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21. 发明申请

US20100216164A1 MAMMALIAN PRICKLE GENE 审中-公开
公开(公告)号：US20100216164A1
公开(公告)日：2010-08-26
申请号：US12392063
申请日：2009-02-24
申请人： Masakazu Takeuchi , Keiko Sato , Yoshimasa Sakamoto , Maki Tawarada , Toshihisa Ohtsuka
发明人： Masakazu Takeuchi , Keiko Sato , Yoshimasa Sakamoto , Maki Tawarada , Toshihisa Ohtsuka
IPC分类号： G01N33/567
CPC分类号： C07K14/47
摘要： The present invention provides the mPrickle gene which encodes a protein present in mammalian PSD fractions. The mPrickle protein is localized in synapses, and binds to the scaffold protein PSD-95. Precipitation of endogenous mPrickle using an anti-mPrickle antibody results in the coprecipitation of NMDA receptors, and thus, mPrickle can be used in drug delivery systems that target NMDA receptors. NMDA receptors are closely related to learning and memory, and are also suggested to be involved in mental disorders. Thus, in the future, mPrickle is expected to be applicable to the diagnosis and/or treatment of neurodegenerative diseases associated with learning/memory, such as mental deterioration and dementia.
摘要翻译：本发明提供编码哺乳动物PSD级分中存在的蛋白质的mPrickle基因。 mPrickle蛋白定位在突触中，并结合到支架蛋白PSD-95。使用抗mPrickle抗体沉淀内源性mPrickle导致NMDA受体的共沉淀，因此，mPrickle可用于靶向NMDA受体的药物递送系统。 NMDA受体与学习记忆密切相关，也被认为与精神障碍有关。因此，将来，mPrickle预期适用于与学习/记忆相关的神经变性疾病的诊断和/或治疗，例如精神恶化和痴呆。

22. 发明申请

US20060292669A1 Mammalian prickle gene 审中-公开
标题翻译：哺乳动物刺刺基因
公开(公告)号：US20060292669A1
公开(公告)日：2006-12-28
申请号：US10536586
申请日：2003-11-28
申请人： Masakazu Takeuchi , Keiko Sato , Yoshimasa Sakamoto , Maki Tawarada , Toshihisa Ohtsuka
发明人： Masakazu Takeuchi , Keiko Sato , Yoshimasa Sakamoto , Maki Tawarada , Toshihisa Ohtsuka
IPC分类号： C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47
摘要： The present invention provides the mPrickle gene which encodes a protein present in mammalian PSD fractions. The mPrickle protein is localized in synapses, and binds to the scaffold protein PSD-95. Precipitation of endogenous mPrickle using an anti-mPrickle antibody results in the coprecipitation of NMDA receptors, and thus, mPrickle can be used in drug delivery systems that target NMDA receptors. NMDA receptors are closely related to learning and memory, and are also suggested to be involved in mental disorders. Thus, in the future, mPrickle is expected to be applicable to the diagnosis and/or treatment of neurodegenerative diseases associated with learning/memory, such as mental deterioration and dementia.
摘要翻译：本发明提供编码哺乳动物PSD级分中存在的蛋白质的mPrickle基因。 mPrickle蛋白定位在突触中，并结合到支架蛋白PSD-95。使用抗mPrickle抗体沉淀内源性mPrickle导致NMDA受体的共沉淀，因此，mPrickle可用于靶向NMDA受体的药物递送系统。 NMDA受体与学习记忆密切相关，也被认为与精神障碍有关。因此，将来，mPrickle预期适用于与学习/记忆相关的神经变性疾病的诊断和/或治疗，例如精神恶化和痴呆。

