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21. 发明授权

US08628650B2 Method and apparatus for measuring isoelectric point using field effect transistor 失效
标题翻译：使用场效应晶体管测量等电点的方法和装置
公开(公告)号：US08628650B2
公开(公告)日：2014-01-14
申请号：US13058120
申请日：2008-12-16
申请人： Chil Seong Ah , Ansoon Kim , Chan Woo Park , Chang-Geun Ahn , Jong-Heon Yang , In Bok Baek , Taeyoub Kim , Gun Yong Sung , Seon-Hee Park , Han Young Yu
发明人： Chil Seong Ah , Ansoon Kim , Chan Woo Park , Chang-Geun Ahn , Jong-Heon Yang , In Bok Baek , Taeyoub Kim , Gun Yong Sung , Seon-Hee Park , Han Young Yu
IPC分类号： B03C5/02
CPC分类号： G01N27/4145
摘要： Provided are a method and apparatus for measuring an isoelectric point using a field effect transistor. The method includes providing a field effect transistor including a substrate, source and drain electrodes disposed on the substrate and spaced apart from each other, and a channel region between the source and drain electrodes, providing a first electrolyte solution having a first concentration to the channel region of the field effect transistor and measuring a first current value of the channel region between the source and drain electrodes, providing a second electrolyte solution having a second concentration greater than the first concentration and measuring a second current value of the channel region between the source and drain electrodes, and determining the isoelectric point of the field effect transistor or a material disposed on the field effect transistor using a difference between the first and second current values.
摘要翻译：提供了使用场效应晶体管测量等电点的方法和装置。该方法包括提供场效应晶体管，该场效应晶体管包括衬底，设置在衬底上的源电极和漏极彼此间隔开的沟道区，以及在源电极和漏电极之间的沟道区域，提供具有第一浓度到沟道的第一电解质溶液区域，并且测量源极和漏极之间的沟道区的第一电流值，提供具有大于第一浓度的第二浓度的第二电解质溶液，并测量源极之间的沟道区的第二电流值和漏电极，并且使用第一和第二电流值之间的差来确定场效应晶体管的等电点或设置在场效应晶体管上的材料。

22. 发明授权

US08529750B2 Apparatus and method for detecting biomolecules 有权
标题翻译：用于检测生物分子的装置和方法
公开(公告)号：US08529750B2
公开(公告)日：2013-09-10
申请号：US13062146
申请日：2008-11-20
申请人： Chil-Seong Ah , Ansoon Kim , Chan-Woo Park , Chang-Geun Ahn , Jong-Heon Yang , In-Bok Baek , Taeyoub Kim , HyeKyoung Yang , Gun-Yong Sung , Seon-Hee Park , Han-Young Yu , Moon-Gyu Jang
发明人： Chil-Seong Ah , Ansoon Kim , Chan-Woo Park , Chang-Geun Ahn , Jong-Heon Yang , In-Bok Baek , Taeyoub Kim , HyeKyoung Yang , Gun-Yong Sung , Seon-Hee Park , Han-Young Yu , Moon-Gyu Jang
IPC分类号： G01N27/414
CPC分类号： G01N33/54373 , B01L3/502761 , B01L2200/143 , B01L2300/0636 , B01L2300/0645 , B01L2300/0867 , B01L2300/163 , B01L2400/0415 , G01N27/4145
摘要： Provided are an apparatus and method for detecting biomolecules. The apparatus includes a FET having a substrate, a source electrode, a drain electrode, a channel region between the source and drain electrodes, and probe molecules fixed to the channel region, wherein the source and drain electrodes are separated on the substrate, a microfluid supplier selectively supplying one of a reference buffer solution of low ionic concentration and a reaction solution of high ionic concentration containing target molecules, to the channel region of the FET to which the probe molecules are fixed, and a biomolecule detector detecting the target molecules by measuring a first current value of the channel region of the FET, and a second current value of the channel region of the FET to which the target molecules and the probe molecules that bind to each other in the reaction solution of high ionic concentration are fixed.
摘要翻译：提供了用于检测生物分子的装置和方法。该装置包括具有基板，源电极，漏电极，源极和漏极之间的沟道区以及固定到沟道区的探针分子的FET，其中源极和漏极在衬底上分离，微流体供应商选择性地将低离子浓度的参考缓冲溶液和含有靶分子的高离子浓度的反应溶液中的一种提供给探针分子固定的FET的通道区域，以及通过测量来检测靶分子的生物分子检测器 FET的沟道区域的第一电流值和在高离子浓度的反应溶液中彼此结合的靶分子和探针分子的FET的沟道区域的第二电流值是固定的。

