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21. 发明授权

US11045435B2 Methods for treating ocular diseases 有权
公开(公告)号：US11045435B2
公开(公告)日：2021-06-29
申请号：US15720785
申请日：2017-09-29
申请人： NATUREWISE BIOTECH & MEDICALS CORPORATION
发明人： George Chung-Yih Chiou , Chia-Nan Chen
IPC分类号： A61K31/185 , A61K9/00 , A61K31/16
摘要： The present invention is related to a method for treating an ocular disease, particularly a diabetes related ocular disease, comprising administering to a subject in need thereof an effective amount of a group of compounds having a structure of Formula A1, wherein the ocular disease is selected from the group consisting of proliferative vitreoretinopathy (PVR), uveitis, glaucoma and age related macular degeneration (AMD), and the diabetes related ocular disease is selected from the group consisting of diabetic retinopathy (DR) and diabetic macular edema (DME).

22. 发明申请

US20110224294A1 CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE 有权
标题翻译：用于抑制HISTONE脱乙酰壳多糖的CINAMIC化合物和衍生物
公开(公告)号：US20110224294A1
公开(公告)日：2011-09-15
申请号：US13114619
申请日：2011-05-24
申请人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Chia-Wei Lin , Jing-Shi Huang , Li-Ling Chi , Ai-Ling Chen , Chi-Yun Lee , Yu-Chen Huang
发明人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Chia-Wei Lin , Jing-Shi Huang , Li-Ling Chi , Ai-Ling Chen , Chi-Yun Lee , Yu-Chen Huang
IPC分类号： A61K31/192 , A61K31/216 , A61K31/165 , A61K31/167 , A61K31/343 , A61P3/10 , A61P35/00 , A61P25/00 , A61P25/14
CPC分类号： A61K31/16 , A61K31/192 , A61K31/343 , C07C69/734 , C07C235/38 , C07C259/06 , C07D307/86 , C07D311/16 , C07D493/04
摘要： The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).
摘要翻译：本发明涉及由下式（I）表示的化合物及其药学上可接受的盐，立体异构体，对映异构体，前药和溶剂合物。该化合物可用作增强神经突生长和预防或治疗与HDAC相关的疾病，特别是肿瘤或细胞增殖性疾病的药剂。特别地，本发明的化合物可以用作抗癌，抗糖尿病和抗神经变性疾病如阿尔茨海默病，亨廷顿氏病，脊髓小脑性共济失调（SCA）和人脊髓性肌萎缩（SMA）的药物。。

23. 发明授权

US07585892B2 Compound for promoting the growth of neural cells 有权
标题翻译：用于促进神经细胞生长的化合物
公开(公告)号：US07585892B2
公开(公告)日：2009-09-08
申请号：US11393619
申请日：2006-03-30
申请人： Chung-Yang Huang , Chia-Nan Chen , Wan-Zo Ho
发明人： Chung-Yang Huang , Chia-Nan Chen , Wan-Zo Ho
IPC分类号： A61K31/353
CPC分类号： C07D311/32 , A61K31/353 , C07D311/22
摘要： Disclosed is a compound capable of promoting the growth and development of neurons, the proliferation of neural stem cells and inducing the neural stem cells to differentiate into neurons, which is represented by a general formula as (I). The compound of the present invention can increase the survival rate of neural cells even at a low cellular density in a culture medium. The compound of the present invention can also promote the growth of neurons, which is revealed by the increase in the thickness, length and number of branches in the neurites (neural fibers). In addition, the compound of the present invention can be used to promote the development of neural stem cells and induce them to differentiate into neurons.
摘要翻译：公开了能够促进神经元生长发育，神经干细胞增殖和诱导神经干细胞分化为神经元的化合物，其由通式（I）表示。本发明的化合物即使在培养基中的细胞密度低的情况下也能增加神经细胞的存活率。本发明的化合物还可以促进神经元的生长，这通过神经突（神经纤维）的分支的厚度，长度和数量的增加而揭示。此外，本发明的化合物可用于促进神经干细胞的发育并诱导它们分化为神经元。

24. 发明申请

US20070232534A1 Compound for promoting the growth of neural cells 有权
标题翻译：用于促进神经细胞生长的化合物
公开(公告)号：US20070232534A1
公开(公告)日：2007-10-04
申请号：US11393619
申请日：2006-03-30
申请人： Chung-Yang Huang , Chia-Nan Chen , Wan-Zo Ho
发明人： Chung-Yang Huang , Chia-Nan Chen , Wan-Zo Ho
IPC分类号： A61K38/18 , A61K31/353 , C07D311/22
CPC分类号： C07D311/32 , A61K31/353 , C07D311/22
摘要： Disclosed is a compound capable of promoting the growth and development of neurons, the proliferation of neural stem cells and inducing the neural stem cells to differentiate into neurons, which is represented by a general formula as (I). The compound of the present invention can increase the survival rate of neural cells even at a low cellular density in a culture medium. The compound of the present invention can also promote the growth of neurons, which is revealed by the increase in the thickness, length and number of branches in the neurites (neural fibers). In addition, the compound of the present invention can be used to promote the development of neural stem cells and induce them to differentiate into neurons.
摘要翻译：公开了能够促进神经元生长发育，神经干细胞增殖和诱导神经干细胞分化为神经元的化合物，其由通式（I）表示。本发明的化合物即使在培养基中的细胞密度低的情况下也能增加神经细胞的存活率。本发明的化合物还可以促进神经元的生长，这通过神经突（神经纤维）的分支的厚度，长度和数量的增加而揭示。此外，本发明的化合物可用于促进神经干细胞的发育并诱导它们分化为神经元。

