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21. 发明授权

US06899711B2 Ablation catheter and method for isolating a pulmonary vein 失效
标题翻译：消融导管和隔离肺静脉的方法
公开(公告)号：US06899711B2
公开(公告)日：2005-05-31
申请号：US10414779
申请日：2003-04-16
申请人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
发明人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
IPC分类号： A61B17/00 , A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.
摘要翻译：一种用于治疗心律失常（例如心房颤动）的导管组件和方法，通过诸如左心房的腔室电隔离血管（例如肺静脉）。导管组件包括导管主体和至少一个电极。导管主体包括近端部分，中间部分和远端部分。中间部分从近端部分延伸并且限定纵向轴线。远侧部分从中间部分延伸并且形成横向于纵向轴线的基本上闭合的环。沿着环设置至少一个电极。利用这种构造，环路被轴向地指向与容器孔周围的室壁接触。在通电时，电极消除围绕血管口的连续病变图案，从而将容器与腔室电隔离。

22. 发明授权

US06773433B2 Ablation catheter and method for isolating a pulmonary vein 有权
标题翻译：消融导管和隔离肺静脉的方法
公开(公告)号：US06773433B2
公开(公告)日：2004-08-10
申请号：US10414757
申请日：2003-04-16
申请人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
发明人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
IPC分类号： A61B1814
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.
摘要翻译：一种用于治疗心律失常（例如心房颤动）的导管组件和方法，通过诸如左心房的腔室电隔离血管（例如肺静脉）。导管组件包括导管主体和至少一个电极。导管主体包括近端部分，中间部分和远端部分。中间部分从近端部分延伸并且限定纵向轴线。远侧部分从中间部分延伸并且形成横向于纵向轴线的基本上闭合的环。沿着环设置至少一个电极。利用这种构造，环路被轴向地指向与容器孔周围的室壁接触。在通电时，电极消除围绕血管口的连续病变图案，从而将容器与腔室电隔离。

23. 发明授权

US08512337B2 Method and system for treatment of atrial tachyarrhythmias 有权
标题翻译：治疗房性快速性心律失常的方法和系统
公开(公告)号：US08512337B2
公开(公告)日：2013-08-20
申请号：US10923073
申请日：2004-08-20
申请人： David E. Francischelli , Rahul Mehra
发明人： David E. Francischelli , Rahul Mehra
IPC分类号： A61B18/12
CPC分类号： A61B18/1445 , A61B18/1402 , A61B2017/2945 , A61B2018/00994 , A61B2018/126 , A61B2018/1432 , A61B2018/1472
摘要： A method of and a system for treatment of atrial tachyarrhythmias. The system includes a set of hemostats having elongated opposing jaws carrying mechanisms for applying ablation energy along the jaws. The jaws having straight and curved configurations selected to allow arrangement of the jaws of along opposite sides of walls of a patient's atrium. Treatment is accomplished by applying of ablation energy to the walls of a patient's artria to create lines of lesion corresponding generally to incisions employed in a Maze type procedure.
摘要翻译：一种治疗房性快速性心律失常的方法和系统。该系统包括一组具有延长的相对的夹爪的止血器，该钳口携带用于沿钳口施加消融能量的机构。钳口具有直的和弯曲的构造，其被选择为允许沿着病人心房的壁的相对侧布置钳口。通过将消融能量施加到患者的肌肉的壁上来实现治疗，以产生通常对于迷宫类型手术中使用的切口相应的损伤线。

24. 发明授权

US07435250B2 Method and apparatus for tissue ablation 有权
标题翻译：组织消融的方法和装置
公开(公告)号：US07435250B2
公开(公告)日：2008-10-14
申请号：US11061425
申请日：2005-02-18
申请人： David E. Francischelli , Richard H. Comben , Michael F. Hoey , Rahul Mehra , Jon M. Ocel , Robert Pearson , Paul V. Trescony , Scott E. Jahns
发明人： David E. Francischelli , Richard H. Comben , Michael F. Hoey , Rahul Mehra , Jon M. Ocel , Robert Pearson , Paul V. Trescony , Scott E. Jahns
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/1445 , A61B2018/00065 , A61B2018/00351 , A61B2018/00577 , A61B2018/1435 , A61B2018/1472 , A61B2218/002
摘要： A device for ablating tissue is provided. The device comprises a conductive element with a channel for irrigating fluid formed therein, which is in contact with a non-conductive microporous interface. All or a portion of the interface may be removable. When the interface is removed, a portion of the conductive element is exposed for use in ablating tissue. Methods of using the device and of removing the interface are also provided.
摘要翻译：提供了用于消融组织的装置。该装置包括导电元件，其具有用于在其中形成的冲洗流体的通道，其与非导电微孔界面接触。界面的全部或部分可以是可移动的。当界面被去除时，导电元件的一部分被暴露以用于消融组织。还提供了使用设备和移除界面的方法。

