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21. 发明申请

US20130073042A1 Medical Implants With Increased Hydrophilicity 有权
公开(公告)号：US20130073042A1
公开(公告)日：2013-03-21
申请号：US13696346
申请日：2011-05-06
申请人： Gary Ghiselli , Peter Whang , Jami Hafiz , Joseph Crudden , Derrick W. Johns
发明人： Gary Ghiselli , Peter Whang , Jami Hafiz , Joseph Crudden , Derrick W. Johns
IPC分类号： A61F2/44 , A61F2/28
CPC分类号： A61F2/442 , A61F2/28 , A61F2/4455 , A61F2210/0071 , A61L27/446 , A61L27/54 , A61L2300/404 , C08L71/12
摘要： Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.

22. 发明公开

EP2942068A1 REGULATION OF BONE GROWTH USING ZEOLITE IN COMBINATION WITH BONE GRAFT SUBSTITUTES 审中-公开
标题翻译：日本食品科技大学学院麻省理工学院KOCHENSPANERSÄTZEN
公开(公告)号：EP2942068A1
公开(公告)日：2015-11-11
申请号：EP15163787.3
申请日：2010-03-30
申请人： Difusion Technologies Inc.
发明人： Johns, Derrick , Geck, Matthew , Whang, Peter , Hafiz, Jami
IPC分类号： A61L27/02 , A61L27/54 , A61L27/44
CPC分类号： A61L27/446 , A61L27/025 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： Medical implants such as bone graft substitutes that include one or more cations are delivered in a local environment to promote osteogenesis. Zeolite loaded with a metal cation in combination with an implant such as a bone graft substitute can be used as an implant in the body to regulate protein transcription and translation. Also disclosed are methods of promoting osteogenesis in a patient in need thereof, methods for modulating bone formation and mineralization by implanting in a patient a medical implant comprising ion-exchangeable cations, and methods of regulating BMP gene expression in bone cells in a patient by controlling the delivery of certain cations through ionexchange via a zeolite incorporated in a bone substitute implanted in a patient so that BMP gene expression can be upregulated or downregulated appropriately.
摘要翻译：包括一种或多种阳离子在内的医用植入物例如骨移植物替代物在局部环境中递送以促进成骨。负载金属阳离子与植入物如骨移植物替代物组合的沸石可以用作体内的植入物以调节蛋白质转录和翻译。还公开了在有需要的患者中促进成骨的方法，通过在患者中植入包含可离子交换阳离子的医疗植入物来调节骨形成和矿化的方法，以及通过控制来调节患者骨细胞中BMP基因表达的方法通过离子交换通过掺入植入患者的骨替代物中的沸石递送某些阳离子，使得BMP基因表达可以适当地上调或下调。

23. 发明公开

EP2413900A1 REGULATION OF BONE GROWTH USING ZEOLITE IN COMBINATION WITH BONE GRAFT SUBSTITUTES 审中-公开
标题翻译：与KNOCHENSPANERSÄTZEN联合与沸石骨骼生长的控制权
公开(公告)号：EP2413900A1
公开(公告)日：2012-02-08
申请号：EP10759287.5
申请日：2010-03-30
申请人： Difusion Technologies, Inc.
发明人： JOHNS, Derrick , GECK, Matthew , WHANG, Peter , HAFIZ, Jami
IPC分类号： A61K9/00
CPC分类号： A61L27/446 , A61L27/025 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： Medical implants such as bone graft substitutes that include one or more cations are delivered in a local environment to promote osteogenesis. Zeolite loaded with a metal cation in combination with an implant such as a bone graft substitute can be used as an implant in the body to regulate protein transcription and translation. Also disclosed are methods of promoting osteogenesis in a patient in need thereof, methods for modulating bone formation and mineralization by implanting in a patient a medical implant comprising ion-exchangeable cations, and methods of regulating BMP gene expression in bone cells in a patient by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in a bone substitute implanted in a patient so that BMP gene expression can be upregulated or downregulated appropriately.

24. 发明授权

US09492584B2 Post-charging of zeolite doped plastics with antimicrobial metal ions 有权
标题翻译：用抗菌金属离子对掺杂沸石的塑料进行后充电
公开(公告)号：US09492584B2
公开(公告)日：2016-11-15
申请号：US13511176
申请日：2010-11-24
申请人： Joseph J. Crudden , Derrick Johns
发明人： Joseph J. Crudden , Derrick Johns
IPC分类号： A61L27/10 , A61L27/44 , A61L27/54 , C08L71/12
CPC分类号： A61L27/54 , A61L27/10 , A61L27/18 , A61L27/443 , A61L27/446 , A61L27/56 , A61L2202/21 , A61L2300/104 , A61L2300/404 , C08L71/12 , C08L71/00
摘要： Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.
摘要翻译：公开了用抗微生物金属阳离子后载荷陶瓷颗粒的方法。在某些实施方案中，后加载颗粒是沸石，其中沸石已经结合到树脂中，并且该组合用作可植入装置。在某些实施方案中，聚合物是热塑性聚合物，例如聚芳醚醚酮（PEEK）。在某些实施方案中，抗微生物活性的来源包括沸石中所含的离子交换阳离子。在某些实施方案中，公开了通过控制通过离子交换通过装在装置中的沸石的某些阳离子的递送来向装置赋予抗微生物活性的方法。

