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21. 发明授权

US06945128B2 Fluid dispenser 有权
标题翻译：流体分配器
公开(公告)号：US06945128B2
公开(公告)日：2005-09-20
申请号：US09896649
申请日：2001-06-29
申请人： Anthony Ford , Darin McDaniel , Stephen Mead , William Richards , Wayne Showalter , Bobbi Druyor-Sanchez , Bronwen Heilman , Brian McGraw
发明人： Anthony Ford , Darin McDaniel , Stephen Mead , William Richards , Wayne Showalter , Bobbi Druyor-Sanchez , Bronwen Heilman , Brian McGraw
IPC分类号： G01N1/00 , A47K5/12 , B67D7/06 , G01N1/30 , G01N1/31 , G01N35/00 , G01N35/10 , B01L3/02
CPC分类号： G01N35/1016 , G01N1/312 , G01N35/00871 , G01N35/1002 , G01N2001/317 , G01N2035/00881 , G01N2035/1034 , Y10T137/7873 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.
摘要翻译：提供了一种用于自动生物反应系统的方法和装置。在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

22. 发明申请

US20050202292A1 Portable fuel cell power supply 审中-公开
标题翻译：便携式燃料电池电源
公开(公告)号：US20050202292A1
公开(公告)日：2005-09-15
申请号：US11075892
申请日：2005-03-10
申请人： William Richards , Alan Volker , Jaspal Brar
发明人： William Richards , Alan Volker , Jaspal Brar
IPC分类号： H01M8/04 , H01M8/10
CPC分类号： H01M8/04089 , H01M8/04201 , H01M8/04208 , H01M8/0432 , H01M8/04365 , H01M8/0444 , H01M8/04664 , H01M8/04686 , H01M2008/1095 , H01M2250/30 , Y02B90/18
摘要： A portable proton exchange membrane fuel cell power supply system has a high pressure hydrogen gas supply that is provided from hydrogen storage cylinders that are enclosed in a case that has through holes for ventilation to prevent hydrogen gas concentrations from reaching explosive levels. Enclosed in a second case are a fuel cell stack, control unit, variable speed air compressor and power inverter. The cases incorporate lightweight, high-strength non-metallic materials and foam insulation to render the contents shock resistant. In operation a hydrogen gas connection line is made to extend between the hydrogen cylinders and the fuel cell that is connected through quick disconnect valves. The compressor is also connected to the fuel cell through a quick disconnect valve. Start up of the fuel cell is accomplished with a battery supplying power to the compressor while hydrogen gas is supplied at the same time.
摘要翻译：便携式质子交换膜燃料电池电源系统具有由氢气储存筒提供的高压氢气供应，所述氢气储存缸被封闭在具有用于通风的通孔的壳体中，以防止氢气浓度达到爆炸水平。封闭在第二种情况是燃料电池堆，控制单元，变速空气压缩机和电力逆变器。这些情况包括轻质，高强度非金属材料和泡沫绝缘，使内容物抗冲击。在操作中，氢气连接管线在氢气缸和通过快速断开阀连接的燃料电池之间延伸。压缩机还通过快速断开阀连接到燃料电池。在同时供给氢气的同时，通过向压缩机供电的电池来实现燃料电池的启动。

23. 发明申请

US20050135972A1 Method and apparatus for modifying pressure within a fluid dispenser 审中-公开
标题翻译：用于改变流体分配器内的压力的方法和装置
公开(公告)号：US20050135972A1
公开(公告)日：2005-06-23
申请号：US10913932
申请日：2004-08-06
申请人： Charles Lemme , Vincent Rizzo , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
发明人： Charles Lemme , Vincent Rizzo , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
IPC分类号： G01N1/31 , G01N35/00 , G01N35/10 , B01L3/00
CPC分类号： G01N1/312 , G01N35/1002 , G01N35/1016 , G01N2001/317 , G01N2035/1034
摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.
摘要翻译：提供了一种用于自动生物反应系统的方法和装置。在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

24. 发明授权

US08147773B2 Method and apparatus for modifying pressure within a fluid dispenser 有权
标题翻译：用于改变流体分配器内的压力的方法和装置
公开(公告)号：US08147773B2
公开(公告)日：2012-04-03
申请号：US13050707
申请日：2011-03-17
申请人： Charles D. Lemme , Vincent R. Rizzo, Jr. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
发明人： Charles D. Lemme , Vincent R. Rizzo, Jr. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
IPC分类号： B01L3/02
CPC分类号： G01N1/312 , G01N35/1002 , G01N35/1016 , G01N2001/317 , G01N2035/1034
摘要： A fluid dispenser useful in automated biological reaction systems comprising a barrel having a reservoir chamber, the barrel having an upper portion and a lower portion, a cap located on top of the upper portion of the barrel and connected to the reservoir chamber, the cap having an external surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being located in the hole in the cap at the point where a downward force is applied against the cap, a coupler having a dispense chamber, the coupler being coaxial with the barrel and wherein the barrel lower portion moves into the dispense chamber during dispensing of fluid, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.
摘要翻译：一种用于自动生物反应系统的流体分配器，包括具有储存室的桶，所述桶具有上部和下部，盖位于桶的上部的顶部并连接到储存室，盖具有具有穿过其中的至少一个孔的外表面，包括偏置构件和孔封闭器的阀，所述阀位于所述盖中的向下施加在所述盖上的点处的孔中;耦合器，具有分配室耦合器与筒同轴，并且其中筒子下部在分配流体期间移动到分配室中，并且位于盖和储存室之间的通风口，排气口包括通气口和由矾土材料构成的排气材料。

