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21. 发明申请

US20110071116A1 ANTIMICROBIAL N-HALOGENATED AMINO ACID SALTS 审中-公开
标题翻译：抗微生物N-氢化氨基酸
公开(公告)号：US20110071116A1
公开(公告)日：2011-03-24
申请号：US12953627
申请日：2010-11-24
申请人： L. Wayne Schneider , Wesley Wehsin Han , Masood A. Chowhan , David W. Stroman , W. Dennis Dean , Michael S. Gaines
发明人： L. Wayne Schneider , Wesley Wehsin Han , Masood A. Chowhan , David W. Stroman , W. Dennis Dean , Michael S. Gaines
IPC分类号： A01N57/18 , A61K31/185 , C07C309/04 , A01P1/00 , A61P31/00
CPC分类号： C07C303/32 , A01N37/44 , A01N41/08 , A61K31/145 , A61L12/08 , A61L12/10 , A01N33/12 , A01N57/20 , A01N2300/00 , C07C309/14
摘要： The present invention relates to a formulation comprising a N-halogenated amino acid and a phase transfer agent. The present invention also describes a method for disinfecting and/or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid salt for a time sufficient to disinfect and/or clean the lens.
摘要翻译：本发明涉及包含N-卤代氨基酸和相转移剂的制剂。本发明还描述了一种消毒和/或清洁隐形眼镜的方法，包括使隐形眼镜与包含N-卤代氨基酸盐的制剂接触足以消毒和/或清洁镜片的时间。

22. 发明申请

US20170182201A1 SYSTEM FOR DISINFECTING CONTACT LENSES 审中-公开
公开(公告)号：US20170182201A1
公开(公告)日：2017-06-29
申请号：US15300296
申请日：2015-03-23
申请人： Novartis AG
发明人： Robert Carey Tucker
IPC分类号： A61L12/12 , C02F1/461 , C02F1/66 , B08B3/08
CPC分类号： A61L12/124 , A61L12/023 , A61L12/10 , B08B3/08 , C02F1/461 , C02F1/66 , C02F2201/46115 , C02F2307/02 , C11D3/0078 , C11D3/3947 , C11D11/007
摘要： The present invention is generally directed to a hydrogen peroxide-based lens care system for disinfecting contact lenses. Unlike hydrogen peroxide-based system known in the prior art, a lens care system of the present invention involves electrochemically neutralizing of hydrogen peroxide after any desired period of disinfection time for which contact lenses have been immersed in a hydrogen peroxide-based lens care solution.

23. 发明授权

US09622480B2 Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide 有权
公开(公告)号：US09622480B2
公开(公告)日：2017-04-18
申请号：US14718852
申请日：2015-05-21
申请人： S.K. PHARMACEUTICALS, INC.
发明人： Hampar L. Karagoezian
IPC分类号： A01N59/00 , A61K9/00 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/22 , A61K33/40 , A61K33/20
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

24. 发明申请

US20150024987A1 CONTACT LENS CARE PREPARATION AND PACKAGING SOLUTION 有权
标题翻译：联系人眼镜护理准备和包装解决方案
公开(公告)号：US20150024987A1
公开(公告)日：2015-01-22
申请号：US14381870
申请日：2012-03-02
申请人： Yosuke Matsuoka , Norio Iwakiri , Mao Maruhashi , Nobuyuki Sakamoto
发明人： Yosuke Matsuoka , Norio Iwakiri , Mao Maruhashi , Nobuyuki Sakamoto
IPC分类号： A61L12/10
CPC分类号： A61L12/10 , A61L12/08 , A61L12/14 , C11D3/0078 , C11D3/3719 , C11D3/3765 , C11D3/3773 , C11D3/3784
摘要： Provided are a contact lens care preparation capable of imparting durable surface lubricity and amebic adhesion inhibitory effect to a contact lens surface through a simple treatment, and a contact lens packaging solution utilizing the same. The contact lens care preparation is composed of a solution containing 0.01 to 2 weight/volume % of a polymer having particular monomer units with a phosphorylcholine-like group, particular (meth)acrylamide derivative units, and particular monomer units with a hydrophobic group at a particular ratio, and a weight average molecular weight of 5,000 to 2,000,000, and is useful as a contact lens packaging solution.
摘要翻译：提供能够通过简单的处理赋予隐形眼镜表面耐久的表面润滑性和抗坏血酸粘附抑制作用的隐形眼镜护理制剂，以及使用该隐形眼镜护理制剂的隐形眼镜包装溶液。隐形眼镜护理制剂由含有0.01〜2重量/体积％的具有磷酸胆碱基的特定单体单元的聚合物，特定的（甲基）丙烯酰胺衍生物单元和具有疏水基团的特定单体单元的溶液组成，特别的比例，重均分子量为5,000〜2,000,000，可用作隐形眼镜包装溶液。