23. 发明授权

US08018595B2 Apparatus for detecting bio materials and method for detecting bio materials by using the apparatus 有权
标题翻译：用于检测生物材料的装置和使用该装置检测生物材料的方法
公开(公告)号：US08018595B2
公开(公告)日：2011-09-13
申请号：US12406851
申请日：2009-03-18
申请人： Chul Huh , Kyung Hyun Kim , Hyunsung Ko , Wanjoong Kim , Gun Yong Sung , Seon-Hee Park , Bong-Kyu Kim
发明人： Chul Huh , Kyung Hyun Kim , Hyunsung Ko , Wanjoong Kim , Gun Yong Sung , Seon-Hee Park , Bong-Kyu Kim
IPC分类号： G01N21/00
CPC分类号： G01N21/77 , G01N21/554 , G01N2021/7783
摘要： Provided is an apparatus for detecting bio materials and a method for detecting bio materials by using the apparatus. The apparatus includes a bio material reacting unit, an optical source unit, and a detecting unit. The bio material reacting unit includes bio sensing materials immobilized on gold nanoparticles. The optical source unit emits light toward the bio material reacting unit. The detecting unit measures variations of surface absorbance of the gold nanoparticles by detecting light transmitted through the bio material reacting unit before and after a bio material is bound to the bio sensing materials.
摘要翻译：提供了一种用于检测生物材料的装置和通过使用该装置检测生物材料的方法。该装置包括生物材料反应单元，光源单元和检测单元。生物材料反应单元包括固定在金纳米颗粒上的生物传感材料。光源单元向生物材料反应单元发射光。检测单元通过在生物材料结合到生物传感材料之前和之后检测透过生物材料反应单元的光来测量金纳米颗粒的表面吸光度的变化。

24. 发明申请

US20100227419A1 LAB-ON-A-CHIP AND METHOD OF DRIVING THE SAME 有权
标题翻译： LAB-ON-A-CHIP及其驱动方法
公开(公告)号：US20100227419A1
公开(公告)日：2010-09-09
申请号：US12738683
申请日：2008-10-17
申请人： Moon-Youn Jung , Dong-Ho Shin , Minsuk Jeong , Sanghee Kim , Hye-Yoon Kim , Seon-Hee Park
发明人： Moon-Youn Jung , Dong-Ho Shin , Minsuk Jeong , Sanghee Kim , Hye-Yoon Kim , Seon-Hee Park
IPC分类号： G01N33/543 , G01N33/53 , G01N30/00
CPC分类号： G01N33/49
摘要： Provided is a lab-on-a-chip. The lab-on-a-chip includes a first region where a lower substrate and an upper substrate are bonded to each other, a second region where the lower and upper substrates are not bonded, and a gap adjusting member disposed at an end of the second region that is opposite to a boundary between the first and second regions, the gap adjusting member being configured to adjust a gap between the first and second substrates to control a capillary force.
摘要翻译：提供了一个芯片实验室。芯片实验室包括下基板和上基板彼此接合的第一区域，下基板和上基板未接合的第二区域，以及设置在该基板的末端的间隙调节构件所述第二区域与所述第一和第二区域之间的边界相对，所述间隙调节构件被配置为调节所述第一和第二基板之间的间隙以控制毛细管力。

25. 发明申请

US20090112480A1 METHOD AND APPARATUS FOR CLUSTERING GENE EXPRESSION PROFILES BY USING GENE ONTOLOGY 审中-公开
标题翻译：通过使用基因本体聚集基因表达谱的方法和装置
公开(公告)号：US20090112480A1
公开(公告)日：2009-04-30
申请号：US12053315
申请日：2008-03-21
申请人： Minho Kim , Ho-Youl Jung , Myunggeun Chung , Pora Kim , Soo-Jun Park , Seon-Hee Park
发明人： Minho Kim , Ho-Youl Jung , Myunggeun Chung , Pora Kim , Soo-Jun Park , Seon-Hee Park
IPC分类号： G01N33/48
CPC分类号： G16B25/00 , G16B5/00
摘要： Provided are a method and apparatus for clustering gene expression profiles by using the Gene Ontology (GO). The method includes: selecting one or more GO terms from a GO tree; receiving gene expression data sets; classifying the gene expression data sets into groups according to the GO terms; firstly clustering gene expression data belonging to each of the groups based on a similarity of the gene expression data; and secondly clustering the gene expression data sets by using the result of the first clustering as a seed.
摘要翻译：提供了通过使用基因本体（GO）聚类基因表达谱的方法和装置。该方法包括：从GO树中选择一个或多个GO条款; 接收基因表达数据集; 根据GO条款将基因表达数据集分为组; 首先基于基因表达数据的相似性对属于每个组的基因表达数据进行聚类; 其次使用第一次聚类的结果作为种子对基因表达数据集进行聚类。

