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21. 发明公开

EP1720586A1 APPARATUS AND METHODS FOR ENZYMATIC DEBRIDEMENT OF SKIN LESIONS 失效转让
标题翻译：装置脱除皮肤伤害
公开(公告)号：EP1720586A1
公开(公告)日：2006-11-15
申请号：EP05703144.5
申请日：2005-01-27
申请人： Ramot at Tel-Aviv University Ltd. , Enzysurge Ltd.
发明人： FREEMAN, Amihay , HIRSZOWICZ, Eran , BE'ERI-LIPPERMAN, Michal
IPC分类号： A61M3/02 , A61M27/00 , A61K38/48 , A61M35/00
CPC分类号： A61M3/0258 , A61B10/0035 , A61B10/02 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61B2017/3411 , A61K38/48 , A61K38/4886 , A61M1/0088 , A61M3/0241 , A61M3/0283 , A61M3/0287 , A61M27/00 , C12M45/09 , C12N5/0629 , C12N2509/00
摘要： The present invention relates to apparatus for debridement of devitalized tissue in skin lesions, comprising a plurality of height- and angle-adjustable inlet tubes (204) and at least one outlet tube (206) and means (230) to form an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.

22. 发明公开

EP0051747A1 Gerät zur Entfernung von Warzen mit Flüssigstickstoff 失效
标题翻译： Gerätzur Entfernung von Warzen mitFlüssigstickstoff。
公开(公告)号：EP0051747A1
公开(公告)日：1982-05-19
申请号：EP81108004.3
申请日：1981-10-07
申请人： MESSER GRIESHEIM GMBH
发明人： Volker, Wolfgang , Weinknecht, Bernd , Jankowski, Detlef
IPC分类号： A61B17/36
CPC分类号： A61B18/02 , A61B2017/00774
摘要： Bei einem Gerät zur Entfernung von Warzen mit Flüssigstickstoff ist ein metallischer Kühlstab (12) vorgesehen, in dessen Innerem ein Temperaturfühler (4) angeordnet ist. Durch eine Kabelverbindung wird der Temperaturfühler mit einem elektrischen Temperaturmeßgerät verbunden. Zur Warzenentfernung wird die Kabelverbindung gelöst und über den Kühlstab ein lsolierrohr geschoben, mit dem der Kühlstab ergriffen und die Behandlung durchgeführt wird. Eine Temperaturkontrolle während der Behandlung ist nicht möglich. Der behandelnde Arzt benötigt daher viel Erfahrung, um die Kältezufuhr möglichst optimal zu dosieren.
Um die Behandlung zu vereinfachen, wird der Kühlstab von einem pistolenähnlichen Griff (1) aufgenommen, in dem das Temperaturmeßgerät (5) angeordnet ist und auf dem sich die Temperaturanzeige (8, 9) befindet. Die Temperaturanzeige kann optisch oder akustisch erfolgen. Optimiert wird das Gerät durch eine auf dem Griff angeordnete Einrichtung (10) zur Zeitmessung.
摘要翻译：在使用液氮除去疣的装置中，设置金属冷却杆（12），其内部设置有温度传感器（4）。温度传感器通过电缆连接连接到电气温度测量装置。为了去除疣，电缆连接被分离，并且绝缘管被推到冷却杆上，用该管将冷却杆夹紧并进行处理。治疗期间的温度检查是不可能的。因此，治疗医师需要大量的经验才能使冷量达到最佳效果。为了简化处理，冷却杆被保持在手枪状握持部（1）中，其中布置有温度测量装置（5），并且温度显示器（8,9）位于该手柄上。可以通过视觉或声音来指示温度。该装置通过布置在把手上的时间测量装置（10）进行优化。

23. 发明授权

EP3113605B1 MARKING TISSUE SURFACES FOR TREATMENT OF LESIONS BY ELECTRICAL NANOPULSES 有权转让
公开(公告)号：EP3113605B1
公开(公告)日：2018-10-31
申请号：EP15758252.9
申请日：2015-02-23
申请人： Pulse Biosciences, Inc.
发明人： BLANCO, Cesar Escobar , FORSTER, Elena Tovkan , TAKAHASHI, Stefani Reiko
IPC分类号： A01K11/00 , A61N1/04 , A61N1/05 , A61B5/00
CPC分类号： A61B90/39 , A61B5/444 , A61B18/1206 , A61B18/1402 , A61B2017/00747 , A61B2017/00774 , A61B2018/00452 , A61B2018/143 , A61B2090/3904 , A61B2090/3937 , A61N1/0468 , A61N1/0502 , A61N1/328
摘要： This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.

