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21. 发明申请

US20090101499A1 Protein-Immobilized membrane, method for immobilization of protein, enzyme-immobilized electrode, and biosensor 审中-公开
标题翻译：蛋白质固定化膜，固定蛋白质的方法，固定酶的电极和生物传感器
公开(公告)号：US20090101499A1
公开(公告)日：2009-04-23
申请号：US11920782
申请日：2006-05-18
申请人： Koji Katsuki , Hideaki Yamaoka
发明人： Koji Katsuki , Hideaki Yamaoka
IPC分类号： G01N27/26 , C12N11/16
CPC分类号： G01N27/3272 , C07K14/705 , C07K14/80 , C12N9/0006 , C12N11/06 , C12N11/08 , C12Q1/006 , G01N2333/80
摘要： The present invention relates to a protein-immobilized membrane (14) including a cell membrane homologous layer (14A) and a protein (14B) immobilized to the cell membrane homologous layer (14A), where the protein contains cytochrome or a cytochrome complex. The present invention also relates to a method for forming a protein-immobilized membrane (14), and an enzyme-immobilized electrode and a biosensor (X1) provided with a protein-immobilized membrane (14). Preferably, the cell membrane homologous layer (14A) may contain a phospholipid polymer, and the protein (14B) may be CyGDH including an α subunit having a glucose dehydrogenase activity and cytochrome C having a function of electron transfer.
摘要翻译：本发明涉及固定在细胞膜同源层（14A）上的细胞膜同源层（14A）和蛋白质（14B）的蛋白质固定化膜（14），其中蛋白质含有细胞色素或细胞色素复合物。本发明还涉及一种形成固定蛋白质的膜（14）的方法，以及具有固定蛋白质的膜（14）的酶固定化电极和生物传感器（X1）。优选地，细胞膜同源层（14A）可以含有磷脂聚合物，并且蛋白质（14B）可以是包含具有葡萄糖脱氢酶活性的α亚基和具有电子转移功能的细胞色素C的CyGDH。

22. 发明授权

US07351375B2 Implement and device for analysis 有权
标题翻译：实施和分析设备
公开(公告)号：US07351375B2
公开(公告)日：2008-04-01
申请号：US10483442
申请日：2002-07-16
申请人： Norimasa Noda , Koji Katsuki , Kotaro Kado
发明人： Norimasa Noda , Koji Katsuki , Kotaro Kado
IPC分类号： G01N33/00
CPC分类号： G01N27/3272
摘要： The present invention relates to an analyzing implement (1) having a capillary for movement of a specimen liquid. The capillary has inner surfaces (21c, 32c) provided with a first and a second opposed electrodes opposed to each other. The implement (1) includes, for example, a substrate (20), a cover (40) and a spacer (30) between the substrate (20) and the cover (40). In this case, the capillary is provided by the substrate (20), the cover (40) and the spacer (30). Preferably, capillary forming surfaces (31c, 32c) of the spacer (30) are electrically conductive, in which case the surfaces (31c, 32c) provide the first and the second electrodes.
摘要翻译：本发明涉及一种具有用于移动样本液体的毛细管的分析工具（1）。毛细管具有设置有彼此相对的第一和第二相对电极的内表面（21c，32c）。工具（1）例如包括在基板（20）和盖（40）之间的基板（20），盖（40）和间隔件（30）。在这种情况下，毛细管由基板（20），盖（40）和间隔件（30）提供。优选地，间隔件（30）的毛细管形成表面（31c，32c）是导电的，在这种情况下，表面（31c，32c）提供第一和第二电极。