25. 发明授权

US08840914B2 Method of manufacturing antimicrobial implants of polyetheretherketone 有权
标题翻译：制造聚醚醚酮抗菌植入物的方法
公开(公告)号：US08840914B2
公开(公告)日：2014-09-23
申请号：US13653896
申请日：2012-10-17
申请人： DiFusion Technologies, Inc.
发明人： Joseph J. Crudden , Jami Hafiz , James E. Deaton , John R. Pepper , Derrick Johns
IPC分类号： A61F2/44 , B29C45/00 , A61L27/18 , A61L27/54 , B29L31/00 , B29K709/02 , B29K71/00 , B29K105/00
CPC分类号： B29C45/0013 , A61L27/18 , A61L27/54 , A61L2300/104 , A61L2300/404 , B29B13/022 , B29B13/06 , B29C43/003 , B29C43/26 , B29C43/32 , B29C43/52 , B29C45/0001 , B29C45/0005 , B29C45/0053 , B29K2071/00 , B29K2105/0011 , B29K2105/04 , B29K2105/12 , B29K2105/16 , B29K2307/04 , B29K2505/14 , B29K2709/02 , B29K2995/0056 , B29K2995/0072 , B29L2031/7532 , Y10T29/4998 , C08L71/12 , C08L71/00
摘要： Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.
摘要翻译：公开了具有抗微生物特性的可植入式医疗装置，优选具有PEEK的方法。通过将含有抗微生物金属阳离子的陶瓷颗粒结合到熔融的PEEK树脂中来产生抗微生物效果，随后允许其冷却并且通过注射成型，切割和机械加工或其它技术实现其最终形状。

26. 发明申请

US20130004585A1 Method Of Manufacturing Antimicrobial Implants Of Polyetheretherketone 有权
标题翻译：制备聚醚醚酮抗菌植入物的方法
公开(公告)号：US20130004585A1
公开(公告)日：2013-01-03
申请号：US13512702
申请日：2010-12-10
申请人： Joseph J. Crudden , Jami Hafiz , James E. Deaton , John R. Pepper , Derrick Johns
发明人： Joseph J. Crudden , Jami Hafiz , James E. Deaton , John R. Pepper , Derrick Johns
IPC分类号： A61K33/06 , A61P31/04
CPC分类号： B29C45/0013 , A61L27/18 , A61L27/54 , A61L2300/104 , A61L2300/404 , B29B13/022 , B29B13/06 , B29C43/003 , B29C43/26 , B29C43/32 , B29C43/52 , B29C45/0001 , B29C45/0005 , B29C45/0053 , B29K2071/00 , B29K2105/0011 , B29K2105/04 , B29K2105/12 , B29K2105/16 , B29K2307/04 , B29K2505/14 , B29K2709/02 , B29K2995/0056 , B29K2995/0072 , B29L2031/7532 , Y10T29/4998 , C08L71/12 , C08L71/00
摘要： Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.
摘要翻译：公开了具有抗微生物特性的可植入式医疗装置，优选具有PEEK的方法。通过将含有抗微生物金属阳离子的陶瓷颗粒结合到熔融的PEEK树脂中来产生抗微生物效果，随后允许其冷却并且通过注射成型，切割和机械加工或其它技术实现其最终形状。

27. 发明申请

US20120141599A1 Regulation Of Bone Growth Using Zeolite In Combination With Bone Graft Substitutes 审中-公开
标题翻译：使用沸石联合骨移植替代物调节骨生长
公开(公告)号：US20120141599A1
公开(公告)日：2012-06-07
申请号：US13260571
申请日：2010-03-30
申请人： Derrick Johns , Matthew Geck , Peter Whang , Jami Hafiz
发明人： Derrick Johns , Matthew Geck , Peter Whang , Jami Hafiz
IPC分类号： A61K33/38 , A61K33/30 , A61F2/44 , A61K33/34
CPC分类号： A61L27/446 , A61L27/025 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： Medical implants such as bone graft substitutes that include one or more cations are delivered in a local environment to promote osteogenesis. Zeolite loaded with a metal cation in combination with an implant such as a bone graft substitute can be used as an implant in the body to regulate protein transcription and translation. Also disclosed are methods of promoting osteogenesis in a patient in need thereof, methods for modulating bone formation and mineralization by implanting in a patient a medical implant comprising ion-exchangeable cations, and methods of regulating BMP gene expression in bone cells in a patient by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in a bone substitute implanted in a patient so that BMP gene expression can be upregulated or downregulated appropriately.
摘要翻译：包括一种或多种阳离子在内的医用植入物例如骨移植物替代物在局部环境中递送以促进成骨。负载有金属阳离子与植入物如骨移植物替代物组合的沸石可以用作体内的植入物以调节蛋白质转录和翻译。还公开了在有需要的患者中促进成骨的方法，通过在患者体内植入包括可离子交换的阳离子的医疗植入物来调节骨形成和矿化的方法，以及通过控制来调节患者骨细胞中的BMP基因表达的方法通过离子交换通过掺入植入患者的骨替代物中的沸石递送某些阳离子，使得BMP基因表达可以适当地上调或下调。

28. 发明公开

EP2413900A4 REGULATION OF BONE GROWTH USING ZEOLITE IN COMBINATION WITH BONE GRAFT SUBSTITUTES 审中-公开
标题翻译：与KNOCHENSPANERSÄTZEN联合与沸石骨骼生长的控制权
公开(公告)号：EP2413900A4
公开(公告)日：2014-03-12
申请号：EP10759287
申请日：2010-03-30
申请人： DIFUSION TECHNOLOGIES INC
发明人： JOHNS DERRICK , GECK MATTHEW , WHANG PETER , HAFIZ JAMI
IPC分类号： A61L27/02 , A61L27/44 , A61L27/54
CPC分类号： A61L27/446 , A61L27/025 , A61L27/54 , A61L2300/414 , A61L2430/02

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