25. 发明授权

US07378055B2 Automated molecular pathology apparatus having fixed slide platforms 有权
标题翻译：具有固定滑动平台的自动分子病理装置
公开(公告)号：US07378055B2
公开(公告)日：2008-05-27
申请号：US10424372
申请日：2003-04-28
申请人： Charles Lemme , Devon Campbell , Andrew Ghusson , David Bryant , Kurt Reinhardt , William Richards , Vincent Rizzo , Wayne Showalter
发明人： Charles Lemme , Devon Campbell , Andrew Ghusson , David Bryant , Kurt Reinhardt , William Richards , Vincent Rizzo , Wayne Showalter
IPC分类号： G01N35/10
CPC分类号： G01N1/312 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides.
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂，洗涤和盖玻片溶液带到载玻片上。或者，幻灯片保持在固定位置，同时将试剂，洗涤和盖玻片溶液带到载玻片上。

26. 发明申请

US20080038836A1 AUTOMATED HIGH VOLUME SLIDE STAINING SYSTEM 有权
标题翻译：自动高容积滑动系统
公开(公告)号：US20080038836A1
公开(公告)日：2008-02-14
申请号：US11876059
申请日：2007-10-22
申请人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter
发明人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter
IPC分类号： G01N35/00
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.
摘要翻译：一种自动滑块处理装置，包括以堆叠方式布置的多个工作站，以及用于在各个工作站之间运送滑块的运输/升降机。

27. 发明授权

US07146894B2 Automated microtome blade changer 失效
公开(公告)号：US07146894B2
公开(公告)日：2006-12-12
申请号：US09844833
申请日：2001-04-27
申请人： Kendall B. Hendrick , Darin McDaniel , Miroslav Holubec , William Richards , Vincent Rizzo
发明人： Kendall B. Hendrick , Darin McDaniel , Miroslav Holubec , William Richards , Vincent Rizzo
IPC分类号： B26D7/26
CPC分类号： G01N1/06 , Y10S83/954 , Y10T83/18 , Y10T83/6492 , Y10T83/6536 , Y10T83/9457
摘要： An automated rotary microtome blade changing apparatus, comprising an upper stage being adapted to releasably engage a supply cartridge and a waste cartridge, the upper stage having a loading segment adapted to engage and move blades contained within the supply cartridge into a cutting position; clamping means for releasably holding the blades in place for cutting operations; power means for driving the movement of blades and clamping mechanisms; and electronic control means for integrating all of the functions of the apparatus.

28. 发明授权

US07121789B2 Arrangement for mounting a non-rotating component 有权
标题翻译：用于安装非旋转部件的布置
公开(公告)号：US07121789B2
公开(公告)日：2006-10-17
申请号：US10910336
申请日：2004-08-04
申请人： William Richards
发明人： William Richards
IPC分类号： F01D25/24
CPC分类号： F01D25/246 , F01D9/042
摘要： An arrangement 22 for mounting a non-rotating component 28 of a gas turbine engine 10, defining a portion of a gas path of the gas turbine engine 10 comprising: a non-rotating component 28 having an opening 23 to a receptacle 25; and a fastener 30 for retaining the non-rotating component 28, comprising a neck portion 34 and a head portion 32, wherein the neck portion 34 of the fastener 30 extends through the opening 23 in the non-rotating component 28 and the head portion 32 is retained, at least partially, within the receptacle 25.
摘要翻译：用于安装燃气涡轮发动机10的非旋转部件28的装置22，其限定燃气涡轮发动机10的气体路径的一部分，包括：具有开口23的非旋转部件28到容器25; 以及用于保持非旋转部件28的紧固件30，其包括颈部34和头部32，其中紧固件30的颈部34延伸穿过非旋转部件28中的开口23和头部32 至少部分地保持在容器25内。

29. 发明申请

US20050114035A1 Method for binding site identification 审中-公开
标题翻译：方法用于结合位点识别
公开(公告)号：US20050114035A1
公开(公告)日：2005-05-26
申请号：US10502583
申请日：2003-01-20
申请人： Daniel Robinson , William Richards , Meir Glick
发明人： Daniel Robinson , William Richards , Meir Glick
IPC分类号： C12N9/00 , C07K2/00 , C12Q1/37 , C12Q1/42 , C12Q1/68 , C40B30/02 , G01N33/48 , G01N33/50 , G06F19/16 , G06F19/18 , G06F19/00
CPC分类号： G16B15/00 , G16B20/00 , G16B35/00 , G16C20/60
摘要： A method for identifying a binding site for a ligand on a macromolecule and the configuration of the ligand when bound, said method comprising using a multiscale approach to represent the ligand as a plurality of models having different levels of detail.
摘要翻译：用于鉴定大分子上的配体的结合位点和结合时配体的配置的方法，所述方法包括使用多尺度方法将配体表示为具有不同细节水平的多个模型。

30. 发明授权

US06582962B1 Automated molecular pathology apparatus having independent slide heaters 有权
公开(公告)号：US06582962B1
公开(公告)日：2003-06-24
申请号：US09690296
申请日：2000-10-17
申请人： William Richards , Charles D. Lemme , Kimberly Christensen , Ethel R. Macrea
发明人： William Richards , Charles D. Lemme , Kimberly Christensen , Ethel R. Macrea
IPC分类号： G01N3500
CPC分类号： G01N35/1002 , G01N1/30 , G01N1/31 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platforms radially mounted to the carousel for heating the slides and sensing the temperature of each. The heating system also permits automated de-waxing if necessary.

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