26. 发明授权

US5857979A Method for analyzing electroencephalogram using correlation dimension 失效
标题翻译：使用相关维度分析脑电图的方法
公开(公告)号：US5857979A
公开(公告)日：1999-01-12
申请号：US892940
申请日：1997-07-15
申请人： Chang-Su Ryu , Seon-Hee Park , Seung-Hwan Kim
发明人： Chang-Su Ryu , Seon-Hee Park , Seung-Hwan Kim
IPC分类号： A61B10/00 , A61B5/0476 , G06F17/00
CPC分类号： A61B5/0476
摘要： This invention provides a method for analyzing an electroencephalogram(EEG) using the correlation dimension by which the brain states can be discriminated. The method uses a time-delay determining method necessary for reconstructing vectors from the EEG time series, and a relative ratio of a correlation exponent.
摘要翻译：本发明提供了一种使用相关维度分析脑电图（EEG）的方法，通过该维度可以区分大脑状态。该方法使用从EEG时间序列重建矢量所需的时间延迟确定方法以及相关指数的相对比。

27. 发明授权

US08805621B2 Apparatus and method for comparing protein structure using 3D RDA and Fourier descriptor 有权
标题翻译：使用3D RDA和傅里叶描述符比较蛋白质结构的装置和方法
公开(公告)号：US08805621B2
公开(公告)日：2014-08-12
申请号：US11928672
申请日：2007-10-30
申请人： Chan-Yong Park , Sung-Hee Park , Dae-Hee Kim , Soo-Jun Park , Seon-Hee Park
发明人： Chan-Yong Park , Sung-Hee Park , Dae-Hee Kim , Soo-Jun Park , Seon-Hee Park
IPC分类号： G01N31/00 , G06F19/16 , G06F19/10
CPC分类号： G06F19/16 , G06F19/10
摘要： Provided is an apparatus and method for comparing a protein structure, which can search a protein similar to an inquiry protein in a 3D protein database in real time by describing a feature of a protein structure by using a three-dimensional (3D) relative directional angle (RDA) and a Fourier descriptor. The apparatus includes: a 3D RDA coder configured to code a 3D RDA of a target protein data or an inquiry protein data inputted from the outside; a Fourier transformer configured to obtain Fourier coefficients by Fourier transforming 3D RDA coding values coded by the 3D RDA coder; a comparator configured to compare the obtained Fourier coefficient of the target protein data with the obtained Fourier coefficient of the inquiry protein data; and a data generator configured to output protein data in order from high similarity to low similarity according to the comparison result of the comparator.
摘要翻译：提供了一种用于比较蛋白质结构的装置和方法，其可以通过使用三维（3D）相对方向角度描述蛋白质结构的特征来实时搜索与3D蛋白质数据库中的查询蛋白质相似的蛋白质（RDA）和傅立叶描述符。该装置包括：3D RDA编码器，被配置为对目标蛋白质数据的3D RDA或从外部输入的查询蛋白质数据进行编码; 傅立叶变换器，被配置为通过傅里叶变换来获得傅里叶系数，所述三维RDA编码值由3D RDA编码器编码; 比较器，将获得的目标蛋白质数据的傅立叶系数与所求得的蛋白质数据的傅里叶系数进行比较; 以及数据生成器，其被配置为根据比较器的比较结果从高相似性到低相似性的顺序输出蛋白质数据。

28. 发明授权

US08394595B2 Lab-on-a-chip and method of driving the same 有权
标题翻译：芯片实验室及其驱动方法
公开(公告)号：US08394595B2
公开(公告)日：2013-03-12
申请号：US12738683
申请日：2008-10-17
申请人： Moon-Youn Jung , Dong-Ho Shin , Minsuk Jeong , Sanghee Kim , Hye-Yoon Kim , Seon-Hee Park
发明人： Moon-Youn Jung , Dong-Ho Shin , Minsuk Jeong , Sanghee Kim , Hye-Yoon Kim , Seon-Hee Park
IPC分类号： G01N33/53
CPC分类号： G01N33/49
摘要： Provided is a lab-on-a-chip. The lab-on-a-chip includes a first region where a lower substrate and an upper substrate are bonded to each other, a second region where the lower and upper substrates are not bonded, and a gap adjusting member disposed at an end of the second region that is opposite to a boundary between the first and second regions, the gap adjusting member being configured to adjust a gap between the first and second substrates to control a capillary force.
摘要翻译：提供了一个芯片实验室。芯片实验室包括下基板和上基板彼此接合的第一区域，下基板和上基板未接合的第二区域，以及设置在该基板的末端的间隙调节构件所述第二区域与所述第一和第二区域之间的边界相对，所述间隙调节构件被配置为调节所述第一和第二基板之间的间隙以控制毛细管力。