23. 发明申请

US20060224658A1 Sample analyzing method and sample analyzing device 有权
标题翻译：样品分析方法和样品分析仪
公开(公告)号：US20060224658A1
公开(公告)日：2006-10-05
申请号：US10522394
申请日：2003-07-23
申请人： Yoshiharu Sato , Koji Katsuki
发明人： Yoshiharu Sato , Koji Katsuki
IPC分类号： G06G7/00
CPC分类号： G01N27/3274
摘要： This invention relates to a technique for analyzing a sample. A sample analyzer (1) provided by the invention includes: a voltage applier (12) for applying a voltage to a reaction field which includes a sample; a response measurer (13) for measurement of a response to the voltage applied to the reaction field; a selector (11) for selecting a first voltage application state for measurement of a first response for use in calculation necessary for analyzing the sample or a second voltage application state for measurement of a second response for use in determining whether or not the reaction field has been supplied with a target amount of the sample; an arithmetic operator (17) for calculation necessary for analyzing the sample based on the first response; a determiner (17) for determination, based on the second response, on whether or not the reaction field has been supplied with the target amount of sample; and a controller (15) which makes the selector select the second voltage application state after making the selector select the first voltage application state.
摘要翻译：本发明涉及一种用于分析样品的技术。本发明提供的样品分析仪（1）包括：用于对包括样品的反应场施加电压的电压施加器（12）; 响应测量器（13），用于测量对施加到反应场的电压的响应; 选择器（11），用于选择用于测量用于分析样本所需的计算的第一响应的第一电压施加状态或用于确定反应场是否具有的第二响应的第二电压施加状态已提供样品的目标量; 用于基于第一响应分析样本所需的计算的算术运算器（17）; 基于第二响应确定反应场是否已经提供了目标量的样品的确定器（17）; 以及在使选择器选择第一电压施加状态之后使选择器选择第二电压施加状态的控制器（15）。

24. 发明授权

US09357957B2 Measuring apparatus, measuring system, electric power supply apparatus, and electric power supply method 有权
标题翻译：测量装置，测量系统，电力供应装置和电力供应方法
公开(公告)号：US09357957B2
公开(公告)日：2016-06-07
申请号：US13574266
申请日：2011-01-17
申请人： Koji Katsuki , Yasunori Shiraki
发明人： Koji Katsuki , Yasunori Shiraki
IPC分类号： G01R21/00 , A61B5/1473 , G01R31/36 , H01M10/44
CPC分类号： A61B5/1473 , G01R21/00 , G01R31/36 , H01M10/44 , Y10T307/615
摘要： A technique is provided, which makes it possible to continuously supply the driving electric power stably to a sensor even when the continuous monitoring period ranges over a long period of time when the numerical information is measured in relation to a test substance contained in a sample.
摘要翻译：提供了一种技术，即使当连续监视期间在相对于包含在样本中的测试物质测量数值信息的长时间段的范围内时，也可以将驱动电力稳定地供给传感器。

25. 发明授权

US09271671B2 Sensor and method for removing interfering substance 有权
标题翻译：用于去除干扰物质的传感器和方法
公开(公告)号：US09271671B2
公开(公告)日：2016-03-01
申请号：US13641022
申请日：2011-03-28
申请人： Yasunori Shiraki , Koji Katsuki , Kazuya Iketani
发明人： Yasunori Shiraki , Koji Katsuki , Kazuya Iketani
IPC分类号： A61B5/1473 , A61B5/1486 , A61B5/00 , G01N27/327 , G01N1/34
CPC分类号： G01N27/3274 , A61B5/14735 , A61B5/14865 , A61B5/6848 , A61B5/6865 , C25F1/00 , G01N1/34 , G01N27/3272 , G01N27/40
摘要： A technique is provided, wherein any influence, which would be otherwise exerted on a reaction of an objective substance caused by a reagent enzyme by an interfering substance contained in a specimen, is suppressed in relation to an electrochemical sensor for measuring the objective substance contained in the specimen. A sensor comprises a substrate; a detecting unit which is provided on the substrate and which detects an objective substance; a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in a sample on the other hand; and removing unit which removes the interfering substance adhered to the filter.
摘要翻译：提供了一种技术，其中对于用于测量包含在试样中的干扰物质的由试剂酶引起的目标物质的反应的任何影响被抑制在与用于测量样品中所含的目标物质的电化学传感器标本。传感器包括基板; 检测单元，其设置在所述基板上并检测目标物质; 覆盖检测单元的过滤器，其一方面允许目标物质的渗透，另一方面调节包含在样品中的干扰物质的渗透; 以及去除附着在过滤器上的干扰物质的去除单元。