25. 发明申请

US20190053526A1 COMPOSITION FOR ENHANCING IMMUNITY OF INSECTS AND METHOD THEREOF 审中-公开
公开(公告)号：US20190053526A1
公开(公告)日：2019-02-21
申请号：US16104499
申请日：2018-08-17
申请人： NatureWise Biotech & Medicals Corporation
发明人： Yu-Cheng KUO , Chung-Yang HUANG , Chia-Chung HOU , Chi-Jung CHEN
IPC分类号： A23L33/105 , A61K8/49 , A23K10/30 , A23K20/10
摘要： Provided is a use of a Macaranga tanarius preparation or extract for manufacturing a composition for enhancing immunity of an insect, particularly a bee. Also provided is a method for enhancing immunity of an insect, particularly a bee. The method comprises administering an effective amount of a composition of the present invention to the insect.

26. 发明授权

US09956254B2 Extract of taiwanese propolis for treating ocular diseases 有权
公开(公告)号：US09956254B2
公开(公告)日：2018-05-01
申请号：US14632894
申请日：2015-02-26
申请人： Chi Chou Liao
发明人： Chi Chou Liao
IPC分类号： A61K35/24 , A61K35/37 , A61K35/64 , A61K35/644
CPC分类号： A61K35/644 , A61P27/02
摘要： The present invention provides a method for treating an ocular disease in a subject in need thereof, comprising administering an effective amount of an extract of Taiwanese propolis (TP) or an active component thereof to the subject. Also provided is a pharmaceutical composition for treating an ocular disease, which comprises an effective amount of an extract of TP or an active component thereof, and a pharmaceutically acceptable carrier.

27. 发明授权

US08784873B2 Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly 有权
标题翻译：使用组蛋白脱乙酰酶抑制剂改变皇家果冻中的MRJP3蛋白
公开(公告)号：US08784873B2
公开(公告)日：2014-07-22
申请号：US12507545
申请日：2009-07-22
申请人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jung Chen , Wei-Jan Huang , Li-Ling Chi
发明人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jung Chen , Wei-Jan Huang , Li-Ling Chi
IPC分类号： A23K1/165 , A61K31/352
CPC分类号： A61K31/353 , A01K53/00 , A61K31/185 , A61K35/644 , Y02P20/582
摘要： The invention provides a method of changing a ratio of 68 to 64 kDa protein of MRJP3 in a royal jelly, a method of producing a royal jelly comprising MRJP3 having a changed ratio of 68 to 64 kDa protein relative to a control royal jelly and the royal jelly produced thereform. Also provided is a method of promoting the growth of the larva of a queen bee comprising feeding the larva of the queen bee a royal jelly of the invention. Further provided is a method of producing bee larva, pupa and queen bees with sizes larger than normal.
摘要翻译：本发明提供了改变皇家果冻中MRJP3的68至64kDa蛋白的比例的方法，包括相对于对照蜂王浆和皇室的具有68至64kDa蛋白质变化比例的MRJP3的蜂王浆的生产方法果冻生产。还提供了促进雌蜂的幼虫生长的方法，包括将本发明的蜂王浆的雌蜂喂给蜂王浆。还提供了一种生产尺寸大于正常的蜜蜂幼虫，蛹和雌蜂的方法。

28. 发明申请

US20100144856A1 PRENYLFAVANONE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译： PRENYLFAVANONE化合物及其用途
公开(公告)号：US20100144856A1
公开(公告)日：2010-06-10
申请号：US12330991
申请日：2008-12-09
申请人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Li-Ling Chi , Pen-Yuan Chen , Chia-Wei Lin
发明人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Li-Ling Chi , Pen-Yuan Chen , Chia-Wei Lin
IPC分类号： A61K31/352 , C07D311/30 , A61P35/00 , A61P25/00
CPC分类号： C07D311/32 , A61K31/352
摘要： The present invention relates to new prenylflavanone compounds and a pharmaceutical composition comprising at least one of the compounds.
摘要翻译：本发明涉及新的异戊二烯基黄酮化合物和包含至少一种化合物的药物组合物。

29. 发明申请

US20230038230A1 COMPOSITION AND METHOD FOR TREATING A DRUG-RESISTANT CANCER 有权
公开(公告)号：US20230038230A1
公开(公告)日：2023-02-09
申请号：US17828983
申请日：2022-05-31
申请人： NatureWise Biotech & Medicals Corporation
发明人： Chung-Yang HUANG , Chia-Chung HOU
IPC分类号： A61K31/085 , A61P35/00 , A61K31/495
摘要： The present invention provides a combination and method for treating a Temozolomide (TMZ)-resistant cancer patient, which comprises a combination of TMZ and an isoform-selective HDAC8 inhibitor, such as BMX at an effective relative ratio to overcome TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the β-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition.

30. 发明申请

US20110054014A1 PRENYLFLAVANONE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：丙烯腈化合物及其用途
公开(公告)号：US20110054014A1
公开(公告)日：2011-03-03
申请号：US12942719
申请日：2010-11-09
申请人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Li-Ling Chi , Pen-Yuan Chen , Chia-Wei Lin
发明人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Li-Ling Chi , Pen-Yuan Chen , Chia-Wei Lin
IPC分类号： A61K31/353 , A61P25/28 , A61P25/00 , A61P35/00
CPC分类号： C07D311/32
摘要： The present invention relates to new prenylflavanone compounds and a pharmaceutical composition comprising at least one of the compounds.
摘要翻译：本发明涉及新的异戊二烯基黄酮化合物和包含至少一种化合物的药物组合物。

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