29. 发明申请

US20110165557A1 APPARATUS AND METHOD FOR DETECTING BIOMOLECULES 有权
标题翻译：检测生物分子的装置和方法
公开(公告)号：US20110165557A1
公开(公告)日：2011-07-07
申请号：US13062146
申请日：2008-11-20
申请人： Chil-Seong Ah , Ansoon Kim , Chan-Woo Park , Chang-Geun Ahn , Jong-Heon Yang , In-Bok Baek , Taeyoub Kim , HyeKyoung Yang , Gun-Yong Sung , Seon-Hee Park , Han-Young Yu , Moon-Gyu Jang
发明人： Chil-Seong Ah , Ansoon Kim , Chan-Woo Park , Chang-Geun Ahn , Jong-Heon Yang , In-Bok Baek , Taeyoub Kim , HyeKyoung Yang , Gun-Yong Sung , Seon-Hee Park , Han-Young Yu , Moon-Gyu Jang
IPC分类号： C12Q1/70 , G01N27/00 , C12M1/34 , G01N27/416 , G01N33/53 , G01N33/00 , G01N33/573
CPC分类号： G01N33/54373 , B01L3/502761 , B01L2200/143 , B01L2300/0636 , B01L2300/0645 , B01L2300/0867 , B01L2300/163 , B01L2400/0415 , G01N27/4145
摘要： Provided are an apparatus and method for detecting biomolecules. The apparatus includes a FET having a substrate, a source electrode, a drain electrode, a channel region between the source and drain electrodes, and probe molecules fixed to the channel region, wherein the source and drain electrodes are separated on the substrate, a microfluid supplier selectively supplying one of a reference buffer solution of low ionic concentration and a reaction solution of high ionic concentration containing target molecules, to the channel region of the FET to which the probe molecules are fixed, and a biomolecule detector detecting the target molecules by measuring a first current value of the channel region of the FET, and a second current value of the channel region of the FET to which the target molecules and the probe molecules that bind to each other in the reaction solution of high ionic concentration are fixed.
摘要翻译：提供了用于检测生物分子的装置和方法。该装置包括具有基板，源电极，漏电极，源极和漏极之间的沟道区以及固定到沟道区的探针分子的FET，其中源极和漏极在衬底上分离，微流体供应商选择性地将低离子浓度的参考缓冲溶液和含有靶分子的高离子浓度的反应溶液中的一种提供给探针分子固定的FET的通道区域，以及通过测量来检测靶分子的生物分子检测器 FET的沟道区域的第一电流值和在高离子浓度的反应溶液中彼此结合的靶分子和探针分子的FET的沟道区域的第二电流值是固定的。

30. 发明申请

US20110139637A1 METHOD AND APPARATUS FOR MEASURING ISOELECTRIC POINT USING FIELD EFFECT TRANSISTOR 失效
标题翻译：使用场效应晶体管测量电压点的方法和装置
公开(公告)号：US20110139637A1
公开(公告)日：2011-06-16
申请号：US13058120
申请日：2008-12-16
申请人： Chil Seong Ah , Ansoon Kim , Chan Woo Park , Chang-Geun Ahn , Jong-Heon Yang , In Bok Baek , Taeyoub Kim , Gun Yong Sung , Seon-Hee Park , Han Young Yu
发明人： Chil Seong Ah , Ansoon Kim , Chan Woo Park , Chang-Geun Ahn , Jong-Heon Yang , In Bok Baek , Taeyoub Kim , Gun Yong Sung , Seon-Hee Park , Han Young Yu
IPC分类号： G01N27/403 , G01N27/414
CPC分类号： G01N27/4145
摘要： Provided are a method and apparatus for measuring an isoelectric point using a field effect transistor. The method includes providing a field effect transistor including a substrate, source and drain electrodes disposed on the substrate and spaced apart from each other, and a channel region between the source and drain electrodes, providing a first electrolyte solution having a first concentration to the channel region of the field effect transistor and measuring a first current value of the channel region between the source and drain electrodes, providing a second electrolyte solution having a second concentration greater than the first concentration and measuring a second current value of the channel region between the source and drain electrodes, and determining as the isoelectric point of the field effect transistor or a material disposed on the field effect transistor using a difference between the first and second current values.
摘要翻译：提供了使用场效应晶体管测量等电点的方法和装置。该方法包括提供场效应晶体管，该场效应晶体管包括衬底，设置在衬底上的源电极和漏极彼此间隔开的沟道区，以及在源电极和漏电极之间的沟道区域，提供具有第一浓度到沟道的第一电解质溶液区域，并且测量源极和漏极之间的沟道区的第一电流值，提供具有大于第一浓度的第二浓度的第二电解质溶液，并测量源极之间的沟道区的第二电流值和漏电极，并且使用第一和第二电流值之间的差来确定场效应晶体管的等电点或设置在场效应晶体管上的材料。

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