , C07D213/70 , C07D213/79 , C07D239/40 , C07D277/70 , C07C2101/02 , C07C2101/14 , C07C2102/08
摘要： Unsaturated phenylacetic acid derivatives of the general formula ##STR1## where U is .dbd.O, .dbd.CH--OCH.sub.3, .dbd.N--OCH.sub.3, .dbd.N--NH--CH.sub.3, .dbd.CH.sub.2, .dbd.CH--CH.sub.3, .dbd.CH--CH.sub.2 --CH.sub.3 or .dbd.CH--S--CH.sub.3 andZ.sup.1 and Z.sup.2 are hydrogen, halogen, trifluoromethyl, cyanide, NO.sub.2 or unsubstituted or substituted alkyl, alkenyl, aryl, alkynyl, alkoxy, aryloxy, arylalkoxy, acyloxy, hetaryl, --CO.sub.2 R.sup.1, --CONR.sup.2 R.sup.3, COR.sup.4 or NR.sup.5 R.sup.6, and Z.sup.1 and Z.sup.2 may also form a ring,A is meta or para and is (CH.sub.2).sub.n, CH.dbd.CH, O--(CH.sub.2).sub.n, O--(CH.sub.2).sub.n --CO, CH.sub.2 --O--CO--(CH.sub.2).sub.n, CO--O--(CH.sub.2).sub.n, O--CO--(CH.sub.2).sub.n, O--(CH.sub.2).sub.n --CO--O, O--(CH.sub.2).sub.n+2 --O, CH.sub.2 O--(CH.sub.2).sub.n, CH.sub.2 --S--(CH.sub.2).sub.n CH.sub.2 --NR.sup.7 --(CH.sub.2).sub.n, CH(CN)--O--CO--(CH.sub.2).sub.n, CH.dbd.N--(CH.sub.2).sub.n or CH.dbd.N--O--(CH.sub.2).sub.n.n is from 0 to 20,B is substituted or unsubstituted and is hydrogen, alkyl, cycloalkyl, aryl or hetaryl,R.sup.1 to R.sup.7 are hydrogen or unsubstituted or substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, hetaryl, aralkyl or cycloalkylalkyl, their acid addition products and base addition products, and fungicides and insecticides containing these compounds.
摘要翻译：其中U为= O，= CH-OCH 3，= N-OCH 3，= N-NH-CH 3，= CH 2，= CH-CH 3，= CH-CH 2 -CH 3或= CH-S-CH 3和Z 1和Z 2是氢，卤素，三氟甲基，氰化物，NO 2或未取代或取代的烷基，烯基，芳基，炔基，烷氧基，芳氧基，芳基烷氧基，酰氧基，杂芳基，-CO 2 R 1，-CONR 2 R 3，COR 4或NR 5 R 6 ，Z 1和Z 2也可以形成环，A是间位或对位，是（CH 2）n，CH = CH，O-（CH 2）n，O-（CH 2）n -CO，CH 2 -O-CO- CH 2）n，CO-O-（CH 2）n，O-CO-（CH 2）n，O-（CH 2）n -COO，O-（CH 2）n + 2-O，CH 2 O- ，CH2-S-（CH2）n + L，CH2-NR7-（CH2）n，CH（CN）-O-CO-（CH2）n，CH = N-（CH2）n或CH = NO- ）n。 n为0至20，B为取代或未取代的且为氢，烷基，环烷基，芳基或杂芳基，R1至R7为氢或未取代或取代的烷基，环烷基，烯基，炔基，芳基，杂芳基，芳烷基或环烷基烷基，酸加成产物和碱加成产物，以及含有这些化合物的杀真菌剂和杀虫剂。

29. 发明授权

US3330842A Intermediates in the production of cephalosporin c and derivatives thereof 失效
标题翻译：生产头孢菌素c及其衍生物的中间体
公开(公告)号：US3330842A
公开(公告)日：1967-07-11
申请号：US24072662
申请日：1962-11-28
申请人： WILLIAM GRAHAM
发明人： WILLIAM GRAHAM
IPC分类号： C07C323/22 , C07C323/52 , C07C323/57 , C07C323/58 , C07C327/28 , C07C331/10 , C07C335/08
CPC分类号： C07C323/57 , C07C323/22 , C07C323/52 , C07C323/58 , C07C327/28 , C07C331/10 , C07C335/08

30. 发明授权

US11827586B2 Method for producing amino acid aminoalkyl ester or inorganic acid salt thereof 有权
公开(公告)号：US11827586B2
公开(公告)日：2023-11-28
申请号：US17052541
申请日：2019-05-15
申请人： ASAHI KASEI KABUSHIKI KAISHA
发明人： Nobuhisa Miyake , Kazuhiro Takagaki , Tsubasa Uematsu , Koichi Nakaoka , Masaaki Shinohata
IPC分类号： C07C269/06 , C07C227/18 , C07C249/02 , C07C273/18 , C07C229/08 , C07C229/24 , C07C229/26 , C07C229/36 , C07C251/16 , C07C271/48 , C07C275/10
CPC分类号： C07C269/06 , C07C227/18 , C07C249/02 , C07C273/18 , C07C229/08 , C07C229/24 , C07C229/26 , C07C229/36 , C07C251/16 , C07C271/48 , C07C275/10 , C07C227/18 , C07C229/08 , C07C227/18 , C07C229/24 , C07C227/18 , C07C229/26 , C07C227/18 , C07C229/36 , C07C249/02 , C07C251/08 , C07C249/02 , C07C251/16 , C07C269/06 , C07C271/48 , C07C273/18 , C07C275/10 , C07C319/20 , C07C323/57
摘要： The present invention provides a method for producing an amino acid aminoalkyl ester or an inorganic acid salt thereof by reacting a compound represented by general formula (I) shown below or a compound represented by general formula (III) shown below, or a salt thereof, and at least one compound selected from the group consisting of compounds represented by general formula (IV-I) shown below, compounds represented by general formula (IV-II) shown below, compounds represented by general formula (IV-III) shown below and compounds represented by general formula (IV-IV) shown below, or an inorganic acid salt thereof.

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