25. 发明申请

US20070194486A1 Ophthalmic lens inspection processing aid 审中-公开
标题翻译：眼镜检查加工助剂
公开(公告)号：US20070194486A1
公开(公告)日：2007-08-23
申请号：US11125058
申请日：2005-05-09
申请人： Kerry Sanders , Michael Widman , James Ford , Frank Molock
发明人： Kerry Sanders , Michael Widman , James Ford , Frank Molock
IPC分类号： B28B11/00 , B29B15/00
CPC分类号： A61L12/08 , A61L12/10 , A61L12/14 , B29D11/00192 , B29D11/0098 , C11D3/0078 , C11D7/266 , C11D7/28 , G02C13/00
摘要： The present invention discloses improved methods and systems for inspecting an ophthalmic lens by exposing the ophthalmic lens to a processing aid solution that includes RCO2CH2CH20(CH2CH2O)xCH2CH2O2CR where R comprises (equals) at least one of: CF3CF2(CF2)xCH2; CH3CH2(CH2)xCH2; and Ry[Si(CH3)2o]x(CH2)3, while the lens is contained in a ophthalmic lens receptacle, in order to facilitate the removal of bubbles and center the lens in the ophthalmic lens receptacle with a reduced incidence of ophthalmic lenses being folded over on themselves. The decreased incidence of bubbles and proper positioning of the ophthalmic lens in turn facilitates accurate inspection.
摘要翻译：本发明公开了通过将眼科镜片暴露于包括RCO 2 CH 2 CH 2的加工助剂溶液来检查眼科镜片的改进方法和系统， SUB> 0（CH 2 CH 2 CH 2）x CH 2 CH 2 CH 2 其中R包括（等于）以下中的至少一个：CF 3 CF 2（CF 2）x X CH 2; CH 2 3 CH 2（CH 2）x CH 2 CH 2; 和Ry [Si（CH 3 3）2 O] x（CH 2）3），同时镜片按顺序包含在眼科镜片容器中以便于去除气泡并将透镜居中放置在眼科镜片容器中，其中眼镜片的折叠发生率降低。气泡的发生率降低和眼镜片的适当定位反过来有助于准确检查。

26. 发明申请

US20070104798A1 Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide 审中-公开
标题翻译：含有亚氯酸盐和过氧化氢的协同抗菌制剂
公开(公告)号：US20070104798A1
公开(公告)日：2007-05-10
申请号：US11633355
申请日：2006-12-04
申请人： Hampar Karagoezian
发明人： Hampar Karagoezian
IPC分类号： A61K33/40 , A61K33/14
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
摘要翻译：一种用于眼科和皮肤科产品的抗微生物防腐剂。防腐剂包括约0.005wt。％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。此外，防腐剂在5.0-8.8的pH范围内不产生二氧化氯。还包括用于直接施用于生物的眼睛或皮肤的抗微生物眼科和皮肤病学组合物，其包含约0.005重量％％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。还包括用于治疗眼睛和皮肤疾病（例如伤口，烧伤，感染，溃疡，银屑病等）的干燥和通过将组合物施用于眼睛而在眼睛处消毒和清洁隐形眼镜的方法，或到隐形眼镜。

27. 发明专利

JP2017511185A コンタクトレンズの消毒システム有权
公开(公告)号：JP2017511185A
公开(公告)日：2017-04-20
申请号：JP2016559829
申请日：2015-03-23
申请人：ノバルティスアーゲー , ノバルティスアーゲー
发明人：タッカー，ロバート・キャリー
IPC分类号： A61L12/12 , C02F1/461 , G02C13/00
CPC分类号： A61L12/124 , A61L12/023 , A61L12/10 , B08B3/08 , C02F1/461 , C02F1/66 , C02F2201/46115 , C02F2307/02 , C11D3/0078 , C11D3/3947 , C11D11/007
摘要：本発明は、概して、コンタクトレンズを消毒するための過酸化水素系レンズケアシステムに関する。従来技術で既知の過酸化水素系システムと異なり、本発明のレンズケアシステムは、コンタクトレンズが過酸化水素系レンズケア溶液に浸漬された任意の所望の消毒時間後に、過酸化水素を電気化学的に中和することを含む。

