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21. 发明申请

US20110040345A1 ELECTROMECHANICAL DELAY (EMD) MONITORING DEVICES, SYSTEMS AND METHODS 有权
标题翻译：电子延迟（EMD）监测装置，系统和方法
公开(公告)号：US20110040345A1
公开(公告)日：2011-02-17
申请号：US12637596
申请日：2009-12-14
申请人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61B5/02125 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1459 , A61B5/7239 , A61N1/08 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's electromechanical delay (EMD). Paced cardiac events are caused by delivering sufficient pacing stimulation to cause capture to the patient's heart. A cardiogenic impedance (CI) signal, indicative of cardiac contractile activity in response to the pacing stimulation being delivered, is obtained. One or more predetermined features of the CI signal are detected, and a value indicative of the patient's EMD is determined by determining a time between a delivered pacing stimulation and at least one of the detected one or more features of the CI signal.
摘要翻译：本文提供了可植入系统及其使用的方法，用于监测患者的机电延迟（EMD）。节奏心脏事件是通过提供足够的起搏刺激来引起对患者心脏的捕获而引起的。获得指示响应于起搏刺激被递送的心脏收缩活动的心源阻抗（CI）信号。检测CI信号的一个或多个预定特征，并且通过确定发出的起搏刺激与检测到的CI信号的一个或多个特征中的至少一个之间的时间来确定指示患者的EMD的值。

22. 发明申请

US20090062667A1 Implantable Systemic Blood Pressure Measurement Systems and Methods 有权
标题翻译：植入式系统血压测量系统和方法
公开(公告)号：US20090062667A1
公开(公告)日：2009-03-05
申请号：US11848586
申请日：2007-08-31
申请人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine
发明人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/02116 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0452 , A61B5/6846 , A61B2562/0219 , A61N1/36564 , A61N1/36578 , A61N1/36585
摘要： Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.
摘要翻译：本文提供了可植入系统及其使用方法，用于长期监测动脉血压。使用植入电极和植入的传感器获得指示患者心脏的电活动的第一信号和指示患者心脏的机械活动的第二信号。通过测量第一信号的各个特征相对于第二信号的特征之间的时间，可以确定指示收缩压和舒张压的值。在具体实施例中，这些特征用于确定峰值脉冲到达时间（PPAT），其用于确定指示收缩压的值。此外，可以使用在第二信号的最大峰值处的峰 - 峰幅度和指示收缩压的值来确定指示舒张压的值。

23. 发明授权

US07181276B1 Device and method for preventing the acceleration of cardiac arrhythmias 失效
标题翻译：用于预防心律失常加速的装置和方法
公开(公告)号：US07181276B1
公开(公告)日：2007-02-20
申请号：US10901403
申请日：2004-07-27
申请人： Rose Province , Timothy A. Fayram
发明人： Rose Province , Timothy A. Fayram
IPC分类号： A61N1/38
CPC分类号： A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： An exemplary method includes detecting ventricular fibrillation, delivering a low voltage cardiac stimulus, determining whether the low voltage cardiac stimulus terminated the ventricular fibrillation, and delivering a higher voltage cardiac stimulus if the low voltage cardiac stimulus did not terminate the ventricular fibrillation. In one example, the delivering the low voltage cardiac stimulus occurs within approximately 10 event intervals from the detected onset of ventricular fibrillation; otherwise, delivery of an appropriate higher voltage cardiac stimulus occurs. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心室颤动，递送低电压心脏刺激，确定低电压心脏刺激是否终止心室颤动，以及如果低电压心脏刺激未终止心室颤动则递送较高电压的心脏刺激。在一个示例中，递送低电压心脏刺激发生在从检测到的心室颤动起始的大约10个事件间隔内; 否则，发生适当的较高电压心脏刺激的传递。还公开了其它示例性方法，装置，系统等。

24. 发明授权

US07130183B1 Stackable capacitor having opposed contacts for an implantable electronic medical device 有权
公开(公告)号：US07130183B1
公开(公告)日：2006-10-31
申请号：US11346664
申请日：2006-02-03
申请人： Timothy A. Fayram
发明人： Timothy A. Fayram
IPC分类号： H01G2/10 , A61N1/18
CPC分类号： H01G9/008 , A61N1/3975 , A61N1/3981
摘要： An implantable cardioverter-defibrillator has a housing containing cardioverter-defibrillator circuitry and a capacitor assembly. The capacitor assembly includes at least two flat capacitors each having opposed major surfaces. Each capacitor has an anode contact at one major surface, and a cathode contact at the opposite major surface. The anode contact of one of the capacitors contacts the cathode contact of the other. Each capacitor contact may be a thin metal plate covering the entire surface of the capacitor, with each plate connected to corresponding interleaved cathode or anode flat sheets between the plates. A non-conductive perimeter may enclose the sheets and connect the plates to each other.