23. 发明申请

US20140193421A1 Anti-Human XCR1 Antibodies 有权
标题翻译：抗人XCR1抗体
公开(公告)号：US20140193421A1
公开(公告)日：2014-07-10
申请号：US14240090
申请日：2012-08-30
申请人： Yoshimasa Sakamoto , Miyuki Nishimura , Tetsu Kawano , Yukihisa Sawa , Toshio Imai
发明人： Yoshimasa Sakamoto , Miyuki Nishimura , Tetsu Kawano , Yukihisa Sawa , Toshio Imai
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2319/55
摘要： An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.
摘要翻译：本发明的目的是提供与人XCR1结合的单克隆抗体，其中所述抗体结合至包含至少三个氨基酸的线性或不连续表位，所述氨基酸选自第8,11,12,13,13和14， 16位，17位，22位，23位，第176位和第177位氨基酸。

24. 发明申请

US20120213799A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS 有权
标题翻译：用于治疗炎症性疾病的组合物和方法
公开(公告)号：US20120213799A1
公开(公告)日：2012-08-23
申请号：US13504742
申请日：2010-10-28
申请人： Miyuki Nishimura , Yoshimasa Sakamoto , Tetsu Kawano , Toshio Imai
发明人： Miyuki Nishimura , Yoshimasa Sakamoto , Tetsu Kawano , Toshio Imai
IPC分类号： A61K39/395 , C12N15/13 , A61P29/00 , A61P1/04 , A61P19/02 , C12N1/00 , A61P1/16 , A61P25/00 , C12N15/63 , C12N5/10 , C12P21/02 , C07K16/24 , A61P37/00
CPC分类号： C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/76 , Y10S514/894
摘要： The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.
摘要翻译：本发明的特征在于与人源化抗体相关的组合物和方法，其结合分子链的FKN结合片段。

25. 发明授权

US5423643A Tool clamping/unclamping device 失效
标题翻译：工具夹紧/松开装置
公开(公告)号：US5423643A
公开(公告)日：1995-06-13
申请号：US25252
申请日：1993-03-02
申请人： Shigeru Suzuki , Motonori Kobara , Yasuhiro Hisatomi , Yoshinori Yamaguchi , Hiroshi Yonetani , Kiyoyuki Fukushima , Yoshimasa Sakamoto , Toru Yagami , Toshihide Kamei , Takahiro Kobi , Yoshiaki Sugimoto , Nobuyuki Kimura
发明人： Shigeru Suzuki , Motonori Kobara , Yasuhiro Hisatomi , Yoshinori Yamaguchi , Hiroshi Yonetani , Kiyoyuki Fukushima , Yoshimasa Sakamoto , Toru Yagami , Toshihide Kamei , Takahiro Kobi , Yoshiaki Sugimoto , Nobuyuki Kimura
IPC分类号： B23B31/113 , B23Q3/155 , B23C5/26
CPC分类号： B23B31/113 , B23Q3/1552 , Y10T279/17881 , Y10T408/95 , Y10T409/309408
摘要： This invention provides a tool clamping/unclamping device which allows a tool to be replaced simply and securely by another one in short time, and which prevents a lock nut from being loosened, from yielding a difference in phase, and from dropping off with respect to a main shaft. The tool clamping/unclamping device comprises a tool urging means for holding a tool holding member in its clamped state, a nut positioning means for adjusting the lock nut in its phase in rotation angle position with respect to the main shaft, a nut drop-off preventing means for regulating the amount of rotation angle of the nut, a nut loosening detection means for detecting the position of the nut in the direction of the main shaft, and/or a locking mechanism for engaging a steel ball urged by a spring with a lock hole to thereby lock the lock nut in the direction of rotation. Further, for a hollow main shaft, a relay member is attached thereto, the relay member being formed similarly to the lower end portion of the solid main shaft.
摘要翻译：本发明提供了一种工具夹紧/松开装置，其允许工具在短时间内被另一个简单且可靠地替换，并且防止锁定螺母松动，从而产生相位差，并且相对于主轴。工具夹紧/松开装置包括用于保持工具保持构件处于其夹紧状态的工具推动装置，用于相对于主轴以旋转角度位置相位调节锁紧螺母的螺母定位装置，螺母脱落用于调节螺母的旋转角度的防止装置，用于检测螺母在主轴方向上的位置的螺母松动检测装置和/或用于接合由弹簧推动的钢球的锁定机构，从而锁定锁定螺母在旋转方向上。此外，对于中空主轴，安装有中继构件，中继构件与实心主轴的下端部类似地形成。