26. 发明申请

US20130068000A1 Sensor and Method for Removing Interfering Substance 有权
标题翻译：用于清除干扰物质的传感器和方法
公开(公告)号：US20130068000A1
公开(公告)日：2013-03-21
申请号：US13641022
申请日：2011-03-28
申请人： Yasunori Shiraki , Koji Katsuki , Kazuya Iketani
发明人： Yasunori Shiraki , Koji Katsuki , Kazuya Iketani
IPC分类号： G01N1/34
CPC分类号： G01N27/3274 , A61B5/14735 , A61B5/14865 , A61B5/6848 , A61B5/6865 , C25F1/00 , G01N1/34 , G01N27/3272 , G01N27/40
摘要： A technique is provided, wherein any influence, which would be otherwise exerted on a reaction of an objective substance caused by a reagent enzyme by an interfering substance contained in a specimen, is suppressed in relation to an electrochemical sensor for measuring the objective substance contained in the specimen. A sensor comprises a substrate; a detecting unit which is provided on the substrate and which detects an objective substance; a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in a sample on the other hand; and removing unit which removes the interfering substance adhered to the filter.
摘要翻译：提供了一种技术，其中对于用于测量包含在试样中的干扰物质的由试剂酶引起的目标物质的反应的任何影响被抑制在与用于测量样品中所含的目标物质的电化学传感器标本。传感器包括基板; 检测单元，其设置在所述基板上并检测目标物质; 覆盖检测单元的过滤器，其一方面允许目标物质的渗透，另一方面调节包含在样品中的干扰物质的渗透; 以及去除附着在过滤器上的干扰物质的去除单元。

27. 发明申请

US20120215083A1 MEASURING APPARATUS AND MEASUREMENT METHOD 有权
标题翻译：测量装置和测量方法
公开(公告)号：US20120215083A1
公开(公告)日：2012-08-23
申请号：US13377994
申请日：2010-09-13
申请人： Tomohiro Shoshihara , Yasunori Shiraki , Koji Katsuki
发明人： Tomohiro Shoshihara , Yasunori Shiraki , Koji Katsuki
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/0015 , A61B5/14865 , A61B5/6805
摘要： Disclosed is a measuring device for obtaining numerical information concerning a substance present in the interstitial subcutaneous fluid, the device being equipped with a sensor unit that outputs signals in accordance with the numerical information concerning the substance and an arithmetic unit (control unit) that receives the signals outputted from the sensor unit and arithmetically processes the signals. The sensor unit is equipped with a sensor, some of which is punctured into the skin. The arithmetic unit (control unit) has been disposed so as to be separate from the sensor unit.
摘要翻译：公开了一种用于获得关于间质性皮下液中存在的物质的数值信息的测量装置，该装置具有根据与物质相关的数值信息输出信号的传感器单元和接收该物质的算术单元（控制单元）从传感器单元输出的信号并对信号进行算术处理。传感器单元配有传感器，其中一些被刺入皮肤。算术单元（控制单元）已经被设置成与传感器单元分开。

28. 发明申请

US20120116190A1 Continuous Analysis Device And Sample Component Control System 有权
标题翻译：连续分析装置和样品组件控制系统
公开(公告)号：US20120116190A1
公开(公告)日：2012-05-10
申请号：US13381574
申请日：2010-06-25
申请人： Kazuya Iketani , Koji Katsuki , Yasuhide Kusaka
发明人： Kazuya Iketani , Koji Katsuki , Yasuhide Kusaka
IPC分类号： A61B5/145
CPC分类号： A61B5/14865 , A61B5/002 , A61B5/14532 , A61B5/6849 , A61B2560/0443 , A61B2560/0475 , A61M5/1413 , A61M5/1723 , A61M2230/201
摘要： A continuous analysis apparatus capable of transmitting information about components in body fluid to another apparatus such as medicine dosing apparatus more correctly without giving a user displeasure. The continuous analysis apparatus according to the present invention includes a sensing unit 2 including a sensor that is held in subcutaneous tissue for obtaining information with respect to an objective substance in a sample; and a data holding unit 3 having a storage means for storing the information obtained from the sensor or data corresponding to the information, the sensing unit and the data holding unit having configuration so that they are separably joined to each other.
摘要翻译：一种连续分析装置，其能够更正确地将关于体液中的成分的信息传送到另一装置，例如药剂计量装置，而不会给用户不满。根据本发明的连续分析装置包括：感测单元2，其包括保持在皮下组织中的传感器，用于获取关于样品中的目标物质的信息; 以及数据保持单元3，具有用于存储从传感器获得的信息的存储装置或与信息相对应的数据，感测单元和数据保持单元，其具有使得它们彼此可分离地接合的构造。