24. 发明授权

EP1443988B1 DEVICE FOR CONTROLLED ENZYMATIC REMOVAL AND RETRIEVAL OF TISSUE 有权
标题翻译： DEVICE受控酶去除和组织的恢复
公开(公告)号：EP1443988B1
公开(公告)日：2007-09-12
申请号：EP02749263.6
申请日：2002-07-16
申请人： Ramot at Tel Aviv University Ltd.
发明人： FREEMAN, Amihay
IPC分类号： A61M3/02 , A61M35/00 , A61K38/48 , C12N5/06 , A61B17/54 , A61B10/00
CPC分类号： A61B10/02 , A61B10/0035 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61K38/48 , A61M3/0241 , A61M3/0258 , A61M3/0283 , A61M3/0287 , A61M27/00 , A61M35/00 , C12M45/09 , C12N5/0629 , C12N2509/00
摘要： Methods, devices and pharmaceutical compositions for the controlled, non-surgical removal and retrieval of cells from a plurality of skin lesions and tissue surfaces are disclosed. A synergistic effect of proteolytic digestion of the intracellular matrix and 'stripping' flow is achieved by treating a defined area with a controlled, continuous stream of proteolytic enzyme solution, causing gentle but effective tissue erosion. Isolated cells from the skin lesion and/or tissue surface may be collected from the protease solution stream for histological analysis and/or cell culture, affording a method of 'enzymatic biopsy'. The protease solution may be supplemented with anesthetics, coagulants, anticoagulants and antibiotics to decrease the discomfort, erythema, bleeding, risk of infection and scarring traditionally associated with surgical treatment of skin lesions. Furthermore, in the present invention delivery of precise levels of catalytic activity is ensured by controlled activation of stable, inactivated enzyme stock solutions and powders shortly prior to application.

25. 发明公开

EP1506039A1 ABLATION DEVICE 有权
标题翻译：切除
公开(公告)号：EP1506039A1
公开(公告)日：2005-02-16
申请号：EP03725427.3
申请日：2003-05-21
申请人： Gendel Limited
发明人： MCHALE, A.P.,Gendel Ltd.,Science Innovation Ctr , RUSSELL, L.,Gendel Ltd.,Science Innovation Centre
IPC分类号： A61N7/00 , A61B17/22 , A61N1/32
CPC分类号： A61B17/22004 , A61B18/1477 , A61B2017/00761 , A61B2017/00765 , A61B2017/00774 , A61B2018/1425 , A61N7/00 , A61N2007/0078
摘要： We describe a cell ablation apparatus comprising: electric field signal generating circuitry for generating an electric field signal; an electric field delivery component connected to receive the electric field signal and operable to deliver an electric field to a treatment site; ultrasound signal generating circuitry for generating an ultrasound signal; an ultrasound delivery component connected to receive the ultrasound signal and operable to deliver ultrasound to the treatment site; and a controller operable to control the electric field signal generating circuitry and the ultrasound signal generating circuitry in order to ablate a cell at the treatment site. Various electrode configurations suitable for use in such an apparatus and independently are described.

26. 发明公开

EP1443988A1 DEVICE FOR AND METHOD OF CONTROLLED ENZYMATIC REMOVAL AND RETRIEVAL OF TISSUE 有权
标题翻译： DEVICE受控酶去除和组织的恢复
公开(公告)号：EP1443988A1
公开(公告)日：2004-08-11
申请号：EP02749263.6
申请日：2002-07-16
申请人： Ramot at Tel Aviv University Ltd.
发明人： FREEMAN, Amihay
IPC分类号： A61M3/02 , A61M35/00 , A61K38/48 , C12N5/06 , A61B17/54 , A61B10/00
CPC分类号： A61B10/02 , A61B10/0035 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61K38/48 , A61M3/0241 , A61M3/0258 , A61M3/0283 , A61M3/0287 , A61M27/00 , A61M35/00 , C12M45/09 , C12N5/0629 , C12N2509/00
摘要： Methods, devices and pharmaceutical compositions for the controlled, non-surgical removal and retrieval of cells from a plurality of skin lesions and tissue surfaces are disclosed. A synergistic effect of proteolytic digestion of the intracellular matrix and 'stripping' flow is achieved by treating a defined area with a controlled, continuous stream of proteolytic enzyme solution, causing gentle but effective tissue erosion. Isolated cells from the skin lesion and/or tissue surface may be collected from the protease solution stream for histological analysis and/or cell culture, affording a method of 'enzymatic biopsy'. The protease solution may be supplemented with anesthetics, coagulants, anticoagulants and antibiotics to decrease the discomfort, erythema, bleeding, risk of infection and scarring traditionally associated with surgical treatment of skin lesions. Furthermore, in the present invention delivery of precise levels of catalytic activity is ensured by controlled activation of stable, inactivated enzyme stock solutions and powders shortly prior to application.