25. 发明授权

US06807968B2 Method and system for treatment of atrial tachyarrhythmias 有权
标题翻译：治疗房性快速性心律失常的方法和系统
公开(公告)号：US06807968B2
公开(公告)日：2004-10-26
申请号：US10015690
申请日：2001-12-12
申请人： David E. Francischelli , Rahul Mehra
发明人： David E. Francischelli , Rahul Mehra
IPC分类号： A61B1818
CPC分类号： A61B18/1445 , A61B18/1402 , A61B2017/2945 , A61B2018/00994 , A61B2018/126 , A61B2018/1432 , A61B2018/1472
摘要： A method of and a system for treatment of atrial tachyarrhythmias. The system includes a set of hemostats having elongated opposing jaws carrying mechanisms for applying ablation energy along the jaws. The jaws having straight and curved configurations selected to allow arrangement of the jaws of along opposite sides of walls of a patient's atrium. Treatment is accomplished by applying of ablation energy to the walls of a patient's artria to create lines of lesion corresponding generally to incisions employed in a Maze type procedure.
摘要翻译：一种治疗房性快速性心律失常的方法和系统。该系统包括一组具有延长的相对的夹爪的止血器，该钳口携带用于沿钳口施加消融能量的机构。钳口具有直的和弯曲的构造，其被选择为允许沿着病人心房的壁的相对侧布置钳口。通过将消融能量施加到患者的肌肉的壁上来实现治疗，以产生通常对于迷宫类型手术中使用的切口相应的损伤线。

26. 发明授权

US5439484A Defibrillator employing transvenous and subcutaneous electrodes 失效
标题翻译：除颤器采用经静脉和皮下电极
公开(公告)号：US5439484A
公开(公告)日：1995-08-08
申请号：US230962
申请日：1994-04-21
申请人： Rahul Mehra
发明人： Rahul Mehra
IPC分类号： A61N1/04 , A61N1/05 , A61N1/375 , A61N1/39
CPC分类号： A61N1/375 , A61N1/05 , A61N1/0563
摘要： A defibrillation pulse generator and lead system particularly adapted to allow for implant in a single incision and subcutaneous pocket. The electrode system consists of a right ventricular electrode and a combined, subcutaneously implanted pulse generator housing and flexible periprerally extending electrode. The flexible electrode extends in a generally co-planar relation with respect to the major surfaces of the device housing and may comprise a plurality of electrode segments electrically connected in common with the device housing and distributed over a flexible electrode pad.
摘要翻译：除颤脉冲发生器和引导系统特别适于允许植入在单个切口和皮下袋中。电极系统由右心室电极和组合的，皮下植入的脉冲发生器壳体和柔性的周边延伸电极组成。柔性电极相对于器件壳体的主表面大致共平面地延伸，并且可以包括与器件外壳电连接并分布在柔性电极焊盘上的多个电极段。

27. 发明授权

US5356425A Method and apparatus for treatment of atrial fibrillation and flutter 失效
标题翻译：用于治疗房颤和扑动的方法和装置
公开(公告)号：US5356425A
公开(公告)日：1994-10-18
申请号：US82327
申请日：1993-06-24
申请人： Gust H. Bardy , Rahul Mehra
发明人： Gust H. Bardy , Rahul Mehra
IPC分类号： A61N1/362 , A61N1/365 , A61N1/372
CPC分类号： A61N1/3621 , A61N1/3622 , A61N1/36585
摘要： A stimulator for applying stimulus pulses to the AV nodal fat pad in response to sensed atrial rate exceeding a predetermined rate, in order to reduce the ventricular rate. The device also includes a cardiac pacemaker which serves to pace the ventricle in the event that the ventricular rate is lowered below a pacing rate, and provides for feedback control of the stimulus parameters applied to the AV nodal fat pad, as a function of the determined effect of the stimulus pulses on the ventricular rate.
摘要翻译：用于响应于超过预定速率的感测心房速率将刺激脉冲施加到AV节点脂肪垫的刺激器，以便降低心室率。该装置还包括心脏起搏器，其用于在心室率降低到起搏速率以下的情况下对心室进行调节，并且根据确定的功能提供对应用于AV节点脂肪垫的刺激参数的反馈控制刺激脉冲对心室率的影响。

