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    • 21. 发明授权
    • Combination therapy to combat helminth resistance
    • 联合治疗以抵抗蠕虫抵抗
    • US08809268B2
    • 2014-08-19
    • US13126709
    • 2009-10-29
    • Raffi V. AroianYan Hu
    • Raffi V. AroianYan Hu
    • A61K38/16A61P33/10A61P33/00
    • A61K31/425A61K31/506A61K35/74A61K38/164A61K2300/00
    • Pharmaceutical compositions having at least one crystal protein and a nicotinic acetylcholine receptor agonist in amounts effective to inhibit a parasitic worm or helminth infection in a vertebrate or mammal are described. Methods for treating a parasitic worm or helminth infection in a subject are also described. The methods include administering to the subject a therapeutically effective amount of the at least one crystal protein and a nicotinic acetylcholine receptor agonist. The crystal proteins can be isolated from Bacillus thuringiensis and include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. The nicotinic acetylcholine receptor agonist can be from the levamisole family, which include levamisole, pyrantel, and tribendimidine.
    • 描述了具有至少一种晶体蛋白质和烟碱型乙酰胆碱受体激动剂的药物组合物,其有效抑制脊椎动物或哺乳动物中寄生虫或蠕虫感染的量。 还描述了治疗受试者中寄生虫或蠕虫感染的方法。 所述方法包括向受试者施用治疗有效量的至少一种晶体蛋白质和烟碱乙酰胆碱受体激动剂。 晶体蛋白可以从苏云金芽孢杆菌中分离出来,包括Cry5B,Cry21,Cry14A,Cry6A和Cry13A。 烟碱乙酰胆碱受体激动剂可以来自左旋咪唑家族,其包括左旋咪唑,吡替尼和三苯并咪唑。