25. 发明授权

US5792199A Pacemaker having rate responsive transducer and method for operating same 失效
标题翻译：起搏器具有速率响应传感器及其操作方法
公开(公告)号：US5792199A
公开(公告)日：1998-08-11
申请号：US900083
申请日：1997-07-24
申请人： Timothy A. Fayram , Bruce Kirkpatrick
发明人： Timothy A. Fayram , Bruce Kirkpatrick
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： An implantable cardiac pacemaker having a housing containing pacing circuitry, a signal generator, and an electromagnetic transducer. The transducer has an electrical input line connected to the signal generator, and an electrical output line connected to the pacing circuitry. Consequently, a forcing motion on the transducer sends an electrical signal to the pacing circuitry, and operation of the signal generator causes the transducer to vibrate. The pacemaker may also include a disablement switch connected to the signal generator, with the signal generator operating in response to activation of the switch to cause the transducer to generate an audible warning tone while the pacemaker is disabled.
摘要翻译：一种可植入心脏起搏器，其具有包含起搏电路的壳体，信号发生器和电磁换能器。换能器具有连接到信号发生器的电输入线和连接到起搏电路的电输出线。因此，换能器上的强制运动将电信号发送到起搏电路，并且信号发生器的操作导致换能器振动。起搏器还可以包括连接到信号发生器的禁用开关，信号发生器响应于开关的激活而操作，以使得在起搏器被禁用时，换能器产生可听见的警告音。

26. 发明授权

US08548587B2 Devices, systems and methods for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis 有权
$Devices, systems and methods for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis$
标题翻译：用于表征心动过速和/或使用分级分析结果选择治疗心动过速的装置，系统和方法
公开(公告)号：US08548587B2
公开(公告)日：2013-10-01
申请号：US13090079
申请日：2011-04-19
申请人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
发明人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3702
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. At least one of the EGM signal(s) is analyzed to determine whether the EGM signal is fractionated, and the results of the analyzing are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译：本文提供了可植入系统及其使用的方法，用于表征心动过速和/或使用分级分析结果选择治疗心动过速。获得指示心脏电活动的一个或多个电描记图（EGM）信号。分析至少一个EGM信号以确定EGM信号是否被分级，并且分析结果用于表征心动过速和/或选择心动过速的治疗。

27. 发明授权

US08321017B2 Electromechanical delay (EMD) monitoring devices, systems and methods 有权
标题翻译：机电延迟（EMD）监测装置，系统和方法
公开(公告)号：US08321017B2
公开(公告)日：2012-11-27
申请号：US12637596
申请日：2009-12-14
申请人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61N1/368
CPC分类号： A61N1/36585 , A61B5/02125 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1459 , A61B5/7239 , A61N1/08 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： Implantable systems, and methods for use therewith, enable the monitoring of a patient's electromechanical delay (EMD) and arterial blood pressure. Paced cardiac events are caused by delivering sufficient pacing stimulation to cause capture. A cardiogenic impedance (CI) signal, indicative of cardiac contractile activity in response to the pacing stimulation being delivered, is obtained. One or more predetermined features of the CI signal are detected, and a value indicative of the patient's EMD is determined by determining a time between a delivered pacing stimulation and at least one of the detected one or more features of the CI signal. The value indicative of EMD can be used to more accurately determine metrics indicative of pulse arrival time (PAT), which can be used to estimate arterial blood pressure.
摘要翻译：可植入系统及其使用的方法能够监测患者的机电延迟（EMD）和动脉血压。节奏心脏事件是由提供足够的起搏刺激引起的捕获引起的。获得指示响应于起搏刺激被递送的心脏收缩活动的心源阻抗（CI）信号。检测CI信号的一个或多个预定特征，并且通过确定发出的起搏刺激与检测到的CI信号的一个或多个特征中的至少一个之间的时间来确定指示患者的EMD的值。可以使用指示EMD的值来更精确地确定指示脉冲到达时间（PAT）的度量，其可用于估计动脉血压。