28. 发明申请

US20160199526A1 OPHTHALMIC SOLUTION 审中-公开
标题翻译： OPHTHALMIC解决方案
公开(公告)号：US20160199526A1
公开(公告)日：2016-07-14
申请号：US14914066
申请日：2014-08-05
申请人： NOF CORPORATION
发明人： Shunsuke SAKURAI , Koji MIYAMOTO , Yohei TAKADA , Yoshihisa SHIMAMURA , Mao MARUHASHI , Nobuyuki SAKAMOTO
IPC分类号： A61L12/10 , A61L12/14
CPC分类号： A61L12/10 , A61K9/0048 , A61K31/155 , A61K47/02 , A61K47/32 , A61K47/34 , A61K47/38 , A61L12/14 , A61L12/141 , A61L12/142
摘要： Provided is an ophthalmic solution of which preservative component, hexamethylene biguanide, contained therein is inhibited from being adsorbed on soft contact lenses and eye droppers. The ophthalmic solution contains, at a specific ratio, (A) hydroxypropyl methylcellulose having 28.0 to 30.0 mass % methoxy groups and 7.0 to 12.0 mass % hydroxypropoxy groups, both with respect to the total amount of the hydroxypropyl methylcellulose, at a methoxy group/hydroxypropoxy group ratio of 2.5 to 4.0 by mass, wherein a 2 mass % aqueous solution of the hydroxypropyl methylcellulose at 20° C. has a viscosity of 50 to 4000 mPa·s; (B) sodium chloride or potassium chloride; (C) hexamethylene biguanide or a salt thereof; (D) 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer; and (E) water.
摘要翻译：本发明提供了防止其中含有六亚甲基双胍的防止组分被吸收在软性隐形眼镜和滴眼剂上的眼用溶液。该眼用溶液在甲氧基/羟丙氧基上以特定比例含有（A）具有28.0〜30.0质量％甲氧基的羟丙基甲基纤维素和7.0〜12.0质量％羟丙氧基，相对于羟丙基甲基纤维素的总量组合比为2.5〜4.0质量％，其中羟丙基甲基纤维素在20℃下的2质量％水溶液的粘度为50〜4000mPa·s; （B）氯化钠或氯化钾; （C）六亚甲基双胍或其盐; （D）2-甲基丙烯酰氧基乙基磷酸胆碱/甲基丙烯酸丁酯共聚物; 和（E）水。

29. 发明申请

US20150264936A1 SYNERGISTIC ANTIMICROBIAL PREPARATIONS CONTAINING CHLORITE AND HYDROGEN PEROXIDE 有权
标题翻译：含有氯化氢和过氧化氢的协同抗微生物制剂
公开(公告)号：US20150264936A1
公开(公告)日：2015-09-24
申请号：US14718852
申请日：2015-05-21
申请人： S.K. Pharmaceuticals, Inc.
发明人： Hampar L. Karagoezian
IPC分类号： A01N59/00
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
摘要翻译：一种用于眼科和皮肤科产品的抗微生物防腐剂。防腐剂包括约0.005wt。％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。此外，防腐剂在5.0-8.8的pH范围内不产生二氧化氯。还包括用于直接施用于生物的眼睛或皮肤的抗微生物眼科和皮肤病学组合物，其包含约0.005重量％％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。还包括用于治疗眼睛和皮肤疾病（例如伤口，烧伤，感染，溃疡，银屑病等）的干燥和通过将组合物施用于眼睛而在眼睛处消毒和清洁隐形眼镜的方法，或到隐形眼镜。

30. 发明授权

US08460701B2 Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide 有权
公开(公告)号：US08460701B2
公开(公告)日：2013-06-11
申请号：US12874443
申请日：2010-09-02
申请人： Hampar L. Karagoezian
发明人： Hampar L. Karagoezian
IPC分类号： A61K33/40 , A61K9/127 , A61K9/14 , A61P27/04 , A61P31/00 , A61P17/00 , A01P1/00 , A01N59/08
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

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