28. 发明授权

US5165403A Difibrillation lead system and method of use 失效
标题翻译：分散引线系统及其使用方法
公开(公告)号：US5165403A
公开(公告)日：1992-11-24
申请号：US661568
申请日：1991-02-26
申请人： Rahul Mehra
发明人： Rahul Mehra
IPC分类号： A61N1/39
CPC分类号： A61N1/3918 , A61N1/395
摘要： A method of cardioverting the atrium of a human heart, comprising insertion of first and second elongated electrodes tranvenously into the heart and associated vessels. One electrode is preferably located in the coronary sinus and great vein of the heart. The other electrode is preferably located in the vicinity of the atrium of the heart, spaced from the electrode located in the coronary sinus. In response to detection of fibrillation or in response to manual triggering, a defibrillation pulse is applied between the first and second electrodes to effect atrial cardioversion.
摘要翻译：一种心脏转移心脏心房的方法，包括将第一和第二细长电极静脉插入心脏和相关血管。一个电极优选位于冠状窦和心脏的大静脉。另一个电极优选位于与位于冠状窦中的电极间隔开的心脏心房附近。响应于原纤维的检测或响应于手动触发，在第一和第二电极之间施加除颤脉冲以实现心房复律。

29. 发明授权

US5144960A Transvenous defibrillation lead and method of use 失效
标题翻译：变形导线及其使用方法
公开(公告)号：US5144960A
公开(公告)日：1992-09-08
申请号：US672285
申请日：1991-03-20
申请人： Rahul Mehra , Paul DeGroot , Marye S. Norenberg
发明人： Rahul Mehra , Paul DeGroot , Marye S. Norenberg
IPC分类号： A61N1/04 , A61N1/05 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/0563
摘要： An implantable transvenous defibrillation/cardioversion lead. The lead extends from a proximal end carrying electrical connectors to a bifurcated distal end. Distal to the bifurcation are a first, generally straight leg and a second, curved leg. In use, the distal end of the first, generally straight leg is located in the apex of the right ventricle and the distal end of the second, generally curved leg is located in the outflow tract from the right ventricle, with the point of bifurcation located approximately adjacent the tricuspid valve. Elongated coil electrodes are provided extending along the straight and curved legs, distal to the point of bifurcation of lead. The lead may be used in conjunction with a subcutaneous or othe additional defibrillation/cardioversion electrode.
摘要翻译：可植入静脉除颤/心脏复律导联。引线从承载电连接器的近端延伸到分叉的远端。分叉的远端是第一个，一般是直的腿和一个第二个弯曲的腿。在使用中，第一个大致直的腿部的远端位于右心室的顶点，第二个大致弯曲的腿部的远端位于右心室的流出道中，分叉点位于大致邻近三尖瓣。细长的线圈电极沿着直线和弯曲的腿延伸，远离铅的分叉点。铅可以与皮下或额外的除颤/心脏复律电极结合使用。

30. 发明授权

US08834464B2 Ablation catheters and associated systems and methods 有权
标题翻译：消融导管及相关系统和方法
公开(公告)号：US08834464B2
公开(公告)日：2014-09-16
申请号：US13560942
申请日：2012-07-27
申请人： Mark T. Stewart , James Skarda , David E. Francischelli , Rahul Mehra
发明人： Mark T. Stewart , James Skarda , David E. Francischelli , Rahul Mehra
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00065 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00375 , A61B2018/00404 , A61B2018/00898 , A61B2018/1407 , A61B2018/1435 , A61B2018/1472
摘要： An ablation catheter assembly includes an elongate catheter body having a proximal portion, a distal portion and a lumen therethrough. A helical structure associated with the catheter distal portion carries a plurality of independently operable electrodes and is transformable between a low-profile configuration wherein a straightening element is positioned in the lumen and an expanded configuration wherein the straightening element is at least partially retracted from the spiral structure. When the helical structure is in the expanded configuration, a laterally offset tip portion extends distally therefrom.
摘要翻译：消融导管组件包括细长的导管主体，其具有近端部分，远侧部分和通过其中的内腔。与导管远端部分相关联的螺旋结构携带多个可独立操作的电极，并可在其中矫正元件位于内腔中的低轮廓构型和扩张构型之间变形，其中矫正元件至少部分地从螺旋结构体。当螺旋结构处于膨胀构型时，横向偏移的尖端部分从其向远侧延伸。

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