26. 发明授权

US4103416A Method of manufacturing an hermatically sealed electrical terminal 失效
标题翻译：制造密封电气端子的方法
公开(公告)号：US4103416A
公开(公告)日：1978-08-01
申请号：US733013
申请日：1976-10-15
申请人： Yoshimasa Sakamoto
发明人： Yoshimasa Sakamoto
IPC分类号： H01R43/20 , H01B17/30 , H01B17/26
CPC分类号： H01B17/305 , F05C2201/0466 , F05C2253/12 , Y10S439/935 , Y10T29/49121 , Y10T29/49812
摘要： An electrical terminal device comprises a metallic body or support cut through which an iron-chronmium alloy, conductive lead wire extends in an insulated and sealed manner. The free ends of the lead wire or wires extend out of the cup. A glass-to-metal seal is provided between the wires and the cup. The free ends of the lead wires are partially plated or coated with a layer of an oxidation resistant metal. A portion intermediate the free ends is provided with a layer of chromium oxide to improve the seal between the lead wire and a fused glass bead held in an aperture in said support cup. The method of manufacturing such devices comprises partially plating a nickel, copper or other metal which is resistant to oxidation in a hydrogen atmosphere at high temperature and humidity, on the surface of the terminal end portions of the lead wires, while the intermediate portion where the conductor is secured to a glass bead is left free of such a plating. The intermediate portion is then oxidized to provide a chromium oxide layer on the intermediate portion of the lead wire by a selective oxidation of the chromium component. A hermetic seal is then provided between the intermediate portion or rather the chromium oxide layer of the intermediate portion and a glass bead as well as between the glass bead and the cup. The oxide layers on the exposed surfaces of the support cup and on the lead wire, if any, are then removed in a reducing atmosphere.
摘要翻译：电气终端装置包括金属体或支撑体，铁合金合金，导电引线以绝缘和密封的方式延伸。引线或电线的自由端延伸出杯子。电线和杯之间设有玻璃 - 金属密封。引线的自由端部分镀覆或涂覆有抗氧化金属层。设置有自由端中间部分的铬氧化物层，以改善引线与保持在所述支承杯孔中的熔融玻璃珠之间的密封。制造这种装置的方法包括在引线的末端部分的表面部分地镀覆耐高温和高湿的氢气氛中的耐氧化的镍，铜或其它金属，而中间部分导体被固定在玻璃珠上，没有这种电镀。然后中间部分被氧化，以通过铬组分的选择性氧化在引线的中间部分上提供氧化铬层。然后在中间部分之间或中间部分的铬氧化物层和玻璃珠之间以及玻璃珠和杯之间提供气密密封。然后在还原气氛中除去支撑杯和引线的暴露表面上的氧化物层（如果有的话）。

27. 发明授权

US09371389B2 Anti-human XCR1 antibodies 有权
标题翻译：抗人XCR1抗体
公开(公告)号：US09371389B2
公开(公告)日：2016-06-21
申请号：US14240090
申请日：2012-08-30
申请人： Yoshimasa Sakamoto , Miyuki Nishimura , Tetsu Kawano , Yukihisa Sawa , Toshio Imai
发明人： Yoshimasa Sakamoto , Miyuki Nishimura , Tetsu Kawano , Yukihisa Sawa , Toshio Imai
IPC分类号： C07K16/00 , C12P21/08 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2319/55
摘要： An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.
摘要翻译：本发明的目的是提供与人XCR1结合的单克隆抗体，其中所述抗体结合至包含至少三个氨基酸的线性或不连续表位，所述氨基酸选自第8,11,12,13,13和14， 16位，17位，22位，23位，第176位和第177位氨基酸。