27. 发明公开

KR1020070057699A 피부 병소의 효소적 괴사조직제거를 위한 장치와 방법 无效
标题翻译：装置和方法进行皮肤脱落的脱发
公开(公告)号：KR1020070057699A
公开(公告)日：2007-06-07
申请号：KR1020067016325
申请日：2005-01-27
申请人： 라모트 앳 텔 아비브 유니버시티 리미티드 , 엔지설지 리미티드
发明人： 프리만,아미헤이 , 히르스조위크즈,에란 , 베'에리-리프페르만,마이클
IPC分类号： A61M27/00 , A61M3/00 , A61M35/00 , A61B17/00
CPC分类号： A61M3/0258 , A61B10/0035 , A61B10/02 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61B2017/3411 , A61K38/48 , A61K38/4886 , A61M1/0088 , A61M3/0241 , A61M3/0283 , A61M3/0287 , A61M27/00 , C12M45/09 , C12N5/0629 , C12N2509/00
摘要： The present invention relates to apparatus for debridement of devitalized tissue in skin lesions, comprising a plurality of height- and angle-adjustable inlet tubes (204) and at least one outlet tube (206) and means (230) to form an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.
摘要翻译：本发明涉及用于在皮肤病变中清创失活的组织的装置，包括多个高度和角度可调的入口管（204）和至少一个出口管（206）和用于形成封闭密封件的装置（230）皮肤病变。所述多个入口管适于将连续的酶溶液流引导到所述表面并进入所述损伤的所述伤口床的整个体积，并且所述至少一个出口适于去除所述酶溶液，从所述病变排出的流体和来自闭塞的皮肤损伤的组织碎片。

28. 发明授权

US10492807B1 Skin treatment system with adjustable height wand 有权
公开(公告)号：US10492807B1
公开(公告)日：2019-12-03
申请号：US15925743
申请日：2018-03-19
申请人： Envy Medical, inc.
发明人： N. Brendon Boone, III , Basil M. Hantash , Kenneth B. Karasiuk , Steven E. Wojcik
IPC分类号： A61B17/22 , A61B17/3205 , A61B17/50 , A61B17/32 , A61B17/00
CPC分类号： A61B17/22 , A61B17/3205 , A61B17/50 , A61B2017/00774 , A61B2017/22079 , A61B2017/320004
摘要： A distance between a surface of a treatment head and tip opening of a skin treatment hand piece is adjustable. In an implementation, the distance is adjusted by moving the tip opening relative to the treatment head surface. Different distances may be used to treat different skin types, problems, and conditions. In an implementation, the hand piece includes a fluid delivery and a vacuum or suction mechanism to provide various therapeutic benefits to the skin.

29. 发明授权

US09918727B1 Skin treatment system with adjustable height wand 有权
公开(公告)号：US09918727B1
公开(公告)日：2018-03-20
申请号：US14733877
申请日：2015-06-08
申请人： Envy Medical, Inc.
发明人： N. Brendon Boone, III , Basil M. Hantash , Kenneth B. Karasiuk , Steven E. Wojcik
IPC分类号： A61B17/22 , A61B17/50 , A61B17/3205 , A61B17/00 , A61B17/32
CPC分类号： A61B17/22 , A61B17/3205 , A61B17/50 , A61B17/545 , A61B2017/00774 , A61B2017/22079 , A61B2017/320004 , A61M35/003
摘要： A distance between a surface of a treatment head and tip opening of a skin treatment hand piece is adjustable. In an implementation, the distance is adjusted by moving the tip opening relative to the treatment head surface. Different distances may be used to treat different skin types, problems, and conditions. In an implementation, the hand piece includes a fluid delivery and a vacuum or suction mechanism to provide various therapeutic benefits to the skin.

30. 发明申请

US20140221906A1 PATCH SYSTEM FOR THE TREATMENT OF WARTS AND METHOD FOR SAME 审中-公开
标题翻译：用于处理战争的PATCH系统和方法
公开(公告)号：US20140221906A1
公开(公告)日：2014-08-07
申请号：US13914183
申请日：2013-06-10
申请人： Jake W. Townsend
发明人： Jake W. Townsend
IPC分类号： A61K9/70 , A61K31/437 , A61K31/60 , A61B17/22 , A61M35/00
CPC分类号： A61K9/7084 , A61B2017/00774 , A61F2013/00506 , A61K9/7092 , A61K31/4745 , A61K31/60 , A61M35/00 , A61K2300/00
摘要： The present system and method relates in general to treating warts using a triple combination of therapies contained within a kit. The therapies are easy for a patient to self-apply, eliminating the need for constant physician supervision. The first therapy involves a patient applying a patch within the kit to a wart, which may be in the form of a transdermal patch. The patch may contain a first medicine, such as salicylic acid, and be worn for a period of twelve hours. Once removed, the second therapy involves using an ablative tool to gently slough away the treated wart, said ablative tool being contained within the kit. The third therapy involves applying a second patch, which may contain a second medicine, such as imiquimod, and also be worn for a period of twelve hours. This three step process may be repeated until the wart is fully treated.
摘要翻译：本系统和方法一般涉及使用包含在试剂盒内的治疗的三重组合来治疗疣。治疗方便患者自我应用，无需持续医师监督。第一种疗法包括将试剂盒内的贴片应用于疣的患者，疣可以是透皮贴剂的形式。贴剂可以含有第一种药物，例如水杨酸，并且可以穿戴12小时。一旦移除，第二种治疗方法就是使用烧伤工具轻轻地脱掉处理过的疣，所述烧伤工具包含在试剂盒内。第三种疗法包括应用可包含第二种药物如咪喹莫特的第二片剂，并且还可以穿戴12小时。可以重复这一步骤，直到疣完全治疗。

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