29. 发明申请

US20120029942A1 User-Specific Data Provision System, User-Specific Data Provision Method, Server Device, and Handheld Device 审中-公开
标题翻译：用户特定数据提供系统，用户特定数据提供方法，服务器设备和手持设备
公开(公告)号：US20120029942A1
公开(公告)日：2012-02-02
申请号：US13259907
申请日：2010-04-09
申请人： Koji Katsuki , Go Shionoya , Kazuya Iketani
发明人： Koji Katsuki , Go Shionoya , Kazuya Iketani
IPC分类号： G06Q50/24
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/117 , A61B5/14546 , A61B5/411 , G06F19/3418 , G06Q50/24
摘要： A user-specific data provision system includes: a handheld device transmitting user-specific information held specifically by a user and user's biometric information acquired by measuring biometric information of the user; the server device receiving the user-specific information and the user's biometric information; and a medical facility terminal receiving information transmitted from the server device, a server device including an access point information determining unit acquiring access point information representing an access point to which the handheld device belongs at present and determining whether the access point is changed or not, at least one of the handheld device and the server device, further including a biometric information prediction determining unit determining whether or not the user's biometric information satisfies a predetermined criterion, wherein the server device transmits the user-specific information to the medical facility terminal when determining that the access point is changed and/or when determining that the predetermined criterion is satisfied.
摘要翻译：用户特定的数据提供系统包括：手持设备发送由用户特别保存的用户特定信息和通过测量用户的生物测定信息获取的用户的生物特征信息; 所述服务器设备接收所述用户特定信息和所述用户的生物特征信息; 以及医疗设备终端，接收从服务器装置发送的信息，服务器装置包括：接入点信息确定单元，获取表示当前手持设备所属的接入点的接入点信息，并确定接入点是否改变; 所述手持设备和所述服务器设备中的至少一个还包括生物信息预测确定单元，用于确定所述用户的生物特征信息是否满足预定标准，其中，当确定所述用户特定信息时，所述服务器设备将所述用户特定信息发送到所述医疗设施终端接入点被改变和/或当确定满足预定标准时。

30. 发明申请

US20120029332A1 Method of Continuously Measuring Substrate Concentration 审中-公开
标题翻译：连续测量底物浓度的方法
公开(公告)号：US20120029332A1
公开(公告)日：2012-02-02
申请号：US13256525
申请日：2010-03-15
申请人： Koji Katsuki , Masashi Tsukada
发明人： Koji Katsuki , Masashi Tsukada
IPC分类号： A61B5/1468 , C12Q1/54 , G01N27/00
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849
摘要： Analysis equipment is provided, which is capable of fulfilling a demand for miniaturization and ensuring high sensitivity, and which can be produced easily. The present invention relates to a method of continuously measuring a substrate concentration based on a response when a voltage is applied to a sensor. The present invention includes a response voltage application step of applying a response voltage E2 at which a response attributed to a substrate is obtained and a non-response voltage application step of applying a non-response voltage E1 at which the response attributed to the substrate is not obtained or is not substantially obtained. Preferably, the response voltage application step and the non-response voltage application step are repeated alternately.
摘要翻译：提供分析设备，其能够满足小型化的需求并确保高灵敏度，并且可以容易地制造。本发明涉及一种当将电压施加到传感器时基于响应连续测量衬底浓度的方法。本发明包括：响应电压施加步骤，其施加响应电压E2，在该响应电压E2处获得归因于基板的响应;以及非响应电压施加步骤，施加响应归因于该基板的非响应电压E1 未获得或基本不获得。优选地，交替地重复响应电压施加步骤和非响应电压施加步骤。

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