28. 发明授权

US08491901B2 Neutralizing anti-CCL20 antibodies 有权
标题翻译：中和抗CCL20抗体
公开(公告)号：US08491901B2
公开(公告)日：2013-07-23
申请号：US13300352
申请日：2011-11-18
申请人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
发明人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
摘要翻译：本发明涉及对人CC趋化因子配体20（CCL20）具有结合特异性的新型人源化，嵌合和鼠抗体。本发明还涉及所述抗体的重链和轻链。本发明还涉及分离的核酸，重组载体和宿主细胞，其包含编码所述抗体的重链和/或轻链的序列，以及制备所述抗体的方法。本发明的抗CCL20抗体可用于治疗例如炎性和自身免疫性疾病和癌症的治疗应用。

29. 发明申请

US20120148592A1 NEUTRALIZING ANTI-CCL20 ANTIBODIES 有权
标题翻译：中性抗CCL20抗体
公开(公告)号：US20120148592A1
公开(公告)日：2012-06-14
申请号：US13300352
申请日：2011-11-18
申请人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
发明人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12P21/08 , C12N5/071 , A61P35/00 , A61P29/00 , A61P19/02 , A61P31/20 , A61P19/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C07K16/18
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
摘要翻译：本发明涉及对人CC趋化因子配体20（CCL20）具有结合特异性的新型人源化，嵌合和鼠抗体。本发明还涉及所述抗体的重链和轻链。本发明还涉及分离的核酸，重组载体和宿主细胞，其包含编码所述抗体的重链和/或轻链的序列，以及制备所述抗体的方法。本发明的抗CCL20抗体可用于治疗例如炎性和自身免疫性疾病和癌症的治疗应用。

30. 发明申请

US20110008769A1 DOPAMINERGIC NEURON PROGENITOR CELL MARKER 187A5 有权
标题翻译：多巴胺神经元细胞标记187A5
公开(公告)号：US20110008769A1
公开(公告)日：2011-01-13
申请号：US12296915
申请日：2007-04-11
申请人： Yuchi Ono , Yoshimasa Sakamoto
发明人： Yuchi Ono , Yoshimasa Sakamoto
IPC分类号： C12Q1/68 , C07H21/04 , C07K16/18 , G01N33/53 , C12N5/00 , C07K14/47 , C07K7/06 , C07K7/08
CPC分类号： C07K14/705 , A61K35/30 , A61K38/00 , C07K16/28 , C12Q1/6881 , C12Q2600/158 , G01N33/5058 , G01N33/5073 , G01N33/56966 , G01N2333/70571 , Y10S530/81
摘要： An object of the present invention is to provide a probe, a primer, a primer set and an antibody for use in the detection or selection of a dopaminergic neuron progenitor cell. The present invention provides a probe, a primer and a primer set for use in the detection or selection of a mesencephalon dopaminergic neuron progenitor cell, and preferably a dopaminergic neuron proliferative progenitor cell, which can hybridize with a nucleotide sequence of a 187A5 gene, or a complementary sequence thereto, and an antibody for use in the detection or selection of a mesencephalon dopaminergic neuron progenitor cell, and preferably a dopaminergic neuron progenitor cell, which is capable of binding to a 187A5 protein.
摘要翻译：本发明的目的是提供用于检测或选择多巴胺能神经元祖细胞的探针，引物，引物组和抗体。本发明提供了用于检测或选择中脑多巴胺能神经元祖细胞的探针，引物和引物组，优选多巴胺能神经元增殖祖细胞，其可以与187A5基因的核苷酸序列杂交，或其互补序列，以及用于检测或选择能够结合187A5蛋白的中脑多巴胺能神经元祖细胞，优选多巴胺能神经元祖细胞的抗体。

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