28. 发明申请

US20120271368A1 DEVICES, SYSTEMS AND METHODS FOR CHARACTERIZING A TACHYCARDIA AND/OR SELECTING TREATMENT FOR A TACHYCARDIA USING RESULTS OF A FRACTIONATION ANALYSIS 有权
标题翻译：使用分析分析结果表征TACHYCARDIA和/或选择TACHYCARDIA处理的装置，系统和方法
公开(公告)号：US20120271368A1
公开(公告)日：2012-10-25
申请号：US13090079
申请日：2011-04-19
申请人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
发明人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3702
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. At least one of the EGM signal(s) is analyzed to determine whether the EGM signal is fractionated, and the results of the analyzing are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译：本文提供了可植入系统及其使用的方法，用于表征心动过速和/或使用分级分析结果选择治疗心动过速。获得指示心脏电活动的一个或多个电描记图（EGM）信号。分析至少一个EGM信号以确定EGM信号是否被分级，并且分析结果用于表征心动过速和/或选择心动过速的治疗。

29. 发明申请

US20120271367A1 DEVICES, SYSTEMS, AND METHODS FOR CHARACTERIZING A TACHYCARDIA AND/OR SELECTING TREATMENT FOR A TACHYCARDIA USING RESULTS OF A DOMINANT FREQUENCY ANALYSIS 有权
标题翻译：使用主要频率分析结果表征TACHYCARDIA和/或选择TACHYCARDIA处理的设备，系统和方法
公开(公告)号：US20120271367A1
公开(公告)日：2012-10-25
申请号：US13090059
申请日：2011-04-19
申请人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
发明人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61B5/04014 , A61B5/0464 , A61B5/7257 , A61N1/3622
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a dominant frequency analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. For at least one of the EGM signal(s) a dominant frequency (DF) analysis is performed, and the results of the DF analysis are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译：本文提供的可植入系统及其使用的方法用于表征心动过速和/或使用主频率分析的结果来选择治疗心动过速。获得指示心脏电活动的一个或多个电描记图（EGM）信号。对于至少一个EGM信号进行主频（DF）分析，并且DF分析的结果用于表征心动过速和/或选择心动过速的治疗。

30. 发明申请

US20120215275A1 IMPLANTABLE SYSTEMS AND METHODS FOR USE THEREWITH FOR MONITORING AND MODIFYING ARTERIAL BLOOD PRESSURE WITHOUT REQUIRING AN INTRAVASCULAR PRESSURE TRANSDUCER 有权
标题翻译：不需要输血管压力传感器的可植入式系统和方法，用于监测和修改血管内血压
公开(公告)号：US20120215275A1
公开(公告)日：2012-08-23
申请号：US13033484
申请日：2011-02-23
申请人： Brian Jeffrey Wenzel , Michael E. Benser , Taraneh Ghaffari Farazi , Timothy A. Fayram , Edward Karst , Allen Keel , Wenbo Hou , Jong Gill
发明人： Brian Jeffrey Wenzel , Michael E. Benser , Taraneh Ghaffari Farazi , Timothy A. Fayram , Edward Karst , Allen Keel , Wenbo Hou , Jong Gill
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61B5/0031 , A61B5/02125 , A61B5/02158 , A61B5/02416 , A61B5/042 , A61B5/0452 , A61N1/36507 , A61N1/36585
摘要： Embodiments of the present invention are directed to implantable systems, and methods for use therewith, that monitor and modify a patient's arterial blood pressure without requiring an intravascular pressure transducer. In accordance with an embodiment, for each of a plurality of periods of time, there is a determination one or more metrics indicative of pulse arrival time (PAT), each of which are indicative of how long it takes for the left ventricle to generate a pressure pulsation that travels from the patient's aorta to a location remote from the patient's aorta. Based on the one or more metrics indicative of PAT, the patient's arterial blood pressure is estimated. Changes in the arterial blood pressure are monitored over time. Additionally, the patient's arterial blood pressure can be modified by initiating and/or adjusting pacing and/or other therapy based on the estimates of the patient's arterial blood pressure and/or monitored changes therein.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，其不需要血管内压力传感器来监测和修改患者的动脉血压。根据实施例，对于多个时间段中的每一个，存在确定指示脉搏到达时间（PAT）的一个或多个指标，每个指标指示左心室产生多长时间从患者主动脉行进到远离患者主动脉的位置的压力脉动。基于指示PAT的一个或多个指标，估计患者的动脉血压。随着时间的推移监测动脉血压的变化。此外，可以通过基于患者的动脉血压的估计和/或其中监测的变化来启动和/或调整起搏和/或其他治疗来改变患者的动脉血压。

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